Abstracts tagged "IgG4 Related Disease"

Abstract Number: 1480 • ACR Convergence 2020
Abatacept for the Treatment of IgG4-Related Disease
Mark Matza¹, Cory Perugino¹, Liam Harvey², Zachary Wallace³, Hang Liu⁴, Shiv Pillai⁵ and John H. Stone⁶, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, ³Massachusetts General Hospital, Newton, MA, ⁴Massachusetts General Hospital, Cambridge, MA, ⁵Harvard Medical School, Cambridge, MA, ⁶Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: To assess the efficacy and safety of abatacept (ABA) for the treatment of IgG4-related disease (IgG4-RD). To date, there are no FDA-approved treatments available…
Abstract Number: 1619 • ACR Convergence 2020
Immunoglobulin G Subclass Ordering Patterns for IgG4-Related Disease at an Academic Medical Center
Lena Eder¹ and David Leverenz², ¹Duke University Hospital, Chapel Hill, NC, ²Duke University, DURHAM, NC
Background/Purpose: We have noticed an increasing number of serum IgG4 levels ordered over the last several years at our institution. This study was performed to…
Abstract Number: 0077 • ACR Convergence 2020
Mimickers of Immunoglobulin G4-Related Disease
Madiha Ahmad¹, Robert Spandorfer² and Arezou Khosroshahi³, ¹Emory University, Decatur, ²Emory University School of Medicine, Atlanta, GA, ³Emory University, Atlanta, GA
Background/Purpose: Immunoglobulin G4-related disease (IgG4-RD) is a fibro inflammatory condition of unclear etiology. This rare condition can affect any organ system and has protean manifestations…
Abstract Number: 115 • 2019 ACR/ARP Annual Meeting
CD8+ Cytotoxic T Lymphocytes Are Clonally-expanded in IgG4-related Disease and Home to Affected Tissues
Cory Perugino¹, Naoki Kaneko ², Takashi Maehara ², Jesper Kers ³, Hang Liu ⁴, Vinay Mahajan ⁴, Yesim Tuncay ⁴, Zachary Wallace ¹, Lloyd Liang ¹, Sydney Montesi ⁵, John Stone ⁶ and Shiv Pillai ⁷, ¹Massachusetts General Hospital, Boston, ²Kyushu University, Fukuoka, Japan, ³University of Amsterdam, Amsterdam, Netherlands, ⁴Ragon Institute of MGH, MTI and Harvard, Cambridge, ⁵Massachusetts General Hospital, Boston, MA, ⁶Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁷Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a chronic immune-mediated fibrotic disease often causing multi-organ involvement. We have previously reported the association of SLAMF7+ CD4+ cytotoxic T…
Abstract Number: 372 • 2019 ACR/ARP Annual Meeting
Periaortitis and Coronary Arteritis in IgG4-Related Disease: Eastern Mediterranean Experience
Gozde Kubra Yardımcı ¹, Alper Sarı ¹, Abdulsamet Erden ², Ertugrul Cagri Bolek ¹, Bayram Farisoğulları ¹, Levent Kilic ³, Berkan Armagan ⁴, Umut Kalyoncu ⁵, Tuncay Hazırolan ⁶, Ali İhsan Ertenli ¹ and Omer Karadag⁷, ¹Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, ²Ministry of Health Ankara City Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ³Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ⁴Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Ankara, Turkey, ⁵Hacettepe University Department of Rheumatology, Ankara, Turkey, ⁶Hacettepe University, Division of Radiology, Ankara, ⁷Hacettepe University Vasculitis Centre, Ankara, Turkey / Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Ankara, Turkey
Background/Purpose: Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that may involve multiple organ systems. IgG4-RD can also lead to large vessel vasculitis and…
Abstract Number: 945 • 2019 ACR/ARP Annual Meeting
Comparison of Clinical Manifestations in IgG4 Related Disease Patients with/without Aortitis/Periaortitis and Periarteritis: A Prospective Cohort Study of 587 Patients with IgG4-RD Disease
Linyi Peng ¹, Wen Zhang ² and Panpan Zhang¹, ¹Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (People's Republic)
Background/Purpose: We aimed to clarify the clinical features of IgG4-related disease (IgG4-RD) with/without aortitis/periaortitis and periarteritis (PAO/PA), and evaluate the treatment efficacy of patients with…
Abstract Number: 972 • 2019 ACR/ARP Annual Meeting
Disease Severity Is Linked to an Increase in Autoantibody Diversity in IgG4-related Disease
Hang Liu¹, Cory Perugino ², Musie Ghebremichael ¹, Zachary Wallace ², Sydney Montesi ³, John Stone ⁴ and Shiv Pillai ⁵, ¹Ragon Institute of MGH, MTI and Harvard, Cambridge, ²Massachusetts General Hospital, Boston, ³Massachusetts General Hospital, Boston, MA, ⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁵Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: The oligoclonal expansion in IgG4-related disease (IgG4-RD) of both plasmablasts and tissue-infiltrating CD4+ cytotoxic T lymphocytes, the identification of specific auto-antigens as B cell…
Abstract Number: 1708 • 2019 ACR/ARP Annual Meeting
Azathioprine and Glucocorticoid Combination Might Be a Good Treatment Option to Achieve Remission in Patients with IgG4-related Disease
Aydan Köken Avşar¹, Onay Gercik ², Gercek Can ³, Berrin Zengin ⁴, Sinem Burcu Kocaer ⁵, Atilla Okan Kılıç ⁶, Sadettin Uslu ⁷, Ali Karakaş ⁵, Merih Birlik ⁵, Servet Akar ⁸ and Fatos Onen ⁹, ¹Dokuz Eylul University School of Medicine, Rheumatology,, Türkiye, Izmir, Turkey, ²Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ³Dokuz Eylul University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Izmir, Turkey, ⁴Dokuz Eylul University School of Medicine, Rheumatology,, Turkey,Izmir, Izmir, Turkey, ⁵Division of Rheumatology, Dokuz Eylül University School of Medicine, İzmir, Turkey, Turkey,Izmir, Izmir, Turkey, ⁶Dokuz Eylul University School of Medicine, Internal Medıcıne, Turkey,Izmir, Izmir, Turkey, ⁷Division of Rheumatology, Dokuz Eylül University School of Medicine, İzmir, Turkey, Izmir, Turkey, ⁸Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey, ⁹Dokuz Eylul University School of Medicine, Division of Rheumatology, İzmir, Turkey
Background/Purpose: IgG4-related disease is a recently recognised inflammatory disease of unkown etiology, often seen in men over the age of 50 and may affect many…
Abstract Number: 1709 • 2019 ACR/ARP Annual Meeting
Juvenile-Onset IgG4-Related Disease: A Systematic Review
Eduardo Martin-Nares¹, Talia Díaz-Prieto ², Enrique Faugier-Fuentes ², Luis A. Aparicio Vera ² and Gabriela Hernandez-Molina ¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Rheumatology, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Background/Purpose: IgG4-related disease (IgG4-RD) presenting in the pediatric age is rare. Natural history and outcomes are not well defined. The aim of this study was…
Abstract Number: 1710 • 2019 ACR/ARP Annual Meeting
Chemokine and Cytokine Tear Profile of Patients with IgG4-Related Disease
Eduardo Martin-Nares¹, Luis Llorente ¹, Guadalupe Lima ¹, Diego Hernández-Ramírez ¹, Isela Chan-Campos ¹, Vanessa Saavedra-González ¹ and Gabriela Hernandez-Molina ¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The lacrimal gland is frequently involved in both IgG4-related disease (IgG4-RD) and Sjögren’s syndrome (SS) and presents with swelling and/or dry eye symptoms. Although…
Abstract Number: 1711 • 2019 ACR/ARP Annual Meeting
Distinctive Imaging Features Between IgG4-Related Ophthalmic Disease and Graves’ Orbitopathy: A Comparative Study
Eduardo Martin-Nares¹, Oziel Amaya-Piña ², Rosa Delia Delgado Hernández ² and Gabriela Hernandez-Molina ¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Radiology and Molecular Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: IgG4-related ophthalmic disease (IgG4-ROD) may present as a cause of orbital myositis leading to proptosis and diplopia. This clinical scenario can be mistakenly diagnosed…
Abstract Number: 2821 • 2019 ACR/ARP Annual Meeting
Clonal Expansion of a Specific Subset of Cytotoxic CD4+T Cells and Tissue Apoptosis in Patients with IgG4-related Disease
Cory Perugino¹, Naoki Kaneko ², Jesper Kers ³, Takashi Maehara ², Hamid Mattoo ⁴, Hang Liu ⁵, Vinay Mahajan ⁵, Musie Ghebremichael ⁵, Hugues Allard-Chamard ⁵, Yesim Tuncay ⁵, Emanuel Della Torre ⁶, Zachary Wallace ¹, Lloyd Liang ¹, Sydney Montesi ⁷, John Stone ⁸ and Shiv Pillai ⁹, ¹Massachusetts General Hospital, Boston, ²Kyushu University, Fukuoka, Japan, ³University of Amsterdam, Amsterdam, Netherlands, ⁴Sanofi, Cambridge, ⁵Ragon Institute of MGH, MTI and Harvard, Cambridge, ⁶Hospital San Raffaele, milan, Italy, ⁷Massachusetts General Hospital, Boston, MA, ⁸Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁹Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: In IgG4-related disease (IgG4-RD), both activated B cells and CD4+ cytotoxic T lymphocytes (CD4+CTLs) expand clonally, accumulate in tissues, likely recognize distinct epitopes on…
Abstract Number: 371 • 2018 ACR/ARHP Annual Meeting
Therapeutic Efficacy and Safety of Iguratimod in Treating Mild IgG4-Related Diseases
Wen Zhang¹ and Panpan Zhang², ¹Rheuamtology, Peking Union Medical College Hospital, Beijing, China, ²Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: To evaluate the therapeutic efficacy and safety of Iguratimod in the treatment of mild IgG4 related disease (IgG4-RD). Methods: Thirty patients with newly diagnosed…
Abstract Number: 1779 • 2018 ACR/ARHP Annual Meeting
Is the Number of IgG4+ Plasma Cells Observed By Immunostaining Important Beyond Its Diagnostic Utility in IgG4-Related Disease?
Eduardo Martín Nares¹, Jacobo Guerrero Castillo², Arturo Angeles Angeles² and Gabriela Hernandez-Molina¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The histopathological findings in IgG4-related disease (IgG4-RD) includes the presence of dense lymphoplasmacytic infiltrate, obliterative phlebitis, storiform fibrosis and the presence of marked IgG4+…
Abstract Number: 1781 • 2018 ACR/ARHP Annual Meeting
Retrospective Analysis of IgG4-RD Patient Population at the Cleveland Clinic between 2007-2017
Chan Mi Lee¹, Mohamed Alalwani², Richard Prayson^1,3 and Carmen E. Gota^1,4, ¹Education, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, ²Hospital Medicine, Cleveland Clinic, Cleveland, OH, ³Anatomic Pathology, Cleveland Clinic, Cleveland, OH, ⁴Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH
Background/Purpose: IgG4-related disease (IgG4-RD) is a rare multisystem fibro-inflammatory condition, characterized by organ mass lesions, IgG4+ lymphoplasmacytic infiltrate, and storiform fibrosis. To gain better understanding…

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