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Abstracts tagged "Granulomatosis with Polyangiitis (GPA)"

  • Abstract Number: 2049 • ACR Convergence 2020

    Nasal Bacteria Associated with Disease Activity and ANCA Levels in Granulomatosis with Polyangiitis

    Rennie Rhee1, Jiarui Lu1, Kyle Bittinger2, Antoine Sreih1, Jung-Jin Lee3, Lisa Mattei3, Brendan Kelly4, Peter C. Grayson5, Hongzhe Lee4, Ronald Collman4 and Peter Merkel1, 1University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3Children's Hospital of Philadelphia, Philadelphia, 4University of Pennsylvania, Philadelphia, 5Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Nasal bacteria have been linked to disease activity in granulomatosis with polyangiitis (GPA) with most studies focused on Staphylococcus aureus. Our previous study identified…
  • Abstract Number: 2050 • ACR Convergence 2020

    Autoantibodies Targeting Complement Receptors C3aR and C5aR1 Are Decreased in ANCA-associated Vasculitis and Correlate with a Higher Relapse Rate

    Sebastian Klapa1, Antje Müller2, Andreas Koch3, Anja Kerstein-Staehle4, Wataru Kaehler3, Harald Heidecke5, Susanne Schinke6, Markus Huber-Lang7, Martin Nitschke8, Silke Pitann9, Christian Karsten10, Gabriela Riemekasten11 and Peter Lamprecht2, 1University of Lübeck and Institute of Experimental Medicine, Christian-Albrechts-University of Kiel c/o German Naval Medical Institute, Department of Rheumatology and Clinical Immunology, Luebeck, Germany, 2University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, 3Institute of Experimental Immunology, Christian-Albrechts-University Kiel, c/o German Naval Medical Institute, Kronshagen, Germany, 4University of Lübeck, Dept Rheumatology and Clinical Immunology, Luebeck, Germany, 5CellTrend GmbH, Luckenwalde, Germany, 6University of Lübeck, Department of Rheumatology and Clinical Immunology, Luebeck, Germany, 7Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, Ulm, Germany, 8Department of Internal Medicine I, Transplant Center, University of Lübeck, Luebeck, Germany, 9University of Lübeck, Department of Rheumatology and Clinical Immunology,, Luebeck, Germany, 10Institute of Systemic Inflammation Research, University of Lübeck, Luebeck, Germany, 11University of Lübeck, Department of Rheumatology and Clinical Immunology,, Lübeck, Germany

    Background/Purpose: Activation of the alternative and common terminal complement pathways has been shown in ANCA-associated vasculitis (AAV). Circulating titers of the anaphylatoxin C5a are increased…
  • Abstract Number: 2051 • ACR Convergence 2020

    Localized versus Systemic Granulomatosis with Polyangiitis: Data from the French Vasculitis Study Group Database

    Michele Iudici1, Christian Pagnoux2, Delphine Courvoisier3, Pascal Cohen4, Mohamed Hamidou5, Achille Aouba6, François Lifermann7, Marc Ruivard8, Olivier Aumaitre9, Bernard Bonnotte10, Julien Campagne11, Olivier Decaux12, Eric Hachulla13, Alexandre Karras14, Chahéra Khouatra15, Noémie Jourde-Chiche16, Jean-François Viallard17, Pascal Godmer18, Claire Blanchard-Delaunay19, Alain Le Quellec20, Thomas Quéméneur21, Claire de Moreuil22, Alexis Regent4, Benjamin Terrier4, Luc Mouthon4, Loïc Guillevin4 and Xavier Puechal4, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University and Geneva University Hospitals, Geneva, Switzerland, 2Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 3Division of rheumatology, Geneva University Hospitals, Geneva, Switzerland, 4National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, 5Department of Internal Medicine, Hôtel-Dieu, CHU Nantes, Nantes, France, 6Department of Internal Medicine, CHU Côte de Nacre, Caen, France, 7Department of Internal Medicine, CH Côte d’Argent, Dax, France, 8Department of Internal Medicine, CHU Estaing, Clermont Ferrand, France, 9Department of Internal Medicine, CHU Gabriel Montpied, Clermont Ferrand, France, 10CHU Dijon, Dijon, France, 11Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 12CHU Rennes, Rennes, France, 13Department of Internal Medicine, CHRU, Lille Cedex, France, 14Department of Nephrology, Hôpital Européen Georges Pompidou, Paris, France, 15Department of Respiratory Medicine, CHU Louis Pradel, Lyon, France, 16Department of Nephrology, CHU de la Conception, Marseille, France, 17Department of Internal Medicine, CHU Haut-Lévêque, Bordeaux, France, 18Department of Internal Medicine, CH Bretagne Atlantique, Vannes, France, 19Department of Internal Medicine, CH, Niort, France, 20Department of Internal Medicine, CHU Saint Eloi, Montpellier, France, 21Department of Internal Medicine, CH, Valenciennes, France, 22Department of Internal Medicine, CHU Cavale Blanche, Brest, France

    Background/Purpose: The clinical picture at onset and evolution of localized forms of granulomatosis with polyangiitis (L-GPA) have already been investigated but, to our knowledge, have…
  • Abstract Number: 0060 • ACR Convergence 2020

    ANCA-associated Vasculitis in Caucasian and Hispanics of the Inland Empire of Southern California

    Sandy Lee1, Patil Injean1, Paulina Tran2, Deepa Panikkath1 and Christina Downey1, 1Loma Linda University Medical Center, Redlands, CA, 2UC Riverside School of Medicine, Riverside, CA

    Background/Purpose: ANCA-associated vasculitis (AAV) is often studied in the Caucasian population with few studies looking at the disease in other races. Disease presentation and treatment…
  • Abstract Number: 1032 • ACR Convergence 2020

    Epidemiology and Geographic Evaluation of ANCA-associated Vasculitis (AAV) at a Rural Academic Health Center Utilizing an Electronic Health Record (EHR)

    Eva Rottmann1, Jason Bankert2, Andrea Berger2, Lester Kirchner2, Joseph Dewalle2, Marissa Meissner3, Jason George2, Ion Dan Bucaloiu2, Jaya Prakash Sugunaraj2, Sudheer Penupolu2 and David Bulbin1, 1Geisinger Health System, Danville, PA, 2Geisinger Medical Center, Danville, PA, 3Geisinger Medical Center, Danville

    Background/Purpose: ANCA-associated vasculitis has a reported prevalence ranging from 3.2 to 9.1 cases per 100,000 individuals, but little is known of geographic variations. The aim of…
  • Abstract Number: 1417 • ACR Convergence 2020

    Risk of Relapse of ANCA-associated Vasculitis in Patients of 75 Years and Older: A Retrospective Study

    Sara Thietart1, Guillaume Beinse2, Perrine Smets3, Alexandre Karras4, Carole Philipponnet5, Jean-François Augusto6, Khalil El Karoui7, Rafik Mesbah8, Dimitri Titeca Beauport9, Mohamed Hamidou10, Pierre-Louis Carron11, Julien Campagne12, Karim Sacre13, Pascal Cohen1, Eric Liozon14, Claire Blanchard-Delaunay15, Alex Kostianovsky16, Christian Pagnoux17, Luc Mouthon1, Loïc Guillevin18, Benjamin Terrier1 and Xavier Puéchal for the French Vasculitis Study Group1, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, 2Inserm UMR 1138, Centre de Recherche des Cordeliers, Paris, France, 3Department of Internal Medicine, Centre Hospitalier Universitaire Clermont-Ferrand Hôpital Gabriel-Montpied, Clermont Ferrand, France, 4Department of Nephrology, Hôpital Européen Georges Pompidou, Paris, France, 5Department of Nephrology, CHU Clermont-Ferrand, Clermont-Ferrand, Clermont Ferrand, France, 6Department of Nephrology-Dialysis-Transplantation, CHU Angers, Angers, France, 7Department of Nephrology and Transplantation, Hôpital Universitaire Henri-Mondor, Creteil, France, 8Department of Nephrology, CH Boulogne-sur-Mer, Boulogne-Sur-Mer, France, 9Department of Nephrology, Amiens University Medical Center, Amiens, France, 10Department of Internal Medicine, Hôtel-Dieu, CHU Nantes, Nantes, France, 11Department of Nephrology-Dialysis-Transplantation, CHU Grenoble-Alpes, Grenobles, France, 12Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 13Département de Médecine Interne, Hôpital Bichat, APHP, Paris, France, 14Department of Internal Medicine and Clinical Immunology, Limoges University Hospital, Limoges, France, 15Department of Internal Medicine, CH, Niort, France, 16Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno", Buenos Aeres, Argentina, 17Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 18Department of Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France

    Background/Purpose: ANCA-associated vasculitis (AAV) frequently occurs among older patients, with different clinical presentations than the younger. Little is known on the outcome of older patients…
  • Abstract Number: 1418 • ACR Convergence 2020

    Clinical Presentations and Follow-up Results of Granulomatosis with Polyangiitis: An Analysis of 8 Years Clinical Experience with 220 Patients from a National Referral Center

    Seyed Behnam Jazayeri1, Farzaneh Kianifar2, Samira Alesaeidi2, Soheil Tavakolpour3, Amir Teimourpour4 and Sasan Dabiri2, 1Tehran university of medical scienses, Tehran, Iran, 2Tehran university of medical sciences, Tehran, Iran, 3Dana-faber cancer institute, Harvard Medical School, Boston, MA, 4Department of epidemiology and bio-statistics, Tehran university of medical sciences, Tehran, Iran

    Background/Purpose: Granulomatosis with polyangiitis (GPA) is a rare and life-threatening autoimmune disease. Due to the extremely low prevalence of GPA, monitoring of clinical characteristics and…
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