Abstracts tagged "hyperuricemia"

Abstract Number: 1913 • 2012 ACR/ARHP Annual Meeting
Complete Tophus Response in Patients with Chronic Gout Initiating Pegloticase Treatment
Michael A. Becker¹, Neil J. Gonter², Janet E. Pope³, Raymond L. Malamet⁴ and Herbert S. B. Baraf⁵, ¹Medicine, University of Chicago, Chicago, IL, ²Rheumatology Associates of North Jersey, Teaneck, NJ, ³Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁴Global Medical Affairs, Savient Pharmaceuticals, Inc., Bridgewater, NJ, ⁵Arthritis & Rheumatism Associates, Wheaton, MD
Background/Purpose: Pegloticase, a recombinant modified mammalian uricase that acts via enzymatic degradation of uric acid to allantoin, is approved in the US for the treatment…
Abstract Number: 1916 • 2012 ACR/ARHP Annual Meeting
Serum Uric Acid As a Biomarker for Mitigation of Infusion Reactions in Patients Treated with Pegloticase for Refractory Chronic Gout
Herbert S. B. Baraf¹, Robert A. Yood², John S. Sundy³, Faith D. Ottery⁴ and Michael A. Becker⁵, ¹Arthritis & Rheumatism Associates, Wheaton, MD, ²Reliant Medical Group, Worcester, MA, ³Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, ⁴Medical Affairs, Savient Pharmaceuticals, Inc., East Brunswick, NJ, ⁵Medicine, University of Chicago, Chicago, IL
Background/Purpose: Using data pooled from the randomized, placebo-controlled trials (RCTs) of pegloticase, post-hoc analyses of urate-lowering, antibody titers and the patterns of infusion-related reactions (IRs)…
Abstract Number: 170 • 2012 ACR/ARHP Annual Meeting
Relative Risk of Infusion Reactions with KRYSTEXXA® (pegloticase) From Post-Approval Safety Data: Results From Sept 2010 to June 2012
Raymond L. Malamet¹, Tina L. Howson², Anthony E. Yeo³, Kenneth M. Bahrt⁴ and Marsha Wolfson³, ¹Global Medical Affairs, Savient Pharmaceuticals, Inc., Bridgewater, NJ, ²Savient Pharmaceuticals, Inc., Bridgewater, NJ, ³Savient Pharmaceuticals, Inc., East Brunswick, NJ, ⁴Medical Affairs, Savient Pharmaceuticals, Inc., Bridgewater, NJ
Background/Purpose: During randomized clinical trials (RCTs) with pegloticase, the incidence of infusion-related reactions (IRs) was 26% including 5 cases of anaphylaxis (determined post-hoc using published…

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