Abstract Number: 806 • 2018 ACR/ARHP Annual Meeting
Estradiol Levels Are Elevated in Older Men with Diffuse Cutaneous SSc and Are Associated with Decreased Survival
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix deposition (ECM), leading to dermal and internal organ fibrosis. As in other…Abstract Number: 2411 • 2018 ACR/ARHP Annual Meeting
The Ovarian Reserve Measuring the Anti-Müllerian Hormone Is Not Diminished in Patients with Rheumatoid Arthritis Compared to the Healthy Population
Background/Purpose: Rheumatoid Arthritis (RA) is the most prevalent chronic inflammatory arthritis, affecting 0.5-1% worldwide population and predominates in females. Altered fertility has been reported due…Abstract Number: 1308 • 2017 ACR/ARHP Annual Meeting
Answering Reproductive Health Questions That Your Patients Want to Know: Impediments to Family Building and Risks of Contraception
Background/Purpose: Women with arthritis wonder whether they will be able to have the children they desire. They also worry that oral contraceptives may worsen their…Abstract Number: 1983 • 2016 ACR/ARHP Annual Meeting
Pain and Sensitization in Women with Aromatase Inhibitor-Associated Arthralgias
Background/Purpose: Aromatase inhibitors (AIs) are the preferred treatment for estrogen receptor positive breast cancer in postmenopausal women, but are frequently associated with arthralgias, which can…Abstract Number: 2582 • 2015 ACR/ARHP Annual Meeting
Increased Morbidity and Mortality in Female Versus Male Tumor Necrosis Factor-Transgenic Mice
Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating condition with a 2-3 fold greater prevalence in women than men. Additionally, women have worse disease outcomes…Abstract Number: 2221 • 2014 ACR/ARHP Annual Meeting
Reduction of Ovarian Reserve in Adult Patients with Dermatomyositis
Background/Purpose: Dermatomyositis (DM) affects female gender during reproductive age, in which ovarian reserve and future fertility are major topics of interest. However, there is no…Abstract Number: 1198 • 2014 ACR/ARHP Annual Meeting
Prolactin Is Locally Produced in the Synovium of Patients with Inflammatory Arthritic Diseases and Promotes Macrophage Activation
Background/Purpose The sex hormone prolactin (PRL) has immunomodulatory properties, can be produced by immune cells, and elevated PRL serum levels have been reported in rheumatoid…Abstract Number: 333 • 2014 ACR/ARHP Annual Meeting
Deletion of the Prolactin Receptor Aggravates the Course of Antigen-Induced Arthritis
Background/Purpose: Prolactin (PRL), the hormone essential for lactation, may protect against joint damage in rheumatoid arthritis. PRL frequently increases in the circulation of patients with…Abstract Number: L12 • 2013 ACR/ARHP Annual Meeting
Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Demonstrates Efficacy and Significantly Reduces Proinflammatory Cytokines in Patients with Active Longstanding Rheumatoid Arthritis with High Gonadotropin Levels: A Proof-of-Concept, Double-Blind, Randomized Trial
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and treatment options can be improved. Gonadotropin-releasing hormone (GnRH) stimulates immune responses (1). Inhibiting GnRH, by…Abstract Number: 1255 • 2013 ACR/ARHP Annual Meeting
Ovarian Dysfunction In Adult Childhood-Onset Systemic Lupus Erythematosus Patients: A Possible Role Of Methotrexate?
Background/Purpose: Reduction of ovarian reserve has been observed in childhood-onset SLE (c-SLE) and adult SLE populations, and most of them were limited to follicle stimulating…Abstract Number: 628 • 2013 ACR/ARHP Annual Meeting
Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease. The sex hormone estrogen (E2) is present at elevated levels…Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting
Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…Abstract Number: 573 • 2013 ACR/ARHP Annual Meeting
Absence Of Estrogen Receptor Alpha Reduces The Number and Function Of Bone Marrow Derived Plasmacytoid Dendritic Cells In Lupus Prone Mice
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9:1 ratio compared to men. Previous work in our laboratory…Abstract Number: 1240 • 2012 ACR/ARHP Annual Meeting
Serum Anti-Müllerian Hormone Can Be Used to Determine Ovarian Reserve in Women with Rheumatoid Arthritis
Background/Purpose: Planning of pregnancy is important in women with rheumatoid arthritis (RA). It is preferred to start a pregnancy after adjustment of medication and when…Abstract Number: 1184 • 2012 ACR/ARHP Annual Meeting
Negative Association Between Testosterone Levels and Risk of Future Rheumatoid Factor Negative Rheumatoid Arthritis in Men
Background/Purpose: Rheumatoid arthritis (RA) is a heterogeneous disease with female predominance. Sex hormones have been suggested to play a part in the pathogenesis. We have previously…
ACR Meeting Abstracts