Abstracts tagged "Genetics and rheumatoid arthritis (RA)"

Abstract Number: 81 • 2018 ACR/ARHP Annual Meeting
Additive Effects of Functional Rheumatoid Arthritis (RA) LBH Risk Alleles on LBH Gene Transcription
Gyrid Nygaard, Deepa Hammaker, David L. Boyle and Gary S. Firestein, Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development gene) is dysregulated in RA, with a SNP associated with increased RA risk located in an upstream enhancer. This…
Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting
Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing
Aleksander Lenert¹ and David W. Fardo², ¹Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, ²Biostatistics, College of Public Health, University of Kentucky, Lexington, KY
Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
Abstract Number: 2789 • 2017 ACR/ARHP Annual Meeting
Deficiency of the Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Induces Replication Stress in RA Fibroblast-like Synoviocytes (FLS) and Exacerbates Arthritis Severity
Shinji Matsuda¹, Deepa Hammaker², Katheryn Topolewski³, Karoline Briegel⁴, Steven Dowdy⁵, David L. Boyle⁶, Wei Wang⁷ and Gary S. Firestein⁸, ¹Medicine, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³UC San Diego, La Jolla, CA, ⁴University of Miami, Miami, FL, ⁵UC San Diego School of Medicine, La Jolla, CA, ⁶University of California San Diego, La Jolla, CA, ⁷Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁸Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development) was recently identified as an RA risk gene that has abnormally methylated loci and a functional enhancer SNP in…
Abstract Number: 2826 • 2017 ACR/ARHP Annual Meeting
Fine-Mapping Identifies Causal Variants for RA and T1D in DNASE1L3, Sirpg, MEG3, TNFAIP3 and CD28/CTLA4 Loc
Harm-Jan Westra¹, Marta Martinez-Bonet², Suna Onengut³, Annette Lee⁴, Yang Luo¹, Nikola Teslovich¹, Jane Worthington⁵, Javier Martín⁶, TWJ Huizinga⁷, Lars Klareskog⁸, Solbritt Rantapää Dahlqvist⁹, Wei-Min Chen³, Aaron Quinlan¹⁰, John Todd¹¹, Stephen Eyre⁵, Peter Nigrovic², Peter Gregersen⁴, Stephen Rich³ and Soumya Raychaudhuri¹², ¹Division of Genetics and Rheumatology, Department of Medicine, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Department of Public Health Sciences, University of Virginia, Charlottesville, VA, ⁴The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ⁵Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁶Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁹University of Umeå, Umeå, Sweden, ¹⁰Department of Human Genetics, University of Utah, Salt Lake City, UT, ¹¹JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, ¹²Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: While genome-wide association studies have identified risk loci for rheumatoid arthritis and other autoimmune diseases, in very few instances have causal variants driving risk…
Abstract Number: 58 • 2016 ACR/ARHP Annual Meeting
Detecting Novel Candidate Risk Genes in Rheumatoid Arthritis with Gene-Based Association Testing
Aleksander Lenert¹ and David Fardo², ¹Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, ²Biostatistics, College of Public Health, University of Kentucky, Lexington, KY
Background/Purpose: Rheumatoid arthritis (RA) is driven by immune-system dysfunction with contribution from genetic risk factors. Emerging data from genomewide association studies (GWAS) of single nucleotide…
Abstract Number: 989 • 2016 ACR/ARHP Annual Meeting
A Randomized Controlled Trial of Rheumatoid Arthritis Risk Disclosure Personalized to Genetics, Autoantibodies, and Lifestyle Among Unaffected First-Degree Relatives: The Personalized Risk Estimator for RA (PRE-RA) Family Study
Jeffrey A. Sparks¹, Maura D. Iversen², Zhi Yu³, Nellie A. Triedman³, Maria G. Prado³, Rachel Miller Kroouze⁴, Sarah S. Kalia⁵, Elinor A. Mody³, Simon M. Helfgott³, Derrick J. Todd³, Paul F. Dellaripa³, Bonnie L. Bermas³, Kevin D. Deane⁶, Karen H. Costenbader³, Bing Lu³, Robert C. Green⁵ and Elizabeth W. Karlson³, ¹Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, MA, ³Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose : Disclosure of genetic risk information alone has had limited impact on changing health behaviors in research trials. Prior studies have not evaluated whether…
Abstract Number: 1239 • 2015 ACR/ARHP Annual Meeting
Significant Impact of Microrna-Target Gene Networks on the Genetics of Rheumatoid Arthritis
Yukinori Okada^1,2 and Toshihiro Tanaka^3,4, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ³Bioresource Research Center, Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Background/Purpose: MicroRNA (miRNA), a short endogenous noncoding RNA, has a major role in the degradation and translational repression of a specific gene through its binding…
Abstract Number: 2102 • 2014 ACR/ARHP Annual Meeting
A Tissue-Specific Lincrna in the TRAF1-C5 Risk Locus As a Putative Cis-Regulator, Bridging Genetics and Disease
Tobias Messemaker¹, Rute Marques¹, Tom Huizinga¹, Alwin Adriaans¹, Aleida Bakker¹, Arend Berendsen¹, Nina Daha², R E M Toes¹, Harald Mikkers³ and Fina Kurreeman¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose In the last decade genome wide association studies (GWAS) have identified genetic polymorphisms that associate with Rheumatoid arthritis (RA). However, the way these genetic…
Abstract Number: 2084 • 2014 ACR/ARHP Annual Meeting
Are Genetic Markers Associated with Myocardial Infarction in Patients with Early Rheumatoid Arthritis?
Lisbeth Ärlestig¹, Petros Zamout², Lena Innala³, Eva Freyhult⁴, Solveig Wållberg Jonsson² and Solbritt Rantapää-Dahlqvist², ¹Public Health & Clinical Medicine/Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umea, Sweden, ²Public Health & Clinical Medicine/Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden, ³Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden, ⁴Bioinformatics Infrastructure for Life Sciences, Uppsala, Sweden
Background/Purpose Cardiovascular disease (CVD) are increased in patients with rheumatoid arthritis (RA). Traditional as well as disease related risk factors seem to contribute to the…
Abstract Number: 2008 • 2014 ACR/ARHP Annual Meeting
Personalized Risk Education for Rheumatoid Arthritis Improves Self-Perceived Risk Accuracy and Risk Factor Knowledge in First-Degree Relatives
Jeffrey A. Sparks¹, Maura D. Iversen^1,2,3, Rachel Miller Kroouze^1,4, Nellie A. Triedman¹, Taysir G. Mahmoud¹, Sarah S. Kalia⁴, Michael L. Atkinson⁵, Robert C. Green⁴ and Elizabeth W. Karlson¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, ³Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden, ⁴Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose Having a first-degree relative (FDR) with RA increases personal RA risk by four-fold. Other RA risk factors include demographics, genetics, auto-antibodies, and behaviors. We…
Abstract Number: 162 • 2013 ACR/ARHP Annual Meeting
Genotypic and Haplotypic Effects Of 7 Single-Nucleotide Polymorphisms In the CRP Gene On Levels Of C-Reactive Protein and DAS28 In a Cohort Of 180 Untreated Newly Diagnosed Rheumatoid Arthritis Patients (OPERA Study)
Christian G. Ammitzbøll¹, Rudi Steffensen², Peter Junker³, Mikkel Østergaard⁴, Julia Johansen⁵, Jan Pødenphant⁶, Merete Lund Hetland^7,8, Hanne M. Lindegaard⁹, Torkell Ellingsen¹⁰ and Kristian Stengaard-Pedersen¹, ¹Arhus University Hospital, Aarhus, Denmark, ²Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ³University of Southern Denmark, Odense, Denmark, ⁴Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁵Copenhagen University and Glostrup Hospital, Copenhagen, Denmark, ⁶Copenhagen University at Gentofte, Hellerup, Denmark, ⁷Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ⁸Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, ⁹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark
Background/Purpose: Single nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the basal C-reactive protein (CRP) expression and its response to…
Abstract Number: 2400 • 2013 ACR/ARHP Annual Meeting
Targeted Exon Resequencing For Korean Rheumatoid Arthritis
So-Young Bang¹, Kwangwoo Kim², Young-Ji Na², Jaemoon Lee³, Youngho Park⁴, Sun Young Lee⁵, Adnan Ahmad Ansari⁵, Chan-Bum Choi⁶, Yoon-Kyoung Sung², Tae-Hwan Kim⁷, Jae-Bum Jun⁸, Dae-Hyun Yoo⁸, Junghee Jung⁹, Hwanseok Rhee¹⁰, Jong-Young Lee¹¹, Bok-Ghee Han¹², Sung-Min Ahn¹³, Sungho Won³, Hye-Soon Lee¹⁴ and Sang-Cheol Bae⁸, ¹Hanyang University Guri Hospital, Guri, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Department of Applied Statistics, Chung-Ang University, Seoul, South Korea, ⁴Chung-Ang University, Seoul, South Korea, ⁵Gachon University, Incheon, South Korea, ⁶Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁸Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁹Bioinfomatics Center, Macrogen Inc, Seoul, South Korea, ¹⁰Bioinfomatics Center, Macrogen Inc, Seoul, South Korea, ¹¹Center for Genome Science, Korea National Institute of Health, Osong, South Korea, ¹²Korea National Institute of Health, Osong, South Korea, ¹³Deapartment of Translational Medicine, Gachon University, Incheon, South Korea, ¹⁴Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disorder with heritability estimated at 65% characterized by arthritis and autoantibodies formation against citrullinated peptides (ACPA). Although…

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