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Abstracts tagged "IgG4 Related Disease"

  • Abstract Number: 2093 • 2017 ACR/ARHP Annual Meeting

    Comparison of Clinical and Laboratory Features of Patients with and without Allergic Conditions in IgG4-Related Disease: A Single-Center Experience in Japan

    Takako Saeki, Tomoyuki Ito, Maasa Tamura, Seiichi Yoshikawa and Hajime Yamazaki, Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan

    Background/Purpose:  Although patients with IgG4-related disease (IgG4-RD) sometimes have accompanying allergic conditions, few data on the relationship between allergic conditions and IgG4-RD have been available.…
  • Abstract Number: 2101 • 2017 ACR/ARHP Annual Meeting

    The Clinical Characteristics of IgG4 Related Disease in China: With 346 Cases Reported

    Panpan Zhang1, Wen Zhang2, Jizhi Zhao3, Mu Wang3, Ruie Feng3, Xiaowei Liu3, Xuemei Li3, Yamin Lai3, Xuejun Zeng3, Juhong Shi3, Huijuan Zhu3, Huadan Xue3, Wei Zhang3, Hua Chen4, Yunyun Fei3, Linyi Peng3, Xiaofeng Zeng5 and Fengchun Zhang3, 1Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, 2Rheuamtology, Peking Union Medical College Hospital, Beijing, China, 3Peking Union Medical College Hospital, Beijing, China, 4Rheumatology, Peking Union Medical College Hospital, Beijing, China, 5Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: To study the clinical characteristics of IgG4-RD patients in China Methods: Patients were recruited from a prospective cohort study of IgG4-RD in Peking Union…
  • Abstract Number: 2705 • 2017 ACR/ARHP Annual Meeting

    Aberrant Expression and Function of Human Circulating T Follicular Helper Cells and Its Subsets in IgG4 Related Disease

    Yu Chen1, Wen Zhang2, Panpan Zhang3, Yanan Zhu1 and Hongxian Yang3, 1Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 2Rheuamtology, Peking Union Medical College Hospital, Beijing, China, 3rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

    Background/Purpose: To study the expression and function of T follicular helper cells and its subsets in IgG4-related disease(IgG4-RD). Methods: Flow cytometry was performed to analyze…
  • Abstract Number: 2873 • 2017 ACR/ARHP Annual Meeting

    DNA Microarray Analysis Identifies Nuclear Receptor Subfamily 4 Group a Member 2 (NR4A2) As a Novel Molecule Involved in the Pathogenesis of Sjogren’s Syndrome

    Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Hanae Kudo, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose:Some reports on DNA microarray analysis in labial salivary glands (LSGs) of Sjögren’s syndrome (SS) and healthy controls (HCs) showed that the genes associated with…
  • Abstract Number: 1283 • 2016 ACR/ARHP Annual Meeting

    Utility of FDG-PET Imaging and Serological Biomarkers for Diagnosing Lymphadenopathy of IgG4-Related Diseas

    Hiroaki Dobashi, Hiroki Ozaki, Atsushi Kondo, Risa Wakiya, Hiromi Shimada, Shusaku Nakashima, Miharu Izumikawa and Tomohiro Kameda, Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan

    Background/Purpose:  IgG4-related disease (IgG4-RD) is not rare and clinically important disease. It is difficult to confirm the diagnosis because IgG4 positive lymphocyte infiltrates various organs.…
  • Abstract Number: 1286 • 2016 ACR/ARHP Annual Meeting

    Inflammatory Activity of IgG4-Related Disease Lesions Assessed By Quantitative Positron Emission Tomography Correlates with Circulating Plasmablasts Levels

    Alvise Berti1, Carla Canevari2, Francesca Gallivanone3, Marco Lanzillotta4, Emanuele Bozzalla Cassione4, Corrado Campochiaro5, Giuseppe Alvise Ramirez4, Maria Grazia Sabbadini4 and Emanuel Della Torre4, 1Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, 2Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy, 3Consiglio Nazionale delle Ricerche, IBFM, Milan, Italy, 4Unit of Medicine and Clinical Immunology, San Raffaele Scientific Institute, Milan, Italy, 5San Raffaele Scientific Institute, Milan, Italy

    Background/Purpose:  18-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan is emerging as a promising imaging technique for diagnosis and staging of IgG4-RD. We aim to correlate…
  • Abstract Number: 1349 • 2016 ACR/ARHP Annual Meeting

    Clinical Analysis of Hypertrophic Pachymeningitis

    Risa Wakiya, Atsushi Kondo, Hiroki Ozaki, Hiromi Shimada, Shusaku Nakashima, Miharu Izumikawa, Tomohiro Kameda and Hiroaki Dobashi, Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan

    Background/Purpose:  Hypertrophic pachymeningitis (HP) is a rare, chronic and inflammatory disorder. HP is characterized by thickening of the cranial dura mater. The cause of HP…
  • Abstract Number: 238 • 2016 ACR/ARHP Annual Meeting

    Identifying Immunoglobulin G4-Related Disease in Archived Pathological Specimens

    Priya Prakash1, Faisal Saeed2, Slavica Bobic3, Kirk Sperber1, Julia Yegudin-Ash1, Humayun Islam2 and Amy Wasserman4, 1Medicine-Rheumatology, New York Medical College / Westchester Medical Center, Valhalla, NY, 2Pathology, New York Medical College / Westchester Medical Center, VALHALLA, NY, 3Medicine-Rheumatology, New York Medical College / Westchester Medical Center, valhalla, NY, 4Medicine - Rheumatology, New York Medical College / Westchester Medical Center, VALHALLA, NY

    Background/Purpose: Immunoglobulin G4-related disease (IgG4-RD) is a recently defined entity characterized by a diffuse or mass forming inflammatory reaction rich in IgG4-positive plasma cells.  Due…
  • Abstract Number: 243 • 2016 ACR/ARHP Annual Meeting

    Eosinophilic Angiocentric Fibrosis : A Mimic of Vasculitis in IgG4 Related Disease Spectrum

    Raphaël Lecomte1, Antoine Néel2, Olivier Malard3, Jérôme Martin4, Michael Hénoux3, Elisabeth Cassagnau5 and Mohamed Hamidou6,7, 1Internal Medicine Department, CHU Nantes, Nantes, France, 2Department of Internal Medicine, Nantes University Hospital, Nantes, France, 3ENT, ENT department, Nantes University Hospital, Nantes, France, 4Immunology laboratory, Immunology laboratory, Nantes University Hospital, Nantes, France, 5Histopathology, Histopathology department, Nantes University Hospital, Nantes, France, 6Hotel Dieu, Service de médecine interne, Hôpital Universitaire de Nantes, Nantes, France, Nantes, France, 7Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France

    Background/Purpose: Eosinophilic angiocentric fibrosis (EAF) is a rare localized fibro-inflammatory lesion involving usually upper respiratory tract and the orbit. It could mimic ENT manifestations of…
  • Abstract Number: 244 • 2016 ACR/ARHP Annual Meeting

    Leflunomide and Glucocorticoids Combination Therapy for the Induction and Maintenance of Remission in Patients with IgG4-Related Disease

    Yiwen Wang1, Dai Gao1, Gui Luo2, Kunpeng Li1, Zheng Zhao1 and Jian Zhu1, 1Rheumatology, Chinese PLA General Hospital, Beijing, China, 2Chinese PLA General Hospital, Beijing, China

    Background/Purpose: Good response could be observed after applying glucocorticoids (GCs) in patients with IgG4-related disease (IgG4-RD), however, the risk of disease relapse was reported relatively…
  • Abstract Number: 892 • 2015 ACR/ARHP Annual Meeting

    Autoimmune Associated Orbital Inflammatory Masses and Response to Immunosuppressive Therapy

    Alina Casian1, Shirish Sangle (joint first author)2, Ritu Malaiya3, Pamela Lutalo4, Louise Nel5, Bina Menon6, Hema Varma7, Miles Stanford8 and David P. D'Cruz5, 1Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, UK, London, United Kingdom, 2Louise Coote Lupus Unit, Guy's and St. Thomas' Hospital, London, United Kingdom, 3Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, 4Rheumatology, St. George's Hospital, London, United Kingdom, 5Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom, 6Rheumatology, Guy's Hospital, London, United Kingdom, 7Radiology, Guy's and St. Thomas' Hospital, London, United Kingdom, 8Ophthalmology, Guy's and St. Thomas' Hospital, London, United Kingdom

    Background/Purpose: To characterize a single centre retrospective case series of patients with orbital inflammatory masses associated with autoimmune diseases including granulomatosis with polyangiitis(GPA)(formerly Wegener’s granulomatosis),…
  • Abstract Number: 1105 • 2015 ACR/ARHP Annual Meeting

    The IgG/IgG4 mRNA Ratio By Quantitative PCR Accurately Diagnoses IgG4-Related Disease and Predicts Treatment Response

    Lowiek Hubers1, Marieke Doorenspleet2, Paulus Klarenbeek3, Emma Culver4, Lucas Maillette de Buy Wenniger5, Roger Chapman4, Stan Van de Graaf6, Joanne Verheij7, Thomas Van Gulik8, Frank Baas9, Ellie Barnes4, Ulrich Beuers1 and Niek De Vries3, 1Dept. of Gastroenterology & Hepatology and Tytgat Institute of Liver and Intestinal Research, Dept. of Gastroenterology & Hepatology and Tytgat Institute of Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Translational Gastroenterology Unit and NDM Oxford University, Translational Gastroenterology Unit and NDM Oxford University, John Radcliffe Hospital/Oxford University, Oxford, United Kingdom, 51Dept. of Gastroenterology & Hepatology and Tytgat Institute of Liver and Intestinal Research, Dept. of Gastroenterology & Hepatology and Tytgat Institute of Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Dept. of Gastroenterology & Hepatology and Tytgat Institute of Liver and Intestinal Research,, Dept. of Gastroenterology & Hepatology and Tytgat Institute of Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 7Dept. of Pathology, Dept. of Pathology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 8Dept. of Surgery, Dept. of Surgery, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 9Dept. of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose : IgG4-associated cholangitis (IAC) and autoimmune pancreatitis (AIP) are major manifestations of IgG4-related disease (IRD). Misdiagnosis and inadequate treatment are common since IAC and…
  • Abstract Number: 1379 • 2015 ACR/ARHP Annual Meeting

    High Serum IgG4 Concentration Is a Risk Factor for Relapse in IgG4-Related Disease

    Sho Sendo1, Jun Saegusa1, Akira Onishi2, Ikuko Naka1, Kosaku Tsuda1, Takaichi Okano1, Kengo Akashi1, Soshi Takahashi1, Miwa Nishida1, Keisuke Nishimura1, Yo Ueda1, Yoshinori Kogata3, Goichi Kageyama1, Goh Tsuji4, Shunichi Kumagai5 and Akio Morinobu1, 1Department of Rheumatology, Kobe University Hospital, Kobe, Japan, 2Department for Rheumatology, Kobe University Hospital, Kobe, Japan, 3Department of Clinical Pathology and Immunology, Kobe University Hospital, Kobe, Japan, 4Center for Rheumatic disease, Shinko Hospital, Kobe, Japan, 5Center for Rheumatic Disease, Shinko Hospital, Kobe, Japan

    Background/Purpose: IgG4-related disease (IgG4-RD) is a recently recognized systemic fibro-inflammatory disease of unknown etiology with multi-organ involvement. Although the organ involvement in IgG4-RD usually improve…
  • Abstract Number: 1380 • 2015 ACR/ARHP Annual Meeting

    Characterization of Lymphocytes Subsets in Peripheral Blood of Untreated IgG4-Related Disease Patients

    Aurélie Grados1, Mikael Ebbo1, Christelle Piperoglou2, Matthieu Groh3, Alexis Regent4, Maxime Samson5, Benjamin Terrier6, Nathalie Morel7, Sylvain Audia5, Francois Maurier8, Julie Graveleau9, Mohamed Hamidou10, Amandine Forestier11, Sylvain Palat12, Emanuelle Bernit1, Gilles Kaplanski13, Frederique Retornaz14, Bernard Bonotte5, Catherine Farnarier15, Jean-Robert Harle16, Nathalie Costedoat-Chalumeau7, Frederic Vely17 and Nicolas Schleinitz1, 1Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, 2Immunology, CIML, AP-HM, Marseille, France, 3National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 4Service de médecine interne, Hôpital Cochin, Paris, France, 5Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 6Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, 7Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, 8HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 9Medecine Interne Hotel Dieu Nantes, Nantes, France, 10Internal Medicine Department, Nantes University Hospital, Nantes, France, 11Internal Medicine, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France, 12Service de Medecine Interne, CHU limoges, Limoges, France, 13Internal Medicine hopital conception, Aix-Marseille Université, Marseille, France, 14Conseil General 13 cellule recherche, Marseille, France, 15Laboratoire d'immunologie, Hopital de la Conception, Marseille, France, 16Internal Medicine, Aix-Marseille Université, APHM, Marseille, France, 17CIML, Laboratoire d'Immunologie Conception AP-HM, Aix-Marseille université, Marseille, France

    Background/Purpose: IgG4-related disease (IgG4-RD) is associated with characteristic pathological changes including lymphoplasmocytic infiltration with abundant IgG4 positive plasma cells, storiform fibrosis and obliterative phlebitis. The…
  • Abstract Number: 1381 • 2015 ACR/ARHP Annual Meeting

    The Relationship Between Serum Cholinesterase, Number of Organ Involvement and Fibrotic Markers in Japanese Patients with IgG4-Related Disease

    Hirofumi Nishikawa1, Yoshinori Taniguchi1, Yoshiko Shimamura1, Kosuke Inoue1, Taro Horino1, Susumu Nishiyama2, Yasuhiko Yoshinaga2 and Yoshio Terada1, 1Kochi University, Nankoku, Japan, 2Kurashiki Medical Center, Kurashiki, Japan

    Background/Purpose: To evaluate the relationship between cholinesterase, number of organ involvement and serum fibrotic markers in Japanese patients with IgG4-related disease (IgG4-RD). Methods: The clinical…
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