ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 1000 • ACR Convergence 2021

    Molecular Mechanism of Inhibition of CD38 in Attenuation of Monosodium Urate Crystal-induced Inflammatory Responses in Macrophages

    Huaping Qin1, Patricia Oliveira1, Tiffany Yan1, Robert Terkeltaub2 and Ru Liu Bryan3, 1University of California San Diego, La Jolla, CA, 2VA/UCSD, San Diego, CA, 3University of California San Diego and VASDHS, San Diego, CA

    Background/Purpose: CD38 can function as a degrading enzyme of nicotinamide adenine dinucleotide (NAD), a critical metabolic intermediate serving as enzyme cofactor in redox reactions and…
  • Abstract Number: 1349 • ACR Convergence 2021

    Joint-specific Responses to Tofacitinib and Adalimumab in Patients with Psoriatic Arthritis: Post Hoc Analysis of a Phase 3 Study

    Adrian Ciurea1, Tim Killeen2, Raphael Micheroli1, Norina N Gassman2, Hyejin Jo3, Kenneth Kwok4, Elizabeth Kudlacz4, Oliver Distler1, Caroline Ospelt5 and Mojca Frank-Bertoncelj1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland, 2Pfizer AG, Zurich, Switzerland, 3Pfizer Inc, Groton, CT, 4Pfizer Inc, New York, NY, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

    Background/Purpose: Peripheral joint involvement in PsA varies. In RA, varied joint involvement may reflect site-specific differences in stromal cell transcriptome, including Janus kinase-signal transducer and…
  • Abstract Number: 1809 • ACR Convergence 2021

    Efficacy of Tofacitinib on Enthesitis in Patients with Active Psoriatic Arthritis

    Philip Mease1, Ana-Maria Orbai2, Oliver FitzGerald3, Mohamed Bedaiwi4, Dona L Fleishaker5, Rajiv Mundayat6, Pamela Young7 and Philip S Helliwell8, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland, 4Division of Rheumatology, College of Medicine, King Saud University Medical City, Riyadh, Saudi Arabia, 5Pfizer Inc, Groton, CT, 6Pfizer Inc, New York, NY, 7Pfizer Inc, Collegeville, PA, 8Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Enthesitis (inflammation where the tendon, ligament, or joint capsule insert into the bone) has been associated with higher disease activity and reduced quality of…
  • Abstract Number: 0049 • ACR Convergence 2021

    CC-99677, a Novel, Selective, Oral MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production and Ameliorates Inflammation in the Mannan-Induced Murine Model of Psoriasis and Psoriatic Arthritis

    Rajula Gaur, Kofi Mensah, Jason Stricker, Anastasia Parton, Dorota Cedzik and Francisco Ramírez-Valle, Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: Mitogen-activated protein kinase-activated protein kinase-2 (MK2), a direct downstream target of p38, has been identified as a promising candidate for treatment of inflammatory diseases.…
  • Abstract Number: 0508 • ACR Convergence 2021

    The Impact of Macrophages Stimulated with Malondialdehyde-Acetaldehyde And/or Citrulline Modified Proteins on Fibroblasts Activation

    Nozima Aripova, Michael Duryee, Evan Ryan, Peter Maloley, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: In rheumatoid arthritis (RA), chronic synovial inflammation is accompanied by fibrotic responses that together lead to pannus formation and progressive joint damage. Exposure to…
  • Abstract Number: 1001 • ACR Convergence 2021

    Exosomes Mediate a Cooperative Mechanism of Macrophage/Fibroblast Activation in Systemic Sclerosis

    Rajan Bhandari1, Heetaek Yang2, Noelle Kosarek3, Michael Whitfield4 and Patricia Pioli1, 1Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Geisel School of Medicine, Hanover, NH, 3Dartmouth Geisel School of Medicine, Hartford, VT, 4Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Prior work demonstrates that macrophages (MØs) from patients with Systemic Sclerosis (SSc) produce fibrotic and pro-inflammatory mediators and that cocultured MØs and SSc fibroblasts…
  • Abstract Number: 1426 • ACR Convergence 2021

    Genotype and Transfusion Dependence Predicts Mortality in VEXAS Syndrome, a Newly Described Disease with Overlap Inflammatory and Hematologic Features

    Marcela Ferrada1, Sinisa Savic2, Hugh Alessi3, Daniela Ospina4, Lorena Wilson5, Wendy Goodspeed6, Tannaz Kermani7, Kenneth Warrington8, Matthew Koster8, Bhavisha Patel9, Patrycja Hoffmann10, James Poulter11, Rachel Tattersall12, Amanda Ombrello1, Christopher Duncan13, Elspeth Payne14, Karoline Krause15, Hanna Bonnekoh16, Daniel Kastner17, Peter Grayson18 and David Beck1, 1National Institutes of Health, Bethesda, MD, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 3National Institutes of Health, Bethesda, Maryland, 4NIH/NHGRI, Bethesda, MD, 5National Institutes of Health, Silver Spring, MD, 6National Institutes of Health (NIH), Bethesda, MD, 7University of California Los Angeles, Los Angeles, CA, 8Mayo Clinic, Rochester, MN, 9National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 10National Institutes of Health, Vienna, VA, 11University of Leeds, Leeds, United Kingdom, 12Sheffield Teaching Hospitals NHS Foundation, Sheffield, United Kingdom, 13Translational and Clinical Research institute, Immunity and Inflammation Theme, Newcastle, United Kingdom, 14University College London, Cancer Institute, London, United Kingdom, 15Department of Dermatology and Allergy, Charité, Berlin, Germany, 16Department of Dermatology and Allergy, Charité, Berlin, United Kingdom, 17National Human Genome Research Institute, Bethesda, MD, 18National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly defined disease cause by myeloid-restricted somatic mutations in blood. Missense mutations at codon…
  • Abstract Number: 1822 • ACR Convergence 2021

    Relationships Between Dermatologic Symptoms and Health-related Quality of Life in Patients with Psoriatic Arthritis: Post Hoc Analysis of Two Phase 3 Studies

    Peter C Taylor1, Andrew G Bushmakin2, Joseph C Cappelleri2, Pamela Young3, Rebecca Germino2, Joseph Merola4 and Gil Yosipovitch5, 1University of Oxford, Oxford, United Kingdom, 2Pfizer Inc, Groton, CT, 3Pfizer Inc, Collegeville, PA, 4Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 5University of Miami Miller School, Florida, FL

    Background/Purpose: Dermatologic symptoms of PsA can substantially impact patient (pt) health‑related quality of life (HRQoL);1 itch is the most commonly reported, and among the most…
  • Abstract Number: 0055 • ACR Convergence 2021

    Time Course of Intestinal Permeability and Intestinal Inflammation in Rat Adjuvant-induced Arthritis

    Sophie Hecquet1, Perle Totoson2, Marie-Paule Algros3, Hélène Martin2, Célian Peyronnel2, Maude Tournier2, Clement Prati1, Daniel Wendling1, Céline Demougeot2 and Frank Verhoeven1, 1Service de rhumatologie, CHU de Besançon, Besançon, France, 2PEPITE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, 3Service d'anatomopathologie, CHU de Besançon, Besançon, France

    Background/Purpose: Intestinal inflammation (I-Inf) and increased intestinal permeability (IP) and intestinal damage (ID) have been observed in patients with spondyloarthritis (SpA). However, whether these changes…
  • Abstract Number: 0511 • ACR Convergence 2021

    Tumor Necrosis Factor-α Modulates Endothelial-to-mesenchymal Transition and Increases Protein Tyrosine Phosphatase 1B

    Jorge Romo-Tena1, Jose Esparza-Lopez2, Carmelo Carmona-Rivera3, Luz P blanco3, Mariana Kaplan4 and María de Jesús Ibarra-Sánchez2, 1INNSZ / NIAMS, Mexico City, Mexico, 2INNSZ, Mexico City, Mexico, 3NIAMS, Bethesda, MD, 4National Institutes of Health, Bethesda, MD

    Background/Purpose: Endothelial dysfunction is a hallmark in the pathogenesis of many inflammatory diseases. The endothelial-to-mesenchymal transition (EndoMT) is a process where endothelial cells lose their…
  • Abstract Number: 1006 • ACR Convergence 2021

    MAA Modified and/or Citrullinated Proteins Stimulate Macrophages and Human Fibroblast-Like Synoviocytes to Increase the Secretion/Expression of Fractalkine Ligand (CX3CL1) and Fractalkine Receptor (CX3CR1)

    Nozima Aripova, Michael Duryee, Peter Maloley, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: In rheumatoid arthritis (RA) synovium, activated synovial fibroblasts and macrophages release inflammatory mediators that affect surrounding cells and accelerate disease progression. One such chemokine…
  • Abstract Number: 1439 • ACR Convergence 2021

    Inhibitors of Endogenous Reverse Transcriptases Suppress in Vitro Type I Interferon Responses and in Vivo Antigen-specific T Cell Responses

    Nafeeza Hafeez, Jimmy Zhong, Jared Steranka, Margit Hagel, Greg Bisacchi, Donna Romero, Rosana Kapeller, Dennis Zaller and Wenyan Miao, Rome Therapeutics, Cambridge, MA

    Background/Purpose: Transposable elements (TEs) are mobile DNA elements that can replicate and move from one position to another within the host genome. Through co-evolution, TEs…
  • Abstract Number: 1835 • ACR Convergence 2021

    Secukinumab Effects on Cardiometabolic Risk and Systemic Inflammation in Patients with Psoriasis, Psoriatic Arthritis and Axial Spondyloarthritis: Results from Post Hoc Analyses of Pooled Data from 19 Phase 3/4 Clinical Studies

    Joseph Merola1, Iain McInnes2, Atul Deodhar3, Erhard Quebe-Fehling4, Maher Aassi4, Michael Peine4 and Nehal Mehta5, 1Department of Dermatology and Department of Medicine, Division of Rheumatology; Brigham and Women's Hospital, Harvard Medical School, Newton, MA, 2University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom, 3Oregon Health & Science University, Portland, OR, 4Novartis Pharma AG, Basel, Switzerland, 5NHLBI/National Institutes of Health, Bethesda, MD

    Background/Purpose: Psoriasis (PsO), Psoriatic Arthritis (PsA) and Axial Spondyloarthritis (AxSpA) are chronic immune-mediated inflammatory diseases (IMIDs) requiring long-term treatment. Systemic inflammation in these IMIDs is…
  • Abstract Number: 0084 • ACR Convergence 2021

    COVID-19 Pneumonia in Two Hospitals: Similar Outcomes Despite Differential Use of Tocilizumab

    Leanna Wise1, Lauren Mathias2, Wendy Mack2, Aarya Kafi3, Yash Kothari2, Omkar Rao3 and William Stohl4, 1LAC+USC/Keck Medicine of USC, Pasadena, CA, 2University of Southern California, Los Angeles, CA, 3University of California San Diego, San Diego, CA, 4University of Southern California Keck School of Medicine, Los Angeles, CA

    Background/Purpose: A substantial number of patients with COVID-19 pneumonia develop a hyperinflammatory state. The anti-IL-6 receptor (IL-6R) mAb tocilizumab (TCZ) has been used in such…
  • Abstract Number: 0527 • ACR Convergence 2021

    Role of Terminal Uridylyl Transferase 7 in TNF-α-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts In Vitro

    Anil singh, farheen Shaikh and Salah-uddin Ahmed, Washington State University, Spokane, WA

    Background/Purpose: Terminal uridylyl transferase 7 (TUT7), also known as Zcchc6, is a zinc finger domain-containing protein responsible for terminal uridylation of miRNA, implicated in pre-miRNA…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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