Abstracts tagged "IgG4 Related Disease"

Abstract Number: 2101 • 2017 ACR/ARHP Annual Meeting
The Clinical Characteristics of IgG4 Related Disease in China: With 346 Cases Reported
Panpan Zhang¹, Wen Zhang², Jizhi Zhao³, Mu Wang³, Ruie Feng³, Xiaowei Liu³, Xuemei Li³, Yamin Lai³, Xuejun Zeng³, Juhong Shi³, Huijuan Zhu³, Huadan Xue³, Wei Zhang³, Hua Chen⁴, Yunyun Fei³, Linyi Peng³, Xiaofeng Zeng⁵ and Fengchun Zhang³, ¹Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, ²Rheuamtology, Peking Union Medical College Hospital, Beijing, China, ³Peking Union Medical College Hospital, Beijing, China, ⁴Rheumatology, Peking Union Medical College Hospital, Beijing, China, ⁵Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: To study the clinical characteristics of IgG4-RD patients in China Methods: Patients were recruited from a prospective cohort study of IgG4-RD in Peking Union…
Abstract Number: 2705 • 2017 ACR/ARHP Annual Meeting
Aberrant Expression and Function of Human Circulating T Follicular Helper Cells and Its Subsets in IgG4 Related Disease
Yu Chen¹, Wen Zhang², Panpan Zhang³, Yanan Zhu¹ and Hongxian Yang³, ¹Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ²Rheuamtology, Peking Union Medical College Hospital, Beijing, China, ³rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
Background/Purpose: To study the expression and function of T follicular helper cells and its subsets in IgG4-related disease(IgG4-RD). Methods: Flow cytometry was performed to analyze…
Abstract Number: 2873 • 2017 ACR/ARHP Annual Meeting
DNA Microarray Analysis Identifies Nuclear Receptor Subfamily 4 Group a Member 2 (NR4A2) As a Novel Molecule Involved in the Pathogenesis of Sjogren’s Syndrome
Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Hanae Kudo, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose:Some reports on DNA microarray analysis in labial salivary glands (LSGs) of Sjögren’s syndrome (SS) and healthy controls (HCs) showed that the genes associated with…
Abstract Number: 1066 • 2017 ACR/ARHP Annual Meeting
Invention and Phenotypic Evaluation of Human IgG4-Knock-in Mice
Yoshie Gon, Hajime Yoshifuji, Koji Kitagori, Toshiki Nakajima, Kosaku Murakami, Ran Nakashima, Koichiro Ohmura and Tsuneyo Mimori, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a disorder characterized by elevated serum IgG4 concentration and infiltration of IgG4-positive plasma cells into affected organs, however, the role…
Abstract Number: 238 • 2016 ACR/ARHP Annual Meeting
Identifying Immunoglobulin G4-Related Disease in Archived Pathological Specimens
Priya Prakash¹, Faisal Saeed², Slavica Bobic³, Kirk Sperber¹, Julia Yegudin-Ash¹, Humayun Islam² and Amy Wasserman⁴, ¹Medicine-Rheumatology, New York Medical College / Westchester Medical Center, Valhalla, NY, ²Pathology, New York Medical College / Westchester Medical Center, VALHALLA, NY, ³Medicine-Rheumatology, New York Medical College / Westchester Medical Center, valhalla, NY, ⁴Medicine - Rheumatology, New York Medical College / Westchester Medical Center, VALHALLA, NY
Background/Purpose: Immunoglobulin G4-related disease (IgG4-RD) is a recently defined entity characterized by a diffuse or mass forming inflammatory reaction rich in IgG4-positive plasma cells. Due…
Abstract Number: 243 • 2016 ACR/ARHP Annual Meeting
Eosinophilic Angiocentric Fibrosis : A Mimic of Vasculitis in IgG4 Related Disease Spectrum
Raphaël Lecomte¹, Antoine Néel², Olivier Malard³, Jérôme Martin⁴, Michael Hénoux³, Elisabeth Cassagnau⁵ and Mohamed Hamidou^6,7, ¹Internal Medicine Department, CHU Nantes, Nantes, France, ²Department of Internal Medicine, Nantes University Hospital, Nantes, France, ³ENT, ENT department, Nantes University Hospital, Nantes, France, ⁴Immunology laboratory, Immunology laboratory, Nantes University Hospital, Nantes, France, ⁵Histopathology, Histopathology department, Nantes University Hospital, Nantes, France, ⁶Hotel Dieu, Service de médecine interne, Hôpital Universitaire de Nantes, Nantes, France, Nantes, France, ⁷Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France
Background/Purpose: Eosinophilic angiocentric fibrosis (EAF) is a rare localized fibro-inflammatory lesion involving usually upper respiratory tract and the orbit. It could mimic ENT manifestations of…
Abstract Number: 244 • 2016 ACR/ARHP Annual Meeting
Leflunomide and Glucocorticoids Combination Therapy for the Induction and Maintenance of Remission in Patients with IgG4-Related Disease
Yiwen Wang¹, Dai Gao¹, Gui Luo², Kunpeng Li¹, Zheng Zhao¹ and Jian Zhu¹, ¹Rheumatology, Chinese PLA General Hospital, Beijing, China, ²Chinese PLA General Hospital, Beijing, China
Background/Purpose: Good response could be observed after applying glucocorticoids (GCs) in patients with IgG4-related disease (IgG4-RD), however, the risk of disease relapse was reported relatively…
Abstract Number: 1283 • 2016 ACR/ARHP Annual Meeting
Utility of FDG-PET Imaging and Serological Biomarkers for Diagnosing Lymphadenopathy of IgG4-Related Diseas
Hiroaki Dobashi, Hiroki Ozaki, Atsushi Kondo, Risa Wakiya, Hiromi Shimada, Shusaku Nakashima, Miharu Izumikawa and Tomohiro Kameda, Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan
Background/Purpose: 　IgG4-related disease (IgG4-RD) is not rare and clinically important disease. It is difficult to confirm the diagnosis because IgG4 positive lymphocyte infiltrates various organs.…
Abstract Number: 1286 • 2016 ACR/ARHP Annual Meeting
Inflammatory Activity of IgG4-Related Disease Lesions Assessed By Quantitative Positron Emission Tomography Correlates with Circulating Plasmablasts Levels
Alvise Berti¹, Carla Canevari², Francesca Gallivanone³, Marco Lanzillotta⁴, Emanuele Bozzalla Cassione⁴, Corrado Campochiaro⁵, Giuseppe Alvise Ramirez⁴, Maria Grazia Sabbadini⁴ and Emanuel Della Torre⁴, ¹Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, ²Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy, ³Consiglio Nazionale delle Ricerche, IBFM, Milan, Italy, ⁴Unit of Medicine and Clinical Immunology, San Raffaele Scientific Institute, Milan, Italy, ⁵San Raffaele Scientific Institute, Milan, Italy
Background/Purpose: 18-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan is emerging as a promising imaging technique for diagnosis and staging of IgG4-RD. We aim to correlate…
Abstract Number: 1349 • 2016 ACR/ARHP Annual Meeting
Clinical Analysis of Hypertrophic Pachymeningitis
Risa Wakiya, Atsushi Kondo, Hiroki Ozaki, Hiromi Shimada, Shusaku Nakashima, Miharu Izumikawa, Tomohiro Kameda and Hiroaki Dobashi, Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan
Background/Purpose: Hypertrophic pachymeningitis (HP) is a rare, chronic and inflammatory disorder. HP is characterized by thickening of the cranial dura mater. The cause of HP…
Abstract Number: 1380 • 2015 ACR/ARHP Annual Meeting
Characterization of Lymphocytes Subsets in Peripheral Blood of Untreated IgG4-Related Disease Patients
Aurélie Grados¹, Mikael Ebbo¹, Christelle Piperoglou², Matthieu Groh³, Alexis Regent⁴, Maxime Samson⁵, Benjamin Terrier⁶, Nathalie Morel⁷, Sylvain Audia⁵, Francois Maurier⁸, Julie Graveleau⁹, Mohamed Hamidou¹⁰, Amandine Forestier¹¹, Sylvain Palat¹², Emanuelle Bernit¹, Gilles Kaplanski¹³, Frederique Retornaz¹⁴, Bernard Bonotte⁵, Catherine Farnarier¹⁵, Jean-Robert Harle¹⁶, Nathalie Costedoat-Chalumeau⁷, Frederic Vely¹⁷ and Nicolas Schleinitz¹, ¹Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ²Immunology, CIML, AP-HM, Marseille, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁴Service de médecine interne, Hôpital Cochin, Paris, France, ⁵Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ⁶Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁸HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁹Medecine Interne Hotel Dieu Nantes, Nantes, France, ¹⁰Internal Medicine Department, Nantes University Hospital, Nantes, France, ¹¹Internal Medicine, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France, ¹²Service de Medecine Interne, CHU limoges, Limoges, France, ¹³Internal Medicine hopital conception, Aix-Marseille Université, Marseille, France, ¹⁴Conseil General 13 cellule recherche, Marseille, France, ¹⁵Laboratoire d'immunologie, Hopital de la Conception, Marseille, France, ¹⁶Internal Medicine, Aix-Marseille Université, APHM, Marseille, France, ¹⁷CIML, Laboratoire d'Immunologie Conception AP-HM, Aix-Marseille université, Marseille, France
Background/Purpose: IgG4-related disease (IgG4-RD) is associated with characteristic pathological changes including lymphoplasmocytic infiltration with abundant IgG4 positive plasma cells, storiform fibrosis and obliterative phlebitis. The…
Abstract Number: 1381 • 2015 ACR/ARHP Annual Meeting
The Relationship Between Serum Cholinesterase, Number of Organ Involvement and Fibrotic Markers in Japanese Patients with IgG4-Related Disease
Hirofumi Nishikawa¹, Yoshinori Taniguchi¹, Yoshiko Shimamura¹, Kosuke Inoue¹, Taro Horino¹, Susumu Nishiyama², Yasuhiko Yoshinaga² and Yoshio Terada¹, ¹Kochi University, Nankoku, Japan, ²Kurashiki Medical Center, Kurashiki, Japan
Background/Purpose: To evaluate the relationship between cholinesterase, number of organ involvement and serum fibrotic markers in Japanese patients with IgG4-related disease (IgG4-RD). Methods: The clinical…
Abstract Number: 1382 • 2015 ACR/ARHP Annual Meeting
Clinical and Serum IgG4 Characteristics of a Unique British Columbian IgG4-Related Disease Cohort
Luke Chen¹, Andre Mattman², Sujin Park³, Brian Skinnider⁴, Graham Slack⁴ and Mollie Carruthers⁵, ¹Hematology, University of British Columbia, Vancouver, BC, Canada, ²Medical Biochemistry, University of British Columbia, Vancouver, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Pathology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder that is known to have protean manifestations and variably elevated serum IgG4 concentrations. We present the serum…
Abstract Number: 1384 • 2015 ACR/ARHP Annual Meeting
Comparison of IgG4-Related and Non-IgG4-Related Retroperitoneal Fibrosis; A 12 Year Retrospective Study
Piyush Poddar^1,2, Steven Billings³, Leonard H. Calabrese⁴ and Carmen E. Gota⁵, ¹Rheumatology, Sanford Medical center, Bismarck, ND, ²Rheumatology, Cleveland Clinic, Cleveland, OH, ³Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, ⁴Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH, ⁵Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH
Comparison of IgG4-related and Non-IgG4-related Retroperitoneal fibrosis; a 12 year Retrospective Study Background/Purpose: Retroperitoneal fibrosis (RPF) is a rare disease characterized by a progressive proliferation…
Abstract Number: 1385 • 2015 ACR/ARHP Annual Meeting
Efficacy and Tolerance of Rituximab in IgG4-Related Disease: A Retrospective Multicentric Study in 24 Patients
Mikael Ebbo¹, Aurélie Grados¹, Maxime Samson², Clarisse Carra-Dallière³, Agnieszka Pozdzik⁴, Pierre Labauge³, Sylvain Palat⁵, Jean-Marie Berthelot⁶, Jean-Loup Pennaforte⁷, Alain Wynckel⁸, Celine Lebas⁹, Thomas Quémeneur¹⁰, Karine Dahan¹¹, Jean-Jacques Boffa¹¹, Bertrand Godeau¹², Nicolas Limal¹², Franck Carbonnel¹³, Anne Herber¹⁴, Gaëlle Leroux¹⁵, Patrice Cacoub¹⁶, Alexis Mathian¹⁷, Eric Hachulla¹⁸, Nathalie Costedoat-Chalumeau¹⁹, Jean-Robert Harle²⁰ and Nicolas Schleinitz¹, ¹Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ²Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ³Neurology, CHRU de Montpellier, Montpellier, France, ⁴Nephrology, Erasme Hospital, Cliniques Universitaires de Bruxelles, Bruxelles, Belgium, ⁵Service de Medecine Interne, CHU limoges, Limoges, France, ⁶Rhumatologie, CHU Nantes, Nantes, France, ⁷Internal Medicine, CHU de Reims, Reins, France, ⁸Nephrolohy, CHU de Reims, Reims, France, ⁹Nephrology, CHRU de Lille, Lille, France, ¹⁰CH Valenciennes, Valenciennes, France, ¹¹Nephrology, Tenon Hospital, Paris, France, ¹²Internal Medicine, Mondor Hospital, Creteil, France, ¹³Gastro-enterology, CHU Bicêtre, Le Kremlin Bicêtre, France, ¹⁴Gastro-enterology, CH de Chartres, Chartres, France, ¹⁵Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ¹⁶Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, ¹⁷Internal Medecine Department, Pitie-Salpetriere Hospital, Paris, France, ¹⁸FAI²R, Hôpital Claude Huriez, CHRU Lille, LILLE, France, ¹⁹Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ²⁰Internal Medicine, Aix-Marseille Université, APHM, Marseille, France
Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition with characteristic histopathological lesions. Nearly all anatomic sites can be involved with a risk of organ…

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