ACR Meeting Abstracts

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Abstracts tagged "gout"

  • Abstract Number: 2012 • ACR Convergence 2024

    Safety, Tolerability and Efficacy of Pegloticase Administered with a Shorter Infusion Duration in Subjects with Uncontrolled Gout Receiving Methotrexate: Primary Findings of the AGILE Open-label Trial

    Orrin Troum1, John Botson2, Fang Fang3, Katie Obermeyer3, Supra Verma3 and Brian LaMoreaux4, 1Providence Health Care/Doctor's of St John's (MDSJ) Santa Monica, CA, Santa Monica, CA, 2Orthopedic Physicians Alaska, Anchorage, AK, 3Amgen, Inc., Thousand Oaks, CA, 4Amgen, Inc., Deerfield, IL

    Background/Purpose: Pegloticase, infused every 2 weeks over ≥2 hrs, lowers serum urate (SU) in patients with refractory gout. Decreasing infusion time is expected to improve…
  • Abstract Number: 2559 • ACR Convergence 2024

    Relationship Between Serum Urate and Changes in Dual Energy Computed Tomography MSU Crystal Volume over One Year in People with Gout: An Individual Participant Data Analysis

    Brooke Kelly1, Gregory Gamble1, Anne Horne1, Anthony Doyle1, Jill Drake2, Opetaia Aati1, Chang-Nam Son1, Ramanamma Kalluru3, Kieran Latto1, Lisa Stamp4 and Nicola Dalbeth1, 1University of Auckland, Auckland, New Zealand, 2University of Otago, Christchurch, New Zealand, 3Health New Zealand, Auckland, New Zealand, 4University of Otago, Christchurch, Christchurch, New Zealand

    Background/Purpose: The dynamics of monosodium urate (MSU) crystal changes across a range of serum urate concentrations in people with gout are unknown. The aim of…
  • Abstract Number: 0142 • ACR Convergence 2024

    The Impact of Hospital Region on Mortality and Other Outcomes in Patients with Gout: A Two-Year Nationwide Analysis

    Nidaa Rasheed1, kHALED ABDULLAH2 and Candice Reyes3, 1UCSF Fresno, Fresno, CA, 2UCSF FRESNO, FRESNO, 3VACCHCS, Fresno, CA

    Background/Purpose: Gout is characterized by chronic inflammatory arthritis caused by the deposition of monosodium urate crystals and leads to increased risk of complications, such as…
  • Abstract Number: 0283 • ACR Convergence 2024

    Prophylaxis of Gout Flares in Patients with Renal Impairment: Dosing Adjustments with Colchicine Oral Solution Informed by a Pharmacokinetic Model

    Jaymin Shah, Elaine Chan and Dmitri Lissin, Scilex Holding Company, Palo Alto, CA

    Background/Purpose: Patients receiving colchicine for prophylaxis of gout flares are at risk for dose-related gastrointestinal toxicity (nausea, vomiting, diarrhea, abdominal pain) if they have pre-existing…
  • Abstract Number: 1088 • ACR Convergence 2024

    Prospective Evaluation of Carotid Atherosclerosis, Urate Deposits and Inflammation After One Year of Treatment in Newly Diagnosed Gout

    Cristina Rodríguez Alvear, Agustín Martínez Sanchís, Irene Calabuig Sais and Mariano Andrés, Rheumatology section, Dr. Balmis General University Hospital-ISABIAL, Alicante, Spain, Alicante, Spain

    Background/Purpose: Carotid atherosclerosis is prevalent in patients with gout. A prior cross-sectional study at our hospital demonstrated an association between tophi and positive Power Doppler…
  • Abstract Number: 1289 • ACR Convergence 2024

    Gout Education for Primary Care Providers: A Scoping Review

    Madeline O’Sullivan1, Michael Battistone2, Gary Kunkel3, Kalani Raphael1, Lydia Howes4, Naomi Schlesinger1 and Andrea Barker2, 1University of Utah, Salt Lake City, UT, 2Salt Lake City VA, Salt Lake City, UT, 3University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 4University of Utah, 10 N 1900 E, UT

    Background/Purpose: Gout is the most common inflammatory arthritis. Despite widespread availability of effective therapies and management guidelines from ACR and EULAR, many gout patients remain…
  • Abstract Number: 2013 • ACR Convergence 2024

    Elevated Serum Allantoin and Allantoin/uric Acid Ratio as Indicators of Oxidative Stress in Severe Gout and Cardiovascular Comorbidities

    Lenka Hasikova1, Petr Kozlik2, Kveta Kalikova3, Petr Dusek4, Marketa Pavlikova1, Blanka Stiburkova5 and Jakub Závada6, 1Institute of Rheumatology, Prague, Czech Republic; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Department of Analytical Chemistry, Faculty of Science, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Department of Neurology and Centre of Clinical Neuroscience and Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, Prague, Czech Republic, 5Institute of Rheumatology, Prague, Czech Republic and Department of Paediatrics and Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Charles University, Praha, Czech Republic

    Background/Purpose: Uric acid (UA) can be non-enzymatically oxidized into allantoin and other products by reactive oxygen species under conditions of increased oxidative stress. Consequently, allantoin…
  • Abstract Number: 2560 • ACR Convergence 2024

    Continuous Reduction in Ultrasound Detected Crystal Depositions over 5 Years Follow-up: Results from the NOR-Gout Study

    Hilde B Hammer1, Lars F Karoliussen1, Lene Terslev2, Espen A. Haavardsholm3 and Tillmann Uhlig1, 1Diakonhjemmet hospital, Oslo, Norway, 2Rigshospitalet-Glostrup & COPECARE, Glostrup, Denmark, 3Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, and University of Oslo (UiO), Institute of Clinical Medicine, Oslo, Norway, Oslo, Norway

    Background/Purpose: Ultrasound (US) is sensitive for detecting monosodium urate (MSU) crystal depositions in gout, described as double contour (DC), tophi and aggregates. Depositions decreased during…
  • Abstract Number: 0178 • ACR Convergence 2024

    Are Participants in Gout Clinical Trials Representative of People with Gout in the General Population?

    Jendy Liu, Gregory Gamble and Nicola Dalbeth, University of Auckland, Auckland, New Zealand

    Background/Purpose: Ensuring study participants are representative of the general population is important to ensure that efficacy and safety findings of clinical trials are generalizable in…
  • Abstract Number: 0355 • ACR Convergence 2024

    Improvements in Patient-Reported Outcomes After Treatment with SEL-212 in Adults with Refractory Gout: Results from Two Randomized Phase 3 Trials

    Vibeke Strand1, Puja Khanna2, Alan Kivitz3, Nana Kragh4, Aletta Falk5, Rehan Azeem6, Hugues Santin-Janin7 and Herbert Baraf8, 1Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, 2University of Michigan, Ann Arbor, MI, 3Altoona Center for Clinical Research, Duncansville, PA, 4Sobi, Kongens Lyngby, Denmark, 5Sobi, Stockholm, Sweden, 6Sobi Inc., Waltham, MA, 7Sobi, BETTENDORF (68560), France, 8Center for Rheumatology and Bone Research, Wheaton, MD

    Background/Purpose: Patients (pts) with gout have impaired health-related quality of life (HRQoL) relating to acute or chronic inflammation from elevated serum uric acid (sUA) levels.…
  • Abstract Number: 1089 • ACR Convergence 2024

    Endothelial Activation in Gout

    Michael Toprover1, Binita Shah2, Kamelia Drenkova2, Michael Pillinger3 and Michael Garshick4, 1New York University Langone Health, New York, NY, 2NYU Langone Health, New York, NY, 3New York University Grossman School of Medicine, New York,, NY, 4NYU Langone Health, Tenafly, NJ

    Background/Purpose: Gout is the most common inflammatory arthritis and is associated with increased cardiovascular (CV) disease and cardiovascular mortality. Our prior studies have suggested that…
  • Abstract Number: 1293 • ACR Convergence 2024

    Educational Quality Improvement (QI) Project to Improve Inpatient Purine Restricted Diet Order Placement for Patients Admitted with Gout Flares

    OKEOGHENE AKPOIGBE1, COMFORT ANIM-KORANTENG2, BETTINA ESCOLANO3, NI NI LWIN1, JOANNA PANGILINAN1 and Amanda Sammut4, 1New York City Health and Hospitals/Harlem in Affliation with Columbia University, NEW YORK, NY, 2New York City Health and Hospitals/Harlem in Affliation with Columbia University, Bronx, NY, 3New York City Health and Hospitals/Harlem in Affliation with Columbia University, NEW YORK, 4New York City Health and Hospitals/Harlem. Rheumatology Department, Chappaqua, NY

    Background/Purpose: Gout is a chronic, but treatable, inflammatory disease characterized by intermittent flares involving the deposition of monosodium urate crystals in and around joints. It…
  • Abstract Number: 2014 • ACR Convergence 2024

    Effect of a Whole Food Plant-Based Diet in Patients with Gout: A Pilot Randomized Controlled Trial

    Anna Kretova1, Carlijn Wagenaar1, Wendy Walrabenstein2, Daisy Vedder2, Dirkjan van Schaardenburg2 and Martijn Gerritsen1, 1Reade Rheumatology Center, Amsterdam, Netherlands, 2Amsterdam UMC, Amsterdam, Netherlands

    Background/Purpose: An unhealthy diet is an important modifiable risk factor for hyperuricemia and gout and is also associated with obesity and metabolic syndrome (MetS), known…
  • Abstract Number: 2561 • ACR Convergence 2024

    Circulating Proteomic Profiles and Incident Gout Risk: Prospective Cohort Study of >48,000 Men and Women

    Natalie McCormick1, Amit Joshi2, Robert Terkeltaub3, Tony Merriman4, Matthew Nayor5, Chio Yokose6 and Hyon K. Choi7, 1Massachusetts General Hospital, Boston, MA, 2Channing Division of Network Medicine, Boston, MA, 3Retired, San Diego, CA, 4University of Alabama at Birmingham, Homewood, AL, 5Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 6Massachusetts General Hospital, Waltham, MA, 7Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Detailed characterization of the plasma proteome may provide insights into the dynamic molecular changes preceding gout.  A previous cross-sectional study of pre-existing gout (n=330…
  • Abstract Number: 0206 • ACR Convergence 2024

    Urate Lowering Therapy to Acute Treatment Ratio (ULTrA) Index – a Novel Quality Indicator Associated with Reduced Hospital Admissions for Gout

    May Shuen Tang, Frank Sen Hee Tay, Amelia Santosa, Shikha Kumari, Pamela Lim, Htet Htet Aung, Su Zin Thinn, Peter Cheung and Manjari Lahiri, National University Hospital, Singapore, Singapore

    Background/Purpose: Gout is sub-optimally managed with under-prescribed urate lowering therapy (ULT) leading to frequent flares, increased healthcare utilization and cost.To study the burden of gout…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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