ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "genetics"

  • Abstract Number: 2837 • 2019 ACR/ARP Annual Meeting

    Asymptomatic Monosodium Urate Crystal Deposition Associates with Increased Expression of Pro-Inflammatory Genes

    Gabriela Sandoval-Plata1, Kevin Morgan 2, Tamar Guetta-Baranes 2, Ana Valdes 3, Michael Doherty 4 and Abhishek Abhishek 5, 1Human Genomics and Molecular Genetics, School of Life Sciences, University of Nottingham / Academic Rheumatolog, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom, 2Human Genomics and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, England, United Kingdom, 3Academic Rheumatology, School of Medicine, University of Nottingham / Nottingham NIHR BRC, Nottingham UK, Nottingham, England, United Kingdom, 4Academic Rheumatology, Division of Rheumatology,School of Medicine, University of Nottingham, Nottingham, UKArthritis Research UK Pain Centre, Nottingham, UKNational Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, England, United Kingdom, 5Academic Rheumatology, School of Medicine, University of Nottingham,Nottingham,UK National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham,UK, Nottingham, England, United Kingdom

    Background/Purpose: Persistent hyperuricaemia is a prerequisite for gout. However, only 10% of people with hyperuricaemia develop symptomatic gout, whereas 25-35% have asymptomatic monosodium urate (MSU)…
  • Abstract Number: 1933 • 2019 ACR/ARP Annual Meeting

    Tumorigenesis Related Gene Identification in Dermatomyositis Using Meta-Analysis

    Jihad Aljabban1, Saad Syed 2, Sharjeel Syed 3, Kalyn Hoffman 4, Laith Hasan 5, Nikhil Adapa 1, Zahir Allarakhia 6, Dexter Hadley 7, Mohamad Aljabban 8 and Wael Jarjour 9, 1Ohio State University College of Medicine, Columbus, 2Stanford School of Medicine, Stanford, 3Stanford School of Medicine, Stanford, CA, 4The Ohio State University College of Medicine, Columbus, OH, 5Tulane School of Medicine, New Orleans, 6Ohio State University College of Medicine, Columbus, OH, 7Institute for Computational Health Sciences, San Francisco, 8Genesys Health Systems, Grand Blanc, MI, 9Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Dermatomyositis (DM) is a progressive, systemic autoimmune disease-causing inflammatory changes in the skin and skeletal muscles.  DM is associated with carcinomas of the ovary,…
  • Abstract Number: 1934 • 2019 ACR/ARP Annual Meeting

    Tripartite Motif (TRIM) Gene Family Expression in Dermatomyositis

    Jihad Aljabban1, Sharjeel Syed 2, Saad Syed 3, Zarife Sahenk 4, Noah Weisleder 5, Kevin McElhanon 5, Kalyn Hoffman 6, Nikhil Adapa 1, Zahir Allarakhia 7, Laith Hasan 8, Dexter Hadley 9, Mohamad Aljabban 10 and Wael Jarjour 11, 1Ohio State University College of Medicine, Columbus, 2Stanford School of Medicine, Stanford, CA, 3Stanford School of Medicine, Stanford, 4Department of Neurology, Research Institute at Nationwide Children’s Hospital, Columbus, OH, 5Dorothy M. Davis Heart and Lung Research Institute & Dept. of Physiology & Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, 6The Ohio State University College of Medicine, Columbus, OH, 7Ohio State University College of Medicine, Columbus, OH, 8Tulane School of Medicine, New Orleans, 9Institute for Computational Health Sciences, San Francisco, 10Genesys Health Systems, Grand Blanc, MI, 11Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Dermatomyositis (DM) is a progressive, systemic autoimmune disease causing inflammatory changes to the skin and skeletal muscles. TRIM family proteins are composed of approximately…
  • Abstract Number: 1935 • 2019 ACR/ARP Annual Meeting

    Multi-Organ System Meta-Analytic Approach to Investigating Sarcoidosis

    Jihad Aljabban1, Saad Syed 2, Sharjeel Syed 3, Nikhil Adapa 1, Laith Hasan 4, Zahir Allarakhia 5, Dexter Hadley 6, Mohamad Aljabban 7 and Wael Jarjour 8, 1Ohio State University College of Medicine, Columbus, 2Stanford School of Medicine, Stanford, 3Stanford School of Medicine, Stanford, CA, 4Tulane School of Medicine, New Orleans, 5Ohio State University College of Medicine, Columbus, OH, 6Institute for Computational Health Sciences, San Francisco, 7Genesys Health Systems, Grand Blanc, MI, 8Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Sarcoidosis (SD) is a granulomatous inflammatory disease with a heterogenous presentation and no definite etiology. SD usually begins in the lungs, skin, or lymph…
  • Abstract Number: 1947 • 2019 ACR/ARP Annual Meeting

    Integrating Genetic Risk Scores and Pre-Diagnostic Metabolomics to Infer Dysregulated Mechanisms in Rheumatoid Arthritis in Women

    Su H. Chu1, Jing Cui 2, Jeffrey Sparks 2, Bing Lu 2, Clary Clish 3, Jessica Lasky-Su 1, Elizabeth Karlson 2 and Karen Costenbader 2, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Broad Institute of MIT and Harvard, Boston, MA

    Background/Purpose: Rheumatoid arthritis genetic risk scores (RA-GRS) improve RA risk prediction, but the added predictive value over lifestyle risk factors is modest. Several human leukocyte…
  • Abstract Number: 1954 • 2019 ACR/ARP Annual Meeting

    Association of Functional (GA)n Microsatellite Polymorphism in the FLI1 Gene with Susceptibility to Human Systemic Sclerosis

    Aya Kawasaki1, Keita Yamashita 2, Takashi Matsushita 3, Hiroshi Furukawa 4, Yuya Kondo 5, Naoko Okiyama 6, Shouhei Nagaoka 7, Kota Shimada 8, Shoji Sugii 9, Masao Katayama 10, Shunsei Hirohata 11, Akira Okamoto 12, Noriyuki Chiba 13, Eiichi Suematsu 14, Keigo Setoguchi 15, Kiyoshi Migita 16, Takayuki Sumida 5, Shigeto Tohma 17, Minoru Hasegawa 18, Yasuhito Hamaguchi 3, Shinichi Sato 19, Yasushi Kawaguchi 20, Kazuhiko Takehara 3 and Naoyuki Tsuchiya 1, 1Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan, 3Department of Dermatology, Kanazawa University, Kanazawa, Japan, 4Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 5Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 6Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 7Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan, 8Department of Rheumatic Diseases, Tokyo Metropoitan Tama Medica Center, Fuchu, 9Department of Rheumatic Diseases, Tokyo Metropoitan Tama Medica Center, Fuchu, Japan, 10National Hospital Organization Nagoya Medical Center, Nagoya, Japan, 11Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Tatsuno, Japan, 12National Hospital Organization HImeji Medical Center, Himeji, Hyogo, Japan, 13National Hospital Organization Morioka Medical Center, Morioka, Iwate, Japan, 14National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, 15Tokyo Metropolitan Cancer and Infectious Dease Center Komagome Hospital, Tokyo, Tokyo, Japan, 16Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan, 17National Hospital Organization Tokyo National Hospital, Kiyose, Japan, 18Department of Dermatology, Fukui University, Fukui, 19University of Tokyo Graduate School of Medicine, Department of Dermatology, Tokyo, Japan, 20Department of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose: Susceptibility genes which can account for the characteristic features of systemic sclerosis (SSc) such as fibrosis, vasculopathy and autoimmunity remain to be determined. A…
  • Abstract Number: 1959 • 2019 ACR/ARP Annual Meeting

    Pleiotropy of Systemic Lupus Erythematosus (SLE) Risk Alleles: Association with Increased Risk for Type 1 Diabetes (T1D) Complications Through a PTPN22 Polymorphism

    Vivian Kawai1, Mingjian Shi 1, Qiping Feng 2, Cecilia Chung 1, Ge Liu 2, Nancy Cox 2, Dan Roden 2, C. Michael Stein 1 and Jonathan Mosley 2, 1Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville

    Background/Purpose: Patients with SLE have increased risk of cardiovascular events and a higher prevalence of metabolic conditions compared to the general population. Inflammation is a…
  • Abstract Number: 1960 • 2019 ACR/ARP Annual Meeting

    Pleiotropy of Genetic Predisposition to Rheumatoid Arthritis Increases the Risk for Autoimmune Disease

    Vivian Kawai1, Mingjian Shi 1, Qiping Feng 2, Cecilia Chung 1, Ge Liu 2, Nancy Cox 2, Dan Roden 2, C. Michael Stein 1 and Jonathan Mosley 2, 1Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder that is associated with increased risk of cardiovascular disease, cardiometabolic disorders, and autoimmune disease. Thus, we…
  • Abstract Number: 2021 • 2019 ACR/ARP Annual Meeting

    Higher Genetic Risk Load in Patients with More Diverse Manifestations in a Korean Systemic Lupus Erythematosus Cohort

    So-Young Bang1, Eunji Ha 2, Hyuk-Hee Kwon 3, Hyun-Seung Yoo 4, Juyeon Kang 1, Ji-Soong Kim 1, Bora Nam 1, Jung-Min Shin 1, Yeon-Kyung Lee 1, Tae-Han Lee 5, Hye-Soon Lee 6, Kwangwoo Kim 2 and Sang-Cheol Bae 1, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 2Kyung Hee University, Seoul, Republic of Korea, 3Hanyang University Hospital, Guri, 4Hanyang University Hospital, Guri, Republic of Korea, 5Hanyang University, Seoul, 6Department of Internal Medicine, Hanyang University Guri Hospital,Hanyang University School of Medicine, Guri, Korea, Guri, Republic of Korea

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with diverse heterogeneous phenotypes. Although many studies of SLE presented estimates of high heritability, impact…
  • Abstract Number: 1965 • 2018 ACR/ARHP Annual Meeting

    Association of HLA Class II Alleles with Relapse and Interstitial Lung Disease in Myeloperoxidsae (MPO) -ANCA Positive Vasculitis in a Japanese Population

    Aya Kawasaki1, Ken-ei Sada2, Fumio Hirano3,4, Shigeto Kobayashi5, Hidehiro Yamada6, Hiroshi Furukawa1,7, Kenji Nagasaka8, Takahiko Sugihara9, Kunihiro Yamagata10, Takayuki Sumida11, Shigeto Tohma12,13, Shoichi Ozaki6, Hiroshi Hashimoto14, Hirofumi Makino15, Yoshihiro Arimura16, Masayoshi Harigai17 and Naoyuki Tsuchiya1, 1University of Tsukuba, Faculty of Medicine, Molecular and Genetic Epidemiology Laboratory, Tsukuba, Japan, 2Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 3Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Rheumatology, Tokyo, Japan, 4Tokyo Medical and Dental UniversityGraduate School of Medical and Dental Sciences, Department of Lifetime Clinical Immunology, Tokyo, Japan, 5Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 6St. Marianna University, School of Medicine, Department of Internal Medicine, Kawasaki, Japan, 7National Hospital Organization Sagamihara l Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara, Japan, 8Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 9Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 10University of Tsukuba, Faculty of Medicine, Department of Nephrology, Tsukuba, Japan, 11Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 12National Hospital Organization Tokyo Hospital, Sagamihara, Japan, 13National Hospital Organization Tokyo National Hospital, Kiyose, Japan, 14Juntendo University School of Medicine, Tokyo, Japan, 15Okayama University Hospital, Okayama, Japan, 16Kyorin University School of Medicine, First Department of Internal Medicine, Tokyo, Japan, 17Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan

    Background/Purpose: The high prevalence of microscopic polyangiitis (MPA) and myeloperoxidase (MPO)-ANCA positive patients as well as frequent occurrence of interstitial lung disease (ILD) constitute unique…
  • Abstract Number: 1976 • 2018 ACR/ARHP Annual Meeting

    Sequencing of the MHC Region Defines HLA-DQA1 As Driven Risk for Anti-Citrullinated Protein Antibodies (ACPA)-Positive Rheumatoid Arthritis in Han Population

    Jianping Guo1, Tao Zhang2, Hongzhi Cao2, Xiaowei Li2, Mengru Liu1, Yundong Zou1 and Zhan-Guo Li1, 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China

    Background/Purpose: The strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed to HLA-DRB1. However, due to…
  • Abstract Number: 1977 • 2018 ACR/ARHP Annual Meeting

    Transcriptional Perturbation of RA-Risk Enhancer By CRISPR-DEADCAS9 Regulates LONG Range GENE Targets

    Kate Duffus1, Maria Imran2, Gisela Orozco3, Helen Ray-Jones2, Antony Adamson2 and Stephen Eyre4, 1Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, 2University of Manchester, Manchester, United Kingdom, 3Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, 4NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

    Background/Purpose: Findings from genome wide association studies in complex diseases indicate over 90% of genetic variants associated with risk of developing disease are found outside…
  • Abstract Number: 1980 • 2018 ACR/ARHP Annual Meeting

    Comprehensive Association Analysis between Rare and Common ABCG2 Variants and Gout Susceptibility

    Hirotaka Matsuo1, Toshihide Higashino1, Tappei Takada2, Hirofumi Nakaoka3, Yu Toyoda4, Blanka Stiburkova5, Hiroshi Nakashima6, Seiko Shimizu1, Makoto Kawaguchi7, Akiyoshi Nakayama8, Yuka Aoki1, Misaki Ishino1, Yusuke Kawamura1, Kenji Wakai9, Rieko Okada10, Tatsuo Hosoya11, Kimiyoshi Ichida12, Hiroshi Ooyama13, Hiroshi Suzuki2, Ituro Inoue3, Tanya J. Major14, Tony R. Merriman14 and Nariyoshi Shinomiya1, 1Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan, 2Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, 3Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan, 4Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine,, The University of Tokyo, Tokyo, Japan, 5Department of Pediatrics and Adolescent Medicine, Charles University and General University Hospital in Prague, First Faculty of Medicine, Prague, Czech Republic, 6Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Japan, 7National Defense Medical College, Tokorozawa, Japan, 8Dept Integrative Physiol, National Defense Medical College, Tokorozawa, Japan, 9Nagoya University Graduate School of Medicine, Nagoya, Japan, 10Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan, 11Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, 12Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 13Ryougoku East Gate Clinic, Tokyo, Japan, 14University of Otago, Dunedin, New Zealand

    Background/Purpose: We have reported that ABCG2 has an important role in both renal and intestinal urate excretion and these common variants as rs72552713 (Q126X) and…
  • Abstract Number: 71 • 2018 ACR/ARHP Annual Meeting

    Association of Shared Epitope and Poor Prognostic Factors in RA

    Evo Alemao1, Joshua Bryson1, Christine K Iannaccone2, Michelle Frits2, Nancy A. Shadick3 and Michael Weinblatt2, 1Bristol-Myers Squibb, Princeton, NJ, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: There is a strong genetic association between RA and human leukocyte antigen (HLA) regions, particularly HLA-DRB1 alleles with the shared epitope (SE). SE alleles…
  • Abstract Number: 2027 • 2018 ACR/ARHP Annual Meeting

    Whole Exome Trio Sequencing Implicates DOCK2 in Juvenile Idiopathic Arthritis

    Laura A McIntosh1,2, Yoshinori Fukui3, Thomas A. Griffin4, Kenneth Kaufman1,2,5, Jarek Meller6,7, Sherry Thornton8, Halima Moncrieffe1,2 and Susan D Thompson1,2, 1Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Department of Pediatrics, University of Cincinnati, Cincinnati, OH, 3Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 4Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC, 5US Department of Veterans Affairs Medical Center, Cincinnati, OH, 6Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 7Department of Environmental Health, University of Cincinnati, Cincinnati, OH, 8Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood and has a strong genetic component to disease risk. Genome-wide association studies…
  • « Previous Page
  • 1
  • …
  • 16
  • 17
  • 18
  • 19
  • 20
  • …
  • 26
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology