inflammation and interferons Archives

Abstract Number: 975 • ACR/ARHP Annual Meeting 2018
Alteration of Vascular Inflammatory Markers in SLE By Anifrolumab in the Phase IIb Muse Study
KA Casey¹, WI White¹, Nickie L. Seto², Martin Playford³, MA Smith¹, P Carlucci², B Yu⁴, L Wang⁵, G Illei⁴, Nehal Mehta³ and Mariana J. Kaplan², ¹MedImmune, Gaithersburg, MD, ²NIAMS, Bethesda, MD, ³NHLBI, Bethesda, MD, ⁴MedImmune, Gaithersberg, MD, ⁵AstraZeneca, Gaithersburg, MD
Background/Purpose: Cardiovascular disease is a leading cause of death for patients with systemic lupus erythematosus (SLE), and the disease is widely known to feature premature…
Abstract Number: 2349 • ACR/ARHP Annual Meeting 2017
Interferon Signature in Childhood Rheumatic Diseases
Hafize Emine Sonmez¹, İ. Çağatay Karaaslan², Ezgi Deniz Batu³, Banu Anlar⁴, Betul Sozeri⁵, Adriana Almeida de Jesus⁶, Raphaela Goldbach-Mansky⁷ and Seza Ozen⁸, ¹Department of Pediatrics, Divison of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ²Department of Molecular Biology, Hacettepe University, Ankara, Turkey, ³Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Department of Pediatrics, Division of Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁵Pediatric Rheumatology, Ümraniye Tranning and Research Hospital, İstanbul, Turkey, ⁶National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, ⁷Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ⁸Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Several rheumatic diseases are characterized by overexpression of type I interferon(IFN)-inducible or viral response genes, termed the IFN signature. Recently this signature has been…
Abstract Number: 2875 • ACR/ARHP Annual Meeting 2017
Molecular Features Define Unique Sjögren’s Syndrome Patient Subsets
Judith A. James¹, Joel M. Guthridge², Hua Chen³, Rufei Lu³, Rebecka L. Bourn³, Alan N. Baer⁴, Ghaith Noaiseh⁵, Anne Parke⁶, Andreea Coca⁷, Tammy Utset⁸, Mark C. Genovese⁹, Teresa Aberle³, Daniel J. Wallace¹⁰, Karen Boyle¹¹, Lynette Keyes-Elstein¹², Nathalie Franchimont¹³, Eugene St. Clair¹⁴, Virginia Pascual¹⁵, Paul J. Utz¹⁶ and Kathy L. Sivils², ¹Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ⁵University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶University of Connecticut, Farmington, CT, ⁷University of Rochester Medical Center, Rochester, NY, ⁸University of Chicago, Chicago, IL, ⁹Stanford University Medical Center, Palo Alto, CA, ¹⁰UCLA, Beverly Hills, CA, ¹¹Rho Federal Systems, Inc, Chapel Hill, NC, ¹²Rho Federal Systems, Inc., Chapel Hill, NC, ¹³Biogen, Cambridge, MA, ¹⁴Department of Medicine, Duke University Medical Center, Durham, NC, ¹⁵Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX, ¹⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Immunologic heterogeneity in primary Sjogren’s syndrome (pSS) poses a challenge when selecting a therapeutic for a given patients or when assembling patient cohorts for…
Abstract Number: 1202 • ACR/ARHP Annual Meeting 2014
Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE
Bo Qu¹, Jianchang Cao², Feifei Zhang² and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, ³The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose Systemic lupus erythematosus (SLE) is characterized by the uncontrolled inflammation along with over produced inflammatory cytokines, among which type I interferon (IFN) is recognized…

Abstracts tagged "inflammation and interferons"

Alteration of Vascular Inflammatory Markers in SLE By Anifrolumab in the Phase IIb Muse Study

Interferon Signature in Childhood Rheumatic Diseases

Molecular Features Define Unique Sjögren’s Syndrome Patient Subsets

Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE