Abstracts tagged "inflammation and osteoarthritis"

Abstract Number: 1045 • 2018 ACR/ARHP Annual Meeting
The Coll2-1 Peptide of Collagen Type II: A New Actor of Synovitis in Osteoarthritis
Cécile Lambert¹, Didier Borderie², Jean-Emile Dubuc³, François Rannou² and Yves Henrotin^4,5, ¹Bone and Cartilage Research Unit, University of Liege, Liege, Belgium, ²Inserm umr 1124, Laboratory of pharmacology, toxicology and cell signaling, University Paris Descartes, Paris, France, ³Orthopaedic Department, University Clinics St Luc, Brussels, Belgium, ⁴Physical Therapy and Rehabilitation, Princess Paola Hospital, Marche-en-Famenne, Belgium, ⁵Bone and Cartilage Research Unit, University of Liege, Liège, Belgium
Background/Purpose: We evaluated the inflammatory effect of Coll2-1 peptide in osteoarthritic synoviocytes and rats by comparing peptide-induced inflammatory reaction with the one induced by bovine…
Abstract Number: 1046 • 2018 ACR/ARHP Annual Meeting
Distinct Balance of TNF-α/IL-10 in Circulating and Infiltrating CD163+ Macrophages between Rapidly and Slowly Progressive Symptomatic Knee Osteoarthritis
Li Wang, Wenmin Wang, Hui Chu, Xifu Shang and Xiaomei Li, Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
Background/Purpose: There is a subtype of osteoarthritis (OA), which shows higher level of inflammation and higher risk of disease progression. In the current study, we…
Abstract Number: 934 • 2017 ACR/ARHP Annual Meeting
Effectiveness of FX006 Intra-Articular Injection in Patients with Knee Osteoarthritis Who Present with and without Clinical Inflammation at Baseline: A Pooled Analysis of Data from 3 Double-Blind, Randomized, Parallel-Group Clinical Trials
Herbert S. B. Baraf¹, Christian Lattermann², Deryk G. Jones³, Philip G. Conaghan⁴, Joelle Lufkin⁵, James Johnson⁶, Scott Kelley⁵ and Neil Bodick⁵, ¹Center for Rheumatology and Bone Research, Wheaton, MD, ²University of Kentucky, Orthopaedic Surgery and Sports Medicine, Lexington, KY, ³Ochsner Sports Medicine Institute, New Orleans, LA, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Flexion Therapeutics, Inc., Burlington, MA, ⁶Summit Analytical, Denver, CO
Background/Purpose: Inflammation is a key contributor to osteoarthritis (OA).1 OA pain is mediated by interactions between inflammatory cytokines and other features including local tissue damage,…
Abstract Number: 2006 • 2017 ACR/ARHP Annual Meeting
Altered Microcirculation As a Proxy for Inflammation in Hand Osteoarthritis Can Reliably be Assessed Using Fluorescence Optical Imaging
Ida K. Haugen¹, Sigrid Hestetun¹, Benedict Drude², Gerd R. Burmester³, Tore K Kvien⁴ and Sarah Ohrndorf², ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, ⁴Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Previous studies in systemic inflammatory joint diseases have suggested that Fluorescence Optical Imaging (FOI) is a reliable and sensitive tool for the detection of…
Abstract Number: 2119 • 2016 ACR/ARHP Annual Meeting
Wogonin, a Plant-Derived Flavonoid, Exert Anti-Inflammatory and Chondroprotective Effects through the Activation Nrf2/HO-1 Signaling in Human OA Chondrocytes
Mohammad N. Khan, Abdul Haseeb, Sara Haynie and Tariq M Haqqi, Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Methods: Primary human OA chondrocytes were isolated by enzymatic digestion of the cartilage obtained from OA patients who underwent total knee arthroplasty at…
Abstract Number: 2143 • 2016 ACR/ARHP Annual Meeting
A Small Molecule, SM04690, Has Inhibitory Effects on the Wnt Pathway and Inflammation in Vitro, with Potential Implications for the Treatment of Osteoarthritis
Vishal Deshmukh¹, Maureen Ibanez¹, Charlene Barroga¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Osteoarthritis (OA) involves thinning cartilage and increased subchondral bone. Amongst many cellular processes, inflammation has been associated with OA. Wnt signaling plays a…
Abstract Number: 342 • 2015 ACR/ARHP Annual Meeting
The Effect of Erosive Status on Systemic Inflammatory Biomarkers in Hand Osteoarthritis
Alexander Mathiessen¹, Nina Østerås², Tore K. Kvien³, Hilde Berner Hammer⁴ and Ida K. Haugen⁵, ¹Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology,, Diakonhjemmet Hospital, Oslo, Norway, ³Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵P.O. Box 23, Diakonhjemmet Hospital, Vinderen, Norway
Background/Purpose : It is debated whether erosive hand osteoarthritis (OA) is a separate inflammatory subset of hand OA, or just a severe form of the same…
Abstract Number: 1139 • 2015 ACR/ARHP Annual Meeting
Differential Inflammatory Profile in Experimental Models of Arthritis
Ana C. Ortiz¹, Anne Crilly¹, Lynette Dunning¹, Carmen Huesa¹, C. S. Goodyear², John C. Lockhart¹, William R. Ferrell² and Iain B. McInnes², ¹Institute of Biomedical and Environmental Health Research, University of the West of Scotland, Paisley, United Kingdom, ²Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: While osteoarthritis (OA) in humans is characterized by cartilage degradation, osteophyte formation and joint remodeling, inflammation and synovitis are now recognized to contribute to…
Abstract Number: 2115 • 2015 ACR/ARHP Annual Meeting
Intra-Operative Synovitis Predicts Worse Pain and Function 2 Years after Total Knee Arthroplasty for Osteoarthritis
Lisa Mandl¹, Shivi Duggal², Kelly McHugh³, Xian Wu⁴, Geoffrey H. Westrich², Thomas Sculco², John A. Carrino⁵, Edward F. DiCarlo⁶, Steven R. Goldring¹ and Charles Cornell², ¹Hospital for Special Surgery, New York, NY, ²Orthopedics, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, ⁵Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Laboratory Medicine, Hospital for Special Surgery, New York, NY
Intra-Operative Synovitis Predicts Worse Pain and Function 2 Years After Total Knee Arthroplasty for Osteoarthritis Background/Purpose: Total knee arthroplasty (TKA) is one of the most common…
Abstract Number: 1016 • 2014 ACR/ARHP Annual Meeting
Reduced Expression of Circadian Rhythm Genes in Human Osteoarthritis Cartilage: NR1D1 Suppression Alters Chondrocyte Response to IL-1β Stimulation
Ryuichiro Akagi¹, Kathleen M. Fisch¹, Oscar Alvarez-Garcia¹, Takeshi Teramura¹, Yuta Muramatsu¹, Masahiko Saito², Takahisa Sasho³, Andrew I. Su¹ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ³Orthopaedic Surgery, Chiba University School of Medicine, Chiba, Japan
Background/Purpose NR1D1 is a negative regulator of BMAL1, a core clock gene that regulate circadian rhythmicity. Involvement of NR1D1 in inflammatory process has been reported,…
Abstract Number: 1014 • 2014 ACR/ARHP Annual Meeting
Harpagide, a Low Molecular Weight Natural Product, Suppresses IL-1â-Induced IL-6 Expression By Blocking the Activation of p38 MAPK and Transcription Factors CEBPâ and AP-1 in Primary Human Osteoarthritis Chondrocytes
Abdul Haseeb¹ and Tariq Haqqi², ¹Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: There is growing evidence that shows the involvement of IL-6 in cartilage degradation during OA. Significant correlation between IL-6 levels in serum as well…
Abstract Number: 55 • 2013 ACR/ARHP Annual Meeting
Glucocorticoid Receptor Modulator Compound A Does Not Induce Leptin In Human Osteoarthritic Synovial Fibroblasts and In Dedifferentiated Chondrocytes
Olivier Malaise¹, Biserka Relic², Edith Charlier¹, Mustapha Zeddou¹, Florence Quesada-Calvo³, Sophie Neuville⁴, Dominique de Seny² and Michel G. Malaise², ¹Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, ²Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ³Gastroenterology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, ⁴GIGA Research - University of Liège - CHU of Liège, Liège, Belgium
Background/Purpose: Leptin is generally considered detrimental in osteoarthritis (OA) as it can induce IL-8 in synovial fibroblasts (SF) and matrix metalloproteinases in chondrocytes. We recently…
Abstract Number: 28 • 2012 ACR/ARHP Annual Meeting
Role of Microrna 455 Networks in Mesenchymal Cell Differentiation and Osteoarthritis
Fumiaki Ayabe¹, Shigeru Miyaki², Diana Brinson¹, Satoshi Yamashita³, Hiroyuki Nakahara¹, Koji Otabe¹, Stuart Duffy¹, Shawn Grogan⁴, Shuji Takada³, Martin K. Lotz¹ and Hiroshi Asahara⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan, ³Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan, ⁴The Scripps Research Institute, La Jolla, CA, ⁵Molecular & Experimental Med, The Scripps Research Institute, La Jolla, CA
Background/Purpose: The objectives of this study were to identify cartilage specific microRNAs (miRNAs, miR-) that are regulated by SOX9 and are increased in chondrogenesis, to…
Abstract Number: 6 • 2012 ACR/ARHP Annual Meeting
The Effect of Hydrogen Sulfide Donors On Inflammatory Mediators in Human Articular Osteoarthritic Chondrocytes
Elena F. Burguera¹, Angela Vela Anero², Rosa Meijide Failde² and Francisco J. Blanco¹, ¹Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Department of Medicine, University of A Coruña, A Coruña, Spain
Background/Purpose: Hydrogen sulfide (H2S) has recently been proposed as an endogenous mediator of inflammation in several pathology models. The aim of this work was to…

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