ACR Meeting Abstracts

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Abstracts tagged "genetics"

  • Abstract Number: 1632 • 2013 ACR/ARHP Annual Meeting

    Identification Of a Novel Systemic Lupus Erythematosus Risk Locus Between FCHSD2 and P2RY2 In Koreans

    Christopher J. Lessard1,2, Satria Sajuthi3, So-Young Bang4, Hye-Soon Lee5, Young Mo Kang6, Chang-Hee Suh7, Won Tae Chung8, Soo-Kon Lee9, Jung-Yoon Choe10, Seung-Cheol Shim11, Shin-Seok Lee12, Ji Hee Oh13, Young Jin Kim14, Jong-Young Lee14, Bok-Ghee Han14, Patrick M. Gaffney15, Timothy J. Vyse for SLEGEN16, John B. Harley17,18, Carl D. Langefeld3, Sang-Cheol Bae19, Kathy L. Sivils1,2 and Betty P. Tsao20, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 4Hanyang University Guri Hospital, Guri, South Korea, 5Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, 6Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 7Department of Rheumatology, Ajou University Hospital, Suwon, South Korea, 8Division of Rheumatology, Department of Internal Medicine, Dong-A University Hospital, Busan, South Korea, 9Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 10Catholic University of Daegu School of Medicine, Daegu, South Korea, 11Division of Rheumatology, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, South Korea, 12Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 13Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Osong, South Korea, 14Korea National Institute of Health, Osong, South Korea, 15Oklahoma Medical Research Foundation, Oklahoma City, OK, 16King's College London, Guy's Hospital, London, United Kingdom, 17Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 18US Department of Veterans Affairs Medical Center, Cincinnati, OH, 19Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 20Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, heterogeneous autoimmune disorder characterized by inflammation, loss of tolerance to self-antigens, and dysregulated interferon responses. Although >40…
  • Abstract Number: 1635 • 2013 ACR/ARHP Annual Meeting

    Identification Of Novel Genetic Associations Within Major Histocompatibility Complex (MHC) Class I and Class II In Systemic Lupus Erythematosus (SLE) Patients:  An Examination Of Epitopes Of Early Autoimmunity

    Gerard Dumancas1, Chee Paul Lin2, Indra Adrianto1, Jennifer A. Kelly1, Stuart B. Glenn1, Jourdan Anderson2, John B. Harley3,4, Timothy J. Vyse5, Robert P. Kimberly6, Marta E. Alarcon-Riquelme7, Carl D. Langefeld8, Betty P. Tsao9, Lindsey A. Criswell10, Chaim O. Jacob11, Patrick M. Gaffney12, Kathy Sivils12, Judith A. James12,13 and Courtney Montgomery2, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4US Department of Veterans Affairs Medical Center, Cincinnati, OH, 5Medical & Molecular Genetics, King's College London, London, United Kingdom, 6Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 7Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, 8Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 9Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, 10Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, 11Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 12Oklahoma Medical Research Foundation, Oklahoma City, OK, 13College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, multiple organ involvement, strong genetic predisposition and specifically, to be associated with…
  • Abstract Number: 1480 • 2013 ACR/ARHP Annual Meeting

    Prevalance Of Rare Variants In Methotrexate Pathway Genes: Implications From The National Heart Lung Blood Institute (NHLBI) Exome Sequencing Project

    Fardina Malik, Internal Medicine, Alton Memorial Hospital, Alton, IL

    Background/Purpose: Inter-individual variation to methotrexate (MTX) therapy in patients with rheumatoid arthritis (RA) is attributed at least in part to the presence of genetic variation…
  • Abstract Number: 160 • 2013 ACR/ARHP Annual Meeting

    Association Analysis Of The Organic Anion Transporter 4 and Urate Transporter 1 Locus With Gout In New Zealand Case-Control Sample Sets Reveals Multiple Ancestral-Specific Effects

    Tony R. Merriman1, Amanda Phipps-Green1, Jade E. Hollis-Moffatt2, Marilyn E. Merriman1, Ruth Topless1, Grant Montgomery3, Brett Chapman3, Lisa K. Stamp4, Nicola Dalbeth5 and Tanya Flynn2, 1Department of Biochemistry, University of Otago, Dunedin, New Zealand, 2University of Otago, Dunedin, New Zealand, 3Queensland Institute of Medical Research, Brisbane, Australia, 4University of Otago, Christchurch, New Zealand, 5Medicine, University of Auckland, Auckland, New Zealand

    Background/Purpose: There are genetic variants in urate transporters SLC22A11 (OAT4) and SLC22A12 (URAT1) that influence serum urate levels in European Caucasian. However, there is no…
  • Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting

    The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts

    Max Brenner1,2, Teresina Laragione1,2 and Percio Gulko1,2, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…
  • Abstract Number: 179 • 2013 ACR/ARHP Annual Meeting

    The Association Between Single Nucleotide Polymorphism ABCG2 rs2231142 and Hyperuricemia: A Case-Control Study

    Bingqing Zhang1, Weigang Fang2, Yun Zhang3,4, Shufen Liu3, Yuanjie Li3 and Xuejun Zeng2, 1Peking Union Medical College, Beijing, China, 2Medicine, Peking Union Medical College Hospital, Beijing, China, 3Peking Union Medical College Hospital, Beijing, China, 4Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

    Background/Purpose:     The prevalence of hyperuricemia and gout in China increased markedly in the past decades. Genome-wide association studies in Caucasian population have identified multiple…
  • Abstract Number: 891 • 2013 ACR/ARHP Annual Meeting

    A Single Amino Acid In The β1 Chain Of HLA-DR Explains The Majority Of The HLA Association With Giant Cell Arteriti

    Javier Martin1, F. David Carmona2, Jose Ezequiel Martin3, Aurora Serrano1, Lara Bossini-Castillo4, Roser Solans5, Jose A. Miranda-Filloy6, Santos Castañeda7, Maria C. Cid8, Jose A. Hernandez9, Inmaculada C. Morado10, Javier Narvaez11, Ricardo Blanco12, Bernardo Sopeña13, M. Jesus García-Villanueva14, Jordi Monfort15, Norberto Ortego-Centeno16, Ainhoa Unzurrunzaga17, Begoña Marí-Alfonso18, Cesar Magro19, Ana Hidalgo-Conde20, Marta Conde-Jaldon21, María F. González-Escribano21, Paul de Bakker22, Bobby P.C. Koeleman23 and Miguel A. González-Gay24, 1Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 2Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, 3Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 4Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 5Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, 6Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 7Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, 8Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 9Hospital Clinic. University of Barcelona, IDIBAPS,, Barcelona, Spain, 10Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 11Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain, 13Thrombosis and Vasculitis Unit-Internal Medicine, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain, 14Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, 15Reumatologia, Hospital del Mar, Barcelona, Spain, 16Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain, 17Internal Medicine, Hospital de Galdakano, Vizcaya, Spain, 18Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Spain, 19Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 20Internal Medicine, Hospital Universitario Virgen de la Victoria, Málaga, Spain, 21Immunology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 22Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 23Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 24Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose: Giant cell arteritis (GCA) is a polygenic inflammatory disease affecting medium- and large-sized blood vessels in people elder than 50-years old. Although it is…
  • Abstract Number: 157 • 2013 ACR/ARHP Annual Meeting

    Application Of a Multiplex Gene Polymorphism Assay For Variants Associated With Rheumatoid Arthritis Susceptibility: Results Of 168 Single Nucleotide Polymorphisms In The Optima Study

    Jeffrey F. Waring1, Viswanath Devanarayan2, Kenneth Idler1, Feng Hong2, Josef S. Smolen3, Arthur Kavanaugh4, Hartmut Kupper5, Hendrik Schulze-Koops6 and Alla Skapenko7, 1AbbVie Inc., North Chicago, IL, 2AbbVie Bioresearch Center, Worchester, MA, 3Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 4University of California San Diego, La Jolla, CA, 5AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 6Division of Rheumatology, University of Munich, Munich, Germany, 7Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose: Genetic factors have been identified that may be associated with the development and severity of rheumatoid arthritis (RA), disease progression, or response to treatment.…
  • Abstract Number: 892 • 2013 ACR/ARHP Annual Meeting

    The Functional PTPN22 Variant R620W Is Strongly Associated With Giant Cell Artetitis Predisposition

    F. David Carmona1, Sarah L. Mackie2, Aurora Serrano3, Ana Marquez4, Roser Solans5, Jose A. Miranda-Filloy6, Jose Hernández-Rodríguez7, Maria C. Cid8, Santos Castañeda9, Inmaculada C. Morado10, Javier Narvaez11, Ricardo Blanco12, Bernardo Sopeña13, M. Jesus García-Villanueva14, Jordi Monfort15, Norberto Ortego-Centeno16, Ainhoa Unzurrunzaga17, Begoña Marí-Alfonso18, Julio Sánchez-Martín19, Eugenio de Miguel20, Cesar Magro21, Enrique Raya22, Niko Braun23, Joerg Latus24, Øyvind Molberg25, Benedicte A. Lie26, Frank Moosig27, Torsten Witte28, Ann W. Morgan2, Miguel A. González-Gay29 and Javier Martin3, 1Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, 2NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 4Instituto de Parasitología y Biomedicina 'López-Neyra' (IPBLN-CSIC), Granada, Spain, 5Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, 6Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 7Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 8Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 9Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, 10Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 11Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 13Thrombosis and Vasculitis Unit-Internal Medicine, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain, 14Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, 15Reumatologia, Hospital del Mar, Barcelona, Spain, 16Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 17Internal Medicine, Hospital de Galdakano, Vizcaya, Spain, 18Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Spain, 19Rheumatology,, Hospital Universitario 12 de Octubre, Madrid, Spain, 20Rheumatology, University Hospital La Paz - IdiPaz, Madrid, Spain, 21Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 22Rheumatology, University Hospital San Cecilio, Granada, Spain, 23Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, 24Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, 25Oslo University Hospital, Oslo, Norway, 26Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway, 27Department of Clinical Immunology and Rheumatology, University of Luebeck, Bad Bramstedt, Germany, 28Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, 29Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose: The PTPN22/CSK signaling represents one of the common susceptibility pathways in autoimmunity. Considering that the genetic basis of giant cell arteritis (GCA), an autoimmune…
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