Abstracts tagged "immunology"

Abstract Number: 1255 • ACR Convergence 2020
Sjӧgren’s Syndrome Minor Salivary Gland Mesenchymal Stromal Cells Derived Deploy Intact Immune Plasticity and Display Myofibroblast-Like Properties
Sara McCoy¹, Jayeeta Giri¹, Rahul Das¹, Pradyut Paul¹, Andrea Pennati¹, Maxwell Parker¹, Yun Liang¹ and Jacques Galipeau¹, ¹University of Wisconsin, Madison
Background/Purpose: Primary Sjӧgren’s syndrome (pSS) is the second most common systemic autoimmune disease with hallmark features of severe ocular and oral sicca, leading to reduced…
Abstract Number: 1579 • ACR Convergence 2020
Assessing the Effect of Calcineurin Inhibitors for Immune-related Adverse Event Management on Tumor Response
Pankti Reid¹, Daniel Olson² and Thomas Gajewski², ¹University of Chicago, Chicago, IL, ²University of Chicago Medical Center, Department of Medicine, Section of Hematology Oncology, Chicago
Background/Purpose: High grade immune-related adverse events (irAEs) to cancer immune checkpoint inhibitors (ICI) require considerable immunosuppression (IS) with high-dose steroids and steroid-sparing IS (SSIS) for…
Abstract Number: 0071 • ACR Convergence 2020
Significant Enrichment of Transcriptionally Distinct CD206+CD163+ Macrophage Population in Rheumatoid Arthritis Synovial Tissue
Megan Hanlon¹, Mary Canavan², Qingxuan Song³, Candice Low⁴, Phil Gallagher⁵, Ronan Mullan⁶, Conor Hurson⁷, Sunil Nagpal⁸, Douglas Veale⁹ and Ursula Fearon², ¹Molecular Rheumatology, Trinity College Dublin, Dublin 2, Dublin, Ireland, ²Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, ³Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, ⁴EULAR Centre for Arthritis and Rheumatic diseases, St Vincents University Hospital, UCD, Dublin, Ireland, ⁵St Vincents University Hospital, UCD, Dublin, Ireland, ⁶Adelaide and Meath Hospital, Dublin, Dublin, Ireland, ⁷St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, ⁸Janssen Research & Development, Collegeville, PA, ⁹EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland
Background/Purpose: Synovial tissue macrophages are an exquisitely plastic pool of innate cells that play a key role in RA disease progression. However, the precise nature,…
Abstract Number: 0492 • ACR Convergence 2020
Microbiota-induced Intestinal Barrier Dysfunction Initiates the Shuttling of Immune Cells from the Gut to the Joints
Narges Tajik¹, Michael Frech², Carolin Brandl¹, Juan Cañete³, Francesco Ciccia⁴, Georg Schett⁵ and Mario Zaiss⁶, ¹Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, ³Departamento de Reumatología, Hospital Clínic de Barcelona e IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁴Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy, Palermo, Italy, ⁵Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany, ⁶Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany
Background/Purpose: While it is known that microbial dysbiosis is associated with the onset of rheumatoid arthritis, mechanistic insights how it facilitates the development of arthritis…
Abstract Number: 1332 • ACR Convergence 2020
Identifying the as Patient at Risk: Is Aortic Root Diameter Associated with HLA-B27?
Milad Baniaamam¹, Sjoerd C. Heslinga², M. Louis Handoko³, Thelma C. Konings³, Otto Kamp³, Vokko P. van Halm⁴, J. Christiaan van Denderen¹, Irene van der Horst-Bruinsma² and Mike Nurmohamed⁵, ¹Reade, Amsterdam, Netherlands, ²Department of Rheumatology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ³Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ⁴Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, ⁵Amsterdam Rheumatology and immunology Center, location Reade and Amsterdam UMC, VU medical center, Amsterdam, Netherlands
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory joint disease (IJD) associated with cardiac involvement particularly aortic valve regurgitation (AVR). AVR in AS is caused by…
Abstract Number: 1636 • ACR Convergence 2020
8 Years Follow-Up of a Novel Autoinflammatory Disease: CD59 Malfunction Causes Hemolytic Anemia, Recurrent Guillain-Barre Syndrome, and Strokes in Pediatric Populations and Respond Well to Eculizumab and Pozelimab
Dror Mevorach¹ and Netanel Karbian¹, ¹Hadassah-University Hospital, Jerusalem, Yerushalayim, Israel
Background/Purpose: In 2013 we have described the first patients with a novel autoinflammatory disease manifested in 4 children with recurrent Guillain-Barre syndrome and hemolytic anemia…
Abstract Number: 1931 • 2019 ACR/ARP Annual Meeting
Comprehensive Characterization of the Immune Infiltrate of Skin Biopsies from Cutaneous Lupus Erythematosus Patients Using Single Cell RNAseq
Agnes Gardet¹, Thomas Carlile ¹, Will Chou ¹, Kejie Li ¹, Alex Pellerin ¹, Ravi Challa ¹, Will Chen ¹, Chao Sun ¹, Nathalie Franchimont ², Victoria Werth ³ and Dania Rabah ¹, ¹Biogen, Cambridge, ²Biogen, Cambridge, MA, ³Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA
Background/Purpose: The immune infiltrate of skin lesions of Cutaneous Lupus Erythematosus (CLE) patients is known to be rich and complex. Single cell RNAseq (scRNAseq) is…
Abstract Number: 196 • 2018 ACR/ARHP Annual Meeting
Immunology and Immunopharmacology at Point of Care: A Quality Improvement Teaching Initiative for Rheumatology Fellows
Nina Kello¹ and Anne Davidson², ¹Rheumatology, Northwell Health, Donald and Barbara Zucker School of Medicine, Manhasset, NY, ²Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Immunology knowledge in the rheumatology community is important for a better understanding of disease pathogenesis and management, especially in an era of an expanding…
Abstract Number: 1236 • 2018 ACR/ARHP Annual Meeting
Peripheral-Blood B-Cell Subset Disturbances in Whipple’s Disease
Maelle Le Goff¹, Divi Cornec², Dewi Guellec¹, Thierry Marhadour¹, Valérie Devauchelle-Pensec¹, Sandrine Jousse-Joulin¹, Marion Herbette¹, Jean-Michel Cauvin³, Clara Le Guillou³, Yves Renaudineau⁴, Jacques-Olivier Pers⁵ and Alain Saraux¹, ¹Rheumatology, CHU Brest, Brest, France, ²Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France, ³CDC, CHU Brest, Brest, France, ⁴U1227, Université de Brest, inserm, Labex IGO, CHU de brest, Brest, France, ⁵U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France
Background/Purpose: Whipple’s disease (WD) is a rare, systemic, disease caused by the intracellular Gram-positive bacterium Tropheryma whipplei (TW). This ubiquitous commensal organism is transmitted among…
Abstract Number: 751 • 2015 ACR/ARHP Annual Meeting
Rituximab Induced Serum Sickness: A Systematic Review
Paras Karmacharya¹, Dilli Poudel¹, Ranjan Pathak¹, Anthony Donato², Sushil Ghimire¹, Smith Giri³, Madan Aryal¹ and Clifton O. Bingham III⁴, ¹Internal Medicine, Reading Health System, WEST READING, PA, ²Internal medicine, Reading Health System, WEST READING, PA, ³Internal medicine, University of Tennessee Health Science Center, Memphis, TN, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Rituximab (anti-CD20 monoclonal antibody) has been frequently used to treat various autoimmune diseases in which B-cells are participants, and for hematological malignancies in which…
Abstract Number: 3043 • 2015 ACR/ARHP Annual Meeting
IL-17 Expression By Lymphocytes Is Higher in Behcet’s Disease Compared to Takayasu Arteritis
Ali Ugur Unal¹, Rabia Deniz², Aysin Tulunay Virlan³, Filiz Ture Ozdemir³, Imren Aydin Tatli³, Gulsen Ozen¹, Fatma Alibaz-Oner⁴, Gonca Mumcu⁵, Tulin Ergun⁶ and Haner Direskeneli¹, ¹Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ²Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Immunology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Department Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁵Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, ⁶Dermatology, Marmara University Faculty of Medicine, Dermatology, Istanbul, Turkey
Background/Purpose: Interleukin-17 (IL-17) has been associated with the pathogenesis of various inflammatory diseases. The aim of our study was to investigate the expression of Th17-related…
Abstract Number: 1649 • 2014 ACR/ARHP Annual Meeting
High Specificity of Skin Immunoglobulin Deposits for diagnosing SLE in Patients with Lupus Nephritis
Marco Ulises Martinez-Martinez¹, Maria Daniela De Avila², Mario Perales³, Lourdes Baranda⁴, Susana Román Acosta⁵, Jaime Antonio Borjas García⁵ and Carlos Abud-Mendoza¹, ¹Unidad de Investigaciones Reumatológicas, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ²Regional Unit Rheumatology and Osteoporosis, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ³Regional Unit of Rheumatology and Osteoporosis, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁴Regional Unit of Rheumatology and Osteoposis, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁵Nephrology Department, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Background/Purpose: Deposit of different classes of immunoglobulins is the main feature of lupus nephritis;1 because of its high specificity, a patient is classified as having…
Abstract Number: 910 • 2014 ACR/ARHP Annual Meeting
The Selective Sphingosine-1- Phosphate Receptor 1/5 Modulator Siponimod (BAF312) Shows Beneficial Effects in Patients with Active, Treatment Refractory Polymyositis and Dermatomyositis: A Phase IIa Proof-of-Concept, Double-Blind, Randomized Trial
Katalin Danko¹, Jiri Vencovsky², Ingrid E. Lundberg³, Anthony A Amato⁴, Chester V. Oddis⁵, Maria Molnar⁶, Antonette Mallari Moher⁷, Laurence Colin⁸, Florian Muellershausen⁹, David Lee¹⁰ and Peter Gergely⁹, ¹Institute of Rheumatology, University of Debrecen, Hungary, Debrecen, Hungary, ²Institute of Rheumatology, Charles University, Prague, Czech Republic, ³Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary, ⁷Translational Medicine, Novartis Institutes for Biomedical Research (former emplyee), Basel, Switzerland, ⁸Novartis Pharma, Basel, Switzerland, ⁹Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, ¹⁰Novartis Pharmaceuticals Corporation, Basel, Switzerland
Background/Purpose Polymyositis and dermatomyositis (PM/DM) comprise a heterogeneous group of chronic inflammatory muscle diseases where infiltration of lymphocytes in the skeletal muscle plays a key…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].