ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "genetics"

  • Abstract Number: 2089 • 2014 ACR/ARHP Annual Meeting

    The APOL1 Gene Is Not Associated with Lupus Nephritis in Individuals with Enriched Amerindian Ancestry

    Julio Molineros1, Hannah Ainsworth2, Robert Kimberly3, Michelle Petri4, Rosalind Ramsey-Goldman5, Luis M. Vilá6, John D. Reveille7,8, Elizabeth E. Brown9, Swapan Nath1, Carl D. Langfeld10, Bernardo Pons-Estel on behalf of GENLES11, Graciela S. Alarcon12 and Marta E. Alarcon Riquelme1, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Wake Forest, Winston-Salem, NC, 3University of Alabama, Birmingham, AL, 4Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Rheumatology, Northwestern University and Feinberg School of Medicine, Chicago, IL, 6Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, 7Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 8Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, 9University of Alabama at Birmingham, Birmingham, AL, 10Department of Biostatistics, Wake Forest University Health Sciences, Winston-Salem, NC, 11Sanatorio Parque, Rosario, Argentina, 12Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    The APOL1 Gene is not Associated with Lupus Nephritis in Individuals with Enriched Amerindian AncestryBackground/Purpose: The APOL1 gene coding variants G1 and G2 have been…
  • Abstract Number: 90 • 2014 ACR/ARHP Annual Meeting

    Genetic Variants in IL-6, IL-10, C5-TRAF1 and FCRL3 and Progression of Joint Damage in Rheumatoid Arthritis; A Study on Six Cohorts

    H.W. van Steenbergen1, L. Rodriguez-Rodriguez2, E. Berglin3, A. Zhernakova4, R. Knevel1, J. Ivorra-Cortes5, T.W.J. Huizinga1, B. Fernández-Gutiérrez6, P.K. Gregersen7, S. Rantapää-Dahlqvist8 and A.H.M. van der Helm-van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 3Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, 4Genetics, University Medical Center Groningen, Groningen, Netherlands, 5Rheumatology, University Hospital la Fe, Valencia, Spain, 6Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 7The Feinstein Institute for Medical Research, Manhasset, NY, 8Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden

    Background/Purpose Understanding the mechanisms underlying the inter-individual differences in radiographic progression is relevant and heritability studies have shown that genetic factors explain part of these…
  • Abstract Number: 1861 • 2014 ACR/ARHP Annual Meeting

    The Role of Macrophage Migration Inhibitory Factor (MIF) and MIF Gene Polymorphisms in the Pathogenesis of Granulomatosis with Polyangiitis

    Antoine G. Sreih1, Rana Ezzeddine2, Juan Fan3, Lin Leng3, Simon Carette4, David Cuthbertson5, Gary S. Hoffman6, Nader A. Khalidi7, Carol A. Langford8, Carol McAlear9, Paul Monach10, Philip Seo11, Ulrich Specks12, Steven R. Ytterberg13, Peter A. Merkel14 and Richard Bucala15, 1Medicine/Division of Rheumatology, The University of Pennsylvania, Philadelphia, PA, 2Biostatistics, Bristol-Myers Squibb, Wallingford, CT, 3Yale University, New Haven, CT, 4Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 5Department of Biostatistics, University of South Florida, Tampa, FL, 6Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, 7Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, 8Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, 9Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, 10Rheumatology, Boston University, Boston, MA, 11Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 12Frederichs Dr NW, Mayo Clinic, Rochester, MN, 13Division of Rheumatology, Mayo Clinic, Rochester, MN, 14Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 15Rheum/Dept of Int Med, Yale University School of Med, New Haven, CT

    Background/Purpose: Macrophage Migration Inhibitory Factor (MIF) is an immunoregulatory cytokine that may play a central role in the pathogenesis of granulomatous diseases. Two functional polymorphisms…
  • Abstract Number: 1808 • 2014 ACR/ARHP Annual Meeting

    Role of HLA-B*5801 Genetic Testing and a Safety Programme When Initiating Allopurinol Therapy for Chronic Gout Management: A Cost-Effectiveness Analysis

    Di Dong1, Wei Chuen Tan-Koi2,3, Gim Gee Teng4,5, Eric Finkelstein6 and Cynthia Sung7,8, 1Health Services and Systems Research Program, Duke-NUS Graduate Medical School, Singapore, Singapore, 2Vigilance & Compliance Branch, Health Sciences Authority, Singapore, Singapore, Singapore, 3Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 4Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 5Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore, 6Health Services and Systems Research Program, Duke-NUS Graduate Medical School, Singapore., Singapore, Singapore, 7Vigilance & Compliance Branch, Health Products Regulation Group, Health Sciences Authority, Singapore, Singapore, Singapore, 8Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School, Singapore., Singapore, Singapore

    Background/Purpose To conduct a cost-effectiveness analysis from a health system perspective of various strategies in managing chronic gout to mitigate risk of allopurinol-induced Stevens-Johnson Syndrome…
  • Abstract Number: 1480 • 2013 ACR/ARHP Annual Meeting

    Prevalance Of Rare Variants In Methotrexate Pathway Genes: Implications From The National Heart Lung Blood Institute (NHLBI) Exome Sequencing Project

    Fardina Malik, Internal Medicine, Alton Memorial Hospital, Alton, IL

    Background/Purpose: Inter-individual variation to methotrexate (MTX) therapy in patients with rheumatoid arthritis (RA) is attributed at least in part to the presence of genetic variation…
  • Abstract Number: 160 • 2013 ACR/ARHP Annual Meeting

    Association Analysis Of The Organic Anion Transporter 4 and Urate Transporter 1 Locus With Gout In New Zealand Case-Control Sample Sets Reveals Multiple Ancestral-Specific Effects

    Tony R. Merriman1, Amanda Phipps-Green1, Jade E. Hollis-Moffatt2, Marilyn E. Merriman1, Ruth Topless1, Grant Montgomery3, Brett Chapman3, Lisa K. Stamp4, Nicola Dalbeth5 and Tanya Flynn2, 1Department of Biochemistry, University of Otago, Dunedin, New Zealand, 2University of Otago, Dunedin, New Zealand, 3Queensland Institute of Medical Research, Brisbane, Australia, 4University of Otago, Christchurch, New Zealand, 5Medicine, University of Auckland, Auckland, New Zealand

    Background/Purpose: There are genetic variants in urate transporters SLC22A11 (OAT4) and SLC22A12 (URAT1) that influence serum urate levels in European Caucasian. However, there is no…
  • Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting

    The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts

    Max Brenner1,2, Teresina Laragione1,2 and Percio Gulko1,2, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…
  • Abstract Number: 179 • 2013 ACR/ARHP Annual Meeting

    The Association Between Single Nucleotide Polymorphism ABCG2 rs2231142 and Hyperuricemia: A Case-Control Study

    Bingqing Zhang1, Weigang Fang2, Yun Zhang3,4, Shufen Liu3, Yuanjie Li3 and Xuejun Zeng2, 1Peking Union Medical College, Beijing, China, 2Medicine, Peking Union Medical College Hospital, Beijing, China, 3Peking Union Medical College Hospital, Beijing, China, 4Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

    Background/Purpose:     The prevalence of hyperuricemia and gout in China increased markedly in the past decades. Genome-wide association studies in Caucasian population have identified multiple…
  • Abstract Number: 891 • 2013 ACR/ARHP Annual Meeting

    A Single Amino Acid In The β1 Chain Of HLA-DR Explains The Majority Of The HLA Association With Giant Cell Arteriti

    Javier Martin1, F. David Carmona2, Jose Ezequiel Martin3, Aurora Serrano1, Lara Bossini-Castillo4, Roser Solans5, Jose A. Miranda-Filloy6, Santos Castañeda7, Maria C. Cid8, Jose A. Hernandez9, Inmaculada C. Morado10, Javier Narvaez11, Ricardo Blanco12, Bernardo Sopeña13, M. Jesus García-Villanueva14, Jordi Monfort15, Norberto Ortego-Centeno16, Ainhoa Unzurrunzaga17, Begoña Marí-Alfonso18, Cesar Magro19, Ana Hidalgo-Conde20, Marta Conde-Jaldon21, María F. González-Escribano21, Paul de Bakker22, Bobby P.C. Koeleman23 and Miguel A. González-Gay24, 1Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 2Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, 3Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 4Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 5Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, 6Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 7Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, 8Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 9Hospital Clinic. University of Barcelona, IDIBAPS,, Barcelona, Spain, 10Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 11Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain, 13Thrombosis and Vasculitis Unit-Internal Medicine, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain, 14Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, 15Reumatologia, Hospital del Mar, Barcelona, Spain, 16Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain, 17Internal Medicine, Hospital de Galdakano, Vizcaya, Spain, 18Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Spain, 19Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 20Internal Medicine, Hospital Universitario Virgen de la Victoria, Málaga, Spain, 21Immunology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 22Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 23Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 24Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose: Giant cell arteritis (GCA) is a polygenic inflammatory disease affecting medium- and large-sized blood vessels in people elder than 50-years old. Although it is…
  • Abstract Number: 157 • 2013 ACR/ARHP Annual Meeting

    Application Of a Multiplex Gene Polymorphism Assay For Variants Associated With Rheumatoid Arthritis Susceptibility: Results Of 168 Single Nucleotide Polymorphisms In The Optima Study

    Jeffrey F. Waring1, Viswanath Devanarayan2, Kenneth Idler1, Feng Hong2, Josef S. Smolen3, Arthur Kavanaugh4, Hartmut Kupper5, Hendrik Schulze-Koops6 and Alla Skapenko7, 1AbbVie Inc., North Chicago, IL, 2AbbVie Bioresearch Center, Worchester, MA, 3Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 4University of California San Diego, La Jolla, CA, 5AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 6Division of Rheumatology, University of Munich, Munich, Germany, 7Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose: Genetic factors have been identified that may be associated with the development and severity of rheumatoid arthritis (RA), disease progression, or response to treatment.…
  • Abstract Number: 892 • 2013 ACR/ARHP Annual Meeting

    The Functional PTPN22 Variant R620W Is Strongly Associated With Giant Cell Artetitis Predisposition

    F. David Carmona1, Sarah L. Mackie2, Aurora Serrano3, Ana Marquez4, Roser Solans5, Jose A. Miranda-Filloy6, Jose Hernández-Rodríguez7, Maria C. Cid8, Santos Castañeda9, Inmaculada C. Morado10, Javier Narvaez11, Ricardo Blanco12, Bernardo Sopeña13, M. Jesus García-Villanueva14, Jordi Monfort15, Norberto Ortego-Centeno16, Ainhoa Unzurrunzaga17, Begoña Marí-Alfonso18, Julio Sánchez-Martín19, Eugenio de Miguel20, Cesar Magro21, Enrique Raya22, Niko Braun23, Joerg Latus24, Øyvind Molberg25, Benedicte A. Lie26, Frank Moosig27, Torsten Witte28, Ann W. Morgan2, Miguel A. González-Gay29 and Javier Martin3, 1Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, 2NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 4Instituto de Parasitología y Biomedicina 'López-Neyra' (IPBLN-CSIC), Granada, Spain, 5Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, 6Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 7Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 8Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 9Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, 10Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 11Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 13Thrombosis and Vasculitis Unit-Internal Medicine, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain, 14Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, 15Reumatologia, Hospital del Mar, Barcelona, Spain, 16Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 17Internal Medicine, Hospital de Galdakano, Vizcaya, Spain, 18Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Spain, 19Rheumatology,, Hospital Universitario 12 de Octubre, Madrid, Spain, 20Rheumatology, University Hospital La Paz - IdiPaz, Madrid, Spain, 21Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 22Rheumatology, University Hospital San Cecilio, Granada, Spain, 23Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, 24Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, 25Oslo University Hospital, Oslo, Norway, 26Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway, 27Department of Clinical Immunology and Rheumatology, University of Luebeck, Bad Bramstedt, Germany, 28Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, 29Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose: The PTPN22/CSK signaling represents one of the common susceptibility pathways in autoimmunity. Considering that the genetic basis of giant cell arteritis (GCA), an autoimmune…
  • Abstract Number: 2861 • 2013 ACR/ARHP Annual Meeting

    Accounting For Parental Load and Identification Of Multiple Risk Variants For Anti-Ro Congenital Heart Block Through High-Density Genotyping Of Immune-Related Loci

    Robert M. Clancy1, Jill P. Buyon2, Nathalie Costedoat-Chalumeau3, Antonio Brucato4, Kateri Levesque5, Véronique Ramoni6, Miranda C. Marion7, Mary Comeau8, Satria Sajuthi9, Paula S. Ramos10, Robert P. Kimberly11, Timothy D. Howard12 and Carl D. Langefeld13, 1Medicine, New York University School of Medicine, New York, NY, 2Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Internal Medicine, Hopital Cochin, Paris, France, 4Internal Medicine, USC Internal Medicine, Ospedali Riuniti, Bergamo, Italy, 5Medicine Interne, Hopital Cochin, Paris, France, 6Rheumatology, Rheumatology University of Pavia, Pavia, Italy, 7Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 8Wake Forest University Health Sciences, Winston-Salem, NC, 9Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 10Department of Medicine, Medical University of South Carolina, Charleston, SC, 11Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 12Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 13Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC

    Background/Purpose:  Anti-Ro associated congenital heart block (CHB) exhibits a 33% concordance rate in monozygotic twins, 17.5% recurrence of disease and a high sibling risk ratio…
  • Abstract Number: 180 • 2013 ACR/ARHP Annual Meeting

    Familial Aggregation Of Female Premenopausal Gout –Monogenic, Polygenic Or Clinical Coincidence?

    Bingqing Zhang1, Shufen Liu2, Nuo Si3, Yun Zhang2,4 and Xuejun Zeng5, 1Peking Union Medical College, Beijing, China, 2Peking Union Medical College Hospital, Beijing, China, 3Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 4Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 5Medicine, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: Primary gout is a multifactorial disease, in which genetic background and environmental factors interact with each other. Genetic predisposition is particularly prominent in those…
  • Abstract Number: 2739 • 2013 ACR/ARHP Annual Meeting

    Immunochip Analysis Identifies New Susceptibility Loci For Systemic Sclerosis: Implications For Pathogenesis

    Maureen D. Mayes for the US Scleroderma GWAS Group1, Lara Bossini-Castillo for the Spanish Scleroderma Group2, Olga Gorlova3, Jose Ezequiel Martin4, Xiaodong Zhou1, Wei Chen5, Shervin Assassi1, Jun Ying5, John D. Reveille1, Peter K. Gregersen6, Annette T. Lee7, Maria Teruel8, Francisco David Carmona4, Bobby P.C. Koeleman9, Matthew A. Brown and the Immunochip Consortium10, Christopher P. Denton11, Murray Baron for the Canadian Scleroderma Research Group12, Jasper Broen13, T.R.D.J. Radstake13 and Javier Martin4, 1Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 2Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 3Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 4Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 5Department of Epidemiology, UT M.D. Anderson Cancer Center, Houston, TX, 6Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 7Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 8Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 9Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 10Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, 11Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, 12Rheumatology, Jewish General Hospital, Montreal, QC, Canada, 13Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose : The purpose of this study was to identify SSc risk loci shared with other autoimmune diseases on the Immunochip and to fine-map previously…
  • Abstract Number: 2697 • 2013 ACR/ARHP Annual Meeting

    Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis

    Tibor A. Rauch1, Beata Tryniszewska1, Andras Vida1, Timea Ocsko1, Sandor Szanto2, Holly L. Rosenzweig3, Matthew A. Brown4, Gethin P Thomas5, Katalin Mikecz1 and Tibor T. Glant1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rheumatology, University of Debrecen, Debrecen, Hungary, 3Oregon Health & Science University, Portland, OR, 4Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, 5Translational Reserch Institute, University of Queensland Diamantina Institute, Woolloongabba, Australia

    Background/Purpose: Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90%…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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