Abstracts tagged "inflammation and rheumatoid arthritis"

Abstract Number: 964 • 2015 ACR/ARHP Annual Meeting
Neutrophil Extracellular Traps Are Not Only Targets for ACPA-Positive IgG from Rheumatoid Arthritis Patients but Also Directly Trigger Pro- and Anti-Inflammatory Effects Partly Mediated By the C1q Complement Protein
Matthieu Ribon¹, Sarra Seninet¹, Katarzyna Matyja¹, Mireille Sebbag², Cyril Clavel², Julie Mussard¹, Guy Serre², Marie-Christophe Boissier³ and Patrice Decker¹, ¹Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²University of Toulouse, UMR 5165 CNRS-1056 Inserm, Toulouse, France, ³Rheumatology Department, Avicenne Hospital, AP-HP, Bobigny, France
Background/Purpose: Activated neutrophils (PMN) form neutrophil extracellular traps (NET). Those structures are expelled chromatin fibers composed of DNA and associated proteins. The process, NETosis, is…
Abstract Number: 1457 • 2014 ACR/ARHP Annual Meeting
Stem Cell Growth Factor Expression in Rheumatoid Arthritis
Youn Jung Woo¹, Young Ae Baik¹, Yong-Beom Park², Soo-Kon Lee³, William H. Robinson⁴ and Jason Jungsik Song³, ¹Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Stem cell growth factor (SCGF) is a member of the C-type lectin superfamily, encoded by gene CLEC11A. SCGF is not related to stem cell…
Abstract Number: 1434 • 2014 ACR/ARHP Annual Meeting
The Longitudinal Association Between Inflammation and Blood Pressure in Rheumatoid Arthritis
Chih-Chin Liu¹, Daniel H. Solomon², Rishi Desai³, Seoyoung C. Kim⁴ and Katherine Liao⁵, ¹Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³PharmacoEpidemiology & PharmacoEconomics, Brigham and Women's Hospital, Boston, MA, ⁴Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose Inflammation is hypothesized to have direct effects on arterial endothelial and vasomotor function, functions which regulate blood pressure (BP). While inflammation has been implicated…
Abstract Number: 809 • 2013 ACR/ARHP Annual Meeting
IgM Rheumatoid Factor As a Potentiator Of Anti-Citrullinated Protein Antibody Mediated Inflammation In Rheumatoid Arthritis
Jeremy Sokolove¹, Danye Cheng², Dannette S. Johnson³, Ted R. Mikuls⁴ and William H. Robinson⁵, ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ³Rheumatology, Jackson VA and University of Mississippi Medical Center, Jackson, MS, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: The co-occurrence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) is well described in rheumatoid arthritis (RA), and has been associated with…
Abstract Number: 2311 • 2012 ACR/ARHP Annual Meeting
Total Glucosides of Paeony Th1 and Th17 Cell Differentiation by Blocking STAT1 and STAT3 Activation in Vivo
Ningli Li¹ and JP Lin², ¹Shanghai Institute of Immunology, Institute of medical sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Shanghai Institute of Immunology, Institute of medical sciences,Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background/Purpose: Th1 and Th17 cells play very importent role in the lesions of human rheumatoid arthritis (RA). Total glucoside of paeony (TGP), an active compound extracted from…
Abstract Number: 820 • 2012 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis Incident Fractures Are Associated with an Increased Risk of Cardiovascular Events
Orla Ni Mhuircheartaigh¹, Cynthia S. Crowson², Sherine E. Gabriel³, Veronique L. Roger⁴, L. Joseph Melton III⁵ and Shreyasee Amin⁶, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN, ⁴Health Sciences Research and Cardiology, Mayo Clinic, Rochester, MN, ⁵Department of Hlth Sciences, Mayo Clinic, Rochester, MN, ⁶Health Sciences Research and Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Rheumatoid Arthritis (RA) is associated with an increased risk for both fracture (fx) and cardiovascular disease (CVD) and there is increasing evidence establishing a…
Abstract Number: 408 • 2012 ACR/ARHP Annual Meeting
Alpha-Enolase Facilitates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Kichul Shin¹, Ji Ah Park², Seyeon Bae³, Jae Seung Kang³ and Yeong Wook Song⁴, ¹Rheumatology, College of Medicine, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine,, Seoul National Hospital, Seoul, South Korea, ³Department of Anatomy and Tumor Immunity Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea
Background/Purpose:Alpha-enolase (ENO1) is a multifunctional glycolytic enzyme ubiquitously expressed in the cytoplasm. Citrullinated ENO1 is reported to be a candidate autoantigen in rheumatoid arthritis (RA),…

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