Abstracts tagged "human leukocyte antigens (HLA)"

Abstract Number: 2466 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Rheumatoid Arthritis (RA) Among Shared Epitope-Negative (SE-) Mothers with Shared Epitope-Positive (SE+) Children
Giovanna Cruz¹, Lindsey A. Criswell², Xiaorong Shao³, Hong L. Quach¹, Janelle Noble⁴, Nikolaos Patsopoulos⁵, Michael Busch⁶ and Lisa F. Barcellos¹, ¹Epidemiology, University of California, Berkeley, Berkeley, CA, ²Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Genetic Epidemiology and Genomics Lab, Division of Epidemiology, University of California, Berkeley, Berkeley, CA, ⁴Children's Hospital Oakland Research Institute (CHORI), Oakland, CA, ⁵Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁶Blood Systems Research Institute, San Francisco, CA
Background/Purpose RA (RA [MIM 180300]) disproportionately affects women of reproductive age, implicating pregnancy-related factors. Fetal microchimerism (FMC), or the persistence of a small population of…
Abstract Number: 1919 • 2014 ACR/ARHP Annual Meeting
HLA-B27 Expression Shapes the Intestinal Microbiota
Mark Asquith¹, Phoebe Lin², Tejpal Gill³, Justine Debelius⁴, Patrick Stauffer⁵, Sean Davin⁵, Gail Ackermann⁴, Robert A. Colbert³, Rob Knight⁴ and James Rosenbaum^1,6, ¹Division of Rheumatology, Oregon Health and Science University, Portland, OR, ²Casey Eye Institute, Oregon Health and Science University, Portland, OR, ³NIAMS/NIH, Bethesda, MD, ⁴University of Colorado Boulder, Boulder, CO, ⁵Oregon Health and Science University, Portland, OR, ⁶Dever's Eye Institute, Legacy Hospital, Portland, OR
Background/Purpose The intestinal microbiota plays a central role in both health and disease. Beyond shaping local immune responses in the gut, it is increasingly clear…
Abstract Number: 627 • 2014 ACR/ARHP Annual Meeting
HLA Markers for Disease Severity Are Associated with a Higher Burden of Atherosclerosis in Patients with Psoriatic Disease
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose Recent evidence supports the link between the extent of inflammation and cardiovascular risk in patients with psoriatic disease (PsD). We aimed to investigate the…
Abstract Number: 626 • 2014 ACR/ARHP Annual Meeting
The Impact of the Interaction Between Human Leukocyte Antigen Alleles and Obesity on Psoriatic Arthritis Risk
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Proton Rahman³, Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Human Leukocyte Antigen (HLA) class I alleles and obesity are risk factors for psoriatic arthritis (PsA). We aimed to assess whether there is an…
Abstract Number: 625 • 2014 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Associations Identified Contribution of Multiple Class I and II HLA Genes on Risk of Psoriasis and Its Clinical Subtypes
Yukinori Okada¹, Buhm Han², Lam C. Tsoi³, Philip E. Stuart⁴, Eva Ellinghaus⁵, Trilokraj Tejasvi⁶, Vinod Chandran⁷, Fawnda Pellett⁸, Remy Pollock⁹, Anne M. Bowcock¹⁰, Gerald G. Krueger¹¹, Michael Weichenthal⁵, John J. Voorhees⁶, Proton Rahman¹², Peter K. Gregersen¹³, Andre Franke¹⁴, Rajan P. Nair⁶, Gonçalo R. Abecasis¹⁵, Dafna D. Gladman⁷, James T. Elder⁶, Paul IW. de Bakker¹⁶ and Soumya Raychaudhuri¹⁷, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, ³Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, ⁴Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Christian-Albrechts-University of Kiel, Kiel, Germany, ⁶University of Michigan Medical School, Ann Arbor, MI, ⁷University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸University of Toronto, Toronto, ON, Canada, ⁹Rheumatology, University of Toronto, Toronto, ON, Canada, ¹⁰Imperial College, London, United Kingdom, ¹¹Dermatology, University of Utah, Salt Lake City, UT, ¹²Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ¹³The Feinstein Institute for Medical Research, Manhasset, NY, ¹⁴Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, ¹⁵University of Michigan, Ann Arbor, MI, ¹⁶University Medical Center, Utrecht, Netherlands, ¹⁷Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Psoriasis vulgaris (PsV) risk is strongly associated with genetic variation within the major histocompatibility complex (MHC) region, although its fine genetic architecture has not…
Abstract Number: 597 • 2014 ACR/ARHP Annual Meeting
Inflammatory Burden in Recent-Onset Axial Spondyloarthritis
Juan Jose Aznar Sánchez¹, Raul Veroz Gonzalez¹, Adela Gallego Flores¹, Tamara Libertad Rodriguez Araya¹, Piter José Cossio Jimenez² and Eugenio Chamizo Carmona¹, ¹Rheumatology, Hospital de Mérida, Mérida, Spain, ²Hospital de Mérida, Mérida, Spain
Background/Purpose Patients with Non-Radiographic Axial Spondylarthritis (non-Rx AxSpA) don't presnt with different clinical manifestations than patients with Ankilosing Spondylitis (AS), although the inflammatory burden measured…
Abstract Number: 85 • 2014 ACR/ARHP Annual Meeting
Protective Association of HLA-DRB1*13:02 Against MPO-ANCA Positive ANCA-Associated Vasculitis in a Japanese Population
Naoyuki Tsuchiya¹, Narumi Hasebe¹, Ken-ei Sada², Shigeto Kobayashi³, Hidehiro Yamada⁴, Hiroshi Furukawa⁵, Kunihiro Yamagata⁶, Takayuki Sumida⁷, Nobuyuki Miyasaka⁸, Seiichi Matsuo⁹, Shigeto Tohma⁵, Shoichi Ozaki¹⁰, Hiroshi Hashimoto¹¹, Hirofumi Makino², Masayoshi Harigai¹² and Aya Kawasaki¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ³Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, ⁴Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁵Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁶Department of Internal Medicine (Nephrology), Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁷Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁸Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ⁹Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹⁰Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ¹¹Juntendo University School of Medicine, Tokyo, Japan, ¹²Department of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose Epidemiology of antineutrophil cytoplasmic antibody (ANCA) – associated vasculitis (AAV) is substantially different between European and Asian populations. In the Japanese population, the majority…
Abstract Number: 176 • 2013 ACR/ARHP Annual Meeting
Identification Of Major Histocompatibility Complex Class II Alleles Associated With Systemic Sclerosis Through Imputation Strategy
Jose Ezequiel Martin¹, Carmen P. Simeón², Norberto Ortego-Centeno³, Patricia Carreira⁴, Miguel A. Gonzalez-Gay^5,6, Nicolas Hunzelmann⁷, Shervin Assassi⁸, Filemon K. Tan⁸, Frank C. Arnett⁸, Xiaodong Zhou⁸, T.R.D.J. Radstake^9,10, Maureen D. Mayes¹¹, Paul de Bakker^12,13, Javier Martin^1,14 and B. P. C. Koeleman¹³, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain, ³Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁴Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁷Department of Dermatology, University of Cologne, Cologne, Germany, ⁸Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁹Laboratory for Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ¹⁰Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹¹University of Texas Health Science Center at Houston, Houston, TX, ¹²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹³Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁴Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain
Background/Purpose: Different alleles of MHC class II molecules have been associated either with risk to systemic sclerosis (SSc) or its subphenotypes. Due to the high…
Abstract Number: 2778 • 2013 ACR/ARHP Annual Meeting
Mortality In United States Veterans With The HLA-B27 Gene
Jessica Walsh¹, Brian C. Sauer², Daniel O. Clegg¹, Grant W. Cannon³, Xi Zhou⁴ and Chiachen Teng⁴, ¹Division of Rheumatology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT, ²Epdemiology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT, ³Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁴Epidemiology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT
Background/Purpose : HLA-B27 (B27) is carried by in 6-8% of Americans and is strongly associated with spondyloarthritis (SpA). SpA has been associated with premature mortality.…
Abstract Number: 2770 • 2013 ACR/ARHP Annual Meeting
Complex Functional Effects Within The HLA Contribute To Sjögren’s Syndrome Pathogenesis and May Influence Both Transcriptional Regulation and Peptide Binding
Christopher J. Lessard^1,2, He Li¹, Indra Adrianto¹, John A. Ice¹, Mikhail G. Dozmorov³, Roland Jonsson⁴, Maureen Rischmueller⁵, Gunnel Nordmark⁶, Xavier Mariette⁷, Corinne Miceli-Richard⁸, Marie Wahren-Herlenius⁹, Torsten Witte¹⁰, Michael T. Brennan¹¹, Roald Omdal¹², Lars Rönnblom¹³, Patrick M. Gaffney¹, Wan-Fai Ng¹⁴, Nelson L. Rhodus¹⁵, Barbara M. Segal¹⁶, Jonathan D. Wren¹, R. Hal Scofield^1,17,18, Juan-Manuel Anaya¹⁹, John B. Harley^20,21, Courtney G. Montgomery¹ and Kathy L. Sivils^1,2, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ⁶Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁷Paris-Sud University, Paris, France, ⁸Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁹Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁰Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹¹Nidcr NIH, Carolinas Medical Center, Charlotte, NC, ¹²Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹³Department of Medical Science, Uppsala University, Uppsala, Sweden, ¹⁴Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ¹⁵University of Minnesota, Minneapolis, MN, ¹⁶Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁷Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ¹⁹School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, ²⁰Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²¹US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a common, heterogeneous exocrinopathy. Etiology involves complex environmental, genetic and genomic influences driving innate and adaptive autoimmune responses. This…
Abstract Number: 1875 • 2013 ACR/ARHP Annual Meeting
A Dense Mapping Of Human Leukocyte Antigen Region For Study Of Interaction With Smoking In The Development Of Rheumatoid Arthritis
Xia Jiang¹, Henrik Källberg¹, Lisbeth Ärlestig², Solbritt M. Rantapää-Dahlqvist³, Lars Klareskog⁴, Leonid Padyukov⁵ and Lars Alfredsson⁶, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ³Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁶Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
Abstract Number: 1635 • 2013 ACR/ARHP Annual Meeting
Identification Of Novel Genetic Associations Within Major Histocompatibility Complex (MHC) Class I and Class II In Systemic Lupus Erythematosus (SLE) Patients: An Examination Of Epitopes Of Early Autoimmunity
Gerard Dumancas¹, Chee Paul Lin², Indra Adrianto¹, Jennifer A. Kelly¹, Stuart B. Glenn¹, Jourdan Anderson², John B. Harley^3,4, Timothy J. Vyse⁵, Robert P. Kimberly⁶, Marta E. Alarcon-Riquelme⁷, Carl D. Langefeld⁸, Betty P. Tsao⁹, Lindsey A. Criswell¹⁰, Chaim O. Jacob¹¹, Patrick M. Gaffney¹², Kathy Sivils¹², Judith A. James^12,13 and Courtney Montgomery², ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁴US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁵Medical & Molecular Genetics, King's College London, London, United Kingdom, ⁶Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, ⁸Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ¹⁰Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ¹¹Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ¹²Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, multiple organ involvement, strong genetic predisposition and specifically, to be associated with…
Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Xia Jiang¹, Henrik Källberg¹, Leonid Padyukov², Lars Klareskog³ and Lars Alfredsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
Abstract Number: 522 • 2012 ACR/ARHP Annual Meeting
Genetic Variation in the NCR3 Locus Is Associated with Anti-SSA⁄SSB Positive Primary Sjögren′s Syndrome in Scandinavian Samples
Gunnel Nordmark¹, Maija-Leena Eloranta¹, Per Eriksson², Elke Theander³, Helena Forsblad-d'Elia⁴, Roald Omdal⁵, Marie Wahren-Herlenius⁶, Roland Jonsson⁷ and Lars Rönnblom¹, ¹Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²Rheumatology/AIR, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ³Dept of Rheumatology, Skane University Hospital, Lund University, Malmö, Sweden, ⁴Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ⁵Department of Internal Medicine, Stavanger university Hospital, Stavanger, Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁶Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Broegelmann Research Laboratory, the Gade Institute, University of Bergen, Bergen, Norway
Background/Purpose: Candidate gene studies in primary Sjögren’s syndrome (pSS) have identified polymorphisms in genes involved in the type I interferon (IFN) system and the type…
Abstract Number: 2116 • 2012 ACR/ARHP Annual Meeting
The Associations of HLA-DR Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis
Mehret Birru Talabi¹, Rachel Mackey², Larry W. Moreland³, Jan Dorman⁴, Kevin D. Deane⁵, Jeremy Sokolove⁶, V. Michael Holers⁷, William H. Robinson⁸, Brian Wallitt⁹ and Lewis Kuller¹⁰, ¹Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴School of Nursing, University of Pittsburgh School of Nursing, Pittsburgh, PA, ⁵Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁶Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁸Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁹Washington Hospital Center, Baltimore, MD, ¹⁰Epidemiology, University of Pittsburgh, Pittsburgh, PA
Title: The Associations of HLA-DRβ1 Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid ArthritisBackground/Purpose: This study…

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