ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 887 • 2019 ACR/ARP Annual Meeting

    Critical Role of the Cholinergic System Involvement in Osteoarthritis

    Alice Courties1, Ariane Do 1, Sarah Leite 2, Audrey Pigenet 2, Morgane Belle 3, Geoffroy Nourissat 4, Alain Sautet 5, Alain Chedotal 3, Uwe Maskos 6, Francis Berenbaum 7 and Jérémie Sellam 1, 1Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, 2Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, 3Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France, Paris, France, 4Chirurgie orthopédique, Clinique Maussins, Groupe Ramsay générale de santé, 67 rue de Romainville, 75019, Paris, Paris, France, 5Chirurgie orthopédique, AP-HP Hôpital Saint-Antoine, Paris, Paris, France, 6Unité de neurobiologie intégrative des systèmes cholinergiques, CNRS UMR 3571, Institut Pasteur, Paris, Paris, France, 7Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France

    Background/Purpose: The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred as the 'cholinergic anti-inflammatory pathway'. ACh interacts with members of…
  • Abstract Number: 979 • 2019 ACR/ARP Annual Meeting

    Platelet Derived Growth Factor Receptor Alpha (PDGFRα) Blockade Inhibits Arthritis in Mice

    Bhanupriya Madarampalli1, Paul Panipinto 1, Erica Chow 1, Kendahl Sugai 1, Fanqi Shi 1 and Erika Noss 1, 1University of Washington, Seattle, WA

    Background/Purpose: The interplay between infiltrating immune cells and activated joint stromal cells drives inflammation, cartilage destruction, and bone erosion in rheumatoid arthritis (RA). Among joint…
  • Abstract Number: 1228 • 2019 ACR/ARP Annual Meeting

    Soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM-1) Ameliorates Monosodium Urate Crystals (MSUC)-induced Inflammation in a Mouse Air-pouch Model of Gout

    Vitaly Kliminski 1 and Yair Molad2, 1Laboratory of Inflammation Research, Felsenstein Medical Research Center, Tel Aviv University, Petach Tikva, Israel, 2Rabin Medical Center, Beilinson Hospital, and Tel Aviv University, Petach Tikva, HaMerkaz, Israel

    Background/Purpose: Myeloid cells membrane-bound TREM-1 (mTREM-1) amplifies toll like receptor (TLR)-4-mediated myeloid cells activation, accompanied by release of soluble TREM-1 (sTREM-1) that acts as a…
  • Abstract Number: 1521 • 2019 ACR/ARP Annual Meeting

    Ixekizumab Is Effective in the Treatment of Radiographic Axial Spondyloarthritis Regardless of the Level of C-Reactive Protein or Magnetic Resonance Imaging Scores

    Walter P. Maksymowych1, Gaia Gallo 2, Rebecca Bolce 3, Fangyi Zhao 2, Vladimir Geneus 3, Mikkel Østergaard 4, Kurisu Tada 5, Atul Deodhar 6 and Lianne Gensler 7, 1University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, 2Eli Lilly and Company, Indianapolis, IN, 3Eli Lilly and Company, Indianapolis, 4Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, 5Juntendo University School of Medicine, Tokyo, Japan, 6Oregon Health & Science University, Portland, OR, 7University San Francisco California, San Francisco, CA

    Background/Purpose: IL-17 plays an important role in the pathogenesis of radiographic axial spondyloarthritis (r-axSpA). Elevated CRP levels in serum predict response to TNF inhibitors (TNFi).1-4…
  • Abstract Number: 1910 • 2019 ACR/ARP Annual Meeting

    Inflammatory Processes in Experimental Spondyloarthritis Are Accompanied by Formation of Ectopic Lymphoid Structures and B Cell Lineage Alterations in the Bone Marrow

    Merlijn Kaaij1, Jan Piet van Hamburg 1, Jasper Rip 2, George Kollias 3, Leonie van Duivenvoorde 1, Martijn Nolte 4, Dominique Baeten 1 and Sander Tas 1, 1Amsterdam Rheumatology & immunology Center, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands, 2Department of Pulmonary Medicine, Erasmus MC, Rotterdam, Rotterdam, Netherlands, 3Division of Immunology, Biomedical Sciences Center ”Alexander Fleming”, Vari, Greece, Vari, Greece, 4Sanquin Research and Landsteiner Laboratory, Molecular & Cellular Hemostasis, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Tumour necrosis factor a (TNF) is important in immune-mediated inflammatory diseases such as spondyloarthritis (SpA). Transmembrane (tm)TNF-transgenic (tg) mice that overexpress tmTNF develop typical…
  • Abstract Number: 1973 • 2019 ACR/ARP Annual Meeting

    Protective Effects of Intra-Articular Formulated Liraglutide in Osteoarthritis: Preclinical Studies

    Francis Berenbaum1, Coralie Meurot 2, Margot Vieubled 2, Laure Sudre 3, carole bougault 4, revital rattenbach 2, celine martin 2 and claire jacques 5, 1Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France, 24P Pharma, Lille, France, 3Sorbonne Université-Inserm CDR Saint-Antoine, paris, France, 4Université de Lyon - CNRS, lyon, France, 5Sorbonne Université-Inserm CDR Saint-Antoine, Paris

    Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease affecting millions of individuals worldwide. Its development has been reported to be associated with cartilage degradation and…
  • Abstract Number: 1992 • 2019 ACR/ARP Annual Meeting

    Adenosine A2A Receptor (A2AR) Stimulation Mitigates Mitochondrial Inflammaging, Enhances Mitochondrial Metabolism and Reduces Reactive Oxygen Species-Mediated Mitochondrial Injury In Vitro and In Vivo in Osteoarthritis

    Cristina Castro1, Carmen Corciulo 2, Maria Solecio 3, Benjamin Friedman 4, Fengxia Liang 5, Zhi Li 6, Samson Jacob 7, David Fenyo 8, Evgeny Pavlov 9 and Bruce Cronstein 4, 1Immunology and Inflammation Training Program at Skirball Institute of Graduate Biomolecular Sciences, New York University School of Medicine (NYUSoM), NYC, 2Division of Translational Medicine NYUSoM, NYC, 3NYU College of Dentistry, NYC, 4Department of Medicine, Division of Rheumatology NYUSoM, NYC, 5Department of Cell Biology, NYU Langone Health, NYC, 6Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYU Langone Helalth, NYC, 7Institute for Systems Genetics, NYU Langone Health, NYC, 8Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYC, 9Basic Science and Craniofacial Biology, NYU College of Dentistry, NYC

    Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population and one of the contributing factors in OA…
  • Abstract Number: 2154 • 2019 ACR/ARP Annual Meeting

    Role of Insulin Resistance and Inflammation on Resting Energy Expenditure in Patients with Rheumatoid Arthritis

    Beatriz Hanaoka1 and Barbara Gower 2, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham

    Background/Purpose: In patients with rheumatoid arthritis(RA), elevated resting energy expenditure(REE) is associated with rheumatoid cachexia and protein catabolism driven by pro-inflammatory cytokines. IR is also…
  • Abstract Number: 2355 • 2019 ACR/ARP Annual Meeting

    Antirheumatic Therapy Is Associated with Reduced Complement Activation in Rheumatoid Arthritis

    Thao Nguyen1, Ingrid Hokstad 2, Gia Deyab 3, Tom Eirik Mollnes 4, Stefan Agewall 4, Morten Fagerland 4, Gro Eilertsen 5, Mark Feinberg 6, Knut Mikkelsen 2, Øystein Førre 4 and Ivana Hollan 7, 1Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 2Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Oppland, Norway, 3Innlandet Hospital Trust, Bærum, Akershus, Norway, 4Oslo University Hospital, Oslo, Norway, 5The Artic University of Norway, Tromsø, Norway, 6Harvard Medical School and Brigham and Women´s Hospital, Boston, Boston, MA, 7Lillehammer Hospital for Rheumatic Diseases and Brigham and Women’s Hospital, Boston, Lillehammer, Oppland, Norway

    Background/Purpose: Inflammation and immune dysregulation appear to significantly contribute to increased risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA). The complement system is a…
  • Abstract Number: 2779 • 2019 ACR/ARP Annual Meeting

    Higher Disease Activity Is Associated with More Spinal Radiographic Progression in Patients with Axial Spondyloarthritis Independently of Prior Exposure to TNF Inhibitors

    Alexandre Sepriano1, Sofia Ramiro 2, Stephanie Wichuk 3, Praveena Chiowchanwisawakit 4, Terrie MacCosham 3, Joel Paschke 5, Désirée van der Heijde 1, Robert B.M. Landewé 6 and Walter Maksymowych 7, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, 3University of Alberta, Edmonton, Canada, 4Mahidol University, Bangkok, Thailand, 5CARE Arthritis, Edmonton, Canada, 6Amsterdam University Medical Center, Amsterdam, Netherlands, 7University of Alberta and CARE Arthritis, Edmonton, Canada

    Background/Purpose: The association between disease activity and spinal radiographic progression in radiographic axial spondyloarthritis (r-axSpA) has been previously shown in a cohort of patients (pts)…
  • Abstract Number: 4 • 2019 ACR/ARP Annual Meeting

    AMP Deaminase 2 Surface Expression Counteracting CD73-Driven Generation of Anti-Inflammatory Extracellular Adenosine

    Lisa Ehlers1, Aditi Kuppe 1, Cindy Strehl 1, Marieluise Kirchner 2, Frank Buttgereit 3 and Timo Gaber 1, 1Charite University Hospital Berlin, Berlin, Germany, 2Max Delbrück Center for Molecular Medicine, BIH Core Facility Proteomics, Berlin, Germany, 3Charité-Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: Adenosine and its nucleotides represent crucial immunomodulators in the extracellular environment. ATP and ADP are released from stressed cells in states of inflammation, whereas…
  • Abstract Number: 24 • 2019 ACR/ARP Annual Meeting

    Role of Trained Immunity in the Pathogenesis of Erdheim-Chester Disease

    Giulio Cavalli1, Riccardo Biavasco 1, Marina Ferrarini 2, Elisabetta Ferrero 2, Eugenio Montini 2, Simone Cenci 2, Cardaci Simone 2 and Lorenzo Dagna 1, 1Vita-Salute San Raffaele University, Milan, Italy, 2IRCCS San Raffaele Hospital, Milan, Italy

    Background/Purpose: Erdheim-Chester disease (ECD) is a chronic inflammatory disease characterized by infiltration of bone and other tissues by foamy macrophages. These cells exhibit activating mutations…
  • Abstract Number: 27 • 2019 ACR/ARP Annual Meeting

    Altered Inflammatory Response of Macrophages in the Fosl-2 Transgenic Mouse Model of Systemic Sclerosis

    Chantal Rufer 1, Michal Rudnik1, Siim Uhtjärv 1, Mara Stellato 1, Florian Renoux 2, Oliver Distler 3 and Gabriela Kania 1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, 3Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Fos-like 2 (Fosl-2) is a transcription factor belonging to the Fos family of proteins which is part of the AP-1 transcription complex. The Fosl-2…
  • Abstract Number: 819 • 2019 ACR/ARP Annual Meeting

    The Long Noncoding RNA HOTTIP Regulates Cell Cycle and Inflammatory Response in Hand Synovial Fibroblasts

    Mojca Frank-Bertoncelj 1, Tadeja Kuret2, Ana Županič 3, Snezna Sodin-Semrl 4, Oliver Distler 5 and Caroline Ospelt 1, 1University Hospital Zürich, Zürich, Switzerland, 2University Hospital Zürich, Zurich, Tajikistan, 3University Hospital Zürich, Zurich, Switzerland, 4University Medical Center Ljubljana, Ljubljana, Slovenia, 5Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Previously we showed that the long noncoding RNA (lncRNA) HOTTIP is exclusively expressed in synovial fibroblasts (SF) from distal joints, such as small joints…
  • Abstract Number: 854 • 2019 ACR/ARP Annual Meeting

    Do Smoking and Socio-economic Factors Independently Influence Imaging Outcomes in Axial Spondyloarthritis? Five-year Data from the DESIR Cohort

    Elena Nikiphorou1, Sofia Ramiro 2, Alexandre Sepriano 3, Adeline Ruyssen Witrand 4, Robert B.M. Landewé 5 and Désirée van der Heijde 3, 1King's College London, London, United Kingdom, 2Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, 3Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology center, Pierre Paul Riquet Hospital, CHU of Toulouse, Paul Sabatier University, UMR 1027, Inserm, France, Toulouse, France, 5Amsterdam University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Smoking and systemic inflammation have been shown to independently associate with radiographic spinal progression in patients with axSpA. Evidence suggests that certain socioeconomic (SE)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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