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Abstracts tagged "IgG4 Related Disease"

  • Abstract Number: 0775 • ACR Convergence 2024

    A Phase 3, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study of Inebilizumab in IgG4-Related Disease (MITIGATE): Primary Efficacy and Safety Findings

    John Stone1, Emma Culver2, Arezou Khosroshahi3, Wen Zhang4, Emanuel Della Torre5, Kazuichi Okazaki6, Yoshiya Tanaka7, Matthias Löhr8, Nicolas Schleinitz9, Lingli Dong10, Hisanori Umehara11, Marco Lanzillotta12, Zachary Wallace13, Mikael Ebbo14, George Webster15, Ferran Martinez Valle16, Manu Nayar17, Vinciane Rebours18, Cory Perugino19, Xinxin Dong20, Yanping Wu20, Nishi Rampal20 and Daniel Cimbora20, 1Massachusetts General Hospital , Harvard Medical School, Concord, MA, 2John Radcliffe Hospital, and Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 3Emory University, Atlanta, GA, 4Peking Union Medical College Hospital, Dong Cheng Qu, China (People's Republic), 5Ospedale San Raffaele, Milan, Italy, 6University of Occupational and Environmental Health, Osaka, Japan, 7Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 8Karolinska Institutet, Stockholm, Sweden, 9Aix Marseille university, AP-HM, Marseille, France, 10Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (People's Republic), 11Department of Rheumatology and Immunology, Nagahama City Hospital,, Nagahama, Shiga 526-0043, Japan, Japan, 12IRCCS Ospedale San Raffaele, Milano, Italy, 13Massachusetts General Hospital, Newton, MA, 14Aix-Marseille Université, Marseille, France, 15University College Hospital London, London, United Kingdom, 16Vall d’Hebron Hospital, Barcelona, Spain, 17Freeman Hospital, Newcastle Upon Tyne, United Kingdom, 18Beaujon Hospital, Université Paris-Cité, France, 19Massachusetts General Hospital, Boston, MA, 20Amgen Inc., Thousand Oaks, CA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a rare, systemic, fibroinflammatory disease characterized by unpredictable and recurring flares, leading to organ damage and decreased quality of life.…
  • Abstract Number: 1113 • ACR Convergence 2024

    2nd Analysis of IgG4-Related Disease in a Diverse Long Island Population: Utilizing Serological and Histological Markers for Assessing Treatment Response

    Young Min Cho1, Alejandro Quintero Villegas2, Matt Means3, Zanos Theodoros2, Lara El Khoury4 and Galina Marder3, 1Northwell, Glen Cove, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY, 3Northwell, Manhasset, NY, 4Division of Rheumatology/Northwell Health, Great Neck, NY

    Background/Purpose: IgG4-RD presents various clinical manifestations, making it challenging to assess treatment responses.  B-cell depletion agents such as Rituximab (RTX) are used in refractory cases.…
  • Abstract Number: 1123 • ACR Convergence 2024

    Serological Elevation of IgG4: Clinical Correlation and Differential Diagnosis

    Pablo Martínez Calabuig1, Laura Salvador Maicas2, Mireia Lucía Sanmartín Martínez3, Iván Jesús Lorente Betanzos3, Jorge Juan Fragío Gil4, Roxana González Mazario5, Amalia Rueda5, juan José Lerma Garrido6, Clara Molina Almela3 and Cristina Campos Fernández7, 1HOSPITAL GENERAL UNIVERSITARIO VALENCIA SPAIN, Ontinyent, Comunidad Valenciana, Spain, 2Consorcio Hospital General Universitario de Valencia, Castellón de la Plana, Comunidad Valenciana, Spain, 3Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain, 4Hospital General Universitario, Valencia, Comunidad Valenciana, Spain, 5Hospital General de Valencia, Valencia, Comunidad Valenciana, Spain, 6Hospital General Universitario Valencia, Valencia, Comunidad Valenciana, Spain, 7Department of Rheumatology. Hospital General Universitario de Valencia, Valencia, Spain

    Background/Purpose: IgG4-related disease (IgG4-RD) is a rare, systemic, immunomediated fibroinflammatory process with uncertain etiology and pathophysiology that can affect multiple organs, presenting common clinical, radiological,…
  • Abstract Number: 1675 • ACR Convergence 2024

    Extended Validation of the IgG4-Related Disease Symptom Severity Index (SSI)

    Isha Jha1, Grace McMahon1, Guy Katz1, Shruthi Srivatsan1, Caleb Bolden1, Ana Fernandes1, Cory Perugino1, John Stone2 and Zachary Wallace3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital , Harvard Medical School, Concord, MA, 3Massachusetts General Hospital, Newton, MA

    Background/Purpose: The Symptom Severity Index (SSI) is a patient-reported outcome measure (PROM) developed for IgG4-related disease (IgG4-RD). The SSI assesses symptoms of IgG4-RD and the…
  • Abstract Number: 1835 • ACR Convergence 2024

    FoxP3Hi CTLA4+ ICOS+ Regulatory T Cells Are Expanded in Patients with Sarcoidosis but Not Systemic Sclerosis or IgG4-Related Disease

    Laura Yockey1, Thomas Guy2, Chinmay Gadiraju3, Ian Doyle1, Jesse Akaa4, Alison Puri5, Zachary Wallace6, Guy Katz1, Sydney Montesi1, John Stone7, Flavia Castelino1, Shiv Pillai8, Andrew Luster9, Vinay Mahajan3 and Cory Perugino1, 1Massachusetts General Hospital, Boston, MA, 2Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 3Brigham and Women's Hospital, Boston, MA, 4Massachussets General Hospital, Boston, MA, 5Boston University, Brookline, MA, 6Massachusetts General Hospital, Newton, MA, 7Massachusetts General Hospital , Harvard Medical School, Concord, MA, 8Harvard Medical School, Cambridge, MA, 9Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: The absence of regulatory T cells (Tregs) results in multiorgan autoimmunity in the context of monogenic “Tregopathies”, but their role in mediating polygenic autoimmune…
  • Abstract Number: 2027 • ACR Convergence 2024

    Clinical Features and Treatment of Retroperitoneal Fibrosis in a Referral Hospital and Literature Review

    Adrián Martín-Gutiérrez1, Javier Loricera2, Fernando Lopez-Gutierrez3 and Ricardo Blanco-Alonso4, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 4Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Retroperitoneal fibrosis (RPF) is usually idiopathic (iRPF), but may be secondary to drugs, neoplasms, infections, or may be part of an IgG4-related disease. Our…
  • Abstract Number: 2031 • ACR Convergence 2024

    A Contemporary Assessment of the Burden of Malignancy in IgG4-Related Disease

    Grace McMahon1, Isha Jha1, Guy Katz1, Cory Perugino1, Ana Fernandes1, John Stone2 and Zachary Wallace3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital , Harvard Medical School, Concord, MA, 3Massachusetts General Hospital, Newton, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder that can affect nearly any organ. Because of the often tumefactive nature of IgG4-RD and its typical…
  • Abstract Number: 2035 • ACR Convergence 2024

    Older Age and Higher Erythrocyte Sedimentation Rate Are Associated with Increased Disease Burden at Diagnosis in a Cohort of IgG4-Related Disease Patients

    Humberto Campos Clemente, Barbara Bayeh, Monica Raquel de Souza Aquino, Fernanda Oliveira de Andrade Lopes, Thiago Quadrante Freitas, Rafael Alves Cordeiro and Henrique Ayres Mayrinki Giardini, Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil

    Background/Purpose: Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition primarily affecting middle-aged males. It is characterized by mass lesions affecting various organs, such as the…
  • Abstract Number: 0007 • ACR Convergence 2024

    Bromodomain 2 of BET Proteins Plays a Crucial Role in Follicular/peripheral Helper T Cell and Plasma Cell Differentiation

    Ryota Sato1, Mitsuhiro Akiyama2, Koichi Oshita3, Yuko Kawano3, Yuki Imura3, Piruzyan Mariam4, Manami Kikuchi3, Mikako Murase3, Sachiko Mochiduki3, Naohiro Hashimoto3, Masayuki Watanabe3, Keiko Yoshimoto5, Tsutomu Takeuchi6, Kenji Chiba7 and Yuko Kaneko5, 1Mitsubishi Tanabe Pharma Corporation, Brighton, MA, 2Keio University School of Medicine, Palo Alto, CA, 3Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 4Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan, 5Keio University School of Medicine, Tokyo, Japan, 6Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 7Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan

    Background/Purpose: Proteins motifs bromodomain 1 (BD1) and BD2 within the BET family proteins regulate gene expression of inflammatory cytokines and lymphocyte proliferation by binding to…
  • Abstract Number: 2037 • ACR Convergence 2024

    Can Tofacitinib Be the Saviour in Treatment of Refractory IgG4-Related Disease : A Multicentre Experience from India

    Jasneet Singh1, SHRUTI BAJAD2 and DHAVAL TANNA3, 1THE MEDICLINIC-ARTHRITIS & RHEUMATOLOGY CENTER, LUDHIANA, Punjab, India, 2Moolchand hospital , Delhi, DELHI, Delhi, India, 3SAURASHTRA RHEUMATOLOGY CENTER, Rajkot, Gujarat, India

    Background/Purpose: We did an observational study  to  assess the  efficacy and safety of the Janus kinase (JAK) inhibitor tofacitinib in patients having refractory IgG4-Related Disease…
  • Abstract Number: 0285 • ACR Convergence 2024

    Anti-THSD7A Antibodies Are Not Broadly Associated with IgG4-Related Disease or IgG4-Related Membranous Nephropathy

    Guy Katz1, Jesse Akaa2, Grace McMahon1, Isha Jha1, Ian Doyle1, Ana Fernandes1, Zachary Wallace3, Shiv Pillai4, John Stone5 and Cory Perugino1, 1Massachusetts General Hospital, Boston, MA, 2Massachussets General Hospital, Boston, MA, 3Massachusetts General Hospital, Newton, MA, 4Harvard Medical School, Cambridge, MA, 5Massachusetts General Hospital , Harvard Medical School, Concord, MA

    Background/Purpose: Membranous nephropathy (MN) is a known manifestation of IgG4-related disease (IgG4-RD). Unlike primary MN, most patients with IgG4-related MN do not have anti-phospholipase 2…
  • Abstract Number: 2045 • ACR Convergence 2024

    Descriptive Study on the Use of Serum Levels of Immunoglobulin G4, Immunoglobulin E and Eosinophil Count as Serum Biomarkers Across Four Clinical Phenotypes of IgG4-Related Disease

    Vineetha Philip1, Soudabeh Daliri2, Alma Aveytia Camacho2, Ruba Memon3, Myriam Guevara2 and Sarah Kazzaz4, 1Houston Methodist Hospital, Sugar Land, TX, 2Houston Methodist, Houston, TX, 3Houston Methodist, Missouri City, TX, 4Houston Methodist Hospital, Houston, TX

    Background/Purpose: IgG4 – Related Disease (IgG4-RD) is a multisystem immune-mediated fibroinflammatory disorder that can affect nearly any organ and can mimic other inflammatory conditions, malignancy…
  • Abstract Number: 0286 • ACR Convergence 2024

    Damage Associated with Disease-Specific Effects and Diagnostic or Therapeutic Procedures Is Highly Prevalent in IgG4-Related Disease

    Guy Katz1, Zachary Wallace2, Cory Perugino1, Grace McMahon1, Isha Jha1, Ana Fernandes1 and John Stone3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Newton, MA, 3Massachusetts General Hospital , Harvard Medical School, Concord, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that can affect nearly any organ or anatomic site. Although the disease responds well to glucocorticoids…
  • Abstract Number: 2051 • ACR Convergence 2024

    Clinical Outcomes and Predictors of Relapse in Patients with IgG4-Related Disease Treated with Rituximab: A Real-World Experience

    Guy Katz1, Zachary Wallace2, Grace McMahon1, Isha Jha1, Ana Fernandes1, Bohang Jiang1, Yuqing Zhang3, Hyon K. Choi4, Cory Perugino1 and John Stone5, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Newton, MA, 3Massachusetts General Hospital, Quincy, MA, 4Massachusetts General Hospital, Lexington, MA, 5Massachusetts General Hospital , Harvard Medical School, Concord, MA

    Background/Purpose: Rituximab (RTX) is often used to treat IgG4-related disease (IgG4-RD), but real-world data on clinical outcomes remain limited. Defining time to relapse and predictors…
  • Abstract Number: 0289 • ACR Convergence 2024

    Effectiveness of Rituximab in IgG4 Related Disease

    Fernando Lopez-Gutierrez1, Javier Loricera2, Cristina Hormigos3, Dalifer Freites Nuñez4, Maria Rodriguez-Laguna5, Patricia Moya Albarado6, Marta López I Gómez7, Hèctor Corominas8, Maite Silva-Díaz9, GUILLERMO GONZALEZ ARRIBAS9, Angel Garcia-Aparicio10, Judit Font Urgelles11, Ivette Casafont-Sole11, Pablo Martínez Calabuig12, Elisabet Castaneda13, Carolina Merino14, Raquel Zas15, Juan Molina-Collada16, Rafael Benito Melero-Gonzalez17, Eva Galindez-Agirregoikoa18, Andrea Hernández-Martín19, Lucia Pantoja20, Ignacio Brana Abascal21, Vega Jovani22, Elia Valls-Pascual23, Natalia Mena Vázquez24, Adela Gallego- Flores25, Noelia Cabaleiro Raña26, Raul Veroz27, Mariano Andres28, Santos Castañeda29 and Ricardo Blanco-Alonso30, and Rituximab in IgG4 Related Disease Spanish Cooperative Group, 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Hospital Clínico San Carlos, Madrid, Madrid, Spain, 4Hospital Clínico San Carlos. Madrid. Spain., Madrid, Spain, 5Resident in Rheumatology, Madrid, Spain, 6Hospital de San Pau, Barcelona, Spain, 7Hospital Universitario Alava, Vitoria, Pais Vasco, Spain, 8Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 9Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, 10Hospital Universitario de Toledo, Toledo, Spain, 11Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 12HOSPITAL GENERAL UNIVERSITARIO VALENCIA SPAIN, Ontinyent, Comunidad Valenciana, Spain, 13Hospital Universitario Infanta Sofía, Madrid, Madrid, Spain, 14Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda (Madrid), Spain, 15Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain, 16Hospital General Universitario Gregorio Marañón, Madrid, Spain, 17CHU Ourense, O Carballino, Spain, 18BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 19Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas, Spain, 20Complejo Hospitalario Segovia, Segovia, Castilla y Leon, Spain, 21Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain, 22National Health system, Alicante, Spain, 23Hospital General de Valencia, Valencia, Comunidad Valenciana, Spain, 24IBIMA, Málaga, Andalucia, Spain, 25Hospital Perpetuo Socorro, Badajoz, Spain, 26Hospital Universitario Montecelo, Pontevedra, Galicia, Spain, 27Hospital de Merida, Merida, Extremadura, Spain, 28Hospital General Universitario de Alicante, Alicante, Spain, 29Hospital Universitario de la Princesa, Madrid, Spain, 30Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disease often associated with elevated serum IgG4 levels. High dose corticosteroids are the cornerstone of treatment, but…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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