ACR Meeting Abstracts

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Abstracts tagged "inflammation and interferons"

  • Abstract Number: 975 • 2018 ACR/ARHP Annual Meeting

    Alteration of Vascular Inflammatory Markers in SLE By Anifrolumab in the Phase IIb Muse Study

    KA Casey1, WI White1, Nickie L. Seto2, Martin Playford3, MA Smith1, P Carlucci2, B Yu4, L Wang5, G Illei4, Nehal Mehta3 and Mariana J. Kaplan2, 1MedImmune, Gaithersburg, MD, 2NIAMS, Bethesda, MD, 3NHLBI, Bethesda, MD, 4MedImmune, Gaithersberg, MD, 5AstraZeneca, Gaithersburg, MD

    Background/Purpose: Cardiovascular disease is a leading cause of death for patients with systemic lupus erythematosus (SLE), and the disease is widely known to feature premature…
  • Abstract Number: 2349 • 2017 ACR/ARHP Annual Meeting

    Interferon Signature in Childhood Rheumatic Diseases

    Hafize Emine Sonmez1, İ. Çağatay Karaaslan2, Ezgi Deniz Batu3, Banu Anlar4, Betul Sozeri5, Adriana Almeida de Jesus6, Raphaela Goldbach-Mansky7 and Seza Ozen8, 1Department of Pediatrics, Divison of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2Department of Molecular Biology, Hacettepe University, Ankara, Turkey, 3Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 4Department of Pediatrics, Division of Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 5Pediatric Rheumatology, Ümraniye Tranning and Research Hospital, İstanbul, Turkey, 6National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 7Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 8Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Several rheumatic diseases are characterized by overexpression of type I interferon(IFN)-inducible or viral response genes, termed the IFN signature. Recently this signature has been…
  • Abstract Number: 2875 • 2017 ACR/ARHP Annual Meeting

    Molecular Features Define Unique Sjögren’s Syndrome Patient Subsets

    Judith A. James1, Joel M. Guthridge2, Hua Chen3, Rufei Lu3, Rebecka L. Bourn3, Alan N. Baer4, Ghaith Noaiseh5, Anne Parke6, Andreea Coca7, Tammy Utset8, Mark C. Genovese9, Teresa Aberle3, Daniel J. Wallace10, Karen Boyle11, Lynette Keyes-Elstein12, Nathalie Franchimont13, Eugene St. Clair14, Virginia Pascual15, Paul J. Utz16 and Kathy L. Sivils2, 1Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, 5University of Pittsburgh Medical Center, Pittsburgh, PA, 6University of Connecticut, Farmington, CT, 7University of Rochester Medical Center, Rochester, NY, 8University of Chicago, Chicago, IL, 9Stanford University Medical Center, Palo Alto, CA, 10UCLA, Beverly Hills, CA, 11Rho Federal Systems, Inc, Chapel Hill, NC, 12Rho Federal Systems, Inc., Chapel Hill, NC, 13Biogen, Cambridge, MA, 14Department of Medicine, Duke University Medical Center, Durham, NC, 15Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX, 16Medicine, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Immunologic heterogeneity in primary Sjogren’s syndrome (pSS) poses a challenge when selecting a therapeutic for a given patients or when assembling patient cohorts for…
  • Abstract Number: 1202 • 2014 ACR/ARHP Annual Meeting

    Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE

    Bo Qu1, Jianchang Cao2, Feifei Zhang2 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, 3The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH

    Background/Purpose Systemic lupus erythematosus (SLE) is characterized by the uncontrolled inflammation along with over produced inflammatory cytokines, among which type I interferon (IFN) is recognized…
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