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Abstracts tagged "IgG4 Related Disease"

  • Abstract Number: 1779 • 2018 ACR/ARHP Annual Meeting

    Is the Number of IgG4+ Plasma Cells Observed By Immunostaining Important Beyond Its Diagnostic Utility in IgG4-Related Disease?

    Eduardo Martín Nares1, Jacobo Guerrero Castillo2, Arturo Angeles Angeles2 and Gabriela Hernandez-Molina1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: The histopathological findings in IgG4-related disease (IgG4-RD) includes the presence of dense lymphoplasmacytic infiltrate, obliterative phlebitis, storiform fibrosis and the presence of marked IgG4+…
  • Abstract Number: 1781 • 2018 ACR/ARHP Annual Meeting

    Retrospective Analysis of IgG4-RD Patient Population at the Cleveland Clinic between 2007-2017

    Chan Mi Lee1, Mohamed Alalwani2, Richard Prayson1,3 and Carmen E. Gota1,4, 1Education, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2Hospital Medicine, Cleveland Clinic, Cleveland, OH, 3Anatomic Pathology, Cleveland Clinic, Cleveland, OH, 4Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH

    Background/Purpose: IgG4-related disease (IgG4-RD) is a rare multisystem fibro-inflammatory condition, characterized by organ mass lesions, IgG4+ lymphoplasmacytic infiltrate, and storiform fibrosis. To gain better understanding…
  • Abstract Number: 1783 • 2018 ACR/ARHP Annual Meeting

    Salivary Gland Disease in IgG4-Related Disease Is Associated with Allergic Histories

    Samantha Sanders1, Emanuel Della Torre2, Cory A. Perugino3, Aidan Long4, Hyon K. Choi4, John H. Stone5 and Zachary Wallace6, 1Harvard Medical School, Boston, MA, 2Unit of Medicine and Clinical Immunology, San Raffaele Scientific Institute, Milan, Italy, 3Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 4Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, 5Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, 6Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: The etiology of IgG4-related disease (IgG4-RD) remains unknown. The role of T-helper type 2 (Th2) cells in the pathogenesis of IgG4-RD is controversial. Given…
  • Abstract Number: 1785 • 2018 ACR/ARHP Annual Meeting

    A Data-Driven Approach to Guide Physicians When Considering the Differential Diagnosis of IgG4-Related Disease

    Mark A. Matza1, Zachary Wallace2 and John H. Stone3, 1Rheumatology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: IgG4-Related Disease (IgG4-RD) is a chronic immune-mediated fibro-inflammatory disorder of unknown etiology.  The differential diagnosis is broad, partly because of the myriad potential organ…
  • Abstract Number: 1787 • 2018 ACR/ARHP Annual Meeting

    How to Better Diagnose IgG4 Related Disease: a Single-Center Based Experience

    Anji Xiong1, Yuan Yang1, Beibei Cui1, Jianhong Sun1, Qibing Xie1, Yi Zhao1, Chunyu Tan1, Min Yang1, Yi Liu1, Honghu Tang1, Pingying Qing1, Lingshu Zhang1, Yubin Luo1, Yan Liang1, Ying Wang1, Yali Ye1, Ling Ma1, Shiyu Yi1 and Yi Liu2, 1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China, 2Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China

    Background/Purpose: Pathology associated with IgG4-related disease (IgG4-RD) has been described in virtually every tissue and organ of the body. The heterogeneous clinical manifestations of IgG4-RD…
  • Abstract Number: 4L • 2017 ACR/ARHP Annual Meeting

    Final Results of an Open Label Phase 2 Study of a Reversible B Cell Inhibitor, Xmab®5871, in IgG4-Related Disease

    John H. Stone1, Zachary S. Wallace2, Cory A. Perugino3, Ana D. Fernandes4, Payal Patel5, Paul A. Foster6 and Debra J. Zack6, 1Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 4Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, 5Rheumatology, Harvard, Boston, MA, 6Xencor, Inc., San Diego, CA

    Background/Purpose: IgG4-related disease (IgG4-RD) is an immune-mediated condition causing fibro-inflammatory lesions that can lead to irreversible organ damage and death. No approved therapies exist. A…
  • Abstract Number: 1882 • 2017 ACR/ARHP Annual Meeting

    Thymus and Activation-Regulated Chemokine (TARC) As Biomarker for IgG4-Related Disease

    Masataka Umeda1,2, Tomoki Origuchi3, Shinya Kawashiri1,4, Tomohiro Koga1,5, Kunihiro Ichinose1, Yushiro Endo1, Sousuke Tsuji1, Ayuko Takatani1, Takashi Igawa1, Toshimasa Shimizu1, Shoichi Fukui1,4, Remi Sumiyoshi1, Ayako Nishino1,6, Naoki Iwamoto1, Mami Tamai1, Hideki Nakamura1 and Atsushi Kawakami1, 1Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Medical Education Development Center, Nagasaki University Hospital, Nagasaki, Japan, 3Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, 4Departments of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, 6Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Background/Purpose: TARC, also known as chemokine ligand 17 (CCR17), is expressed in the thymus and is produced by dendritic cells, endothelial cells, keratinocytes and fibroblasts.…
  • Abstract Number: 2093 • 2017 ACR/ARHP Annual Meeting

    Comparison of Clinical and Laboratory Features of Patients with and without Allergic Conditions in IgG4-Related Disease: A Single-Center Experience in Japan

    Takako Saeki, Tomoyuki Ito, Maasa Tamura, Seiichi Yoshikawa and Hajime Yamazaki, Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan

    Background/Purpose:  Although patients with IgG4-related disease (IgG4-RD) sometimes have accompanying allergic conditions, few data on the relationship between allergic conditions and IgG4-RD have been available.…
  • Abstract Number: 2101 • 2017 ACR/ARHP Annual Meeting

    The Clinical Characteristics of IgG4 Related Disease in China: With 346 Cases Reported

    Panpan Zhang1, Wen Zhang2, Jizhi Zhao3, Mu Wang3, Ruie Feng3, Xiaowei Liu3, Xuemei Li3, Yamin Lai3, Xuejun Zeng3, Juhong Shi3, Huijuan Zhu3, Huadan Xue3, Wei Zhang3, Hua Chen4, Yunyun Fei3, Linyi Peng3, Xiaofeng Zeng5 and Fengchun Zhang3, 1Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, 2Rheuamtology, Peking Union Medical College Hospital, Beijing, China, 3Peking Union Medical College Hospital, Beijing, China, 4Rheumatology, Peking Union Medical College Hospital, Beijing, China, 5Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: To study the clinical characteristics of IgG4-RD patients in China Methods: Patients were recruited from a prospective cohort study of IgG4-RD in Peking Union…
  • Abstract Number: 2705 • 2017 ACR/ARHP Annual Meeting

    Aberrant Expression and Function of Human Circulating T Follicular Helper Cells and Its Subsets in IgG4 Related Disease

    Yu Chen1, Wen Zhang2, Panpan Zhang3, Yanan Zhu1 and Hongxian Yang3, 1Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 2Rheuamtology, Peking Union Medical College Hospital, Beijing, China, 3rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

    Background/Purpose: To study the expression and function of T follicular helper cells and its subsets in IgG4-related disease(IgG4-RD). Methods: Flow cytometry was performed to analyze…
  • Abstract Number: 2873 • 2017 ACR/ARHP Annual Meeting

    DNA Microarray Analysis Identifies Nuclear Receptor Subfamily 4 Group a Member 2 (NR4A2) As a Novel Molecule Involved in the Pathogenesis of Sjogren’s Syndrome

    Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Hanae Kudo, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose:Some reports on DNA microarray analysis in labial salivary glands (LSGs) of Sjögren’s syndrome (SS) and healthy controls (HCs) showed that the genes associated with…
  • Abstract Number: 1066 • 2017 ACR/ARHP Annual Meeting

    Invention and Phenotypic Evaluation of Human IgG4-Knock-in Mice

    Yoshie Gon, Hajime Yoshifuji, Koji Kitagori, Toshiki Nakajima, Kosaku Murakami, Ran Nakashima, Koichiro Ohmura and Tsuneyo Mimori, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: IgG4-related disease (IgG4-RD) is a disorder characterized by elevated serum IgG4 concentration and infiltration of IgG4-positive plasma cells into affected organs, however, the role…
  • Abstract Number: 1175 • 2017 ACR/ARHP Annual Meeting

    Rituximab for Idiopathic and IgG4-Related Retroperitoneal Fibrosis

    Rachel Wallwork1, Zachary S. Wallace2, Cory A. Perugino3, Amita Sharma4 and John H. Stone5, 1Department of Medicine, Massachusetts General Hospital, Boston, MA, 2Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 4Department of Radiology, Massachusetts General Hospital, Boston, MA, 5Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA

    Rituximab for Idiopathic and IgG4-Related Retroperitoneal FibrosisBackground/Purpose: Untreated retroperitoneal fibrosis (RPF) can lead to chronic back and flank pain and/or renal failure. The mainstay of…
  • Abstract Number: 1180 • 2017 ACR/ARHP Annual Meeting

    Multicenter Study on the Rate of Renal Function Deterioration in IgG4-Related Tubulointerstitial Nephritis

    Mitsuhiro Kawano1, Ichiro Mizushima2, Takahiro Matsunaga1, Kazunori Yamada3, Satoshi Hara1, Hiroshi Fujii1, Takako Saeki4, Yoshinori Taniguchi5 and Hitoshi Nakashima6, 1Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan, 2Kanazawa University Hospital, Kanazawa, Japan, 3Department of Advanced Research in Community Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, 4Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan, 5Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School, Kochi, Japan, 6Div of Nephrol & Rheumatol, Dept of Int Med, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Background/Purpose: Only a few reports have focused on the rate of renal function deterioration in IgG4-related tubulointerstitial nephritis (IgG4-TIN). Some cases show acute or progressive…
  • Abstract Number: 1346 • 2017 ACR/ARHP Annual Meeting

    Selective Effect of Rituximab on IgG4 Anti-CCP Autoantibodies in Rheumatoid Arthritis Patients

    Mercedes Rincon1,2, Sarah Kelso3, Janice Bunn4 and Sheldon Cooper5, 1Department of Medicine/Rheumatology, University of Vermont, Burlingont VT, VT, 2Department of Medicine/Immunobiology, University of Vermont, Burlington, VT, 3Department of Medicine/Rheumatology, Univeristy of Vermont, Burlington, VT, 4Mathematics and Statistics, University of Vermont, Burlington, VT, 5Department of Medicine/Rheumatology, University of Vermont, Burlington, VT

    Background/Purpose: Autoantibodies have long been recognized to be present in patients with RA, but it is more recent that autoantibodies against citrullinated proteins (anti-CCP) are…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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