Abstract Number: 104 • 2015 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Identifies SLC8A3 As a Susceptibility Locus for ACPA-Positive Rheumatoid Arthritis
Background/Purpose: Rheumatoid Arthritis (RA) patients with serum anti-citrullinated peptide antibodies (ACPA) have a strong and specific genetic background. We performed a genome-wide association study (GWAS)…Abstract Number: 106 • 2015 ACR/ARHP Annual Meeting
Does the Timing of Phenotype Assessment Influence Association Results in Pharmacogenetics Studies of Anti-TNF Response in Rheumatoid Arthritis?
Background/Purpose: Pharmacogenetics studies of anti-tumor necrosis factor (TNF) response among patients with rheumatoid arthritis (RA) have routinely used assessment of response at a single time-point,…Abstract Number: 108 • 2015 ACR/ARHP Annual Meeting
A New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12
Background/Purpose: Genome-wide association studies (GWASs) and large follow-up studies in European-descent or Asian subjects have identified a number of susceptibility loci for systemic lupus erythematosus…Abstract Number: 1163 • 2015 ACR/ARHP Annual Meeting
Dynamic Regulation of Enhancers and Super-Enhancers in Rheumatoid Arthritis Synovial Finroblasts
Background/Purpose: Enhancers are regulatory elements that modulate transcriptional rates of genes. Super-enhancers (SupE) are extremely large enhancers associated primarily with highly expressed genes that have…Abstract Number: 1239 • 2015 ACR/ARHP Annual Meeting
Significant Impact of Microrna-Target Gene Networks on the Genetics of Rheumatoid Arthritis
Background/Purpose: MicroRNA (miRNA), a short endogenous noncoding RNA, has a major role in the degradation and translational repression of a specific gene through its binding…Abstract Number: 1621 • 2015 ACR/ARHP Annual Meeting
Genetic Contributions to Radiographic Damage in African Americans with Rheumatoid Arthritis on a Panel of Autoimmune Disease Markers
Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune condition affecting 0.5-1% of populations worldwide and having a significant heritable component. A major endophenotype within RA…Abstract Number: 1622 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Analysis and Whole Genome Sequencing Identify Variants Associated with Radiographic Severity of Rheumatoid Arthritis in African Americans
Background/Purpose: Joint damage manifested by bony erosions and joint space narrowing is a major contributor to the morbidity and mortality of RA. Reports in Caucasians…Abstract Number: 2099 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Clinically-Defined Gout Identifies Multiple Risk Loci: A Clue for Future Companion Diagnostics of Gout
Background/Purpose: Gout, caused by hyperuricaemia, is a multifactorial disease. Recently, genome-wide association studies (GWASs) of gout have been reported; however, they included self-reported gout cases.…Abstract Number: 2997 • 2015 ACR/ARHP Annual Meeting
A Genome-Wide Association Study of a Hispanic Systemic Sclerosis Cohort
Background/Purpose: Genome-wide association studies (GWASs) have resulted in the identification of several genetic loci involved in systemic sclerosis (SSc) susceptibility. However, GWASs are normally focused…Abstract Number: 3227 • 2015 ACR/ARHP Annual Meeting
Identification of Novel Protein-Coding Genetic Variants Associated with Takayasu Arteritis
Background/Purpose: Takayasu arteritis is a rare large vessel vasculitis of unclear etiology. Previous studies identified associations between Takayasu arteritis and genetic variants within HLA class…Abstract Number: 86 • 2015 ACR/ARHP Annual Meeting
Auxilin Is a Novel Susceptibility Gene for Congenital Heart Block Modulating Cardiac Function
Background/Purpose: Congenital heart block (CHB) may affect children of women with anti-Ro/SSA and anti-La/SSB autoantibodies. The most recognized manifestation of CHB is an atrioventricular (AV)…Abstract Number: 89 • 2015 ACR/ARHP Annual Meeting
A Longitudinal Genome-Wide Association Study of Anti-Tumor Necrosis Factor Response Among Japanese Patients with Rheumatoid Arthritis
Background/Purpose: Studies of patients with rheumatoid arthritis (RA) to identify genetic biomarkers of anti-tumor necrosis factor (TNF) response have been conducted mostly in Caucasian populations.…Abstract Number: 2454 • 2014 ACR/ARHP Annual Meeting
Genetic Influences on Rheumatoid Arthritis in African-Americans
Background/Purpose: Rheumatoid arthritis (RA) affects 0.5-1% of the population worldwide. The genetics of RA has been analyzed in large European and Asian studies, but much…Abstract Number: 2089 • 2014 ACR/ARHP Annual Meeting
The APOL1 Gene Is Not Associated with Lupus Nephritis in Individuals with Enriched Amerindian Ancestry
The APOL1 Gene is not Associated with Lupus Nephritis in Individuals with Enriched Amerindian AncestryBackground/Purpose: The APOL1 gene coding variants G1 and G2 have been…Abstract Number: 745 • 2014 ACR/ARHP Annual Meeting
Genetic Susceptibility Loci of Idiopathic Interstitial Pneumonitis Do Not Represent Risk for Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) related interstitial lung disease (ILD) has phenotypic similarities to idiopathic interstitial pneumonia (IIP). The objective of this study was to assess…