ACR Meeting Abstracts

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Abstracts tagged "Immunotherapy"

  • Abstract Number: 364 • 2018 ACR/ARHP Annual Meeting

    Elevated sCD40L As a Predictive Biomarker of Immune-Related Adverse Events in Patients Receiving Immune Checkpoint Inhibitors

    Nicholas Meti1, Khashayar Esfahani1,2, Ines Colmegna1,3, Marvin J. Fritzler4, Nathalie A. Johnson1,5, Ciriaco Piccirillo1,6, Wilson H. Miller Jr.1,2 and Marie Hudson1,7, 1Department of Medicine, McGill University, Montreal, QC, Canada, 2Department of Oncology, McGill University, Jewish General Hospital, Rossy Cancer Network, Montreal, QC, Canada, 3Division of Rheumatology, McGill University Health Centre, Montreal, QC, Canada, 4Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 5Division of Hematology, Jewish General Hospital, Montreal, QC, Canada, 6Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada, 7Division of Rheumatology, Jewish General Hospital, Montreal, QC, Canada

    Background/Purpose: The clinical use of immune checkpoint inhibitors (ICI) has led to outstanding clinical outcomes in previously refractory cancers, but ICI have also been associated…
  • Abstract Number: 701 • 2018 ACR/ARHP Annual Meeting

    Network Meta-Analysis of Targeted Immunomodulators in the Treatment of Psoriatic Arthritis Patients without Prior Biologic Treatment

    Vibeke Strand1, M. Elaine Husni2, Jenny Griffith3, Yan Song4, Rakesh Singh5, Jing Zhao6 and Keith A. Betts7, 1Stanford University, Palo Alto, CA, 2Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, 3AbbVie, Inc., North Chicago, IL, 4Analysis Group, Inc., Boston, MA, 5AbbVie Inc., North Chicago, IL, 6Analysis Group Inc, Boston, MA, 7Analysis Group, Inc., Los Angeles, CA

    Background/Purpose: With multiple targeted immunomodulators (TIMs) approved by the FDA for the treatment of psoriatic arthritis (PsA), the relative efficacy and cost-effectiveness of these TIMs…
  • Abstract Number: 1723 • 2018 ACR/ARHP Annual Meeting

    Intensified B-Cell Depletion Therapy in Progressive Systemic Sclerosis Patients: 24 Months Follow-up

    Daniela Rossi1, Irene Cecchi2, Massimo Radin3, Elena Rubini4, Savino Sciascia5 and Dario Roccatello6, 1Department of Medicine and Experimental Oncology, CMID - Center of Research of Immunopathology and Rare Diseases, Turin, Italy, 2Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy., Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 6Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy

    Background/Purpose:Systemic sclerosis (SSc) is a connective tissue autoimmune disease with systemic involvement and a serious medical condition with a high rate of mortality, especially due…
  • Abstract Number: 2095 • 2018 ACR/ARHP Annual Meeting

    Neutralizing CXCL13 Attenuates Neuropsychiatric Disease in Lupus-Prone Mice

    Michelle Huang1, Ariel Stock2 and Chaim Putterman3, 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Despite the many lupus patients affected by neuropsychiatric signs and symptoms, the pathogenesis of neuropsychiatric disease in SLE remains unclear. MRL-lpr/lpr mice, a classic…
  • Abstract Number: 2349 • 2018 ACR/ARHP Annual Meeting

    “I Was Prepared for the Other Side Effects; I Wasn’t Prepared for This One.”: A Qualitative Study of the Patients’ Experience of Inflammatory Arthritis Due to Immune Checkpoint Inhibitor Therapy for Cancer

    Laura C. Cappelli1, Suzanne Grieb2, Ana-Maria Orbai3, Ami A. Shah1 and Clifton O. Bingham III4, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins Bayview Medical Center, Center for Child and Community Health Research, Baltimore, MD, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Patients treated for cancer with immune checkpoint inhibitors (ICI) can develop a variety of adverse events. Inflammatory arthritis (IA) is an increasingly recognized event…
  • Abstract Number: 2683 • 2018 ACR/ARHP Annual Meeting

    Selective Expansion and Targeting of FoxP3+CD127lo Regulatory T Cells By Low-Dose IL-2 Therapy in Active SLE

    Jens Humrich1, Caroline von Spee-Mayer2, Philipp Enghard3, Angelika Rose4, Elise Siegert5, Tobias Alexander5, Falk Hiepe6, Gerd R. Burmester7 and Gabriela Riemekasten8, 1Department of Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, 2Immunology, University Hospital Freiburg, Freiburg, Germany, 3Department of Nephrology, Charité – University Medicine Berlin, Berlin, Germany, 4Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, 5Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 6Rheumatology, Charité – University Medicine Berlin, Berlin, Germany, 7Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, 8Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany

    Background/Purpose: Interleukin-2 (IL-2) is crucial for the growth and survival of regulatory T cells (Treg), and thus for the control of autoimmunity. In previous studies…
  • Abstract Number: 346 • 2018 ACR/ARHP Annual Meeting

    Immune-Related Adverse Events: Development of a Pilot Immune-Related Adverse Events Clinic for Expedited and Effective Patient Care

    Pankti Reid1 and Reem Jan2, 1Internal Medicine, rheumatology, University of Chicago, Chicago, IL, 2Medicine, Rheumatology, University of Chicago, Chicago, IL

    Background/Purpose: The growing use of cancer immunotherapy and checkpoint inhibitors has led to a steep rise in immune-related adverse events (irAEs). Despite expanding research efforts,…
  • Abstract Number: 2976 • 2018 ACR/ARHP Annual Meeting

    Immune Checkpoint Inhibitor-Associated Myositis: A Characteristic Phenotype with a Poor Outcome Related to Concomitant Myocarditis

    Celine Anquetil1,2, Joe-Elie Salem3,4, Benedicte Lebrun-Vignes5, Douglas B Johnson6, Andrew Mammen7,8, Werner Stenzel9, Sarah Leonard-louis10, Olivier Benveniste11,12, Javid J Moslehi3 and Yves Allenbach2,13, 1Internal Medicine and Clinical Immunlogy, Assistance Public - Hopitaux de Paris, Pitié-Salpêtrière University Hospital, PARIS, France, 2CDR en myologie UMR974,, Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, PARIS, France, 3Division of Cardiovascular Medicine and Cardio-Oncology Program, Department of Medicine, Vanderbilt University Medical Center, Nasheville, TN, 4Department of Pharmacology, Regional Center of Pharmacovigilance, INSERM, CIC-1421, Paris, France, 5Department of Pharmacology, Regional Center of Pharmacovigilance, INSERM, CIC-1421, PARIS, France, 6Division of Oncology, Department of Medicine, Vanderbilt University Medical Center, Nasheville, TN, 7National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 8Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 9Charité - Universitätsmedizin, Department of Neuropathology, Berlin, Germany, Berlin, Germany, 10Département de Neuropathologie, Centre de Référence des Maladies Neuro-Musculaires Paris Est, Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Universitaire Pitié-Salpêtrière, Paris, France, 11Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, 12Centre de Recherche en Myologie, UMRS974, Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, Paris, France, 13Internal Medicine and Clinical Immunology, Sorbonne University - Assistance Public - Hopitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: Immune checkpoint inhibitors (ICI) are a major breakthrough in cancer treatment providing frequent durable responses and improving overall survival. Blocking immune checkpoints (Programmed cell…
  • Abstract Number: 350 • 2018 ACR/ARHP Annual Meeting

    Clinical Correlates of Immune-Related Adverse Events for Patients with Melanoma Treated with Checkpoint Inhibitors and a Noted Significant Difference in Peripheral Lymphocyte Counts

    Pankti Reid1, Tara Chongsuwat2, Anisha Dua3 and Jason Luke4, 1Internal Medicine, rheumatology, University of Chicago, Chicago, IL, 2Oncology Research Coordinator, University of Chicago, Chicago, IL, 3Medicine, University of Chicago, Chicago, IL, 4Hematology Oncology, University of Chicago, Chicago, IL

    Background/Purpose: Checkpoint immunotherapy has become the standard of care in treating advanced melanoma. These medications have been associated with immune-related adverse events (irAEs). Accurate methods…
  • Abstract Number: 352 • 2018 ACR/ARHP Annual Meeting

    Polymyalgia Rheumatica-like Syndrome from Checkpoint Inhibitor Therapy: Case Series and Systematic Review of the Literature

    Cassandra Calabrese1, Elizabeth Kirchner1 and Leonard H. Calabrese2, 1Rheumatic & Immunologic Disease, Cleveland Clinic Foundation, Cleveland, OH, 2Rheumatic & Immunologic Disease and Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Rheumatic immune related adverse events (irAEs) from checkpoint inhibitor (ICI) therapy remain poorly understood. In our early experience with rheumatic irAEs we encountered patients…
  • Abstract Number: 353 • 2018 ACR/ARHP Annual Meeting

    Immune-Related Adverse Events Associated with Immunotherapy in Solid Organ Tumors. Study of 102 Cases from a Referral Single Center for Last 3 Years

    José Luis Martín-Varillas1, Íñigo González-Mazón1, Belén Atienza-Mateo1, Marina Delagado Ruiz2, Isabel Bernat Piña2, Diana Prieto Peña3, Monica Calderón Goercke3, Lara Sánchez-Bilbao1, Eva Peña Sainz-Pardo2, Almudena García Castaño2, Miguel Angel González-Gay2 and Ricardo Blanco1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 3Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Immune checkpoint blockade therapy (ICTB) has shown remarkable benefit in different cancer types. Blockade of intrinsic down-regulators of immunity increases the activity of the…
  • Abstract Number: 354 • 2018 ACR/ARHP Annual Meeting

    Rheumatic Complications of Immune Checkpoint Inhibitor Therapy: A Single Center Experience

    Mazen Nasrallah1, Meghan Mooradian2, Eli Miloslavsky3, Justine Cohen2, Justin Gainor2, Donald Lawrence2, Kerry Reynolds2, Minna Kohler4, Ryan Sullivan2 and Sara Schoenfeld1, 1Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Immune checkpoint inhibitors (ICIs) have led to improved outcomes in multiple cancers, but they are associated with immune-related adverse events (irAEs), including inflammatory arthritis.…
  • Abstract Number: 356 • 2018 ACR/ARHP Annual Meeting

    Immune Related Adverse Events from Immune Checkpoint Inhibitors: A Retrospective Analysis from 2004-2017 at the University of North Carolina at Chapel Hill

    Rachel Romero1, Todd Schwartz2, Shruti Saxena Beem1 and Rumey Ishizawar3, 1Division of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Immune checkpoint inhibitors (ICI) targeting CTLA-4, such as ipilimumab (anti-CTLA4), or PD-1/PD-L1, such as nivolumab and pembrolizumab are increasingly utilized in a wide variety…
  • Abstract Number: 357 • 2018 ACR/ARHP Annual Meeting

    Musculoskeletal Immune-Related Adverse Events with Use of Checkpoint Inhibitors in Malignancy: Experience in Sydney, Australia

    Abhishikta Dey1,2, Nicholas Manolios3,4, Georgina Long4,5,6, Richard Kefford3,4,5,7 and Leslie Schrieber8,9, 1Pain Medicine, Royal Prince Alfred Hospital, Camperdown, Australia, 2Royal North Shore Hospital, North Sydney, Australia, 3Westmead Hospital, Sydney, Australia, 4University of Sydney, Sydney, Australia, 5Melanoma Institute Australia, North Sydney, Australia, 6Royal North Shore Hospital, St Leonards, Australia, 7Macquarie University Hospital, Sydney, Australia, 8Royal North Shore Hospital, St Leonards, Sydney, Australia, 9Northern Clinical School, University of Sydney, Sydney, Australia

    Background/Purpose: The strategy of using monoclonal antibodies to inhibit checkpoints on T cells, and enhance T-cell activity against cancer cells has significantly improved the survival…
  • Abstract Number: 1156 • 2017 ACR/ARHP Annual Meeting

    Rheumatic Immune Related Adverse Events from Checkpoint Inhibitor Therapy for Cancer: Long-Term Follow up Data

    Cassandra Calabrese1, Elizabeth Kirchner1, Apostolos Kontzias1, Laura Wood2, Brian Rini2, Vamsidhar Velcheti2 and Leonard H. Calabrese1, 1Rheumatic & Immunologic Disease, Cleveland Clinic Foundation, Cleveland, OH, 2Hematology and Oncology, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: The new and emerging field of immune related adverse events (irAEs) from cancer immunotherapies presents many unanswered questions. The spectrum of irAEs is broad…
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