Abstracts tagged "Idiopathic Inflammatory Myopathies (IIM)"

Abstract Number: 305 • 2015 ACR/ARHP Annual Meeting
The “Sleeve Sign”� in Dermatomyositis
Arash Lahoutiharahdashti¹, Julie J. Paik², Jemima Albayda¹, Andrew Mammen^3,4 and Lisa Christopher-Stine⁵, ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴NIAMS, NIH, Bethesda, MD, ⁵Ste 4100 Rm 409, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Dermatomyositis (DM) is a subset of idiopathic inflammatory myopathies, characterized by proximal skeletal muscle weakness and skin manifestations. Several skin eruptions have been described…
Abstract Number: 948 • 2015 ACR/ARHP Annual Meeting
Autoimmune Myopathies: Effects of Intravenous Immunoglobulin Therapy on Muscle Strength and Predictors of Response
Arash Lahoutiharahdashti¹, Iago Pinal-Fernandez², Jemima Albayda¹, Julie J. Paik³, Sonye K. Danoff⁴, Andrew Mammen⁵ and Lisa Christopher-Stine⁶, ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Autoimmune Systemic Diseases Unit, Vall D’Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain, ³Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Medicine/Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, ⁵Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Ste 4100 Rm 409, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: There is a variable response rate to Intravenous immunoglobulin (IVIG) in patients with autoimmune myopathies. The aim of this study was to determine whether…
Abstract Number: 1240 • 2015 ACR/ARHP Annual Meeting
Systematic Protein-Protein Interaction and Pathway Analyses in the Idiopathic Inflammatory Myopathies
Joanna Parkes¹, Simon Rothwell², Philip Day^1,3, Neil J McHugh⁴, Zoë Betteridge⁵, Robert Cooper⁶, William E. Ollier¹, Hector Chinoy², Janine Lamb⁷ and MYOGEN, ¹Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ²Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, ³Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom, ⁴Rheumatology, Bath Institute of Rheumatic Diseases, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁵Bath Institute of Rheumatic Diseases, Bath Institute of Rheumatic Diseases, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁶MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, ⁷Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, United Kingdom
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies (MSA/MAA). The…
Abstract Number: 1251 • 2015 ACR/ARHP Annual Meeting
Physiological Evidence for Diversification of the IFNα- or IFNβ-Mediated Response Programs in Different Autoimmune Diseases
Tamarah D. de Jong¹, Saskia Vosslamber¹, Elise Mantel¹, Sander de Ridder¹, John G. Wesseling¹, Tineke C.T.M. van der Pouw Kraan², Joep Killestein³, Ingrid E. Lundberg⁴, Jiri Vencovsky^5,6, Irene E.M. Bultink⁷, Alexandre E. Voskuyl⁸, Michiel Pegtel¹, Conny J. van der Laken⁹, Johannes W. Bijlsma⁸ and Cornelis L. Verweij¹, ¹Pathology, VU University medical center, Amsterdam, Netherlands, ²Molecular Cell Biology and Immunology, VU University medical center, Amsterdam, Netherlands, ³Neurology, VU University medical center, Amsterdam, Netherlands, ⁴Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology, Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁶Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁷Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, ⁸Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, ⁹Rheumatology, VU University medical center, Amsterdam, Netherlands
Background/Purpose: Presence of a type I interferon (IFN) signature is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM)…
Abstract Number: 2514 • 2015 ACR/ARHP Annual Meeting
Subclinical Reduced Ovarian Reserve in Adult Polymiositis Patients
Fernando Henrique Carlos de Souza¹, Clovis A Silva², Lucas Yugo Shiguehara Yamakami³, Vilma S. T. Viana⁴, Eloisa Bonfá⁵ and Samuel Katsuyuki Shinjo¹, ¹Rheumatology Division, Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil, ²Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Gynecology Department, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁴Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, ⁵Clínica Médica, Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP (HC-FMUSP), Sao Paulo, Brazil
Background/Purpose: Polymyositis (PM) affects female gender during reproductive age. Ovarian reserve and future fertility are relevant, however there is no study performing a complete assessment…
Abstract Number: 2953 • 2014 ACR/ARHP Annual Meeting
International Immunochip Study in the Idiopathic Inflammatory Myopathies Identifies Novel Susceptibility Loci and Confirms HLA As Strongest Genetic Risk Factor
Simon Rothwell¹, Robert G. Cooper², Ingrid E. Lundberg³, Frederick W. Miller⁴, Peter K. Gregersen⁵, Jiri Vencovsky⁶, Katalin Danko⁷, Lucy R Wedderburn⁸, Vidya Limaye⁹, Albert Selva O'Callaghan¹⁰, Michael G. Hanna¹¹, Pedro Machado¹¹, Lauren M. Pachman¹², Ann M. Reed¹³, Lisa G. Rider⁴, Joanna Cobb¹, Hazel Platt¹⁴, Øyvind Molberg¹⁵, Olivier Benveniste¹⁶, Pernille Mathiesen¹⁷, Timothy Radstake¹⁸, Andrea Doria¹⁹, Jan De Bleecker²⁰, Boel De Paepe²¹, Britta Maurer²², William E. Ollier¹⁴, Leonid Padyukov³, Terrance P. O'Hanlon⁴, Annette Lee²³, Hector Chinoy¹ and Janine Lamb¹⁴, ¹Centre for Genetics and Genomics, Arthritis Research UK, University of Manchester, Manchester, United Kingdom, ²MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, ³Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁵The Feinstein Institute for Medical Research, Manhasset, NY, ⁶Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁷University of Debrecen, University of Debrecen, Debrecan, Hungary, ⁸Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ⁹Royal Adelaide Hospital, Adelaide, Australia, ¹⁰Vall d'Hebron General Hospital, Barcelona, Spain, ¹¹MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom, ¹²Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ¹³Rheumatology, Mayo Clinic, Rochester, MN, ¹⁴Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, United Kingdom, ¹⁵Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ¹⁶Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ¹⁷Paediatric Department, Holbaek University Hospital, Holbaek, Denmark, ¹⁸University Medical Center Utrecht, Utrecht, Netherlands, ¹⁹Department of Medicine - DIMED, University of Padova, Padova, Italy, ²⁰University of Ghent, Ghent, Belgium, ²¹Neuromuscular Reference Center, University of Ghent, Ghent, Belgium, ²²Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²³Genomics & Human Genetics, Feinstein Institute Med Rsch, Manhasset, NY
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes…
Abstract Number: 2727 • 2014 ACR/ARHP Annual Meeting
T Cells Trigger Interstitial Pneumonia in Polymyositis
Akira Takeda^1,2, Yasutsugu Fukushima³, Takaji Matsutani⁴, Yoichiro Haji¹, Chisun Min¹, Ryo Rokutanda¹, Yasuhiro Suyama¹, Mitsumasa Kishimoto⁵, Ken-ichi Yamaguchi¹ and Masato Okada⁶, ¹Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ²Division of Clinical Immunology & Rheumatology, International University of Health and Welfare Hospital, Nasu-shiobara, Japan, ³Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Mibu, Japan, ⁴Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki, Japan, ⁵St. Luke's International Hospital, Tokyo, Japan, ⁶Immuno-Rheumatology Center, St. Luke's International Hospital, tokyo, Japan
Background/Purpose: The lung is frequently affected in connective tissue diseases (CTDs). Polymyositis (PM) is a major CTD characterized by idiopathic inflammatory lesions of muscle and…
Abstract Number: 2212 • 2014 ACR/ARHP Annual Meeting
Serum Adipokines in Dermatomyositis: Correlation with Risk Factors Associated to Cardiovascular Diseases and Metabolic Syndrome
Marilda Guimarães Silva, Suzana Beatriz Veríssimo de Mello and Samuel Katsuyuki Shinjo, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Adipokines are a group of cytokines produced by adipose tissue, which include adiponectin, resistin and leptin. The adiponectin has anti-diabetic, anti-inflammatory and anti-atherogenic effects,…
Abstract Number: 2218 • 2014 ACR/ARHP Annual Meeting
Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Dysfunction and Atrophy Can be Prevented By Pharmacological Upregulation of Heat Shock Protein 70 (HSP) in Cultured Murine Myotubes
Adam P. Lightfoot, Malcolm J. Jackson, Anne McArdle and Robert G. Cooper, Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom
Background/Purpose: The symmetrical proximal muscle weakness typical of myositis often fails to improve completely with any treatment, due to irreversible muscle fibre degeneration. Although inflammatory…
Abstract Number: 2220 • 2014 ACR/ARHP Annual Meeting
Overexpression of Ankyrin Repeat Domain Containing Protein 1 Gene (ANKRD1) in Polymyositis Muscle Biopsies Is Correlated to Hypoxia
Samuel Katsuyuki Shinjo¹, Sueli Mieko Oba-Shinjo², Miyuki Uno² and Suely Kazue Nagahashi Marie², ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: ANKRD1 codes for ankyrin repeat domain containing protein 1, which belongs to the muscle ankyrin repeat protein family involved in a mechano-signaling pathway that…
Abstract Number: 2225 • 2014 ACR/ARHP Annual Meeting
Does Previous Corticosteroid Treatment Affect the Inflammatory Infiltrate Found in Polymyositis Muscle Biopsies?
Mayara Mendes Pinhata¹, Juliana Jesus do Nascimento¹, Suely Kazue Nagahashi Marie² and Samuel Katsuyuki Shinjo¹, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: We conducted this study because there have been no studies evaluating the effect of the use of corticosteroids (CE) on the presence of inflammatory…
Abstract Number: 1268 • 2014 ACR/ARHP Annual Meeting
Study of Autoantibodies in a cohort of Mexican patients with idiopathic inflammatory myopathies
Yelitza Gonzalez-Bello¹, Miguel Angel Ortiz-Villalvazo², Ignacio Garcia-Valladares¹, Gabriel Medrano-Ramírez³, José E. Navarro-Zarza⁴, Lilia Andrade-Ortega⁵, Arnulfo Nava-Zavala⁶, Gerardo Orozco-Barocio¹, Marco Maradiaga-Ceceña⁷, Marvin Fritzler⁸ and Ignacio Garcia-De La Torre⁹, ¹Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, ²Internal Medicine, Hospital Civil de Guadalajara, Guadalajara, Jal., Mexico, ³Rheumatology, Hospital General de Mexico de la Secretaría de Salud, Mexico City, Mexico, ⁴Rheumatology, Hospital General de Chilpancingo, Chilpancingo, Gro., Mexico, ⁵Rheumatology, CMN 20 Noviembre ISSSTE, Mexico City, Mexico, ⁶Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, ⁷Rheumatology, Hospital General de Culiacan de la Secretaría de Salud, Culiacan, Sin., Mexico, ⁸Medicine, University of Calgary, Calgary, AB, Canada, ⁹Immunology and Rheumatology, Universidad de Guadalajara, Guadalajara, Jal., Mexico
Background/Purpose Idiopathic inflammatory myopathies (IIM) are a group of autoimmune disorders characterized by muscle inflammation, progressive weakness with a combination of clinical, electromyography and laboratory…
Abstract Number: 2082 • 2013 ACR/ARHP Annual Meeting
Interferon-Regulated Chemokine and Innate Cytokine Scores Identify Refractory Myositis Patients That Respond Better To Rtuximab Therapy
Consuelo Lopez de Padilla¹, Cynthia S. Crowson², Molly S. Hein³, Helen Khun², Rohit Aggarwal⁴, Marc C. Levesque⁵, Dana P. Ascherman⁶, Chester V. Oddis⁷ and Ann M. Reed³, ¹Rheumatology/Immunology Research, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Medicine / Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Medicine/Rheumatology, University of Miami, Miami, FL, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Serum cytokines play an important role in the pathogenesis of myositis by initiating and perpetuating various cellular and humoral autoimmune processes. The aim of…
Abstract Number: 2084 • 2013 ACR/ARHP Annual Meeting
Increasing Incidence Of Immune Mediated Necrotizing Myopathy In A Single Center
Martin Klein¹, Herman F. Mann², Josef Zámecník³ and Jiri Vencovsky⁴, ¹Institute of Rheumatology, Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Department of Pathology and Molecular Medicine, 2nd Medical School and University Hospital Motol, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Institute of Rheumatology, Prague, Czech Republic
Background/Purpose: Immune mediated necrotizing myopathy (IMNM), characterized histologically by predominant myofiber necrosis with minimal or no inflammatory infiltrate and clinically by response to immunosuppressive therapy,…
Abstract Number: 2063 • 2013 ACR/ARHP Annual Meeting
Identification Of Autoantibodies To Tyrosyl–Transfer RNA Synthetase Associated With Anti-Synthetase Syndrome
Yuko Okamoto¹, Yasuhiro Katsumata¹, Yasushi Kawaguchi¹, Koji Tahara², Kaori Ito², Hiroaki Hattori², Takahisa Gono¹, Kae Takagi¹, Masanori Hanaoka¹, Yuko Ota¹, Hidenaga Kawasumi¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Advanced Medical Technology and Development, BML, Saitama, Japan
Background/Purpose : Autoantibodies directed against the aminoacyl transfer RNA (tRNA) synthetases are associated with myositis, arthritis, Raynaud’s phenomenon, mechanic’s hands, fever, and interstitial lung disease,…

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