Abstracts tagged "Heart disease"

Abstract Number: 2490 • ACR Convergence 2025
Unmasking Mortality Risk: The Impact of Systemic Sclerosis in Stress-Induced Cardiomyopathy
Suryakumar Balasubramanian¹, Laura Rojo Grajales², Ashlyn Narman³, Veera Durga Vaishnavi Kurra⁴, Ramses Ramirez Damera², Alejandro Alvarez Betancourt², Abdul Qudoos Iqbal Mohammed², Hai Ofek², Prachi Anand², Roman Zeltser⁵ and Amgad N. Makaryus⁵, ¹Nassau university Medical center, new york, ²Nassau University Medical Center, East Meadow, NY, ³American University of the Caribbean, East Meadow, NY, ⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
Background/Purpose: Stress-induced cardiomyopathy (SIC), also known as Takotsubo cardiomyopathy (TCM), is characterized by acute left ventricular dysfunction, often triggered by emotional or physical stress. In…
Abstract Number: 0669 • ACR Convergence 2025
Clinical and Laboratory Factors Associated With Biopsy-Confirmed Antimalarial-Induced Cardiomyopathy
Youngmin Kim¹, Norioscar Cabello², Robert Padera², Brittany Weber³ and Karen H. Costenbader⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital, DEDHAM, MA, ⁴Harvard Medical School and Brigham and Women's Hospital, Boston, MA
Background/Purpose: Hydroxychloroquine (HCQ) is widely prescribed in rheumatology, particularly for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Though generally safe, HCQ can cause rare…
Abstract Number: 2413 • ACR Convergence 2025
Hydroxychloroquine and Adverse Cardiovascular Outcomes in Pregnant Patients with Systemic Lupus Erythematosus
Mariana Gonzalez-Treviño¹, Ashley L Ciosek¹, Genessis Maldonado¹, Catherine Deffendall², Tania Ruiz¹, Tracy Frech¹ and Rashmi Dhital³, ¹Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University, Nashville, TN, ³Vanderbilt University Medical Center, Brentwood, TN
Background/Purpose: Hydroxychloroquine (HCQ) is a medication used in SLE during pregnancy. An adverse effect of HCQ includes cardiotoxicity. Hormonal changes during pregnancy may trigger SLE…
Abstract Number: 0655 • ACR Convergence 2025
Blood pressure remains elevated in patients initiating voclosporin with low baseline blood pressure: evidence from patients in routine clinical care
Eric Roberts¹, gabriela Schmajuk² and Jinoos Yazdany³, ¹University of California, San Francisco, SF, CA, ²University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, ³UCSF, San Francisco, CA
Background/Purpose: Hypertension was a common adverse event in RCTs testing voclosporin, an oral calcineurin inhibitor approved in 2021 to treat lupus nephritis (LN). In these…
Abstract Number: 2222 • ACR Convergence 2025
Neonatal Myocardial Strain in Offspring born to Mothers with Systemic Lupus Erythematosus: Pilot Data from the LEGACY Cohort
Reem Farhat¹, Lawrence Rudski², Natalie Dayan³, Catherine Henin⁴, Daniela Villegas Martinez⁴, Sariya Sahussarungsi¹, Pasinee Kanaprach¹, Sasha Bernatsky⁵, Gabriel Altit⁴ and Evelyne Vinet⁵, ¹McGill University, Faculty of Medicine and Health Sciences, Montreal, QC, Canada, ²Jewish General Hospital, Montreal, QC, Canada, ³McGill University Health Centre, Montreal, QC, Canada, ⁴Montreal Children's Hospital, Montreal, QC, Canada, ⁵Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) increases the risk of placenta-mediated adverse pregnancy outcomes (APO) and may impact offspring cardiovascular health. Transplacental maternal anti-Ro antibodies can…
Abstract Number: 0810 • ACR Convergence 2025
Spatial Transcriptomic-based Phenotyping of the Fibroblast Niches in Systemic Sclerosis-associated Primary Heart Involvement
Alexandru Micu¹, Alexandru-Emil Matei², Yi-Nan Li³, Ann-Christin Pecher⁴, Tim Filla⁵, Jörg Henes⁶, Markus Eckstein⁷, Karin Klingel⁸, Jörg Distler⁹ and Andrea-Hermina Györfi¹⁰, ¹Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University, Düsseldorf, Germany, ²Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt am Main, Germany, Düsseldorf, Germany, ³University Hospital of Düsseldorf, Düsseldorf, Germany, ⁴Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology, and Rheumatology, University Hospital Tübingen, Tübingen, Germany, ⁵Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University., Düsseldorf, Germany, ⁶Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology, and Rheumatology, University Hospital Tübingen, Tuebingen, Germany, ⁷Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ⁸Cardiopathology, Institute for Pathology, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, ⁹University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ¹⁰Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University., Düsseldorf, Germany
Background/Purpose: Systemic sclerosis (SSc)-associated primary heart involvement (SSc-pHI) is one of the leading causes of mortality in SSc, yet its underlying cellular and molecular pathomechanisms…
Abstract Number: 2005 • ACR Convergence 2025
Elevated Serum Uric Acid as an Independent Risk Factor for Multiple Stent Placement in Non-Hypertensive, Non-Diabetic Patients with Coronary Artery Disease: A Retrospective Cohort Analysis
qingyan li¹, Jianguo Li¹, Mengwen Niu¹, Tianshu chu¹ and lemei an², ¹Henan Provincial People's Hospital, zhengzhou, China (People's Republic), ²Henan Provincial People's Hospital, zhengzhou
Background/Purpose: While the relationship between serum uric acid (SUA) and coronary artery disease (CAD) remains controversial, emerging evidence suggests a particularly significant association in patients…
Abstract Number: 0458 • ACR Convergence 2025
TyG-BMI Index as a Serological Biomarker for Carotid Plaque and Cardiac Function Changes in Rheumatoid Arthritis
Rebeca L. Polina-Lugo¹, Oscar Azael Garza-Flores², Fernanda M. Garcia-Garcia³, Esteban C. Garza-Gonzalez⁴, Jesus Alberto Cardenas-de la Garza⁵, Iris J. Colunga-Pedraza³, Jose R Azpiri-Lopez⁶, Dionicio A. Galarza-Delgado³, Victor M Fraga-Enriquez⁷ and Diego Azamat Salcedo Almanza⁸, ¹Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, ²Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Guadalupe, Mexico, ³Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ⁴Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, San Nicolas de los Garza, Nuevo Leon, Mexico, ⁵Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Mexico, ⁶Cardiology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ⁷Cardiology Service, Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico, ⁸Radiology Service, Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico
Background/Purpose: The Triglyceride-Glucose-BMI index (TyG-BMI) is a reliable method for detecting insulin resistance (IR), with effectiveness comparable to the gold standard. Elevated TyG-BMI levels have…
Abstract Number: 1913 • ACR Convergence 2025
Do We Screen For and Do We Miss Antimalarial-Induced Cardiomyopathy (AMIC)? Risk Profiles according to Hydroxychloroquine Exposure Duration
Youngmin Kim¹, Robert Padera², Brittany Weber³ and Karen H. Costenbader⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital, DEDHAM, MA, ⁴Harvard Medical School and Brigham and Women's Hospital, Boston, MA
Background/Purpose: Hydroxychloroquine (HCQ) is widely used for autoimmune diseases but carries a risk of antimalarial-induced cardiomyopathy (AMIC) that increases with long-term use and is often…
Abstract Number: 0456 • ACR Convergence 2025
Impact of Rheumatoid Arthritis on mortality and other outcomes in Heart failure: A nationwide analysis.
Nisha Sapkota¹, Samuel Sule-saa¹, Yubraj Aryal², Mark Ntow³, Karuna Bista⁴, Parvathy Rajeev³, jemima Alemonai³, Esther Duodu⁵, Brijesh Ghimire³, Pyae Hein³, Jeffrey Sackey⁶, Muhanned Towfig³, Robert Lamptey³, Temesgen Gobena⁷, Daniel Pinkrah⁷ and Mona Pervil Ulysse⁸, ¹Interfaith Medical Center, One Broolyn Health, Brooklyn, NY, ²Geisinger Medical Center, Danville, PA, ³Interfaith Medical Center, One Broolyn Health, Brooklyn, ⁴Montefiore New Rochelle Hospital, New Rochelle, NY, ⁵Broodale Hospital Medical Center, One Broolyn Health, Brooklyn, ⁶Interfaith Medical Center,One Broolyn Health, Brooklyn, ⁷Interfaith Medical Center, Brooklyn, NY, ⁸Interfaith Medical Center, One Brooklyn Health, Brooklyn
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with systemic inflammation and increased cardiovascular risk, particularly heart failure (HF). Patients with RA and…
Abstract Number: 1868 • ACR Convergence 2025
Global Downregulation of Fli1 in Mice Induces Cardiac Dysfunction via Enhanced β-fatty acid Oxidation and Collagen Deposition
Knowledge Mudhibadhi Moyo¹, Fatima-Ezzahrae El Adili², Maria Trojanowska¹ and Andreea Bujor¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Revere, MA
Background/Purpose: Primary cardiac involvement is a common complication of Systemic sclerosis (SSc), characterized by fibrosis and diastolic dysfunction, presumably due to microvascular dysfunction and repeated…
Abstract Number: 0445 • ACR Convergence 2025
GLP-1 Receptor Agonists Reduce Mortality and Cardiovascular Events in Patients with Rheumatoid Arthritis
Giorgos Loizidis and Ross summer, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Obesity significantly increases cardiovascular morbidity and mortality in rheumatoid arthritis (RA), yet effective strategies for managing obesity-related risks in this population remain limited. Glucagon-like…
Abstract Number: 1856 • ACR Convergence 2025
Spatial Proteomic-based Phenotyping of Fibroblast Populations and their Microenvironment in Systemic Sclerosis Primary Heart Involvement
Ayla Nadja Stuetz¹, Giacomo de Luca², Alexandru-Emil Matei³, Yi-Nan Li⁴, Veronica Batani², Tim Filla⁵, Aleix Rius Rigau⁶, Bilgesu Safak Tümerdem¹, Cosimo Bruni⁷, Maike Büttner-Herold⁸, Stefania Rizzo⁹, Monica De Gaspari⁹, Markus Eckstein¹⁰, Georg Schett¹¹, Cristina Basso⁹, Jörg Distler¹², Marco Matucci-Cerinic¹³ and Andrea-Hermina Györfi¹⁴, ¹Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University, Düsseldorf, Nordrhein-Westfalen, Germany, ²Vita-Salute San Raffaele University. Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy, ³Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt am Main, Germany, Düsseldorf, Germany, ⁴University Hospital of Düsseldorf, Düsseldorf, Germany, ⁵Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University., Düsseldorf, Germany, ⁶Department of Internal Medicine ³, Rheumatology and Clinical Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen. Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, ⁷Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁸Department of Nephropathology, University Hospital Erlangen, Erlangen, Germany, ⁹Cardiovascular Pathology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University and Hospital of Padua, Padua, Italy, ¹⁰Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ¹¹Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, ¹²University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ¹³University San Raffaele Milano, Milano, Milan, Italy, ¹⁴Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University., Düsseldorf, Germany
Background/Purpose: Primary heart involvement (pHI) is one of the leading causes of death in systemic sclerosis (SSc). However, the cellular and molecular pathomechanisms of SSc-pHI…
Abstract Number: 0235 • ACR Convergence 2025
Mortality Trends due to Hypertension Related Deaths in Elderly Patients with Inflammatory Polyarthropathy: A CDC WONDER Analysis of 21 Years
ZAUHA FAWAD MEMON¹, Sibgha Fawad Memon², Matia Fawad Memon², REHAN ISHAQUE³, AHMAD SANAN⁴ and MUHAMMAD MUGHEES⁵, ¹Peoples University of Medical and Health Sciences for Women, Tando Allahyar, Sindh, Pakistan, ²Peoples University of Medical and Health Sciences for Women, Tando Allahyar, Pakistan, ³LIAQUAT UNIVERSITY OF MEDICAL AND HEALTH SCIENCES, Jam Shoro, Sindh, Pakistan, ⁴KHYBER MEDICAL COLLEGE, Peshawer, Pakistan, ⁵Bahria University health Sciences, KARACHI, Pakistan
Background/Purpose: Inflammatory polyarthropathy (IPA) is a group of chronic autoimmune disorders, common among older adults and contribute significantly to systemic inflammation and cardiovascular risk .…
Abstract Number: 1667 • ACR Convergence 2025
Recurrent or Incident Pericarditis With Concurrent Autoimmune Disease: Stable Control With Rilonacept Interleukin-1 Pathway Inhibition
Zachary Daniel¹, Summia Afridi¹, Michael Allen² and Khoa Ngo¹, ¹Albany Medical College, Albany, NY, ²Albany Med, Albany, NY
Background/Purpose: Up to 30% of patients with incident pericarditis will develop recurrent pericarditis (RP), with severe impact on quality of life. More than 20% of…

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