ACR Meeting Abstracts

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Abstracts tagged "hormones"

  • Abstract Number: 806 • 2018 ACR/ARHP Annual Meeting

    Estradiol Levels Are Elevated in Older Men with Diffuse Cutaneous SSc and Are Associated with Decreased Survival

    DeAnna Baker Frost1, Bethany J Wolf2, Christine Peoples3, Katherine Silver4, Maureen Laffoon5, Thomas A. Medsger Jr.3,6 and Carol A. Feghali-Bostwick4, 1Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Public Health Sciences, Medical University of South Carolina, Charleston, SC, 3Department of Medicine, University of Pittsburgh, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA, 4Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, 5Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 6Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix deposition (ECM), leading to dermal and internal organ fibrosis. As in other…
  • Abstract Number: 2411 • 2018 ACR/ARHP Annual Meeting

    The Ovarian Reserve Measuring the Anti-Müllerian Hormone Is Not Diminished in Patients with Rheumatoid Arthritis Compared to the Healthy Population

    Mireia López-Corbeto1, Sara Marsal1, Andrea Pluma2, Sergio Martinez2, Maria Lopez-Lasanta2, Agusti Sellas-Fernandez2, Juan José de Agustín2 and Mireia Barcelo2, 1Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 2Vall d'Hebron Hospital Research Institute, Barcelona, Spain

    Background/Purpose: Rheumatoid Arthritis (RA) is the most prevalent chronic inflammatory arthritis, affecting 0.5-1% worldwide population and predominates in females. Altered fertility has been reported due…
  • Abstract Number: 1308 • 2017 ACR/ARHP Annual Meeting

    Answering Reproductive Health Questions That Your Patients Want to Know: Impediments to Family Building and Risks of Contraception

    Malithi Jayasundara1, Amanda M. Eudy2, Tayseer Haroun3, W. Benjamin Nowell4, Jeffrey R. Curtis5, Rachelle Crow-Hercher6, Charlotte Whitney White6, Seth D. Ginsberg7 and Megan E. B. Clowse8, 1Rheumatology, Duke University, Durham, NC, 2Duke University, Durham, NC, 3Department of Medicine/Division of Rheumatology, Duke University Medical Center, Durham, NC, 4Global Healthy Living Foundation, Upper Nyack, NY, 5University of Alabama at Birmingham, Birmingham, AL, 6Arthritis Power, Upper Nyack, NY, 7Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, 8Duke University Medical Center, Durham, NC

    Background/Purpose: Women with arthritis wonder whether they will be able to have the children they desire. They also worry that oral contraceptives may worsen their…
  • Abstract Number: 1983 • 2016 ACR/ARHP Annual Meeting

    Pain and Sensitization in Women with Aromatase Inhibitor-Associated Arthralgias

    Monica Crespo-Bosque1, Carrie Brown2, Brenda Cartmel3, Maura Harrigan4, Melinda Irwin3 and Tuhina Neogi5, 1Internal Medicine, Boston Medical Center, Boston, MA, 2Boston University School of Public Health, Boston, MA, 3Yale School of Public Health, New Haven, CT, 4Cancer Center, Yale School of Public Health, New Haven, CT, 5Clinical Epidemiology, Boston University School of Medicine, Boston, MA

    Background/Purpose: Aromatase inhibitors (AIs) are the preferred treatment for estrogen receptor positive breast cancer in postmenopausal women, but are frequently associated with arthralgias, which can…
  • Abstract Number: 2582 • 2015 ACR/ARHP Annual Meeting

    Increased Morbidity and Mortality in Female Versus Male Tumor Necrosis Factor-Transgenic Mice

    Richard Bell1, Ronald Wood2, Joe Chakkalakal3, Christopher T. Ritchlin4, Edward Schwarz5 and Homaira Rahimi6, 1Pathology, University of Rochester, Rochester, NY, 2University of Rochester, Rochester, NY, 3Orthopaedics, University of Rochester, Rochester, NY, 4Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 5Orthopedeatrics, University of Rochester, Rochester, NY, 6Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating condition with a 2-3 fold greater prevalence in women than men. Additionally, women have worse disease outcomes…
  • Abstract Number: 2221 • 2014 ACR/ARHP Annual Meeting

    Reduction of Ovarian Reserve in Adult Patients with Dermatomyositis

    Fernando Henrique Carlos de Souza1, Samuel Katsuyuki Shinjo1, Lucas Yugo Shiguehara Yamakami2, Vilma dos Santos Trindade Viana1, Edmund Chada Baracat3, Eloisa Bonfa4 and Clovis Artur Almeida Silva5, 1Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Gynecology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 3Gynecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 4Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 5Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Dermatomyositis (DM) affects female gender during reproductive age, in which ovarian reserve and future fertility are major topics of interest. However, there is no…
  • Abstract Number: 1198 • 2014 ACR/ARHP Annual Meeting

    Prolactin Is Locally Produced in the Synovium of Patients with Inflammatory Arthritic Diseases and Promotes Macrophage Activation

    Man Wai Tang1, Samuel Garcia2, Danielle M. Gerlag3,4, Kris A. Reedquist5 and Paul P. Tak6,7, 1Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4GlaxoSmithKline, Cambridge, United Kingdom, 5Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 6Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 7University of Cambridge, Cambridge & GlaxoSmithKline, UK, Stevenage, United Kingdom

    Background/Purpose The sex hormone prolactin (PRL) has immunomodulatory properties, can be produced by immune cells, and elevated PRL serum levels have been reported in rheumatoid…
  • Abstract Number: 333 • 2014 ACR/ARHP Annual Meeting

    Deletion of the Prolactin Receptor Aggravates the Course of Antigen-Induced Arthritis

    Norma Adan, Maria G. Ledesma-Colunga, Ana L. Reyes-Lopez, Fernando Lopez-Barrera, Gonzalo Martinez de la Escalera and Carmen Clapp, Institute of Neurobiology, National University of Mexico (UNAM), Queretaro, Mexico

    Background/Purpose: Prolactin (PRL), the hormone essential for lactation, may protect against joint damage in rheumatoid arthritis. PRL frequently increases in the circulation of patients with…
  • Abstract Number: 1255 • 2013 ACR/ARHP Annual Meeting

    Ovarian Dysfunction In Adult Childhood-Onset Systemic Lupus Erythematosus Patients: A Possible Role Of Methotrexate?

    Daniel B. Araujo1, Lucas Yamakami2, Eloisa Bonfá3, Vilma S. T. Viana4, Sandra G. Pasoto5, Rosa M. Pereira4, Paulo C. Serafin2, Eduardo F. Borba6 and Clovis A. Silva7, 1Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil, 2Gynecology Department, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 3Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 4Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 6Rheumatology Division; University of São Paulo, São Paulo, Brazil, 7Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil

    Background/Purpose: Reduction of ovarian reserve has been observed in childhood-onset SLE (c-SLE) and adult SLE populations, and most of them were limited to follicle stimulating…
  • Abstract Number: 628 • 2013 ACR/ARHP Annual Meeting

    Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus

    Nicholas A. Young1, Lai-Chu Wu1, Craig Burd2, Alexandra Friedman1, Benjamin Kaffenberger1, Murugesan Rajaram3, Larry S. Schlesinger4, Hayley James5, Margaret Shupnik6 and Wael N. Jarjour7, 1Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, 3Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, 4Center for Microbial Interface Biology, The Ohio State University Wexner Medical Center, Columbus, OH, 5Asthma, Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, VA, 6Endocrinology; Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 7Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease.  The sex hormone estrogen (E2) is present at elevated levels…
  • Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting

    Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?

    Nicholas A. Young1, Giancarlo R. Valiente2, Lai-Chu Wu1, Michael Bruss3, Craig Burd4 and Wael N. Jarjour5, 1Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, 3Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, 5Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…
  • Abstract Number: 573 • 2013 ACR/ARHP Annual Meeting

    Absence Of Estrogen Receptor Alpha Reduces The Number and Function Of Bone Marrow Derived Plasmacytoid Dendritic Cells In Lupus Prone Mice

    Jennifer Scott1, Osama S. Naga2, Melissa A. Cunningham3, Jena Wirth3, Jackie G. Eudaly2 and Gary S. Gilkeson4, 1Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 2Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, 3Med/Rheumatology, MUSC, Charleston, SC, 4Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9:1 ratio compared to men. Previous work in our laboratory…
  • Abstract Number: L12 • 2013 ACR/ARHP Annual Meeting

    Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Demonstrates Efficacy and Significantly Reduces Proinflammatory Cytokines in Patients with Active Longstanding Rheumatoid Arthritis with High Gonadotropin Levels: A Proof-of-Concept, Double-Blind, Randomized Trial

    Anita Kåss1,2, Ivana Hollan3, Peter Torjesen4, Hans Christian Gulseth5 and Øystein T. Førre6, 1Faculty of Medicine, University of Oslo, Oslo, Norway, 2Dept. of Rheumatology, Betanien Hospital, Skien, Norway, 3Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 4Department of Endocrinology, Oslo University Hospital, Oslo, Norway, 5Rheumatology, Betanien Hospital, Skien, Norway, 6Oslo University Hospital, Oslo, Norway

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and treatment options can be improved. Gonadotropin-releasing hormone (GnRH) stimulates immune responses (1). Inhibiting GnRH, by…
  • Abstract Number: 1240 • 2012 ACR/ARHP Annual Meeting

    Serum Anti-Müllerian Hormone Can Be Used to Determine Ovarian Reserve in Women with Rheumatoid Arthritis

    Jenny Brouwer1, Johanna M.W. Hazes2, Joop S.E. Laven3, Izaäk Schipper3 and Radboud J.E.M. Dolhain4, 1Obstetrics & Gynaecology, division of Reproductive Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, 2Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 3Obstetrics & Gynaecology, division of Reproductive Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 4Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands

    Background/Purpose: Planning of pregnancy is important in women with rheumatoid arthritis (RA). It is preferred to start a pregnancy after adjustment of medication and when…
  • Abstract Number: 1184 • 2012 ACR/ARHP Annual Meeting

    Negative Association Between Testosterone Levels and Risk of Future Rheumatoid Factor Negative Rheumatoid Arthritis in Men

    Mitra Pikwer1, Aleksander Giwercman2, Ulf Bergström1, Jan-Åke Nilsson3, Lennart T.H. Jacobsson3 and Carl Turesson3, 1Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden, 3Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a heterogeneous disease with female predominance. Sex hormones have been suggested to play a part in the pathogenesis. We have previously…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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