ACR Meeting Abstracts

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Abstracts tagged "Immune"

  • Abstract Number: 576 • 2017 ACR/ARHP Annual Meeting

    Immunosignature-Based Diagnosis and Prediction of Therapeutic Response Enables Retrospective Patient Stratification in a Phase IIa Clinical Trial for VAY736 in Primary Sjögren’s Syndrome

    Robert Gerwien1, Theodore M. Tarasow2, Jonathan Melnick2, Anna Lei3, Arvind Kinhikar4, Julie Doucet5, Remi Kazma5, Paul Maguire4, Irina Koroleva6, Giulio Macchiarella4, Alexandre Avrameas5, Marie-Anne Valentin5, Stephen Oliver5 and Alessandra Vitaliti5, 1HealthTell, Inc, san ramon, CA, 2HealthTell, Inc., San Ramon, CA, 3Health Tell, San Ramon, CA, 4Novartis, Cambridge, MA, 5Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, 6Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA

    Background/Purpose: Although patient stratification can improve the success rate of clinical trials, efforts to apply this strategy to autoimmune studies such as Sjögren’s syndrome are…
  • Abstract Number: 1388 • 2016 ACR/ARHP Annual Meeting

    Distinct Clinical Correlates of Immune Thrombocytopenic Purpura at Diagnosis of Childhood-Onset and Adult SLE

    Gladys Esteves1, Natali W. Gormezano2, Oriany Pereira1, David Kern1, Katia T. Kozu2, Rosa M R Pereira3, Clovis A Silva4, Eloisa Bonfa5 and Nadia E Aikawa6, 1University of São Paulo, São Paulo, Brazil, 2Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil, 3Rheumatology, University of São Paulo, São Paulo, Brazil, 4Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, 6Rheumatology Division, University of São Paulo, São Paulo, Brazil

    Background/Purpose:  Hematologic abnormalities are common manifestations in systemic lupus erythematosus (SLE) patients. Several studies have demonstrated a higher frequency of immune thrombocytopenic purpura (ITP) in…
  • Abstract Number: 2325 • 2016 ACR/ARHP Annual Meeting

    ANTI-Hmgcr Antibodies Demonstrate High Diagnostic VALUE in the Diagnosis of Immune Mediated Necrotizing Myopathy Following Statin Exposure

    Ora Shovman1, Boris Gilburd2, Chen Chayat3, Chelsea Bentow4, Michael Mahler4 and Yehuda Shoenfeld1,5, 1Zabludowitz Center for Autoimmune Diseases Sheba Medical Center, Zabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel, Ramat Gan, Israel, 2Zabludowitz Center for Autoimmune Diseases Sheba Medical Center, Zabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel, Ramat-Gan, Israel, 3Zabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel, Ramat Gan, Israel, 4Research and Development, Inova Diagnostics, San Diego, CA, 5Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, Tel-Aviv, Israel

    Background/Purpose: Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients…
  • Abstract Number: 101 • 2015 ACR/ARHP Annual Meeting

    New Technologies for Typing Self-Identifying Antigens Encoded By HLA Genes Provide Cost-Effective Alternatives to Identifying B27 Allele Status in Rheumatoid Arthritis Subjects

    Kimberly Robasky1, Jatinder Kaur2, Jennifer Sims1, Melissa Howard1, Eric Earley1 and Eric Lai2, 1EA|Quintiles, Durham, NC, 2Takeda Pharmaceuticals International, Inc., Deerfield, IL

    Background/Purpose: Human leukocyte antigen (HLA) genes code for proteins that allow the immune system to distinguish self from foreign cells. These genes have important indications…
  • Abstract Number: 3264 • 2015 ACR/ARHP Annual Meeting

    Multiplex Serum Protein Analysis in Systemic Sclerosis Defines Potential Anti-Fibrotic Mechanisms and Markers of Response to Hyperimmune Caprine Serum

    Niamh Quillinan1, Kristina E.N. Clark1, Deirdre McIntosh2, Jeffrey Vernes2 and Christopher P. Denton3, 1Rheumatology, UCL Division of Medicine, London, United Kingdom, 2Daval International, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom

    Background/Purpose:   Hyperimmune caprine serum (HICS) administered by subcutaneous injection over 26 weeks has shown benefit for modified Rodnan skin score in diffuse systemic sclerosis…
  • Abstract Number: 208 • 2013 ACR/ARHP Annual Meeting

    Three Approaches To Evaluating Step Therapy Policies For Immune Disorder Specialty Pharmaceuticals

    Michael P. Ingham1, Andrew Paris2, Lorie A. Ellis3 and Chris Kozma4, 1Janssen Scientific Affairs, LLC, Horsham, PA, 2Vigilytics, Victor, NY, 3Health Economics & Outcomes Research, Janssen Scientific Affairs, LLC, Horsham, PA, 4CK Consulting, Saint Helena Island, SC

    Background/Purpose: Rheumatology practices are increasingly exposed to patient health care benefit plans that include “step therapy” (ST) policies which affect medication choice.  Managed care companies…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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