Abstract Number: 355 • 2018 ACR/ARHP Annual Meeting
Association of HLA-DRB1 Shared Epitope Alleles with Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis
Background/Purpose: Immune checkpoint inhibitors (ICI), an important type of cancer therapy, can cause adverse events through immune activation. Inflammatory arthritis (IA) due to ICI treatment…Abstract Number: 64 • 2016 ACR/ARHP Annual Meeting
Enrichment of Immune Pathways in Genes Under Geographically Restricted Adaptation in the Gullah African American Population of South Carolina
Background/Purpose: The reasons for the ethnic disparities in rheumatologic and autoimmune diseases (ADs) are largely unknown. We posit that population-specific selection influencing the allele frequencies…Abstract Number: 1691 • 2016 ACR/ARHP Annual Meeting
The Comparative Immunogenicity of Biologic Therapy and Its Clinical Relevance in Psoriatic Arthritis: A Systematic Review of the Literature
Background/Purpose: Anti-inflammatory biologic agents have been shown to provide significant benefit in controlling disease activity in psoriatic arthritis (PsA) and inhibiting progression of joint damage.…Abstract Number: 61 • 2016 ACR/ARHP Annual Meeting
Killer Immunoglobulin-like Receptors Are Associated with Ankylosing Spondylitis
Background/Purpose: Killer immunoglobulin-like receptors (KIRs) are expressed predominantly on the surface of natural killer (NK) cells and some T-cells and are important in regulating the…Abstract Number: 1622 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Analysis and Whole Genome Sequencing Identify Variants Associated with Radiographic Severity of Rheumatoid Arthritis in African Americans
Background/Purpose: Joint damage manifested by bony erosions and joint space narrowing is a major contributor to the morbidity and mortality of RA. Reports in Caucasians…Abstract Number: 2466 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Rheumatoid Arthritis (RA) Among Shared Epitope-Negative (SE-) Mothers with Shared Epitope-Positive (SE+) Children
Background/Purpose RA (RA [MIM 180300]) disproportionately affects women of reproductive age, implicating pregnancy-related factors. Fetal microchimerism (FMC), or the persistence of a small population of…Abstract Number: 1716 • 2014 ACR/ARHP Annual Meeting
MHC Class I and Class II Genes Influence Systemic Sclerosis Susceptibility, Clinical Presentation and Autoantibody Profile in a Mexican Admixed Population
Background/Purpose: Systemic Sclerosis (SSc) exhibits great clinical and serologic variability in different populations. Herein we determined MHC class I and II alleles and extended haplotypes…Abstract Number: 315 • 2014 ACR/ARHP Annual Meeting
NLRC4-Related Macrophage Activation Syndrome (NLRC4-MAS): A Novel Primary Autoinflammatory Syndrome Caused By Activating Mutations in NLRC4
Background/Purpose: Macrophage Activation Syndrome (MAS) is a life-threatening systemic inflammatory complication of many rheumatic diseases and its causes are unknown. While genetic defects causing impaired…Abstract Number: 2496 • 2013 ACR/ARHP Annual Meeting
HLA-B27 Influence On The Gut Microbiome
Background/Purpose: The interrelationship between the gut microbiome and spondyloarthritis (SpA) has been highlighted by recent findings of (i) Subclinical bowel inflammation in SpA (ii) Antimicrobial…Abstract Number: 1890 • 2013 ACR/ARHP Annual Meeting
Chemokine Receptor Polymorphisms On Chromosome 3 Are Associated With Anticitrullinated Protein Antibody Specificities In African Americans With Rheumatoid Arthritis
Background/Purpose: ACPA antibody specificities to citrullinated autoantigens (e.g., histones, vimentin, fibrinogen) are associated with the preclinical phase of RA and may predict the onset of…Abstract Number: 1896 • 2013 ACR/ARHP Annual Meeting
Arthritis Associated Sequence Alterations Within a Genetic Susceptibility Region Of Mouse Chromosome 3; A Genomic Region Which Is Syntenic With a Prominent Non-MHC Locus In Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that results in inflammatory destruction of synovial joints in affected patients. The involvement of genetic and epigenetic…