ACR Meeting Abstracts

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Abstracts tagged "growth factors and osteoarthritis"

  • Abstract Number: 1036 • 2018 ACR/ARHP Annual Meeting

    Effects of Three Potential Anabolic Disease-Modifying Osteoarthritis Drugs – Sprifermin, Insulin-like Growth Factor 1 and Bone Morphogenetic Protein 7 – on Matrix Production and the Phenotype of Articular Chondrocytes

    Sylvia Muller, Martin Michaelis, Sven Lindemann and Anne Gigout, Merck KGaA, Darmstadt, Germany

    Background/Purpose: Disease-modifying osteoarthritis drugs with an anabolic mode of action should stimulate the growth of new hyaline cartilage. For instance, recombinant human fibroblast growth factor…
  • Abstract Number: 1004 • 2014 ACR/ARHP Annual Meeting

    Elevated Levels of BMP2 Compensate for Loss of TGF-Beta in Articular Cartilage during Experimental Osteoarthritis

    Esmeralda Blaney Davidson1, Arjan van Caam1, Arjen Blom2, Elly Vitters2, Miranda Bennink1, Wim van den Berg2, Fons van de Loo3 and Peter van der Kraan4, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Radboud University Medical Center, Nijmegen, Netherlands

    Background/Purpose: We have demonstrated that TGF-beta signaling via Smad2/3 is drastically reduced in articular cartilage (AC) with age and loss of Smad2/3-signaling predisposed AC for…
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ACR Pediatric Rheumatology Symposium 2020

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