ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "inflammation and systemic sclerosis"

  • Abstract Number: 812 • 2018 ACR/ARHP Annual Meeting

    Inflammatory Stays Inflammatory: A Subgroup of Systemic Sclerosis Characterized By High Morbidity and Inflammatory Resistance to Cyclophosphamide

    Aleksey Mitev1, Daria Feldmann1, Moritz Binder2, Kim Möller3, Anna-Maria Kanne1, Thomas Hügle4, Peter M. Villiger5, Reinhard Voll6, Stephanie Finzel1 and Florian Kollert7, 1Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2Department of Internal Medicine, Mayo Clinic, Rochester, MN, 3Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 4Rheumatology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, 5Rheumatology and Clin Immunol, Bern, Switzerland, 6Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 7Department of Rheumatology, Immunology, and Allergology, Inselspital, University Hospital Bern, Bern, Switzerland

    Background/Purpose: Elevated levels of C-reactive protein (CRP) in systemic sclerosis (SSc) have been linked to early inflammatory stages of the disease. This study has been…
  • Abstract Number: 1707 • 2017 ACR/ARHP Annual Meeting

    Effect of Anabasum (JBT-101) on Gene Expression in Skin Biopsies from Subjects with Diffuse Cutaneous Systemic Sclerosis (dcSSc) and the Relationship of Baseline Molecular Subsets to Clinical Benefit in the Phase 2 Trial

    Viktor Martyanov1, Yolanda Nesbeth2, Guoshuai Cai1, Tammara A. Wood1, Jake Reder2, Scott Constantine3, Barbara White3, Robert F. Spiera4 and Michael L. Whitfield1, 1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Celdara Medical, LLC, Lebanon, NH, 3Corbus Pharmaceuticals, Inc., Norwood, MA, 4Rheumatology, Hospital for Special Surgery, New York, NY

    Background/Purpose: Anabasum (JBT-101) is a non-immunosuppressive, synthetic, CB2 agonist that resolves inflammation and fibrosis in animal models of SSc and reduces TGF-β and collagen production…
  • Abstract Number: 841 • 2016 ACR/ARHP Annual Meeting

    Low Nucleoside Triphosphate Pyrophosphohydrolase Activity Contributes to Pathologic Mineralization in Systemic Sclerosis

    Yue Ding1, Supraja Yeturi1, Claudia Gohr1, Mary Ellen Csuka1 and Ann K. Rosenthal2,3, 1Medicine, Medical College of Wisconsin, Milwaukee, WI, 2Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 3Medicine, Clement J. Zablocki VA Medical Center, Milwaukee, WI

    Background/Purpose: Calcinosis is a major source of morbidity in patients with systemic sclerosis (SS). In addition, increased coronary calcification has been reported in patients with…
  • Abstract Number: 749 • 2014 ACR/ARHP Annual Meeting

    Progranulin Overproduction Due to Fli1 Deficiency Contributes to the Resistance of Dermal Fibroblasts to Tumor Necrosis Factor a in Systemic Sclerosis

    Yohei Ichimura, Yoshihide Asano, Kaname Akamata, Shinji Noda, Takashi Taniguchi, Takehiro Takahashi, Tetsuo Toyama, Yayoi Tada, Makoto Sugaya, Shinichi Sato and Takafumi Kadono, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem fibrotic connective tissue disease characterized by a dysregulated activation of fibroblasts following inflammation, autoimmune attacks, and vascular injuries.…
  • Abstract Number: 2300 • 2012 ACR/ARHP Annual Meeting

    The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro

    Qingmei Liu1, Wenyu Wu2, Wenzheng Tu3, Haiyan Chu1, Yanyun Ma1, Hejian Zou4, Xiaodong Zhou5 and Jiu-Cun Wang1, 1Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, 2Huashan Hospital, Shanghai, China, 3Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, China, 4Rheumatology, Huashan Hospital, Shanghai, China, 5Rheumatology, University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: , Methods: , Results: and Conclusion: Background: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs. Salvianolic acid…
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