Abstracts tagged "growth factors"

Abstract Number: 439 • 2018 ACR/ARHP Annual Meeting
Articular Cartilage from Osteoarthritis Patients Shows Extracellular Matrix Remodeling over the Course of Treatment with Sprifermin (Recombinant human fibroblast growth factor 18)
Ditte Reker¹, Christian S. Thudium², Anne Sofie Siebuhr³, Thorbjørn Gantzel⁴, Christoph Ladel⁵, Martin Michaelis⁵, Morten A. Karsdal², Anne Gigout⁵ and Anne C. Bay-Jensen², ¹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁴cOrthopedic Surgery Unit, Gentofte Hospital, Hellerup, Denmark, ⁵Merck KGaA, Darmstadt, Germany
Background/Purpose: Sprifermin, a truncated form of human fibroblast growth factor 18 (FGF18), is being investigated as a potential cartilage and disease-modifying OA drug. In vitro,…
Abstract Number: 994 • 2018 ACR/ARHP Annual Meeting
Platelet Derived Growth Factor Receptors (PDGFRs) and Their Implication in Inflammatory Arthritis
Bhanupriya Madarampalli¹, Joon Kyung Kim², Paul Panipinto¹, Hannah Labinsky¹ and Vineet Mahajan¹, ¹Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Rheumatoid arthritis (RA) is inflammatory joint disease characterized by immune infiltration and synovial hyperplasia. Hyperplastic synovium contains increased numbers of activated synovial fibroblasts, which…
Abstract Number: 2567 • 2016 ACR/ARHP Annual Meeting
The Effect of Fibroblast Growth Factor 4 on the Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Xiaoxue Feng¹, Shangling Zhu¹, Weixiang Peng², Fang Liu³, Baiyu Zhang¹ and Jianlin Huang¹, ¹Department of Internal Medicine, Division of Rheumatology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Internal Medicine, Division of Rheumatology, Zhu Hai People's Hospital, Zhuhai, China, ³Department of Internal Medicine, Division of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background/Purpose: Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Fibroblast growth factor 4 (FGF4) is a potent mitogen for tumor cells. The…
Abstract Number: 2572 • 2015 ACR/ARHP Annual Meeting
Protective and Therapeutic Effects of Growth Hormone on Collagen-Induced Arthritis
Ricardo J. Villares¹, Gabriel Criado², Rosa P Gomariz³, Yasmina Juarranz³, Javier Leceta³, Graciela Cascio⁴, Jose L. Pablos⁵ and Mario Mellado⁶, ¹Immunology & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, ²Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ³Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, ⁴Immunoloy & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, ⁵Instituto de Investigacion Hospital, Madrid, Spain, ⁶Immunology and Oncology, Centro Nacional de Biotecnología. CNIC, Madrid, Spain
Background/Purpose: Inflammatory (M1) macrophages and T helper 17 (TH17) cells are central to rheumatoid arthritis (RA) pathogenesis. Although the growth hormone [GH]/insulin-like growth factor 1…
Abstract Number: 2793 • 2014 ACR/ARHP Annual Meeting
BMP2 Requires TGF-Beta to Induce Osteophytes during Experimental Osteoarthritis
Esmeralda Blaney Davidson¹, Arjen Blom², Arjan van Caam¹, Elly Vitters², Miranda Bennink¹, Wim van den Berg², Fons van de Loo³ and Peter van der Kraan⁴, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: Osteophytes are a major hallmark of osteoarthritis (OA). Both TGF-beta and BMP2 can induce osteophytes in murine knee joints. We demonstrated that TGF-beta could…
Abstract Number: 1706 • 2014 ACR/ARHP Annual Meeting
Prevention of SU5416-Induced Pulmonary Hypertension in a TGFβ Dependent Genetic Mouse Model of Scleroderma Using the Endothelin Receptor Antagonist Macitentan
Emma C. Derrett-Smith¹, Vincent Sobanski², Sarah Trinder³, Adrian J Gilbane³, Marc Iglarz⁴, David J. Abraham³, Alan M. Holmes⁵ and Christopher P Denton⁶, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, ²UCL Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁴Actelion Pharmaceuticals Ltd., Allschwil, Switzerland, ⁵Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ⁶Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom
Background/Purpose: Pulmonary arterial hypertension (PAH) is an important complication of systemic sclerosis (SSc) that occurs in around 10% of cases. We have previously shown that…
Abstract Number: 1460 • 2014 ACR/ARHP Annual Meeting
Midkine, a Growth Factor, May Play a Pathophysiological Role in Patients with Rheumatoid Arthritis
Emiko Shindo, Tomoko Hasunuma, Shotaro Masuoka, Mai Kawazoe, Hiroshi Sato, Natsuki Fujio, Kotaro Shikano, Makoto Kaburaki, Sei Muraoka, Nahoko Tanaka, Kaichi Kaneko, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Midkine (MK) is known as a heparin-binding growth factor. Recent studies revealed that MK has various functions such as cell proliferation, differentiation, and apoptosis…
Abstract Number: 1036 • 2014 ACR/ARHP Annual Meeting
Synergism Between GM-CSF and IL-17 Causes Enhanced Joint Pathology Via the Production of IL-6 and IL-23
Annemarie E.M. van Nieuwenhuijze¹, Debbie M. Roeleveld², Birgitte Walgreen², Miranda Bennink¹, Monique M. Helsen¹, Liduine van den Bersselaar¹, Ian P. Wicks³, Wim B. van den Berg¹, Fons A. van de Loo¹ and Marije I. Koenders¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
Abstract Number: 1011 • 2014 ACR/ARHP Annual Meeting
Fibroblast Growth Factor-2 and Its Receptor Antagonists in Osteoarthritis
Elina Nummenmaa¹, Mari Hamalainen¹, Teemu Moilanen^1,2, Katriina Vuolteenaho¹ and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: The fibroblast growth factor (FGF) family represents an interesting group of molecules which are involved in the regulation of connective tissue development and metabolism.…
Abstract Number: 31 • 2014 ACR/ARHP Annual Meeting
Interaction of FGF-8 and TNF-a in the Regulation of BMP-Induced Osteoblast Differentiation
Takayuki Katsuyama¹, Fumio Otsuka², Mariko Narazaki¹, Ken-ei Sada¹, Kenichi Inagaki¹, Jun Wada¹ and Hirofumi Makino¹, ¹Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Background/Purpose: Osteoblasts and osteoclasts play important roles in the bone remodeling. When the balance between these cells is disrupted, bone loss or aberrant bone…
Abstract Number: 67 • 2013 ACR/ARHP Annual Meeting
Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) As a Potential Mediator In Osteoarthritis
Richard F. Loeser¹ and David A. Long², ¹Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ²Section Of Molecular Medicine, Wake Forest University, Winston-Salem, NC
Background/Purpose: We recently reported changes in gene expression in knee joint tissue from 12 week-old and 12 month-old mice after OA was induced by surgical…
Abstract Number: 49 • 2013 ACR/ARHP Annual Meeting
Chondrocyte-Specific Bone Morphogenetic Protein-2 Overexpression Results In Severe Aggravation Of Osteophyte Formation In Experimental Osteoarthritis Without Altering Cartilage Damage In Young Mice
Esmeralda N. Blaney Davidson¹, Elly L. Vitters², Miranda B. Bennink³, Fons AJ Loo², Wim B. van den Berg³ and Peter M. van der Kraan², ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: In murine osteoarthritis (OA) models chondrocytes surrounding lesions express elevated levels of Bone Morphogenetic Protein-2 (BMP2). This growth factor is well known for its…

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