ACR Meeting Abstracts

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Abstracts tagged "Genome Wide Association Studies"

  • Abstract Number: 0027 • ACR Convergence 2023

    Association of HLA-DRB1 and ANKRD55/IL6ST Regions with Polymyalgia Rheumatica Diagnosis: A Genome Wide Association Study from UK Biobank and FinnGen

    Mehmet Hocaoglu1, Jamal Mikdashi2, James Perry2 and Charles Hong2, 1University of Maryland School of Medicine, Pittsburgh, PA, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: The existing literature on the genetics of polymyalgia rheumatica (PMR) is limited to candidate gene studies with small sample sizes. There is a need…
  • Abstract Number: 0034 • ACR Convergence 2023

    Genome-Wide Association Study for Loci Associated with Positive Antinuclear Antibodies in a Large Hospital Biobank

    Jing Cui1, Jeong Yee2, Liming Liang3, Jack Ellrodt2, Emily G. Oakes2, Hongshu Guan2 and Karen Costenbader4, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Harvard T.H. Chan School of Public Health, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Antinuclear antibodies (ANA) to intranuclear particles are found in the blood of people with and without autoimmune diseases. To our knowledge, only 1 past…
  • Abstract Number: 0560 • ACR Convergence 2023

    Genetic Determinants of Lupus Nephritis and Kidney Function in Systemic Lupus Erythematosus

    Magdalena Riedl Khursigara1, Nicholas Gold2, Thai-Son Tang3, Daniela Dominguez2, Marisa Klein-Gitelman4, Dafna Gladman5, Daniel Goldman6, Elizabeth Harvey2, Mariko Ishimori7, Caroline Jefferies7, Diane L. Kamen8, Sylvia Kamphuis9, Andrea Knight2, Chia-Chi Lee7, Deborah Levy2, Damien Noone2, Karen Onel10, Christine Peschken11, Michelle Petri6, Janet Pope12, Eleanor Pullenayegum2, Earl Silverman13, Zahi Touma1, Murray Urowitz14, Daniel Wallace7, Joan Wither15 and Linda Hiraki2, 1University of Toronto, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3University of Toronto, Mississauga, ON, Canada, 4Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 5Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, 6Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 7Cedars-Sinai Medical Center, Los Angeles, CA, 8Medical University of South Carolina, Charleston, SC, 9Sophia Children’s Hospital, Rotterdam, Netherlands, 10Hospital for Special Surgery, New York, NY, 11University of Manitoba, Winnipeg, MB, Canada, 12University of Western Ontario, London, ON, Canada, 13Silverman, Toronto, ON, Canada, 14Schroeder Arthritis Institute, Krembil Research Institute; University of Toronto Lupus Clinic; Division of Rheumatology, Toronto, ON, Canada, 15University Health Network, Toronto, ON, Canada

    Background/Purpose: Lupus nephritis (LN) is one of the most common and severe manifestation of SLE. Risk factors for lupus nephritis and renal function decline are…
  • Abstract Number: 0738 • ACR Convergence 2023

    A Genome-wide Association Study Suggests New Susceptibility Loci for Primary Antiphospholipid Syndrome

    Desire Casares1, Manuel Martínez-Bueno2, Maria Orietta Borghi3, Guillermo Pons-Estel4, PRECISESADS Clinical Consortium2, Yu Zuo5, Gerard Espinosa6, Alexandra Zhernakova7, Cisca Wijmenga7, Timothy Radstake8, Lucas van den Hoogen9, Guillermo Reales10, Chris Wallace10, Joel Guthridge11, Judith James11, Ricard Cervera12, Pierluigi Meroni13, Javier Martin14, Jason Knight5, Marta Alarcon-Riquelme15 and Amr Sawalha1, 1University of Pittsburgh, Pittsburgh, PA, 2Centre for Genomics and Oncological Research, Granada, Spain, 3University of Milan, Milan, Italy, 4CREAR, Rosario, Argentina, 5University of Michigan, Ann Arbor, MI, 6Hospital Clinic, Barcelona, Spain, 7University of Groningen, Groningen, Netherlands, 8University Medical Center Utrecht, Carlisle, IL, 9Radboudumc and Sint Maartenskliniek, Nijmegen, Netherlands, 10University of Cambridge, Cambridge, United Kingdom, 11Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Hospital Clínic de Barcelona, Barcelona, Spain, 13IRCCS Istituto Auxologico Italiano, Cusano Milanino, Milan, Italy, 14Instituto de Parasitologia y Biomedicina Lopez-Neyra - CSIC, Granada, Spain, 15Center for Genomics and Oncological Research (GENYO), Granada, Spain

    Background/Purpose: Primary antiphospholipid syndrome (PAPS) is a rare autoimmune disease characterized by the presence of antiphospholipid antibodies and the occurrence of thrombotic events and pregnancy…
  • Abstract Number: 0788 • ACR Convergence 2023

    Whole Exome Sequencing and Evolutionary Action Missense Mutation Analysis Identifies MICB as a New SSc Susceptibility Locus and the Interferon Pathway as Contributors to SSc Pathogenesis

    Shamika Ketkar1, Hongzheng Dai1, Brian Dawson1, Lindsay Burrage1, David Murdock1, Jennifer Asmussen1, Kevin Wilhelm1, Olivier Lichtarge1, Martin Kerick2, Javier Martin3, Shervin Assassi4, Brendan Lee1 and Maureen Mayes5, 1Baylor College of Medicine, Houston, TX, 2Spanish National Research Council, Granada, Spain, 3Instituto de Parasitologia y Biomedicina Lopez-Neyra - CSIC, Granada, Spain, 4University of Texas McGovern Medical School at Houston, Houston, TX, 5Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by fibrosis of the skin and internal organs associated with vasculopathy and autoantibodies and exhibiting wide clinical heterogeneity. Contributors…
  • Abstract Number: 0930 • ACR Convergence 2023

    Genetic Risk Profiles of Patients with Lupus Nephritis to Identify Those at Risk for Kidney Deterioration and Eventual Damage

    Aastha Khatiwada1, bethany wolf2, Isabelle Ayoub3, Juan Mejia-Vilet4, Ana Malvar5, Carl Langefeld6, Brad Rovin3, Jim Oates2 and Betty Tsao2, 1National Jewish Health, Denver, CO, 2Medical University of South Carolina, Charleston, SC, 3Ohio State University, Columbus, OH, 4Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 5Hospital Fernandez, Buenos Aires, Argentina, 6Wake Forest University School of Medicine, Winston-Salem, NC

    Background/Purpose: Many genetic variants are associated with lupus nephritis (LN). Yet, the majority of associated variants have a small effect size; hence, they convey small…
  • Abstract Number: 0336 • ACR Convergence 2022

    Machine Learning Approach for the Prediction of Lupus Nephritis Renal Flares Using Polygenic Risk Score and Electronic Health Record

    Yi-Ming Chen1, Tzu-Hung Hsiao1, Seng-Cho Chou2 and Chi-Wei Chung2, 1Taichung Veterans General Hospital, Taichung, Taiwan, 2Department of Information Management, National Taiwan University, Taipei, Taiwan

    Background/Purpose: Lupus nephritis (LN) flares are associated with risks of renal failure and mortality in patients with systemic lupus erythematous (SLE). It is critical to…
  • Abstract Number: 1146 • ACR Convergence 2022

    Genetic Interactions Between T-Cell Receptor Polymorphisms and HLA Amino Acids Contribute to the Risk of Rheumatoid Arthritis

    Chuan Fu Yap1, Paul Martin2, Darren Plant1, John Bowes1, Kazuyoshi Ishigaki3, Saori Sakaue4, Alex Macgregor5, Suzanne Verstappen1, Anne Barton1, Soumya Raychaudhuri6 and Sebastien Viatte1, 1The University of Manchester, Manchester, United Kingdom, 2The University of Manchester, Oberhaching, Germany, 3Riken, Bunkyo-ku, Tokyo, Japan, 4Broad Institute of Harvard and MIT, Cambridge, MA, 5The University of East Anglia, Norwich, United Kingdom, 6Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) genetic susceptibility has been well studied with five amino acid positions within the HLA explaining most of the association. Although genome…
  • Abstract Number: 1148 • ACR Convergence 2022

    GWAS Identified New Genes in Synovial Fibroblasts Linked to Early Remission in RA

    Marc Maurits1, lydia Abasolo Alcazar2, Erik van den Akker3, Johan Askling4, Anne Barton5, Stephan Blüml6, Stephan Böhringer7, Andrew Cope8, Paul Emery9, Stephen Eyre5, Priya Gaddi5, Isidoro Gonzalez10, Carl Goodyear11, Annette van der Helm-van Mil12, Xinli Hu13, Tom Huizinga3, John D Isaacs14, Scott Jelinsky13, Martina Johannesson4, Samantha Jurado Zapata3, Changlin Ke3, Lars Klareskog4, Dennis Lendrem15, Myles Lewis16, Mingdong Liu3, Paul Martin17, Iain B McInnes18, Raphael Micheroli19, Ann Morgan20, Fraser Morton11, Najib Naamane15, Gisela Orozco5, Caroline Ospelt21, Leonid Padyukov4, Caron Paterson11, Darren Plant5, Duncan Porter22, Arthur Pratt23, Soumya Raychaudhuri24, Louise Reynard15, Luis Rodriguez-Rodriguez25, Daniela Sieghart26, Paul Studenic6, John Taylor27, René Toes3, Marloes Verstappen3, Suzanne Verstappen5, Helga Westerlind4, Aaron Winkler13 and Rachel Knevel3, 1LUMC, Leiden, Netherlands, 2IDISSC Hospital Clinico San Carlos, Madrid, Spain, 3Leiden University Medical Center, Leiden, Netherlands, 4Karolinska Institutet, Stockholm, Sweden, 5The University of Manchester, Manchester, United Kingdom, 6Medical University of Vienna, Vienna, Austria, 7Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Leiden, Netherlands, 8King's College London, Surrey, United Kingdom, 9Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 10Hospital Universitario de La Princesa, Madrid, Spain, 11University of Glasgow, Glasgow, Scotland, United Kingdom, 12Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands, 13Pfizer Inc., Cambridge, MA, 14Institute for Translational and Clinical Research, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom, 15Newcastle University, Newcastle, United Kingdom, 16Queen Mary University of London, London, United Kingdom, 17The University of Manchester, Oberhaching, Germany, 18Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom, 19University Hospital Zurich, Department of Rheumatology, Zürich, Switzerland, 20University of Leeds, Leeds, United Kingdom, 21Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 22Gartnavel General Hospital, Bearsden, United Kingdom, 23Newcastle University, Newcastle upon Tyne, United Kingdom, 24Brigham and Women's Hospital, Boston, MA, 25Instituto de Investigación Sanitaria San Carlos, Rheumatology, Madrid, Spain, 26Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 27University of Leeds, Euclid, OH

    Background/Purpose: In order to understand the genetic factors that lead to early remission in RA, we performed a GWAS to uncover important biological pathways.Methods: We…
  • Abstract Number: 1379 • ACR Convergence 2022

    Association of HLA Alleles with Specific Auto-antibodies in an Ancestrally Diverse Population of Childhood Systemic Lupus Erythematosus (SLE)

    Nicholas Gold1, Fangming Liao1, JingJing Cao1, Daniela Dominguez1, Andrea Knight2, Deborah Levy3 and Linda Hiraki4, 1The Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 3Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease capable of affecting multiple organ systems. Genetic variants in the Human Leukocyte Antigen (HLA) are associated…
  • Abstract Number: 1678 • ACR Convergence 2022

    A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout

    Tony Merriman1, Hirotaka Matsuo2, Riku Takei3, Megan Leask3, Ruth Topless1, Yuya Shirai4, Zhiqiang Li5, Murray Cadzow1, Richard Reynolds3, kenneth saag3, Tayaza Fadason6, Justin O'Sullivan6, Nicola Dalbeth6, Lisa Stamp7, Abhishek Abhishek8, Michael Doherty8, Edward Roddy9, Lennart Jacobsson10, Meliha Kapetanovic11, Mariano Andrès12, Fernando Perez-Ruiz13, Rosa Torres Jimenez14, Timothy Radstake15, Timothy Jansen16, Matthijs Janssen17, Leo Joosten18, Tania Octavia Crisan19, Tom Huizinga20, Frederic LIOTE21, Pascal Richette22, Thomas Bardin23, Tristan Pascart24, Geraldine McCarthy25, Blanka Stiburkova26, Anne Tausche27, Till Uhlig28, Veronique Vitart29, Philip Riches29, Stuart Ralston29, Thomas MacDonald30, Akiyoshi Nakayama2, Masahiro Nakatochi31, Kimiyoshi Ichida32, Tappei Takada33, Chaeyoung Lee34, Matthew Brown35, Philip Robinson36, Catherine Hill37, Hyon Choi38, Nicholas Sumpter3, Marilyn Merriman3, Amanda Phipps-Green1, Wenhua Wei1, Sally McCormick1, Olle Melander39, René Toes20, Hang-Korng Ea21, Fina Kurreeman20, Laura Helbert25, Thibaud Boutin29, Nariyoshi Shinomiya2, Linda Bradbury40, Russell Buchanan41, Susan Lester37, Malcolm Smith42, Maureen Rischmueller43, On behalf of Japan Gout Genomics Consortium (J-Gout)44, On behalf of Japan Multi-Instl Collab Cohort Study (J-MICC)45, Eli Stahl46, Jeff Miner47, Daniel Solomon48, Jing Cui48, Kathleen Giacomini49, Deanna Brackman49, Eric Jorgenson50, On behalf of 23andMe Research Team51, Suyash Shringapure51, Alexander So52, Yukinori Okada4, Changgui Li5, Yongyong Shi53 and Tanya Major1, 1University of Otago, Dunedin, New Zealand, 2National Defense Medical College, Saitama, Japan, 3University of Alabama at Birmingham, Birmingham, AL, 4Osaka University, Suita, Osaka, Japan, 5The Affiliated Hospital of Qingdao University, Qingdao, China, 6University of Auckland, Auckland, New Zealand, 7University of Otago, Christchurch, New Zealand, 8University of Nottingham, Nottingham, United Kingdom, 9Keele University, Keele, United Kingdom, 10Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, 11Lund University, Department for clinical sciences Lund, section of rheumatology and Lund University Hospital Lund and Malmö, Lund, Sweden, 12Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, 13University of the Basque Country, Barakaldo, Spain, 14La Paz University Hospital, Madrid, Spain, 15University Medical College Uthrecht, Utrecht, Netherlands, 16VieCuri Medical Centre, Venlo, Netherlands, 17Rijnstate Hospital, Bennekom, Netherlands, 18Radboudumc, Nijmegen, Netherlands, 19University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Cluj-Napoca, Romania, 20Leiden University Medical Center, Leiden, Netherlands, 21University of Paris, Paris, France, 22Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, 23Hôpital Lariboisiere, Paris, France, 24Lille Catholic University, Lille, France, 25Mater Misericordiae University Hospital, Dublin, Ireland, 26Institute of Rheumatology, Prague, Czech Republic, 27University Clinic 'Carl Gustav Carus' at the Technical University, Dresden, Germany, 28Diakonhjemmet Hospital, Oslo, Norway, 29University of Edinburgh, Edinburgh, Scotland, United Kingdom, 30University of Dundee, Dundee, United Kingdom, 31Nagoya University Hospital, Nagoya, Japan, 32Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan, 33University of Tokyo Hospital, Tokyo, Japan, 34Soongsil University, Seoul, Republic of Korea, 35Genomics England, London, United Kingdom, 36University of Queensland, Brisbane, Australia, 37The Queen Elizabeth Hospital, Adelaide, Australia, 38Massachusetts General Hospital, Lexington, MA, 39Lund University, Malmö, Sweden, 40Gold Coast University Hospital, Brisbane, Australia, 41Austin Health, Heidelberg, Australia, 42Flinders Medical Centre, Adelaide, Australia, 43RheumatologySA, Adelaide, Australia, 44Japan Gout Genomics Consortium (J-Gout), Saitama, Japan, 45Japan Multi-Institutional Collaborative Cohort Study (J-MICC), Nagoya, Japan, 46Regeneron, New York, NY, 47ViscientBio, San Diego, CA, 48Brigham and Women's Hospital, Boston, MA, 49University of California San Francisco, San Francisco, CA, 50Kaiser Permanente, San Francisco, CA, 5123andMe, Inc., Sunnyvale, CA, 52University of Lausanne, Lausanne, Switzerland, 53Shanghai Jiao Tong University, Shanghai, China

    Background/Purpose: Genome-wide association studies (GWAS) in gout have been relatively small (≤13,179 people with gout) and have provided little insight into the progression from hyperuricemia…
  • Abstract Number: 0525 • ACR Convergence 2021

    STEAP3, FZD2 and EGFLAM Are Novel Genetic Risk Loci for Granulomatosis with Polyangitis: A Genome Wide Association Study from UK Biobank

    Mehmet Hocaoglu1, Jamal Mikdashi2, Yi-Ju Chen2, James Perry2 and Charles Hong2, 1University of Maryland Medical Center, Midtown Campus, Baltimore, MD, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Granulomatosis with Polyangitis (GPA) is a systemic ANCA associated small vessel vasculitis. Prior genetic studies demonstrated a strong association of HLA Class II region…
  • Abstract Number: 1669 • ACR Convergence 2020

    Genetics of Age at Diagnosis in Systemic Lupus Erythematosus

    Raffaella Carlomagno1, Fangming Liao2, JingJing Cao2, Dafna Gladman3, Marisa Klein-Gitelman4, Andrea Knight5, Deborah Levy1, Karen Onel6, Andrew Paterson2, Christine Peschken7, Janet Pope8, Zahi Touma9, Murray Urowitz10, Declan Webber1, Joan Wither11, Earl D. Silverman12 and Linda Hiraki13, 1Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 4Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 5Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 6Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 7Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 8Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, 9University of Toronto, Toronto, ON, Canada, 10University Health Network, University of Toronto, Toronto, ON, Canada, 11University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 12Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 13Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Genome wide association studies (GWAS) have identified >90 SNPs associated with systemic lupus erythematosus (SLE) risk. However, there may be additional loci impacting the…
  • Abstract Number: 1860 • ACR Convergence 2020

    An Integrative Approach to Identify Heritable and De Novo Genomic Variations in Psoriatic Arthritis Mutilans and Understand Its Systems Biology

    Sara Rahmati1, Quan Li1, Dafna Gladman2, Proton Rahman3 and Vinod Chandran2, 1University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Memorial University of Newfoundland, Department of Medicine, St John's, Canada

    Background/Purpose: Psoriasis is a chronic autoimmune skin disease that burdens ~3% of North Americans. ~24% of psoriatic patients develop psoriasis arthritis (PsA), an inflammatory disease…
  • Abstract Number: 1954 • ACR Convergence 2020

    Genome-wide Association Study of Sjögren’s Syndrome Identifies Ten New Risk Loci

    Bhuwan Khatri1, Tove Ragna Reksten2, Kandice Tessneer3, Astrid Rasmussen1, R. Scofield1, Simon Bowman4, Joel Guthridge1, Judith James5, Lars Ronnblom6, Blake Warner7, Xavier Mariette8, Roald Omdal9, Javier Martin10, Maria Teruel10, Janicke Liaaen Jensen11, Lara Aqrawi11, Øyvind Palm11, Marie Wahren-Herlenius12, Torsten Witte13, Roland Jonsson14, Maureen Rischmueller15, A Darise Farris1, Marta Alarcon-Riquelme10, Wan-Fai Ng16, Kathy Sivils1, Gunnel Nordmark17 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Bergen, Bergen, Norway, 3Oklahoma Medical Research Foundation, Oklahoma City, 4University Hospitals Birmingham, Birmingham, United Kingdom, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 6Uppsala University, Uppsala, Sweden, 7National Institute of Dental and Craniofacial Research, Bethesda, 8Paris-Sud University, Rueil-Malmaison, France, 9University of Oslo, Stavanger, Norway, 10Center for Genomics and Oncological Research (GENYO), Granada, Spain, 11University of Oslo, Oslo, Norway, 12Karolinska Institute, Stockholm, Sweden, 13Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., Hannover, Germany, 14Haukeland University Hospital, Bergen, Norway, 15The Queen Elizabeth Hospital and Univ of Adelaide, St Peters, South Australia, Australia, 16Newcastle University, Gateshead, United Kingdom, 17Uppsala University, Copenhagen S, Sweden

    Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with exocrine gland dysfunction leading to substantial morbidity, and 10 published genetic susceptibility loci. Our genome-wide…
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