Abstracts tagged "gout"

Abstract Number: 2962 • 2014 ACR/ARHP Annual Meeting
Association of the Toll-like Receptor 4 (TLR4) Gene with Gout
Humaira Rasheed¹, Ruth Topless¹, Richard Day², Diluk Kannangara³, Kenneth Williams³, Linda Bradbury⁴, Matthew Brown⁵, Catherine Hill⁶, Susan Lester⁷, Maureen Rischmueller⁸, Malcolm Smith⁹, Mariano Andrés¹⁰, Thomas Bardin¹¹, Michael Doherty¹², Matthijs Janssen¹³, Tim Jansen¹⁴, Leo Joosten¹⁵, Fernando Perez-Ruiz¹⁶, Timothy Radstake¹⁷, Philip L. Riches¹⁸, Ed Roddy¹⁹, Anne-Kathrin Tausche²⁰, Lisa K. Stamp²¹, Nicola Dalbeth²², Frederic Lioté²³, Alex So²⁴, Cushla McKinney¹ and Tony R. Merriman¹, ¹Department of Biochemistry, University of Otago, Dunedin, New Zealand, ²Dept of Clin Pharmacology, St. Vincent's Hospital, Sydney, Australia, ³University of New South Wales, Sydney, Australia, ⁴The University of Queensland, Brisbane, Australia, ⁵University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Queen Elizabeth Hospital, Adelaide, Australia, ⁷Rheumatology Unit, Queen Elizabeth Hospital, Woodville South, Australia, ⁸Department of Rheumatology, The Queen Elizabeth Hospital, SA, Australia, ⁹Rheumatology Unit Repatriation, Queen Elizabeth Hospital, Adelaide, Australia, ¹⁰Rheumatology Section, Hospital General Universitario de Alicante, Alicante, Spain, ¹¹Clinique de Rhumatologie. Service de Rhumatologie. Centre Viggo Petersen., Hôpital Lariboisière, Paris, France, ¹²Academic Rheumatology, City Hospital, Nottingham, United Kingdom, ¹³Department of Rheumatology, Rijnstate Hospital, Arnhem, Netherlands, ¹⁴Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ¹⁵Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ¹⁶Servicio de Reumatologia, Hospital De Cruces, Baracaldo, Spain, ¹⁷University Medical Center Utrecht, Utrecht, Netherlands, ¹⁸Centre for Rheumatic Diseases, University of Edinburgh, Edinburgh, United Kingdom, ¹⁹Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, United Kingdom, ²⁰Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ²¹University of Otago, Christchurch, New Zealand, ²²Department of Medicine, University of Auckland, Auckland, New Zealand, ²³UFR médicale, Université Paris Diderot, Paris, France, ²⁴Service De Rhumatologie, CHUV, Lausanne, Switzerland
Background/Purpose: Gout results from innate immune response to monosodium urate (MSU) crystals that form in the context of supersaturation of urate. Identification of genetic risk…
Abstract Number: 167 • 2014 ACR/ARHP Annual Meeting
Target Serum Urate: Do Patients Know Their Goal?
Brian W. Coburn¹, Kayli A. Bendlin², Harlan Sayles¹, Kathryn S. Hentzen³, Michaela M. Hrdy³ and Ted R. Mikuls¹, ¹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²Pharmacy, Omaha VA Medical Center, Omaha, NE, ³Omaha VA Medical Center, Omaha, NE
Background/Purpose: Treat-to-target approaches are used to achieve therapeutic goals in conditions such as diabetes and rheumatoid arthritis. This strategy has also been widely endorsed in…
Abstract Number: 2963 • 2014 ACR/ARHP Annual Meeting
The URAT1 Uric Acid Transporter Is Important in Uric Acid Homeostasis and Its Activity May be Altered in Gout Patients and in Drug-Induced Hyperuricemia
Philip K. Tan, Sha Liu and Jeffrey N. Miner, Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: Gout results from chronic hyperuricemia. Most gout patients exhibit an increased renal reabsorption of uric acid which leads to elevated levels of serum uric…
Abstract Number: 166 • 2014 ACR/ARHP Annual Meeting
Risk Factors for Gout Attack Recurrence during Urate-Lowering Allopurinol Treatment
Myeong Jae Yoon¹, Ji Ae Yang², Sang Hyun Joo¹, Sang Jin Lee¹, Jin Young Moon¹, Hyun Mi Kwon¹, Dong Jin Ko¹, Yeong Wook Song¹ and Eun Bong Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose Gout is a recurrent inflammatory arthritis caused by crystal deposition of monosodium urate, which can be prevented urate-lowering agents such as allopurinol. However, gout…
Abstract Number: 2176 • 2014 ACR/ARHP Annual Meeting
Macrophages-Mediated Response to Uric Acid Crystals Is Modulated By Their Functional Polarization
Emma Garcia-Melchor¹, Monica Guma², Jordi Yagüe¹, Manel Juan¹ and Jacquie Harper³, ¹Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain, ²Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ³Arthritis and Inflammation Group, Malaghan Institute of Medical Research, Wellington, New Zealand
Background/Purpose: Macrophages have been involved in both initiation and resolution of gout flares. Accordingly, these cells are characterized by their plasticity as the environment modulates…
Abstract Number: 165 • 2014 ACR/ARHP Annual Meeting
Prevalence of Gout in the Adult Population of France in 2013
Thomas Bardin¹, Pierre Clerson², Stéphane Bouée³, Gerard H. Chales⁴, Michael Doherty⁵, René-Marc Flipo⁶, Charles Lambert⁷, Frédéric Lioté⁸, Thierry Poireaud⁹, Thierry Schaeverbeke¹⁰ and Pascal Richette¹¹, ¹Clinique de Rhumatologie. Service de Rhumatologie. Centre Viggo Petersen., Hôpital Lariboisière, Paris, France, ²Orgametrie, Roubaix, France, ³Cemka, Bourg la Reine, France, ⁴Dept of Rheumatology, CHR - Hopital Sud, Rennes, France, ⁵Division of Rheumatology, Orthopedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, ⁶rheumatology, Rene Salengro hospital, Lille, France, ⁷Ipsen, Boulogne Billancourt, France, ⁸Hôpital Lariboisière & University Paris Diderot, Paris, France, ⁹Menarini, Rungis, France, ¹⁰Rheumatology, Bordeaux University Hospital, Bordeaux, France, ¹¹INSERM 1132, Université Paris-Diderot, Hôpital Lariboisière, Paris, France
Background/Purpose The prevalence of gout has been studied in several Western countries by various methods to approach gout diagnosis, and has been estimated to vary…
Abstract Number: 2179 • 2014 ACR/ARHP Annual Meeting
The Monocyte-Phagocyte System in Gout: Enhanced Inflammasome Activity and Expansion of CD14++CD16+ Monocytes in Patients with Gout
Emma Garcia-Melchor¹, Cesar Diaz-Torne², Monica Guma^3,4, Europa Azucena Gonzalez-Navarro⁵, Francesc Xavier Alemany⁶, Jordi Yagüe¹ and Manel Juan¹, ¹Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain, ²Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ³Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁴Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁵Immunology, Hospital Clinic Barcelona, Barcelona, Spain, ⁶Emergency, Hospital Clinic Barcelona, Barcelona, Spain
Background/Purpose: The central role of the monocyte-macrophage system in gout has been highlighted during the last years. Macrophages initiate the inflammatory response to monosodium urate…
Abstract Number: 160 • 2014 ACR/ARHP Annual Meeting
All Men with Gout Should be Screened for Erectile Dysfunction
Naomi Schlesinger¹, Diane C. Radvanski² and John Kostis³, ¹Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, ²Department of Medicine, Division of Rheumatology, Robert Wood Johnson Medical School, New Brunswick, NJ, ³Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose Erectile dysfunction (ED) is common in the general population. The likelihood of ED increases progressively with age; however, it is not an inevitable consequence…
Abstract Number: 1873 • 2014 ACR/ARHP Annual Meeting
Food Sources of Protein and Risk of Incident Gout in the Singapore Chinese Health Study
Gim Gee Teng^1,2, An Pan³, Jian-Min Yuan⁴ and Woon-Puay Koh^3,5, ¹Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore, ²Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ³Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, ⁴Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, and Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, ⁵Duke-NUS Graduate Medical School Singapore, Singapore, Singapore

Background/Purpose: The Health Professional Follow up Study in Caucasian men showed that intakes of meat and seafood increased risk of gout, while dairy products, especially…
Abstract Number: 157 • 2014 ACR/ARHP Annual Meeting
Can We Diagnose Acute Gout without Joint Aspiration? Results of a Prospective Study of 112 Patients Presenting with Acute Arthritis
Pascal Zufferey, Roxana Valcov, Isabelle Fabreguet, Alexandre Dumusc and Alexander So, DAL, RHU/CHUV, Lausanne, Switzerland
Background/Purpose The gold standard for the diagnosis of acute MSU induced arthritis is crystal identification by microscopy after joint aspiration. Alternative diagnostic tools that have…
Abstract Number: 1223 • 2014 ACR/ARHP Annual Meeting
Enhancement of Proinflammatory Cytokine Production By Uric Acid in Human Cells Via Down Regulation of IL-1Ra
Tania Crisan¹, Maartje Cleophas², Heidi Lemmers³, Helga Toenhake-Dijkstra¹, Mihai Netea¹, Tim Jansen⁴ and Leo Joosten¹, ¹Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud Unversity Medical Center, Nijmegen, Netherlands, ³Internal Medicine, Radboud Univeristy Medical Center, Nijmegen, Netherlands, ⁴Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose Gout is an autoinflammatory disease characterized by the deposition of monosodium urate (MSU) crystals in the joints of hyperuricaemic patients and subsequent attacks of…
Abstract Number: 172 • 2014 ACR/ARHP Annual Meeting
Sleep Apnea and Risk of Incident Gout: A Population-Based Body-Mass Index Matched Cohort Study
Yuqing Zhang¹, Christine Peloquin², Maureen Dubreuil³, Edward Roddy⁴, Na Lu¹, Tuhina Neogi¹ and Hyon K. Choi⁵, ¹Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, ³Rheumatology, Boston University Medical Center, Boston, MA, ⁴Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, ⁵Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Sleep apnea is common among obese individuals with comorbidities (up to ~30%), a typical profile of gout patients. Since hypoxia associated with sleep apnea…
Abstract Number: 1206 • 2014 ACR/ARHP Annual Meeting
Low Dose Colchicine Anti-Inflammatory Effects Are Transduced By AMP-Activated Protein Kinase (AMPK)
Ru Bryan¹, Robert Terkeltaub² and Yun Wang³, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA
Background/Purpose AMPK is a master metabolic energy regulator, whose tissue activity drops in response to nutritional excesses, alcohol consumption, and in obesity, metabolic syndrome and…
Abstract Number: 158 • 2014 ACR/ARHP Annual Meeting
Performance of Joint Ultrasonography in the Diagnosis of Suspected Acute Crystal Arthritis : Results of a Prospective Study of 112 Patients
Pascal Zufferey¹, Isabelle Fabreguet¹, Roxana Valcov¹, Alexandre Dumusc¹ and Alexander K. So Sr.², ¹DAL, RHU/CHUV, Lausanne, Switzerland, ²Dal/Rhu, CHUV, Lausanne, Switzerland
Background/Purpose The gold standard for diagnosing gout and CCP arthritis is the identification of monosodium urate (MSU) crystals in joint fluid. Ultrasound (US) features of…
Abstract Number: 1219 • 2014 ACR/ARHP Annual Meeting
Lack of Gene-Diuretic Interactions on Risk of Incident Gout: The Nurses’ Health Study and Health Professionals Follow-up Study
Ying Bao¹, Tony R. Merriman², Gary Curhan³, Eli A. Stahl⁴, David B. Mount⁵, Robert M. Plenge⁶, Peter Kraft⁷ and Hyon K. Choi⁸, ¹Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, ²Department of Biochemistry, University of Otago, Dunedin, New Zealand, ³German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Renal Division, Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁸Boston University School of Medicine, Boston, MA
Background/Purpose: Diuretics, particularly thiazide and loop diuretics, increase the risk of gout, likely through urate transporters (e.g., OAT4) and volume depletion promoting urate reabsorption. As…

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