ACR Meeting Abstracts

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Abstracts tagged "growth factors"

  • Abstract Number: 439 • 2018 ACR/ARHP Annual Meeting

    Articular Cartilage from Osteoarthritis Patients Shows Extracellular Matrix Remodeling over the Course of Treatment with Sprifermin (Recombinant human fibroblast growth factor 18)

    Ditte Reker1, Christian S. Thudium2, Anne Sofie Siebuhr3, Thorbjørn Gantzel4, Christoph Ladel5, Martin Michaelis5, Morten A. Karsdal2, Anne Gigout5 and Anne C. Bay-Jensen2, 1Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 4cOrthopedic Surgery Unit, Gentofte Hospital, Hellerup, Denmark, 5Merck KGaA, Darmstadt, Germany

    Background/Purpose: Sprifermin, a truncated form of human fibroblast growth factor 18 (FGF18), is being investigated as a potential cartilage and disease-modifying OA drug. In vitro,…
  • Abstract Number: 994 • 2018 ACR/ARHP Annual Meeting

    Platelet Derived Growth Factor Receptors (PDGFRs) and Their Implication in Inflammatory Arthritis

    Bhanupriya Madarampalli1, Joon Kyung Kim2, Paul Panipinto1, Hannah Labinsky1 and Vineet Mahajan1, 1Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Rheumatoid arthritis (RA) is inflammatory joint disease characterized by immune infiltration and synovial hyperplasia. Hyperplastic synovium contains increased numbers of activated synovial fibroblasts, which…
  • Abstract Number: 2567 • 2016 ACR/ARHP Annual Meeting

    The Effect of Fibroblast Growth Factor 4 on the Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

    Xiaoxue Feng1, Shangling Zhu1, Weixiang Peng2, Fang Liu3, Baiyu Zhang1 and Jianlin Huang1, 1Department of Internal Medicine, Division of Rheumatology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Department of Internal Medicine, Division of Rheumatology, Zhu Hai People's Hospital, Zhuhai, China, 3Department of Internal Medicine, Division of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Background/Purpose:  Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Fibroblast growth factor 4 (FGF4) is a potent mitogen for tumor cells. The…
  • Abstract Number: 2572 • 2015 ACR/ARHP Annual Meeting

    Protective and Therapeutic Effects of Growth Hormone on Collagen-Induced Arthritis

    Ricardo J. Villares1, Gabriel Criado2, Rosa P Gomariz3, Yasmina Juarranz3, Javier Leceta3, Graciela Cascio4, Jose L. Pablos5 and Mario Mellado6, 1Immunology & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, 2Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 3Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, 4Immunoloy & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, 5Instituto de Investigacion Hospital, Madrid, Spain, 6Immunology and Oncology, Centro Nacional de Biotecnología. CNIC, Madrid, Spain

    Background/Purpose: Inflammatory (M1) macrophages and T helper 17 (TH17) cells are central to rheumatoid arthritis (RA) pathogenesis.  Although the growth hormone [GH]/insulin-like growth factor 1…
  • Abstract Number: 1460 • 2014 ACR/ARHP Annual Meeting

    Midkine, a Growth Factor, May Play a Pathophysiological Role in Patients with Rheumatoid Arthritis

    Emiko Shindo, Tomoko Hasunuma, Shotaro Masuoka, Mai Kawazoe, Hiroshi Sato, Natsuki Fujio, Kotaro Shikano, Makoto Kaburaki, Sei Muraoka, Nahoko Tanaka, Kaichi Kaneko, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan

    Background/Purpose: Midkine (MK) is known as a heparin-binding growth factor.  Recent studies revealed that MK has various functions such as cell proliferation, differentiation, and apoptosis…
  • Abstract Number: 1036 • 2014 ACR/ARHP Annual Meeting

    Synergism Between GM-CSF and IL-17 Causes Enhanced Joint Pathology Via the Production of IL-6 and IL-23

    Annemarie E.M. van Nieuwenhuijze1, Debbie M. Roeleveld2, Birgitte Walgreen2, Miranda Bennink1, Monique M. Helsen1, Liduine van den Bersselaar1, Ian P. Wicks3, Wim B. van den Berg1, Fons A. van de Loo1 and Marije I. Koenders1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

    Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
  • Abstract Number: 1011 • 2014 ACR/ARHP Annual Meeting

    Fibroblast Growth Factor-2 and Its Receptor Antagonists in Osteoarthritis

    Elina Nummenmaa1, Mari Hamalainen1, Teemu Moilanen1,2, Katriina Vuolteenaho1 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: The fibroblast growth factor (FGF) family represents an interesting group of molecules which are involved in the regulation of connective tissue development and metabolism.…
  • Abstract Number: 31 • 2014 ACR/ARHP Annual Meeting

    Interaction of FGF-8 and TNF-a in the Regulation of BMP-Induced Osteoblast Differentiation

    Takayuki Katsuyama1, Fumio Otsuka2, Mariko Narazaki1, Ken-ei Sada1, Kenichi Inagaki1, Jun Wada1 and Hirofumi Makino1, 1Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 2Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Background/Purpose:   Osteoblasts and osteoclasts play important roles in the bone remodeling.  When the balance between these cells is disrupted, bone loss or aberrant bone…
  • Abstract Number: 2793 • 2014 ACR/ARHP Annual Meeting

    BMP2 Requires TGF-Beta to Induce Osteophytes during Experimental Osteoarthritis

    Esmeralda Blaney Davidson1, Arjen Blom2, Arjan van Caam1, Elly Vitters2, Miranda Bennink1, Wim van den Berg2, Fons van de Loo3 and Peter van der Kraan4, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Radboud University Medical Center, Nijmegen, Netherlands

    Background/Purpose: Osteophytes are a major hallmark of osteoarthritis (OA). Both TGF-beta and BMP2 can induce osteophytes in murine knee joints. We demonstrated that TGF-beta could…
  • Abstract Number: 1706 • 2014 ACR/ARHP Annual Meeting

    Prevention of SU5416-Induced Pulmonary Hypertension in a TGFβ Dependent Genetic Mouse Model of Scleroderma Using the Endothelin Receptor Antagonist Macitentan

    Emma C. Derrett-Smith1, Vincent Sobanski2, Sarah Trinder3, Adrian J Gilbane3, Marc Iglarz4, David J. Abraham3, Alan M. Holmes5 and Christopher P Denton6, 1Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, 2UCL Medical School, London, United Kingdom, 3Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 4Actelion Pharmaceuticals Ltd., Allschwil, Switzerland, 5Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, 6Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom

    Background/Purpose: Pulmonary arterial hypertension (PAH) is an important complication of systemic sclerosis (SSc) that occurs in around 10% of cases.  We have previously shown that…
  • Abstract Number: 67 • 2013 ACR/ARHP Annual Meeting

    Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) As a Potential Mediator In Osteoarthritis

    Richard F. Loeser1 and David A. Long2, 1Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 2Section Of Molecular Medicine, Wake Forest University, Winston-Salem, NC

    Background/Purpose:  We recently reported changes in gene expression in knee joint tissue from 12 week-old and 12 month-old mice after OA was induced by surgical…
  • Abstract Number: 49 • 2013 ACR/ARHP Annual Meeting

    Chondrocyte-Specific Bone Morphogenetic Protein-2 Overexpression Results In Severe Aggravation Of Osteophyte Formation In Experimental Osteoarthritis Without Altering Cartilage Damage In Young Mice

    Esmeralda N. Blaney Davidson1, Elly L. Vitters2, Miranda B. Bennink3, Fons AJ Loo2, Wim B. van den Berg3 and Peter M. van der Kraan2, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: In murine osteoarthritis (OA) models chondrocytes surrounding lesions express elevated levels of Bone Morphogenetic Protein-2 (BMP2). This growth factor is well known for its…
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