Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune inflammatory diseases.
Methods: We evaluated the presence of anti-HMGCR autoantibodies in sera samples from 13 statin-exposed patients who were suspected of having IMNM, 38 patients with different inflammatory and autoimmune rheumatic diseases (systemic lupus erythematous, rheumatoid arthritis, ankylosing spondylitis, systemic sclerosis, polymyositis and anti-phospholipid syndrome) and 29 healthy subjects. The autoantibodies were detected by two assays: a new chemiluminescence QUANTA Flash HMGCR kit utilizing BIO-FLASH system, and QUANTA Lite®HMGCR ELISA kit.
Conclusion: The presence of anti-HMGCR antibodies is a useful biomarker of IMNM in statin-exposed patients. There is a good correlation between the two anti-HMGCR antibody assays evaluated in the present study.
To cite this abstract in AMA style:Shovman O, Gilburd B, Chayat C, Bentow C, Mahler M, Shoenfeld Y. ANTI-Hmgcr Antibodies Demonstrate High Diagnostic VALUE in the Diagnosis of Immune Mediated Necrotizing Myopathy Following Statin Exposure [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/anti-hmgcr-antibodies-demonstrate-high-diagnostic-value-in-the-diagnosis-of-immune-mediated-necrotizing-myopathy-following-statin-exposure/. Accessed November 28, 2020.
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