Abstracts tagged "gout"

Abstract Number: 0682 • ACR Convergence 2020
Role of Inflammatory and Oxidative Stress Pathway Biomarkers in Renal Disease in Gout
Fatima Alduraibi¹, Karina Ricart¹, Rakesh Patel¹, Alexander Szalai¹, Joshua Melnick² and Jasvinder Singh¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham (UAB), Vestavia Hills, AL
Background/Purpose: To understand the role of inflammatory cytokines and oxidative stress biomarkers in the renal disease in people with gout. We hypothesized that higher gout…
Abstract Number: 1472 • ACR Convergence 2020
Assessing Causal Associations of Urate Levels with Type 2 Diabetes and Related Glycemic Traits Using Bidirectional Mendelian Randomization
Natalie McCormick¹, Mark O'Connor¹, Shelby Marozoff², John Choi³, Aaron Leong¹ and Hyon Choi⁴, ¹Massachusetts General Hospital, Boston, MA, ²Arthritis Research Canada, Vancouver, Canada, ³Massachusetts General Hospital, Boston, ⁴Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA
Background/Purpose: Type 2 diabetes (T2D) and gout/hyperuricemia frequently coexist, but the nature and direction of this relationship is unclear. Observational studies have reported positive associations…
Abstract Number: 0600 • ACR Convergence 2020
Gout Increases Length of Stay in Patients Hospitalized for Heart Failure Exacerbation
Daniel DeMizio¹, Guojing Wu², Ying Wei², Joan Bathon³ and Runsheng Wang⁴, ¹Columbia University Irving Medical Center, Division of Rheumatology, Staten Island, NY, ²Columbia University Mailman School of Public Health, Department of Biostatistics, New York, NY, ³Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, ⁴Columbia University Irving Medical Center, Division of Rheumatology, New York, NY
Background/Purpose: There is growing evidence that both the prevalence of gout and its burden on healthcare costs has increased over recent decades. It has been…
Abstract Number: 0662 • ACR Convergence 2020
Cause-Specific Mortality in Patients with Gout in the Veteran’s Health Administration: A Matched Cohort Study
Lindsay Helget¹, Bryant England¹, Punyasha Roul¹, Harlan Sayles¹, Alison Petro¹ and Ted Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Gout is the most common type of inflammatory arthritis, with a prevalence in the Veteran’s Health Administration (VHA) of nearly 6%. While gout flares…
Abstract Number: 0683 • ACR Convergence 2020
Pharmacokinetics of Pegloticase and Methotrexate Polyglutamate(s) in Patients with Uncontrolled Gout Receiving Pegloticase and Co-treatment of Methotrexate
Yang Song¹, Yan Xin¹, Michael Weinblatt², Jason Chamberlain¹, Katie Obermeyer³, Lin Zhao³, Colleen Canavan³, Paul Peloso⁴ and Srini Ramanathan¹, ¹Horizon Therapeutics plc, South San Francisco, CA, ²Brigham and Women's Hospital, Boston, MA, ³Horizon Therapeutics plc, Lake Forest, IL, ⁴Horizon Therapeutics plc, Gurnee, IL
Background/Purpose: In an open-label trial in adult patients with uncontrolled gout (MIRROR open-label [OL] trial) evaluating pegloticase co-treatment with methotrexate (MTX), 78.6% patients maintained serum…
Abstract Number: 1542 • ACR Convergence 2020
The Role of Dual Energy Computed Tomography (DECT) in the Differentiation of Gout and Calcium Pyrophosphate Deposition Disease
Dmitrij Kravchenko¹, Pantelis Karakostas², Peter Brossart³, Charlotte Behning⁴, Carsten Meyer¹ and Valentin Schaefer⁵, ¹Department of Interventional and Diagnostic Radiology, University Hospital Bonn, Bonn, Germany, Bonn, Germany, ²Clinic for Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany, Bonn, Germany, ³Clinic for Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, ⁴Institute for Medical Biometrics, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, ⁵Clinic ofInternal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany, Bonn, Germany
Background/Purpose: Differentiation of gout and calcium pyrophosphate deposition disease (CPPD) is sometimes difficult as patients often present with a similar clinical picture. Arthrocentesis and subsequent…
Abstract Number: 0646 • ACR Convergence 2020
“An Apple Pie a Day Does Not Keep the Doctor Away”. Fictional Depictions of Gout in Contemporary Film and Television
Rachel Murdoch¹, Christina Derksen², Keith Petrie¹ and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²Jacobs University, Bremen, Germany
Background/Purpose: Views about gout as a self-inflicted condition of dietary excess can contribute to stigma and lead to ineffective management strategies. Fictional portrayals of illness…
Abstract Number: 0663 • ACR Convergence 2020
Analysis of Common Gout Comorbidities in the UK Biobank Cohort Reveals Sex-Specific Effects and Genetic Differentiation
Nicholas Sumpter¹, Murray Cadzow², Alexander So³, Richard Reynolds¹ and Tony Merriman², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Otago, Dunedin, New Zealand, ³University of Lausanne, Lausanne, Switzerland
Background/Purpose: This study aimed to estimate the extent to which gout associated genetic variants are associated with the presence/absence of common comorbidities in gout patients…
Abstract Number: 0684 • ACR Convergence 2020
The Shrinking Toe: A Sign of Crystal Dissolution During Urate Lowering Treatment of Severe Gouty Arthropathy
Thomas Bardin¹, Nguyen Dinh Quang², Hieu Le Nghia², Tran Minh Khoi², Hang Korng EA³, Valérie Bousson⁴ and Pascal Richette⁵, ¹Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France, ²Vien Gut Medical Center, Ho Chi Minh City, Vietnam, ³Universite de Paris, AP-HP, INSERM, paris, France, ⁴Lariboisière Hospital, Paris, France, ⁵Department of Rheumatology, Lariboisière Hospital, Paris, France
Background/Purpose: Serum urate (SU) lowering has been reported to improve gout erosions. We observed that it may also lead to compaction of toe MTP or…
Abstract Number: 1550 • ACR Convergence 2020
Change in Tophus Size Measured with Dual-energy CT and Ultrasound: A 1-year Multicenter Follow-up Study
Tristan Pascart¹, Pascal Richette², Sebastien Ottaviani³, Laurène Norberciak¹, Hang Korng EA⁴, Frédéric Lioté⁵, Jérémy Ora⁶, Julie Legrand¹, Valérie Bousson⁶, Elyas Mahdjoub⁷ and Jean--Francois Budzik⁸, ¹GHICL, Lomme, France, ²Department of Rheumatology, Lariboisière Hospital, Paris, France, ³Rheumatology Department, Bichat hospital, APHP, Paris, France, ⁴Universite de Paris, AP-HP, INSERM, paris, France, ⁵AP-HP, Paris, France, ⁶Lariboisière Hospital, Paris, France, ⁷Bichat Hospital, Paris, France, ⁸University of Lille, Lille, France
Background/Purpose: Dual-Energy computed tomography (DECT) and ultrasound are the two techniques able to identify and measure monosodium urate (MSU) crystal deposition, and both are considered…
Abstract Number: 0647 • ACR Convergence 2020
Dual-energy CT versus Ultrasound, Alone or in Combination, for the Diagnosis of Gout: A Diagnostic Performance Study
Jasvinder Singh¹, Fabio Becce², Jean--Francois Budzik³ and Tristan Pascart⁴, ¹University of Alabama at Birmingham, Birmingham, AL, ²Lausanne University, Lausanne, Switzerland, ³University of Lille, Lille, France, ⁴Ghicl, Hôpital Saint-Philibert, department of rheumatology, Lomme, France
Background/Purpose: To examine the diagnostic accuracy of dual-energy computed tomography (DECT) vs. ultrasound or their combination for the diagnosis of gout.Methods: Using data from an…
Abstract Number: 0664 • ACR Convergence 2020
Uric Acid Level Is Associated with Severity of Heart Failure with Preserved Ejection Fraction
Ana B. Arevalo¹, Alba Munoz², Faris Haddadin², Karan Sud², Gustavo Contreras², Shane Murray², Yousaf Ali² and Edgar Argulian², ¹Mount Sinai St. Luke's-West/ Icahn School of Medicine, New York, NY, ²Mount Sinai St. Luke's-West/ Icahn School of Medicine, New York
Background/Purpose: Hyperuricemia (HUC) has been shown to have an impact in the left atrium and left ventricle remodeling leading to the development of heart failure…
Abstract Number: 0685 • ACR Convergence 2020
The Impact of Azathioprine on the Frequency of Persistent Responsiveness to Pegloticase in Patients with Chronic Refractory Gout
Herbert S. Baraf¹, Hope Rainey², Peter Lipsky² and Peter Lipsky³, ¹The Ctr for Rheumatology and Bone Research, Wheaton, MD, ²AMPEL BioSolutions LLC., Charlottesville, VA, ³RILITE Foundation, Charlottesville, VA
Background/Purpose: Pegloticase is a mammalian recombinant uricase coupled to monomethoxy polyethylene glycol that is approved in the US for treatment of patients with chronic refractory…
Abstract Number: 1573 • ACR Convergence 2020
Gout as an Immune-Related Adverse Event from Immune Checkpoint Inhibitors
Kevin Lee¹, Carrie Ye² and Shokrollah Elahi³, ¹Internal Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, University of Alberta, Edmonton, AB, Canada, ³Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Immune checkpoint inhibitors (ICI) are novel treatments approved for various tumours including melanoma, lung and kidney. By interacting with immunoregulatory molecules (programmed death-1 (PD-1),…
Abstract Number: 348 • 2019 ACR/ARP Annual Meeting
Patterns of Newer Gout Medication Use in a U.S. Electronic Health Record-Based Registry
Kenneth Saag¹, Andreas Reimold ², Lang Chen ¹, Huifeng Yun ¹ and Jeffrey Curtis ¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²UT Southwestern Medical Center, Dallas
Background/Purpose: A variety of newer gout therapies have been introduced in recent years, some with potential safety concerns. However, uptake of these therapies and associated…

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