ACR Meeting Abstracts

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Abstracts tagged "gout"

  • Abstract Number: 1185 • 2013 ACR/ARHP Annual Meeting

    More Than One-Third Of Patients Reach Serum Urate Target and Continue To Report Multiple Flares

    Dinesh Khanna1, Puja Khanna2, Chris Storgard3, Scott Baumgartner4 and Robert Morlock5, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 34939 Directors Place, Ardea Bioscience, San Diego, CA, 4Ardea Biosciences, San Diego, CA, 5Ardea Bioscience, San Diego, CA

    Background/Purpose: Gout is a common inflammatory arthritis, and its worldwide prevalence is increasing. EULAR and ACR guidelines recommend a target serum urate (sUA) ≤6 mg/dL.…
  • Abstract Number: 1901 • 2012 ACR/ARHP Annual Meeting

    Chronic  Gout. Improvement According to Outcome Meaures in Rheumatology Domains in Daily Clinical Practice

    Janitzia Vazquez-Mellado1, Betsabé Serrano1, Jaime Mendoza2, Sergio Garcia-Mendez1, V.Chantal Hernández1, Virginia Pascual Ramos3, Ruben Burgos-Vargas1 and Marina Rull-Gabayet2, 1Rheumatology, Hospital General de Mexico, Mexico city, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Dept de Immunología y Reumato, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: OMERACT has proposed domains to evaluate the effect of treatment in patients with acute and chronic gout. Their frequency, time to improve and percentage…
  • Abstract Number: 815 • 2012 ACR/ARHP Annual Meeting

    Exploratory Analysis of Radiographic Change in Patients Treated with Intensive Urate-Lowering Therapy

    Nicola Dalbeth1, Anthony Doyle2, Fiona M. McQueen3, John S. Sundy4 and Herbert S. B. Baraf5, 1Medicine, University of Auckland, Auckland, New Zealand, 2University of Auckland, Auckland, New Zealand, 3Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand, 4Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, 5Arthritis & Rheumatism Associates, Wheaton, MD

    Background/Purpose: In patients with gout, tophi are strongly associated with radiographic damage.  Effective urate-lowering therapy (ULT) reduces tophus size.  However, no studies to date have…
  • Abstract Number: 143 • 2012 ACR/ARHP Annual Meeting

    Proposed Gout Treatment Guidelines and Meeting Serum Urate and Flare Goals

    Jasvinder A. Singh1, David Hagerty2, Chris Storgard3, Robert Mischler4 and Robert Morlock4, 1Department of Medicine, University of Alabama, Tuscaloosa, AL, 2Medical, Ardea Bioscience, San Diego, CA, 34939 Directors Place, Ardea Bioscience, San Diego, CA, 4Ardea Bioscience, San Diego, CA

    Background/Purpose: Although gout is a relatively common condition, treatment is often not ideal with many patients continuing to experience multiple flares and some developing complications…
  • Abstract Number: 1903 • 2012 ACR/ARHP Annual Meeting

    Oxidation of Urate to Allantoin by Myeloperoxidase in Gout

    Lisa K. Stamp1, Irada Khalilova2, Mei Zhang1, Rufus Turner2 and Anthony Kettle2, 1Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand, 2Pathology, University of Otago, Christchurch, Christchurch, New Zealand

    Background/Purpose : Hyperuricaemia is critical for the development of gout and may play a pivotal role in the pathophysiology of hypertension, metabolic syndrome, and cardiovascular…
  • Abstract Number: 816 • 2012 ACR/ARHP Annual Meeting

    Glomerular Filtration Rate, Chronic Kidney Disease and Incidence of Physician Diagnosed Gout

    Eswar Krishnan, Medicine, Standford University, Palo Alto, CA

    Background/Purpose: The kidney is the major organ of urate excretion in humans. Yet, there are few studies that assess whether reduced glomerular filtration and/or kidney…
  • Abstract Number: 144 • 2012 ACR/ARHP Annual Meeting

    Long-Term Safety of Canakinumab in Patients with Gouty Arthritis

    Alexander So1, Reike Alten2, H. Ralph Schumacher3, Mark Bloch4, Thomas Bardin5, Markus R. John6, Gerhard Krammer6, Jan Michael Nebesky6, Aiyang Tao7 and Naomi Schlesinger8, 1Rheumatology, CHUV, Univ of Lausanne, Lausanne, Switzerland, 2Charité Univ Medicine, Berlin, Germany, 3Department of Medicine, University of Pennsylvania and VA Medical Center, Philadelphia, PA, 4Holdsworth House Medical Practice, Sydney, Australia, 5Rheumatology, Hôpital Lariboisière, Paris, France, 6Novartis Pharma AG, Basel, Switzerland, 7Novartis Pharmaceuticals Corporation, East Hanover, NJ, 8UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ

    Background/Purpose: Gouty arthritis (GA) is a chronic inflammatory disease. Targeting the inflammatory pathway through IL-1β inhibition with canakinumab (CAN) may provide significant long-term benefits.  CAN…
  • Abstract Number: 1904 • 2012 ACR/ARHP Annual Meeting

    Patterns of Gout Treatment and Related Outcomes in US Community Rheumatology Practices: the Relation Between Gout Flares, Time in Treatment, Serum Uric Acid Level and Urate Lowering Therapy

    Max I. Hamburger1, John RP Tesser2, John L. Skosey3, Allan H. Morton4 and Karl M. Kilgore5, 1Rheumatology Associates, Melville, NY, 2AZ Arthritis Rheum Assoc, Paradise Valley, AZ, 3Illinois Bone & Joint Institut, Chicago, IL, 4Warren, MI, 5Cetus Group, LLC, Hunt Valley, MD

    Background/Purpose: Study patterns of gout treatment and related outcomes in US community rheumatology practices, specifically the relation between likelihood and severity of gout flares, time…
  • Abstract Number: 817 • 2012 ACR/ARHP Annual Meeting

    Feasibility of Using a Pharnacist-Based Gout Management Clinic to Improve Serum Uric Acid in Gout Patients an a Large Prepaid Health Plan

    Robert D. Goldfien1, Michele S. Ng2, Goldie M. Yip2, Alice Hwe2, Alice Pressman3 and Andy L. Avins3, 1Kaiser Permanente, Richmond, CA, 2Pharmacy, Kaiser Permanente, Oakland, CA, 3Division of Research, Kaiser Permanente, Oakland, CA

    Background/Purpose: Effective treatment for recurrent gout has been hampered by a number of problems including outdated treatment approaches, a failure to treat to target, and…
  • Abstract Number: 145 • 2012 ACR/ARHP Annual Meeting

    Prevalence of Non-Gout Arthritis in Patients with Gout: Not As Sparing As Previously Thought

    Fernando Perez-Ruiz1 and Ana M. Herrero-Beites2, 1Servicio de Reumatologia, Hospital Universitario Cruces, Baracaldo, Spain, 2Physical Medicine Division, Hospital de Gorliz, Gorliz, Spain

    Background/Purpose: the presence of other chronic inflammatory disease has been historically and academically thought to be “protective” conditions for the development of gout. Objective: to…
  • Abstract Number: 1906 • 2012 ACR/ARHP Annual Meeting

    Changes in Gout patient´s Clinical Profile in the Last Two Decades

    Fernando Perez-Ruiz1 and Ana M. Herrero-Beites2, 1Servicio de Reumatologia, Hospital Universitario Cruces, Baracaldo, Spain, 2Physical Medicine Division, Hospital de Gorliz, Gorliz, Spain

    Background/Purpose: to assess whether changes in the clinical profile of gout are observed in a large cohort of gout patients over the last 20 years.…
  • Abstract Number: 741 • 2012 ACR/ARHP Annual Meeting

    Increased Risk of Recurrent Gout Attacks During Hospitalization

    Yuqing Zhang1, Clara Chen2, Hyon K. Choi3, Christine E. Chaisson2, David J. Hunter4 and Tuhina Neogi5, 1Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 2Boston University School of Public Health, Boston, MA, 3Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 4Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 5Clinical Epidemiology, Boston Univ Schl of Med, Boston, MA

    Background/Purpose: While anecdotal evidence suggests that risk of recurrent gout attack increases during hospitalization and gout is one of the most common reasons for in-patient…
  • Abstract Number: 101 • 2012 ACR/ARHP Annual Meeting

    Kidney Function and the Risk of Incident Gout in A Population-Based Cohort of Adults: Atherosclerosis Risk in Communities Study

    Mara McAdams DeMarco1, Anna Kottgen2, Andrew Law3, Janet W. Maynard4, Josef Coresh1 and Alan N. Baer5, 1Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2Renal Division, University Hospital Freiburg, Freiburg, Germany, 3Epidemiology, Johns Hopkins, Baltimore, MD, 4Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose:  The 1-year cumulative incidence of gout in patients with new onset end stage renal disease is 5% and rises to 15% by 5 years,…
  • Abstract Number: 1907 • 2012 ACR/ARHP Annual Meeting

    Pharmacological Management of Gout in Italy in the Years 2005-2009: A Nationwide, Population-Based Study

    Lorenzo Cavagna1, Gianluca Trifirò2, Roberto Caporali3, P. Morabito2, C. Ferrajolo4, S. Pecchioli5, M. Simonetti5, G. Medea6, C. Cricelli7, A. Caputi2, G. Mazzaglia5 and Carlomaurizio Montecucco8, 1Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, 2Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy, 3Division of Rheumatology, IRCCSPoliclinico S. Matteo Foundation, Pavia, Italy, 4Department of Experimental Medicine, Pharmacology Section, Second University of Naples, Naples, Italy, 5Health Search, Italian College of General Practitioners, Italy, 6Italian college of General Practitioner, Italy, 7Italian college of General Practitioner, Pavia (italy), Italy, 8Division of Rheumatology, University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

    Background/Purpose:   Despite the increasing interest on gout, only few nationwide drug utilization studies have been conducted on this topic. The aim of this study…
  • Abstract Number: 742 • 2012 ACR/ARHP Annual Meeting

    Utility of HLA-B5801 Genotyping and Renal Dosing of the Starting Dose of Allopurinol in Preventing Allopurinol Hypersensitivity Syndrome: A Cost-Effectiveness Analysis

    Yanyan Zhu1, Ada Man2, Tuhina Neogi3 and Hyon K. Choi4, 1Clinical Epidemiology, Boston University School of Medicine, Boston, MA, 2Rheumatology, Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Boston, MA, 4Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Allopurinol is the leading choice of urate-lowering therapy (~ 95%) for gout which affects 8.3 million US adults. However, allopurinol is associated with a…
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