Abstracts tagged "Gout and uric acid"

Abstract Number: 1128 • 2018 ACR/ARHP Annual Meeting
Impact of Urate-Lowering Therapy on the Risk of Cardiovascular Events and All-Cause Mortality Among Individuals with Gout
In Ah Choi¹, Hoyeon Jang² and Gil-Won Kang², ¹Division of Rheumatology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of (South), ²Department of Health Informatics and Management, College of Medicine, Chungbuk National University, Cheongju, Korea, Republic of (South)
Background/Purpose: Gout results from an increased body pool of urate that occurs with hyperuricemia. Although urate-lowering therapy (ULT) is beneficial to prevent gout attack, current…
Abstract Number: 1130 • 2018 ACR/ARHP Annual Meeting
Chronic Risk Factors for Recurrent Gout Flares Among Established Gout Patients: A Prospective Cohort Analysis
Yuqing Zhang¹, Jie Wei², Chio Yokose², Sharan K. Rai^3,4 and Hyon K. Choi², ¹Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ³Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ⁴Graduate School of Arts and Sciences, Harvard University, Cambridge, MA
Background/Purpose: Understanding the risk factors for recurrent flares among established gout patients is directly relevant to clinical care; however, relevant data are scarce. A previous…
Abstract Number: 1284 • 2018 ACR/ARHP Annual Meeting
Initial Pegloticase Serum Levels Predict Persistent Responsiveness in Patients with Chronic Refractory Gout
Kenneth Saag¹, Mitchell Feinman², Herbert S. B. Baraf³, Roy Fleischmann⁴, Arthur Kavanaugh⁵ and Peter E. Lipsky⁶, ¹Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²ACME Research, LLC, Orangeburg, SC, ³Arthritis and Rheumatism Associates, Wheaton, MD, ⁴Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, ⁵University of California, San Diego, School of Medicine, La Jolla, CA, ⁶AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: Pegloticase is a pegylated recombinant mammalian uricase approved for treatment of persons with chronic gout refractory to standard urate lowering therapy1. Despite an initial…
Abstract Number: 1285 • 2018 ACR/ARHP Annual Meeting
Comparision of Urate Burden in Well and Poorly Controlled Gout Patients: A Dual-Energy CT Study
Min Kyung Chung¹, Hyeran Hyun², Ji Young Hwang² and Jisoo Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea, Republic of (South)
Background/Purpose: Dual-energy computed tomography (DECT) allows sensitive and quantative detection of monosodium urate (MSU) crystals in patients with gout. Although its usefulness in diagnosing gout…
Abstract Number: 1980 • 2018 ACR/ARHP Annual Meeting
Comprehensive Association Analysis between Rare and Common ABCG2 Variants and Gout Susceptibility
Hirotaka Matsuo¹, Toshihide Higashino¹, Tappei Takada², Hirofumi Nakaoka³, Yu Toyoda⁴, Blanka Stiburkova⁵, Hiroshi Nakashima⁶, Seiko Shimizu¹, Makoto Kawaguchi⁷, Akiyoshi Nakayama⁸, Yuka Aoki¹, Misaki Ishino¹, Yusuke Kawamura¹, Kenji Wakai⁹, Rieko Okada¹⁰, Tatsuo Hosoya¹¹, Kimiyoshi Ichida¹², Hiroshi Ooyama¹³, Hiroshi Suzuki², Ituro Inoue³, Tanya J. Major¹⁴, Tony R. Merriman¹⁴ and Nariyoshi Shinomiya¹, ¹Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan, ²Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, ³Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan, ⁴Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine,, The University of Tokyo, Tokyo, Japan, ⁵Department of Pediatrics and Adolescent Medicine, Charles University and General University Hospital in Prague, First Faculty of Medicine, Prague, Czech Republic, ⁶Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Japan, ⁷National Defense Medical College, Tokorozawa, Japan, ⁸Dept Integrative Physiol, National Defense Medical College, Tokorozawa, Japan, ⁹Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹⁰Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹¹Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, ¹²Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, ¹³Ryougoku East Gate Clinic, Tokyo, Japan, ¹⁴University of Otago, Dunedin, New Zealand
Background/Purpose: We have reported that ABCG2 has an important role in both renal and intestinal urate excretion and these common variants as rs72552713 (Q126X) and…
Abstract Number: 2205 • 2018 ACR/ARHP Annual Meeting
Initial Phase 2 Clinical Data of SEL-212 in Symptomatic Gout Patients: Measurement of Dissolution of Urate Deposits Associated with Monthly Dosing of a Pegylated Uricase (Pegadricase) with Svp-Rapamycin By Dual Energy Computed Tomography
Rehan Azeem¹, Earl Sands¹, Lloyd Johnston², Wesley DeHaan Ph.D.², Alan J. Kivitz³, Takashi Kei Kishimoto², Justin Park¹ and Savvas Nicolaou⁴, ¹Selecta Biosciences, Inc, Watertown, MA, ²Selecta Biosciences, Watertown, MA, ³Altoona Center for Clinical Research, Duncansville, PA, ⁴Radiology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Pegylated uricases are therapies for treatment of severe chronic gout, particularly for rapid resolution of tophi. However, uricases are limited by induction of anti-drug…
Abstract Number: 2238 • 2018 ACR/ARHP Annual Meeting
Non-Coding Urate-Associated Variants Function in a Conserved Lincrna Regulatory Domain That Alters MAF transcription
Megan Leask¹, Tony R. Merriman¹, Amy Dowdle¹, Hamish Salvesen¹, Ruth Topless¹, Tayaza Fadason², Wenhua Wei¹, William Schierding², Justin O'Sullivan² and Julia Horsfield¹, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand
Background/Purpose: Genome-wide association studies (GWAS) have revealed that the large majority of disease-associated single nucleotide polymorphisms (SNPs) are located in the non-coding regions of the…
Abstract Number: 2253 • 2018 ACR/ARHP Annual Meeting
Cardiovascular Disease, Other Purported Risk Factors, and Allopurinol-Associated Severe Cutaneous Adverse Reactions: A General Population-Based Cohort Study
Na Lu¹, Chio Yokose², Hui Xie^1,3, Gloria Li¹, Sharan K. Rai^4,5, Seoyoung C. Kim⁶ and Hyon K. Choi², ¹Arthritis Research Canada, Richmond, BC, Canada, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ³Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada, ⁴Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Graduate School of Arts and Sciences, Harvard University, Cambridge, MA, ⁶Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: A recent US Medicaid study found that in addition to certain races (Asians and Blacks), older age, female sex, chronic kidney disease (CKD), and…
Abstract Number: 2085 • 2017 ACR/ARHP Annual Meeting
Relationship between Gout and Asthma: A National Database Analysis
Yiming Luo¹, Jiehui Xu², Yumeng Wen¹, Alvaro Ramos-Rodriguez³, Changchuan Jiang¹, Shuyang Fang¹, Mustafa Kagalwalla¹ and Neha Ohri⁴, ¹Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, ³Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Division of Rheumatology, Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Gout is an inflammatory disorder related to hyperuricemia and abnormal deposition of monosodium urate crystals in joints or other tissues. The relationship between serum…
Abstract Number: 2843 • 2017 ACR/ARHP Annual Meeting
The Relationship between Serum Urate Concentration and Incident Gout: An Individual Participant Data Analysis
Nicola Dalbeth¹, Amanda Phipps-Green², Christopher Frampton³, Tuhina Neogi⁴, William J. Taylor⁵ and Tony R. Merriman⁶, ¹University of Auckland, Auckland, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Boston University School of Medicine, Boston, MA, ⁵University of Otago, Wellington, New Zealand, ⁶Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Elevated serum urate concentration (hyperuricemia) is considered to be a key risk factor for developing gout. However, the relationship between serum urate and incident…
Abstract Number: 2845 • 2017 ACR/ARHP Annual Meeting
Association between Serum Urate As a Surrogate Endpoint and Flares in People with Gout: An Ecological Study Based on a Systematic Review of Trials and Open Label Extensions
Lisa K. Stamp¹, Melanie Morillon², William Taylor³, Nicola Dalbeth⁴, Marissa Lassere⁵, Jasvinder A. Singh⁶ and Robin Christensen⁷, ¹University of Otago, Christchurch, New Zealand, ²Department of Medicine, Vejle Hospital, Denmark, Odense, Denmark, ³University of Otago, Wellington, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵University of New South Wales, Sydney, Australia, ⁶Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
Background/Purpose: The primary efficacy measure in urate lowering therapy (ULT) trials is usually serum urate (SU). However, it is unknown whether the strength of the…
Abstract Number: 2897 • 2017 ACR/ARHP Annual Meeting
A Non-Coding Genetic Variant Maximally Associated with Serum Urate Levels Is Functionally Linked to HNF4A-Dependent PDZK1 Expression
Tony R. Merriman¹, Sarada Ketharnathan², James Boocock³, Amanda Phipps-Green², Jisha Antony², Megan Leaask², Justin O'Sullivan⁴ and Julia Horsfield², ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of California Los Angeles, Los Angeles, CA, ⁴University of Auckland, Auckland, New Zealand
A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expressionBackground/Purpose: Genome-wide association studies have revealed several dozen genetic…
Abstract Number: 2898 • 2017 ACR/ARHP Annual Meeting
New Mouse Model of Gout Risk Variant, ABCG2 Q141K, Reveals Unexpectedly Severe Molecular and Functional Defect in ABCG2 Mediated Intestinal Uric Acid Secretion
Kazi M. Hoque and Owen M. Woodward, Physiology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Gout is a common arthritic disease resulting from deposition of monosodium urate crystals in joints and is a consequence of having elevated circulating uric…
Abstract Number: 1106 • 2017 ACR/ARHP Annual Meeting
Association between ABCG2 rs2231142 and Poor Response to Allopurinol: Replication and Meta-Analysis
Mary Wallace¹, Rebecca Roberts², Payal Nanavati³, Jeffrey N Miner³, Nicola Dalbeth⁴, Ruth Topless⁵, Tony R. Merriman⁶ and Lisa K. Stamp⁷, ¹Surgical Sciences, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Ardea Biosciences, San Diego, CA, ⁴University of Auckland, Auckland, New Zealand, ⁵Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁶Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ⁷University of Otago, Christchurch, New Zealand
Background/Purpose: Allopurinol is the most widely used urate-lowering drug. However, some patients treated with allopurinol do not achieve serum urate (SU) treatment target of <6mg/dl,…
Abstract Number: 1110 • 2017 ACR/ARHP Annual Meeting
Clinical Features and Risk of Recurrent Attack in Gout Patients According to Serum Urate Levels during an Acute Gout Attack
Jung Sun Lee¹, Seokchan Hong², Oh Chan Kwon², Byeongzu Ghang², Wook Jang Seo³, Doo-Ho Lim⁴, Yong-Gil Kim², Chang Keun Lee² and Bin Yoo², ¹Internal medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), ³Seoul Veterans Hospital, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of (South)
Background/Purpose: To investigate the clinical features and risk of gout recurrence in patients with normouricemia during an acute attack Methods: This study was conducted in…

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