ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0921 • ACR Convergence 2021

    Effect of Secukinumab on Radiographic Progression and Inflammation in Sacroiliac Joints and Spine in Patients with Non-radiographic Axial Spondyloarthritis: 2-year Imaging Outcomes from a Phase III Randomized Trial

    Juergen Braun1, Ricardo Blanco2, Helena Marzo-Ortega3, Lianne Gensler4, Filip Van den Bosch5, Stephen Hall6, Hideto Kameda7, Denis Poddubnyy8, Marleen van de Sande9, Désirée van der Heijde10, Tingting Zhuang11, Anna Stefanska12, Aimee Readie11, Hanno Richards13 and Atul Deodhar14, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2Hospital University Marqués de Valdecilla, IDIVAL, Division of Rheumatology, Santander, Spain, 3NIHR Leeds Biomedical Research Centre and University of Leeds, Leeds, United Kingdom, 4Department of Rheumatology, University of California San Francisco, San Francisco, CA, 5Dept. of Rheumatology - Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, 6Emeritus Research and Monash University, Melbourne, Australia, Melbourne, Australia, 7Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan, 8Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 9Amsterdam UMC, University of Amsterdam, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, 10Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, 11Novartis Pharmaceuticals Corporation, East Hanover, NJ, 12Novartis Ireland Limited, Dublin, Ireland, Dublin, Ireland, 13Novartis Pharma AG, Basel, Switzerland, 14Oregon Health & Science University, Portland, OR

    Background/Purpose: Axial spondyloarthritis (axSpA) is characterized by inflammation of the sacroiliac joints (SIJ) and the spine. Secukinumab (SEC) treatment was clinically efficacious and reduced SIJ…
  • Abstract Number: 1216 • ACR Convergence 2021

    Evidence of a Tendency for Localized Recurrence of Arthritis in Rheumatoid Arthritis Patients

    Sascha Heckert1, Sytske Anne Bergstra1, Xanthe Matthijssen1, Yvonne Goekoop-Ruiterman2, Faouzia Fodili3, Saskia ten Wolde4, Cornelia F. Allaart1 and Tom WJ Huizinga1, 1Leiden University Medical Center, Leiden, Netherlands, 2HagaZiekenhuis, The Hague, Netherlands, 3Stichting ReumaZorg ZWN, Roosendaal, Netherlands, 4Spaarne Gasthuis, Haarlem, Netherlands

    Background/Purpose: Local inflammation may cause synovial fibroblasts to become sensitized, resulting in higher susceptibility to arthritis. Longitudinal assessment of joint involvement in rheumatoid arthritis (RA)…
  • Abstract Number: 1640 • ACR Convergence 2021

    Multisystem Inflammatory Syndrome in Children at Two Tertiary Hospitals in Cape Town, South Africa: Clinical Phenotype and Distinguishing Features from Similar Acute Inflammatory Conditions

    Claire Butters1, Deepthi Abraham2, Heidi Facey-Thomas1, Debbie Abrahams1, Ayodele Faleye3, Helena Rabie2, Christiaan Scott4, Liesl Zühlke5 and Kate Webb6, 1Paediatric Rheumatology, University of Cape Town, Cape Town, South Africa, 2Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa, 3Lagos state university teaching hospital Ikeja, Lagos, Nigeria, 4University of Cape Town, Faculty of Health Science, Cape Town, South Africa, 5Paediatric Cardiology, University of Cape Town, Cape Town, South Africa, 6University of Cape Town, Cape Town, South Africa

    Background/Purpose: Distinguishing Multisystem Inflammatory Syndrome in Children (MIS-C) associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) from acute, pyrexial childhood illness can be challenging.…
  • Abstract Number: 0016 • ACR Convergence 2021

    Structural and Functional Neurobiological Alterations of Salience and Sensorimotor Networks in Juvenile Idiopathic Arthritis

    Hanne van der Heijden1, Jordan Lemme2, Mariesa Cay2, Diana Sibai2, Benjamin Goodlett3, Jeffrey Lo4, Peter Nigrovic5, Margaret Chang4, Esra Meidan4, Olha Halyabar4, Melissa Hazen6, Maria Taylor4, Kacie Hoyt4, Camilo Jaimes7, Lauren Henderson3, Kirsten Ecklund7, Rudy Schreiber8, Robert Sundel4 and Jaymin Upadhyay9, 1Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA/ Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, The Netherlands/ Faculty of Science, Biomedical Sciences Neurobiology, University of Amsterdam, Amsterdam, The Netherlands, Sittard, Netherlands, 2Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA, Boston, MA, 3Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School, Boston, MA, 4Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 5Boston Children's Hospital, Brookline, MA, 6Boston Children's Hospital, Boston, MA, 7Department of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, 8Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, The Netherlands., Maastricht, Netherlands, 9Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA/ Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA USA, Boston, MA

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a common childhood illness, characterized by inflammation of the joint, chronic pain and decreased physical functioning. To date, the…
  • Abstract Number: 0322 • ACR Convergence 2021

    Histopathological Changes in Parotid and Labial Salivary Gland Tissue in Primary Sjögren’s Syndrome Patients After Abatacept Treatment

    Uzma Nakshbandi1, Liseth de Wolff2, Frans Kroese1, Silvia Liefers3, Neelanjana Ray4, Gwenny Verstappen1, Fred Spijkervet3, Marleen Nys5, Arjan Vissink6, Robert Wong7, Bert van der vegt3 and Hendrika Bootsma1, 1University Medical Center Groningen, Groningen, Netherlands, 2University Medical Centre Groningen, Groningen, Netherlands, 3University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Bristol-Myers Squibb Company, Lawrenceville, GA, 5Bristol Myers Squibb, Braine-l'Alleud, Belgium, 6University of Groningen, University Medical Center Groningen, Leek, Netherlands, 7Bristol Myers Squibb, Basking Ridge, NJ

    Background/Purpose: In a previous open-label phase II study, we showed that abatacept treatment might inhibit local formation of autoreactive memory B cells in parotid glands…
  • Abstract Number: 0930 • ACR Convergence 2021

    Effect of Tofacitinib on Spinal Vertebral Body and Posterolateral Element Inflammation and Structural Lesions Using the Canada-Denmark MRI Scoring System in Patients with Ankylosing Spondylitis: Results from a Phase 2 Study

    Mikkel Ostergaard1, Joseph Wu2, Lara Fallon3, Sarah P Sherlock4, Cunshan Wang2, Dona L Fleishaker2, Keith S Kanik2 and Walter Maksymowych5, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark, 2Pfizer Inc, Groton, CT, 3Pfizer Canada, Montréal, QC, Canada, 4Pfizer Inc, Cambridge, MA, 5Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada

    Background/Purpose: The Canada-Denmark (CANDEN) MRI scoring system enables detailed anatomy-based evaluation of inflammatory and structural lesions in spinal vertebral bodies and posterior elements in patients…
  • Abstract Number: 1262 • ACR Convergence 2021

    Fish Oil Supplementation and Pro-inflammatory and Pro-Resolving Lipid Mediators in Patients with and Without Systemic Lupus Erythematosus

    May Choi1, Nancy Cook2, Emma Stevens2, Natalya Gomelskaya2, Gregory Kotler3, JoAnn Manson3, Jessica Lasky-Su2, Raju Tatituri2, Samia Mora2, I-Min Lee3, Charles Serhan2 and Karen Costenbader4, 1Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women's Hospital/ Harvard Medical School, Boston, MA, 4Brigham and Women's Hospital, Belmont, MA

    Background/Purpose: Omega-3 fatty acid-derived “specialized pro-resolving mediators” (SPM) are low-abundance lipid mediators (LM) central to inflammation resolution. In this cross-sectional study, we investigated whether fish…
  • Abstract Number: 1654 • ACR Convergence 2021

    Comparative Characteristics of the Natural Course of Early Rheumatoid Arthritis with Onset at a Young Age (18-49 Years) and Older (50 Years and Older) Patients Who Did Not Take DMARDs, Biologics, Other Targeted Drugs, Corticoids According to the Russian Register of Arthritis OREL

    Azamat Satybaldyev, Galina Gridneva, Anna Misiyuk, Natalia Demidova, Kamalia Kasumova and Evgeny Nasonov, V.A. Nasonova Reseach Institute of Rheumatology, Moscow, Russia

    Background/Purpose: Comparison of frequency of different clinical features of the natural course at the stage of early rheumatoid arthritis (RA) in patients with young and…
  • Abstract Number: 0020 • ACR Convergence 2021

    Citrullination Drives the Expression of Pro-fibrotic Genes in Rheumatoid Arthritis Fibroblast-like Cells

    Peter Maloley, Evan Ryan, Nozima Aripova, Michael Duryee, Bryant England, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The pathophysiology of rheumatoid arthritis (RA) is hallmarked by joint inflammation, thickening of the pannus, and resultant joint destruction. Within the synovial tissue, citrullinated…
  • Abstract Number: 0427 • ACR Convergence 2021

    Increased Risk of Severe Infections and Mortality in Patients with Newly Diagnosed Anti-neutrophil Cytoplasmic Antibody–associated Vasculitis: A Population-based Study

    Kai Zhao1, Hui Xie2, John Esdaile3 and J. Antonio Avina-Zubieta2, 1Simon Fraser University, Coquitlam, BC, Canada, 2Arthritis Research Canada, Richmond, BC, Canada, 3Arthritis Research Canada, Vancouver, BC, Canada

    Background/Purpose: Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a group of multisystem inflammatory diseases of the small blood vessels. Infections are serious complications in AAV…
  • Abstract Number: 0940 • ACR Convergence 2021

    Overactivation of the Kinase IKK2 Causes a Hand Osteoarthritis-Like Phenotype in Mice

    Sergio Ramirez-Perez, kyle Jones, Umesh Gangishetti and Pallavi Bhattaram, Emory University School of Medicine, Atlanta, GA

    Background/Purpose: Hand osteoarthritis (OA) presents the highest prevalence among rheumatic diseases. Synovitis is a defining feature in hand OA that has been associated with radiographic…
  • Abstract Number: 1329 • ACR Convergence 2021

    Guselkumab (TREMFYA®) Maintains Resolution of Dactylitis and Enthesitis in Patients with Active Psoriatic Arthritis: Results Through 2 Years from a Phase 3 Study

    Proton Rahman1, Iain McInnes2, Atul Deodhar3, Georg Schett4, Philip Mease5, May Shawi6, Daniel Cua7, Jonathan Sherlock8, Alexa Kollmeier9, Xie Xu7, Yusang Jiang7, Shihong Sheng7, Christopher Ritchlin10 and Dennis McGonagle11, 1Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, 2University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom, 3Oregon Health & Science University, Portland, OR, 4Universitätsklinikum Erlangen, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany, Erlangen, Germany, 5Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 6Janssen Immunology Global Commercial Strategy Organization, Toronto, ON, Canada, 7Janssen Research & Development, LLC, Spring House, PA, 8Janssen Research & Development, LLC and University of Oxford, Spring House, PA, 9Janssen Research & Development, LLC, La Jolla, CA, 10Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, 11University of Leeds, Leeds, United Kingdom

    Background/Purpose: Guselkumab (GUS), a selective inhibitor of IL-23, significantly improved the diverse manifestations of active psoriatic arthritis (PsA), including dactylitis and enthesitis, in the DISCOVER…
  • Abstract Number: 1670 • ACR Convergence 2021

    Increased Prevalence of Gastroesophageal Disease Among Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis

    Patompong Ungprasert1, Nipith Charoenngam2, Ben Ponvilawan3, Pitchaporn Yingchoncharoen3 and Jerapas Thongpiya4, 1Cleveland Clinic, Cleveland Heights, OH, 2Mount Auburn Hospital, Boston, MA, 3Mahidol University, Bangkok, Thailand, 4Mahdiol University, Bangkok, Thailand

    Background/Purpose: Recent experimental studies have suggested that systemic inflammatory response could lead to impairment of lower esophageal function, resulting in gastroesophageal reflux disease (GERD). Epidemiologic…
  • Abstract Number: 0025 • ACR Convergence 2021

    The Modulatory Capacity of Galectin-3 on the Programmed Death-1 Signaling Axis in Rheumatoid Arthritis

    Kathrine Pedersen1, Morten Aagaard Nielsen2, Malene Hvid1, Bent Deleuran1 and Stinne Greisen1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University / Aarhus University Hopital, Aarhus, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovium. Despite a variety of treatments, 30-40% of RA patients fail…
  • Abstract Number: 0458 • ACR Convergence 2021

    Single Cell Profiling Reveals a Wnt-mediated Transcriptional Gradient That Drives Inflammation in Rheumatoid Arthritis Synovial Fibroblast Pathology

    Alisa Mueller1, Angela Zou1, Emily Taylor2, Triin Major2, David Gardner3, Adam Croft4, Roche Fibroblast Network Consortium5, Andrew Filer2, Christopher Buckley6, Kevin Wei1, Ilya Korsunsky1, Soumya Raychaudhuri1 and Michael Brenner7, 1Brigham and Women's Hospital, Boston, MA, 2University of Birmingham, Birmingham, United Kingdom, 3University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom, 4University of Birmingham, Halesowen, United Kingdom, 5Roche Innovation Center Basel, Basel, Switzerland, 6University of Oxford, Oxford, United Kingdom, 7Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: Synovial fibroblasts are key inflammatory aggressors in rheumatoid arthritis (RA) that mediate cartilage and bone destruction, yet therapies directly targeting these cells are lacking.…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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