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Abstracts tagged "IgG4 Related Disease"

  • Abstract Number: 0536 • ACR Convergence 2024

    A Population Modeling and Simulation of the Effect of Obexelimab Exposure on the QTc Interval in Healthy Volunteers and Patients with Rheumatoid Arthritis or IgG4-Related Disease

    Claire Mukashyaka1, Xiaodong Wang1, Sujata Arora1, Mason Yamashita1, Allen Poma1 and Tanya Fischer2, 1Zenas BioPharma, Waltham, MA, 2Zenas BioPharma, Waltham, CA

    Background/Purpose: Obexelimab is a novel bifunctional antibody that inhibits B cells, CD19-expressing plasma cells, and plasmablast activity and has the potential to provide clinical benefit…
  • Abstract Number: 2507 • ACR Convergence 2024

    IgG4-related Disease Features and Immunological Profile in a Tertiary Center in Sao Paulo-Brazil

    Frederico Pinheiro1, Cristina Orikaza2, Gerson Keppeke3, Emília Sato2 and Alexandre de Souza4, 1Universidade Federal de Sao Paulo - UNIFESP, São Paulo, SP, Brazil, 2Universidade Federal de Sao Paulo, São Paulo, SP, Brazil, 3Universidad Catolica del Norte, São Paulo, Coquimbo, Brazil, 4UNIFESP-EPM, São Paulo, SP, Brazil

    Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic, fibroinflammatory condition affecting almost all organs. It is a rare entity that is continuously being studied worldwide. It…
  • Abstract Number: 0736 • ACR Convergence 2024

    Treatment of IgG4-Related Disease (IgG4-RD) with Elotuzumab, an Inhibitor of SLAM-F7: Report of a Phase 2 Clinical Trial

    John Stone1, Arezou Khosroshahi2, Shounak Majumder3, Cory Perugino4, Ana Fernandes4, Grace McMahon4, Isha Jha4, John Varghese2, Adriana Delgado3, Guy Katz4, Zachary Wallace5, Shiv Pillai4, William Barry6, Ashley Pinckney7, Ellen Goldmuntz8, Beverly Welch9 and Kaitlin McShea9, 1Massachusetts General Hospital , Harvard Medical School, Concord, MA, 2Emory University, Atlanta, GA, 3Mayo Clinic, rochester, MN, 4Massachusetts General Hospital, Boston, MA, 5Massachusetts General Hospital, Newton, MA, 6Rho, Durham, NC, 7Rho, St Louis Park, NC, 8NIAID/ NIH, Washington, DC, 9Rho, Washington, DC

    Background/Purpose: CD4+ cytotoxic T lymphocytes (CD4+ CTLs), plasmablasts, and selected other cells of the T and B cell lineages have been identified as cellular linchpins of…
  • Abstract Number: 0753 • ACR Convergence 2024

    Treatment and Evolution in 134 Patients with Aortitis and Periaortitis. Experience of a Single Referral Centre

    Carmen Secada Gómez1, Javier Loricera2, Adrián Martín-Gutiérrez3, Fernando Lopez-Gutierrez4, Santos Castañeda5 and Ricardo Blanco-Alonso6, 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 5Hospital Universitario de la Princesa, Madrid, Spain, 6Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Aortitis and periaortitis include a heterogeneous group of entities that may be idiopathic or secondary to infectious and non-infectious processes. Therefore, treatment will differ…
  • Abstract Number: 0754 • ACR Convergence 2024

    Clinical Characterization of Aortitis and Periaortitis in a Cohort of 134 Patients from a Single Universitary Center. A Model-based Cluster Analysis

    Carmen Secada Gómez1, Javier Loricera2, Adrián Martín-Gutiérrez3, Fernando Lopez-Gutierrez4, María Nuñez-Sayar5, Ander Ucelay-Aristi5, Isabel Martinez-Rodriguez6, ivan Ferraz-Amaro7, Santos Castañeda8 and Ricardo Blanco-Alonso9, 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 5Cardiovascular Surgery, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 6Nuclear Medicine, Hospital Universitario Marques de Valdecilla,IDIVAL, Santander, Cantabria, Spain, 7Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 8Hospital Universitario de la Princesa, Madrid, Spain, 9Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Aortitis and periaortitis represent the inflammation of the aortic wall and the surrounding periaortic tissues, respectively. Both can be idiopathic or secondary to infectious…
  • Abstract Number: 0775 • ACR Convergence 2024

    A Phase 3, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study of Inebilizumab in IgG4-Related Disease (MITIGATE): Primary Efficacy and Safety Findings

    John Stone1, Emma Culver2, Arezou Khosroshahi3, Wen Zhang4, Emanuel Della Torre5, Kazuichi Okazaki6, Yoshiya Tanaka7, Matthias Löhr8, Nicolas Schleinitz9, Lingli Dong10, Hisanori Umehara11, Marco Lanzillotta12, Zachary Wallace13, Mikael Ebbo14, George Webster15, Ferran Martinez Valle16, Manu Nayar17, Vinciane Rebours18, Cory Perugino19, Xinxin Dong20, Yanping Wu20, Nishi Rampal20 and Daniel Cimbora20, 1Massachusetts General Hospital , Harvard Medical School, Concord, MA, 2John Radcliffe Hospital, and Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 3Emory University, Atlanta, GA, 4Peking Union Medical College Hospital, Dong Cheng Qu, China (People's Republic), 5Ospedale San Raffaele, Milan, Italy, 6University of Occupational and Environmental Health, Osaka, Japan, 7Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 8Karolinska Institutet, Stockholm, Sweden, 9Aix Marseille university, AP-HM, Marseille, France, 10Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (People's Republic), 11Department of Rheumatology and Immunology, Nagahama City Hospital,, Nagahama, Shiga 526-0043, Japan, Japan, 12IRCCS Ospedale San Raffaele, Milano, Italy, 13Massachusetts General Hospital, Newton, MA, 14Aix-Marseille Université, Marseille, France, 15University College Hospital London, London, United Kingdom, 16Vall d’Hebron Hospital, Barcelona, Spain, 17Freeman Hospital, Newcastle Upon Tyne, United Kingdom, 18Beaujon Hospital, Université Paris-Cité, France, 19Massachusetts General Hospital, Boston, MA, 20Amgen Inc., Thousand Oaks, CA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a rare, systemic, fibroinflammatory disease characterized by unpredictable and recurring flares, leading to organ damage and decreased quality of life.…
  • Abstract Number: 1113 • ACR Convergence 2024

    2nd Analysis of IgG4-Related Disease in a Diverse Long Island Population: Utilizing Serological and Histological Markers for Assessing Treatment Response

    Young Min Cho1, Alejandro Quintero Villegas2, Matt Means3, Zanos Theodoros2, Lara El Khoury4 and Galina Marder3, 1Northwell, Glen Cove, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY, 3Northwell, Manhasset, NY, 4Division of Rheumatology/Northwell Health, Great Neck, NY

    Background/Purpose: IgG4-RD presents various clinical manifestations, making it challenging to assess treatment responses.  B-cell depletion agents such as Rituximab (RTX) are used in refractory cases.…
  • Abstract Number: 1123 • ACR Convergence 2024

    Serological Elevation of IgG4: Clinical Correlation and Differential Diagnosis

    Pablo Martínez Calabuig1, Laura Salvador Maicas2, Mireia Lucía Sanmartín Martínez3, Iván Jesús Lorente Betanzos3, Jorge Juan Fragío Gil4, Roxana González Mazario5, Amalia Rueda5, juan José Lerma Garrido6, Clara Molina Almela3 and Cristina Campos Fernández7, 1HOSPITAL GENERAL UNIVERSITARIO VALENCIA SPAIN, Ontinyent, Comunidad Valenciana, Spain, 2Consorcio Hospital General Universitario de Valencia, Castellón de la Plana, Comunidad Valenciana, Spain, 3Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain, 4Hospital General Universitario, Valencia, Comunidad Valenciana, Spain, 5Hospital General de Valencia, Valencia, Comunidad Valenciana, Spain, 6Hospital General Universitario Valencia, Valencia, Comunidad Valenciana, Spain, 7Department of Rheumatology. Hospital General Universitario de Valencia, Valencia, Spain

    Background/Purpose: IgG4-related disease (IgG4-RD) is a rare, systemic, immunomediated fibroinflammatory process with uncertain etiology and pathophysiology that can affect multiple organs, presenting common clinical, radiological,…
  • Abstract Number: 1675 • ACR Convergence 2024

    Extended Validation of the IgG4-Related Disease Symptom Severity Index (SSI)

    Isha Jha1, Grace McMahon1, Guy Katz1, Shruthi Srivatsan1, Caleb Bolden1, Ana Fernandes1, Cory Perugino1, John Stone2 and Zachary Wallace3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital , Harvard Medical School, Concord, MA, 3Massachusetts General Hospital, Newton, MA

    Background/Purpose: The Symptom Severity Index (SSI) is a patient-reported outcome measure (PROM) developed for IgG4-related disease (IgG4-RD). The SSI assesses symptoms of IgG4-RD and the…
  • Abstract Number: 1835 • ACR Convergence 2024

    FoxP3Hi CTLA4+ ICOS+ Regulatory T Cells Are Expanded in Patients with Sarcoidosis but Not Systemic Sclerosis or IgG4-Related Disease

    Laura Yockey1, Thomas Guy2, Chinmay Gadiraju3, Ian Doyle1, Jesse Akaa4, Alison Puri5, Zachary Wallace6, Guy Katz1, Sydney Montesi1, John Stone7, Flavia Castelino1, Shiv Pillai8, Andrew Luster9, Vinay Mahajan3 and Cory Perugino1, 1Massachusetts General Hospital, Boston, MA, 2Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 3Brigham and Women's Hospital, Boston, MA, 4Massachussets General Hospital, Boston, MA, 5Boston University, Brookline, MA, 6Massachusetts General Hospital, Newton, MA, 7Massachusetts General Hospital , Harvard Medical School, Concord, MA, 8Harvard Medical School, Cambridge, MA, 9Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: The absence of regulatory T cells (Tregs) results in multiorgan autoimmunity in the context of monogenic “Tregopathies”, but their role in mediating polygenic autoimmune…
  • Abstract Number: 2027 • ACR Convergence 2024

    Clinical Features and Treatment of Retroperitoneal Fibrosis in a Referral Hospital and Literature Review

    Adrián Martín-Gutiérrez1, Javier Loricera2, Fernando Lopez-Gutierrez3 and Ricardo Blanco-Alonso4, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 4Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Retroperitoneal fibrosis (RPF) is usually idiopathic (iRPF), but may be secondary to drugs, neoplasms, infections, or may be part of an IgG4-related disease. Our…
  • Abstract Number: 2031 • ACR Convergence 2024

    A Contemporary Assessment of the Burden of Malignancy in IgG4-Related Disease

    Grace McMahon1, Isha Jha1, Guy Katz1, Cory Perugino1, Ana Fernandes1, John Stone2 and Zachary Wallace3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital , Harvard Medical School, Concord, MA, 3Massachusetts General Hospital, Newton, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder that can affect nearly any organ. Because of the often tumefactive nature of IgG4-RD and its typical…
  • Abstract Number: 2035 • ACR Convergence 2024

    Older Age and Higher Erythrocyte Sedimentation Rate Are Associated with Increased Disease Burden at Diagnosis in a Cohort of IgG4-Related Disease Patients

    Humberto Campos Clemente, Barbara Bayeh, Monica Raquel de Souza Aquino, Fernanda Oliveira de Andrade Lopes, Thiago Quadrante Freitas, Rafael Alves Cordeiro and Henrique Ayres Mayrinki Giardini, Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil

    Background/Purpose: Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition primarily affecting middle-aged males. It is characterized by mass lesions affecting various organs, such as the…
  • Abstract Number: 0007 • ACR Convergence 2024

    Bromodomain 2 of BET Proteins Plays a Crucial Role in Follicular/peripheral Helper T Cell and Plasma Cell Differentiation

    Ryota Sato1, Mitsuhiro Akiyama2, Koichi Oshita3, Yuko Kawano3, Yuki Imura3, Piruzyan Mariam4, Manami Kikuchi3, Mikako Murase3, Sachiko Mochiduki3, Naohiro Hashimoto3, Masayuki Watanabe3, Keiko Yoshimoto5, Tsutomu Takeuchi6, Kenji Chiba7 and Yuko Kaneko5, 1Mitsubishi Tanabe Pharma Corporation, Brighton, MA, 2Keio University School of Medicine, Palo Alto, CA, 3Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 4Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan, 5Keio University School of Medicine, Tokyo, Japan, 6Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 7Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan

    Background/Purpose: Proteins motifs bromodomain 1 (BD1) and BD2 within the BET family proteins regulate gene expression of inflammatory cytokines and lymphocyte proliferation by binding to…
  • Abstract Number: 2037 • ACR Convergence 2024

    Can Tofacitinib Be the Saviour in Treatment of Refractory IgG4-Related Disease : A Multicentre Experience from India

    Jasneet Singh1, SHRUTI BAJAD2 and DHAVAL TANNA3, 1THE MEDICLINIC-ARTHRITIS & RHEUMATOLOGY CENTER, LUDHIANA, Punjab, India, 2Moolchand hospital , Delhi, DELHI, Delhi, India, 3SAURASHTRA RHEUMATOLOGY CENTER, Rajkot, Gujarat, India

    Background/Purpose: We did an observational study  to  assess the  efficacy and safety of the Janus kinase (JAK) inhibitor tofacitinib in patients having refractory IgG4-Related Disease…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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