Abstracts tagged "growth factors and osteoarthritis"

Abstract Number: 1036 • 2018 ACR/ARHP Annual Meeting
Effects of Three Potential Anabolic Disease-Modifying Osteoarthritis Drugs – Sprifermin, Insulin-like Growth Factor 1 and Bone Morphogenetic Protein 7 – on Matrix Production and the Phenotype of Articular Chondrocytes
Sylvia Muller, Martin Michaelis, Sven Lindemann and Anne Gigout, Merck KGaA, Darmstadt, Germany
Background/Purpose: Disease-modifying osteoarthritis drugs with an anabolic mode of action should stimulate the growth of new hyaline cartilage. For instance, recombinant human fibroblast growth factor…
Abstract Number: 1004 • 2014 ACR/ARHP Annual Meeting
Elevated Levels of BMP2 Compensate for Loss of TGF-Beta in Articular Cartilage during Experimental Osteoarthritis
Esmeralda Blaney Davidson¹, Arjan van Caam¹, Arjen Blom², Elly Vitters², Miranda Bennink¹, Wim van den Berg², Fons van de Loo³ and Peter van der Kraan⁴, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: We have demonstrated that TGF-beta signaling via Smad2/3 is drastically reduced in articular cartilage (AC) with age and loss of Smad2/3-signaling predisposed AC for…