Abstracts tagged "Imaging"

Abstract Number: 0812 • ACR Convergence 2023
Length of Synovial Fluid Monosodium Urate Crystals According to Sonographic Articular Deposits: Advancing in the Crystallization Process
Elena Sansano¹, Mª Carmen López-González², Cristina Rodríguez-Alvear³, Irene Calabuig-Sais³, Agustín Martínez-Sanchís³, Eliseo Pascual³ and Mariano Andrés³, ¹Miguel Hernandez University, Alicante, Spain, ²General University Hospital Dr. Balmis, Alacante, Spain, ³Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain
Background/Purpose: We described bands of fibers having deposited orderly arrayed monosodium urate (MSU) crystals suggesting the need for protein templates to start crystallization [PMID 9709185].…
Abstract Number: 1194 • ACR Convergence 2023
Extent of Subregional Involvement of Subchondral Bone Marrow Lesions in Incident Knee OA Is Associated with Weight-Bearing Knee Pain
Kent Kwoh¹, Frank Roemer², Erin Ashbeck³ and Ali Guermazi⁴, ¹University of Arizona, Tucson, AZ, ²Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, ³University of Arizona Arthritis Center, Tucson, AZ, ⁴Boston University, Boston, MA
Background/Purpose: Subchondral bone marrow lesions (BMLs) have been associated with incident and progressive pain and reported to fluctuate along with concurrent fluctuations in symptoms. While…
Abstract Number: 1650 • ACR Convergence 2023
Optic Nerve Sheath Measurement as a Disease Activity Biomarker in Giant Cell Arteritis
Carolyn Ross¹, Stephanie Ducharme-Benard², Samer Hussein³, Rosalie-Selene Meunier³, Christian Pagnoux⁴ and Jean-Paul Makhzoum¹, ¹Vasculitis Clinic, Canadian Network for Research on Vasculitides, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, ²Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, ³Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, ⁴Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose: Recently, optic nerve sheath (ONS) enhancement using contrast-enhanced magnetic resonance imaging of the brain and orbits was observed in most patients with biopsy-proven GCA.…
Abstract Number: 1926 • ACR Convergence 2023
Use of 18F-FDG PET in Assessing Response to Treatment in Adults with Pulmonary Sarcoidosis: A Systematic Literature Review
Koushan Kouranloo¹, Mathangi Krishnakumar² and Mrinalini Dey³, ¹Rheumatology & Internal Medicine Trainee- Surrey, UK. Education fellow University of Liverpool, Liverpool, United Kingdom, ²Wrexham Maelor Hospital, Wrexham, United Kingdom, ³Queen Elizabeth Hospital, London, United Kingdom; University of Liverpool, Liverpool, United Kingdom
Background/Purpose: Sarcoidosis is a chronic, multisystem, granulomatous disease commonly affecting the lungs. Immunosuppressants, particularly corticosteroids, are the mainstay of treatment. Symptoms, severity and response to…
Abstract Number: 2436 • ACR Convergence 2023
Characterizing Spatial Organization of Immune Infiltrates in Rheumatoid Arthritis Synovia Using Spatial Transcriptomic Analysis
Roopa Madhu¹, Kartik Bhamidipati¹, Anna Helena Jonsson¹, Fan Zhang², Lucy MacDonald³, Youngmi Kim⁴, Yi Cui⁴, STARS BWH¹, Accelerating Medicines Partnership Program RA SLE Network⁵, Mariola Kurowska-Stolarska³, Stefano Alvernini⁶, Ellen Gravallese⁷, Michael Brenner⁷, Soumya Raychaudhuri¹, Kevin Wei⁷ and ilya Korsunsky¹, ¹Brigham and Women's Hospital, Boston, MA, ²University of Colorado, Aurora, CO, ³Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Glasgow, Glasgow, United Kingdom, ⁴Nanostring, Seattle, WA, ⁵Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy, ⁷Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune infiltration of the synovial tissue lining joints. RA is clinically heterogenous, with patients having…
Abstract Number: 0923 • ACR Convergence 2023
Identification of Lupus Nephritis Kidney Immune Populations via Hi-Resolution 20-Plex Immunohistochemistry Single-Cell Spatial Analyses
Caleb Marlin¹, Alessandra Ida Celia², Richard Furie³, Judith James¹, Andrea Fava⁴, Joel Guthridge¹, Avi Rosenberg⁵, Tayte Stephens¹, Christian Wright¹, Jeff Hodgin⁶, Peter Izmirly⁷, H Michael Belmont⁸, Jennifer Anolik⁹, Michelle Petri¹⁰, Jill Buyon¹¹, Diane L. Kamen¹², Chaim Putterman¹³, Accelerating Medicines Partnership in RA/SLE The¹, Chen-Yu Lee⁴ and Xiaoping Yang⁴, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²John Hopkins University of Medicine, Rome, Italy, ³Northwell Health, Manhasset, NY, ⁴Johns Hopkins University, Baltimore, MD, ⁵Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, ⁶University of Michigan, Ann Arbor, MI, ⁷New York University School of Medicine, New York, NY, ⁸NYU School of Medicine, New York, NY, ⁹University of Rochester Medical Center, Rochester, NY, ¹⁰Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, ¹¹NYU Grossman School of Medicine, New York, NY, ¹²Medical University of South Carolina, Charleston, SC, ¹³Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Immunohistochemistry is the gold standard for antibody staining in microscopy. However, a lack of multiplexing limits its utility in the use of discovery. Here…
Abstract Number: 1195 • ACR Convergence 2023
Relationship of Depth-Specific Subchondral Bone Mineral Density to MRI Cartilage Worsening: The Multicenter Osteoarthritis Study
Jean Liew¹, JD Johnston², Gabriela Rabasa¹, Beth Lewis³, John Lynch⁴, James Torner⁵ and Tuhina Neogi⁶, ¹Boston University, Boston, MA, ²University of Saskatchewan, Saskatoon, SK, Canada, ³University of Alabama at Birimingham, Birmingham, AL, ⁴University of California San Francisco, San Francisco, CA, ⁵University of Iowa, Iowa City, IA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: While OA has been considered a disease of cartilage, early subchondral bone changes may precede cartilage abnormalities. Although higher systemic BMD has a known…
Abstract Number: 1690 • ACR Convergence 2023
Apremilast Reduces Inflammation as Measured by MRI of the Hand in Patients with Psoriatic Arthritis: Primary Results from the Phase 4 MOSAIC Study
Mikkel Østergaard¹, Walter P. Maksymowych², Mikael Boesen³, Robert Lambert⁴, Guillermo Valenzuela⁵, Michael Bubb⁶, Olga Kubassova⁷, Jyotsna Reddy⁸, Stephen Colgan⁹, Yuri Klyachkin¹⁰, Cynthia Deignan¹¹, Lihua Tang⁸, Maria Paris⁸ and Philip J. Mease¹², ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark, ²University of Alberta, Edmonton, AB, Canada, ³Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital, Naerum, Denmark, ⁴Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ⁵Integral Rheumatology & Immunology Specialists, Plantation, FL, ⁶University of Florida, Gainesville, FL, ⁷Image Analysis Group, Philadelphia, PA, ⁸Amgen, Inc., Thousand Oaks, CA, ⁹Amgen, Inc., Halton Hills, ON, Canada, ¹⁰Amgen, Inc., Lexington, KY, ¹¹Amgen, Inc., Agoura Hills, CA, ¹²Swedish Medical Center/Providence St. Joseph Health and University of Washington School of Medicine, Seattle, WA
Background/Purpose: PsA is characterized by inflammatory arthritis, enthesitis, dactylitis, and spondylitis. Apremilast (APR) is an oral immunomodulating phosphodiesterase-4 inhibitor approved for the treatment of PsA.…
Abstract Number: 1959 • ACR Convergence 2023
Quantitative Scoring of High Resolution Chest Computed Tomography (HRCT) Images in Myositis and Antisynthetase Syndrome Related Interstitial Lung Disease in Comparison to Scleroderma Related Interstitial Lung Disease
Sangmee Bae¹, Fereidoun Abtin², Grace Kim³, Siamak Moghadam-Kia⁴, Chester V. Oddis⁵, Lila Pourzand², Didem Saygin⁵, Daniel Sullivan⁶, Koichi Yamaguchi⁷, Donald Tashkin³, Christina Charles-Schoeman⁸, Jonathan Goldin³ and Rohit Aggarwal⁵, ¹UCLA Rheumatology, Los Angeles, CA, ²UCLA Radiological Sciences, Los Angeles, CA, ³University of California Los Angeles, Los Angeles, CA, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶UCLA Pulmonology, Pittsburgh, PA, ⁷University of Pittsburgh Medical Center Rheumatology, Pittsburgh, PA, ⁸UCLA Medical Center, Santa Monica, CA
Background/Purpose: High resolution computed tomography (HRCT) of the chest has become an important modality in the evaluation of interstitial lung disease (ILD). A quantitative CT…
Abstract Number: 2525 • ACR Convergence 2023
Comparing Patellar Tendon Characteristics Between Adults with and Without Knee Pain
Samantha Price¹, Karin Silbernagel², David Felson³, Joshua Stefanik⁴ and Patrick Corrigan¹, ¹Saint Louis University, St. Louis, MO, ²University of Delaware, Avondale, PA, ³Boston University, Boston, MA, ⁴Northeastern University, Boston, MA
Background/Purpose: Knee pain is one of the most common types of joint pain leading to disability, limited physical activity, and reduced quality of life. While…
Abstract Number: 0939 • ACR Convergence 2023
HRCT-derived Delta Radiomic Features Classify Response to Anti-Fibrotic Treatment in Experimental and Human Fibrosing Interstitial Lung Disease
David Lauer¹, Luca Romano Kolly¹, Hubert Gabrys², Matthias Brunner¹, Malgorzata Anna Maciukiewicz¹, Thomas Frauenfelder³, Stephanie Tanadini-Lang², Anne-Christine Uldry⁴, Manfred Heller⁴, Kerstin Klein⁵, Oliver Distler⁶, Janine Gote-Schniering¹ and Britta Maurer⁷, ¹University Hospital Bern, Bern, Switzerland, ²University Hospital Zurich, Zurich, Switzerland, ³Dept of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁴University of Bern, Bern, Switzerland, ⁵Department of Rheumatology and Immunology, University Hospital Bern, Bern, Switzerland, ⁶Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁷University Hospital Bern, University Bern, Bern, Switzerland
Background/Purpose: Quantification of response to anti-fibrotic drugs in patients with fibrosing interstitial lung disease (ILD) relies on repeated pulmonary function tests (PFT) and visual evaluation…
Abstract Number: 1286 • ACR Convergence 2023
Impact of Body Mass Index (BMI) on Upper versus Lower Extremity Joints Assessed Using Clinical and Musculoskeletal Ultrasound Measures in Rheumatoid Arthritis Patients
Nicolette Morris¹, Elena Saab², Lucia Chen¹, Jenny Brook¹, Gurjit S Kaeley³, David Elashoff¹ and Veena Ranganath¹, ¹David Geffen School of Medicine, UCLA, Los Angeles, CA, ²Wake Forest University School of Medicine, Los Angeles, CA, ³University of Florida College of Medicine – Jacksonville, Ponte Vedra Beach, FL
Background/Purpose: Tender and swollen joints counts may be differentially affected in rheumatoid arthritis (RA) patients with obesity. A prior study demonstrated an association between increased…
Abstract Number: 1716 • ACR Convergence 2023
High-Throughput Semi-Automated Micro-CT Analysis Identifies the Cuboid Bone as a Sex-Dependent Biomarker of Inflammatory-Erosive Arthritis in TNF-Tg Mice
H. Mark Kenney¹, Kiana Chen², Lindsay Schnur³, Jeffrey Fox³, Ronald Wood³, Lianping Xing⁴, Christopher T Ritchlin⁵, Homaira Rahimi⁶, Edward Schwarz⁶ and Hani Awad³, ¹University of Rochester School of Medicine and Dentistry, Henrietta, NY, ²University of Rochester School of Medicine and Dentistry, Rochester, NY, ³University of Rochester Medical Center, Rochester, NY, ⁴University of Rochester Medical Center, Webster, NY, ⁵University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY, ⁶University of Rochester, Rochester, NY
Background/Purpose: Development of reliable disease activity biomarkers is critical for diagnostics, prognostics, and novel drug development. In the case of preclinical models of inflammatory-erosive arthritis,…
Abstract Number: 1987 • ACR Convergence 2023
Clinical and Imaging Characteristics of Individuals Who Underwent Knee Replacement During Years 3 to 5 in the FORWARD Study: A Post Hoc Analysis
Philip Conaghan¹, Felix Eckstein², Wolfgang Wirth³, Marc Hochberg⁴, Ali Guermazi⁵, Luping Zhao⁶ and Niti Goel⁷, ¹University of Leeds, Leeds, United Kingdom, ²Paracelsus Medical University, Institute of Anatomy & Ludwig Boltzmann Institute, and Chondrometrics GmbH, Salzburg, Austria, ³Paracelsus Medical University, Institute of Anatomy & Ludwig Boltzmann Institute, and Chondrometrics GmbH, Freilassing, Germany, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Boston University, Boston, MA, ⁶TrialSpark, New York, NY, ⁷TrialSpark, Duke University, Durham, NC
Background/Purpose: Sprifermin is an investigational intra-articular (IA) recombinant human truncated fibroblast growth factor-18 (rhFGF-18) therapy evaluated to date in three knee osteoarthritis (KOA) trials (NCT00911469…
Abstract Number: 0167 • ACR Convergence 2023
Healthcare Resource Utilization Associated with Tumor-Induced Osteomalacia: Review of Patient Histories Prior to Entry in Clinical Trial UX023T-CL201
Suzanne Jan de Beur¹, Thomas Carpenter², Kathryn Dahir³, Erik Imel⁴, María Belén Zanchetta⁵, Angela Williams⁶, Zhiyi Li⁷, Matthew Sharp⁶ and Ben Johnson⁶, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Yale School of Medicine, New Haven, CT, ³Vanderbilt University Medical Center, Nashville, TN, ⁴Indiana University School of Medicine, Indianapolis, IN, ⁵Universidad del Salvador, Buenos Aires, Argentina, ⁶Kyowa Kirin International, Marlow, United Kingdom, ⁷Kyowa Kirin North America, Bedminster, NJ
Background/Purpose: Tumor-induced osteomalacia (TIO) is an ultra-rare paraneoplastic disorder, characterized by renal phosphate wasting due to increased production of fibroblast growth factor 23 (FGF23). Chronic…

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