ACR Meeting Abstracts

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Abstracts tagged "Gene Expression"

  • Abstract Number: 1150 • ACR Convergence 2022

    Spatial Transcriptomics Stratifies Health and Psoriatic Disease Severity by Emergent Cellular Ecosystems

    Rochelle Castillo1, Ikjot Sidhu1, Igor Dolgalev1, Ipsita Subudhi1, Di Yan1, Piotr Konieczny1, Brandon Hsieh1, Tinyi Chu2, Rebecca Haberman1, Shanmugapriya Selvaraj1, Tomoe Shiomi1, Rhina Medina1, Parvathy Vasudevanpillai Girija1, Adriana Heguy1, Cynthia Loomis1, Luis Chiriboga1, Shane Meehan1, Christopher Ritchlin3, Maria de la Luz Garcia-Hernandez4, John Carucci1, Andrea Neimann1, Shruti Naik1 and Jose Scher5, 1NYU Langone Health, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 4University of Rochester, West Henrietta, NY, 5New York University School of Medicine, New York, NY

    Background/Purpose: The skin is recognized as a window into the immunopathogenic mechanisms driving the vast phenotypic spectrum of psoriatic disease.Methods: To better decipher the cellular…
  • Abstract Number: 2164 • ACR Convergence 2022

    Profibrotic Alveolar Macrophages as a Potential Biomarker in Systemic Sclerosis-associated Interstitial Lung Disease

    Nikolay Markov1, Karolina Senkow1, Anthony Esposito2, Jonathan Puchalski3, Mridu Gulati3, Erica Herzog3, Danielle Antin-Ozerkis4, Mary Carns5, Alyssa Williams6, Nic Page6, Alexander Misharin1 and Monique Hinchcliff7, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Brigham and Women's Hospital, Department of Medicine, Boston, MA, 3Yale School of Medicine, New Haven, CT, 4Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, 5Northwestern University Division of Rheumatology, Chicago, IL, 6Yale University, New Haven, CT, 7Yale School of Medicine, Westport, CT

    Background/Purpose: Interstitial lung disease (ILD) is a leading cause of death in patients with systemic sclerosis (SSc). Previously, profibrotic monocyte-derived alveolar macrophages (MoAM) expressing (SPP1,…
  • Abstract Number: 0251 • ACR Convergence 2022

    Nuclear Factor of Activated T Cells Cytoplasmic 1 as a Potential Biomarker of Increased Cardiovascular Risk in Patients with Early Rheumatoid Arthritis

    Sara Remuzgo-Martinez1, Fernanda Genre1, Veronica Pulito-Cueto2, Alfonso Corrales1, Virgi Portilla1, Leticia Lera-Gómez1, Belén Atienza-Mateo1, María Sebastián Mora-Gil1, J Gonzalo Ocejo-Vinyals3, Oreste Gualillo4, Ricardo Blanco5, Ivan Ferraz Amaro6, Santos Castañeda7, Raquel Lopez Mejias2 and Miguel Ángel González-Gay8, 1Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2IDIVAL, Santander, Spain, 3Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Hospital Clínico Universitario de Santiago, SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago de Compostela, Spain, 5Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 6Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 7Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 8Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: NFKB1, NKIRAS1, NFATc1, NFATc2 and MTHFR, inflammation and immune response-related genes, predispose to the increased risk of cardiovascular (CV) disease in patients with RA…
  • Abstract Number: 0609 • ACR Convergence 2022

    Macrophage Response to MAA Modified Fibrinogen in the Presence of Peptidyl Arginine Deiminase Inhibitor

    nozima Aripova1, Michael Duryee1, carlos hunter1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The formation of citrullinated (CIT) proteins is catalyzed by a calcium-dependent peptidyl arginine deiminase (PAD). In rheumatoid arthritis (RA), synovial macrophages are main contributors…
  • Abstract Number: 1173 • ACR Convergence 2022

    Single-cell Multi-omic Analysis of a 3D Skin-Like Tissue Model Provides Insights into Molecular and Cellular Drivers of Systemic Sclerosis

    Tamar Abel1, Noelle Kosarek2, Rezvan Parvizi3, Helen Jarnagin1, Mengqi Huang4, Avi Smith5, Michael Mariani1, Dillon Popovich6, Heetaek Yang7, Tammara Wood8, Jonathan Garlick9, Patricia Pioli7 and Michael Whitfield10, 1Dartmouth College, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Lebanon, NH, 3Dartmouth, Lebanon, NH, 4University of Pittsburgh, Pittsburgh, PN, 5Tufts University, Boston, MA, 6Dartmouth College, West Lebanon, NH, 7Geisel School of Medicine at Dartmouth, Lebanon, NH, 8Dartmouth College, Hanover, NH, 9Tufts University School of Dental Medicine, Boston, MA, 10Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Systemic Sclerosis (SSc) currently lacks reliable in vitro models of skin fibrosis constructed from all human cells. We have developed a skin-like tissue model of systemic…
  • Abstract Number: 2225 • ACR Convergence 2022

    Physical Inactivity Is Associated with Increased Expression of T Cell Inflammatory Genes in Systemic Lupus

    Sarah Patterson1, Sebastian Cruz Gonzalez2, Alexandra Tsitsiklis2, Cristina Lanata3, Lenka Maliskova4, Chun Ye1, Zachary Cutts4, Jinoos Yazdany5, Maria Dall'Era6, Lindsey Criswell7, Charles Langelier2, Patricia Katz5 and Marina Sirota8, 1University of California, San Francisco, San Francisco, CA, 2UCSF, San Francisco, CA, 3NIH, Washington, DC, 4University of California, San Francisco, San Francisco, 5UCSF, San Rafael, CA, 6University of California, Division of Rheumatology, San Francisco, CA, 7National Human Genome Research Institute, NIH, Bethesda, MD, 8UCSF, SF

    Background/Purpose: Prior studies show an independent association between greater physical activity and lower inflammatory markers among adults in the general population, but the impact of…
  • Abstract Number: 0266 • ACR Convergence 2022

    Expression of Cytokine and Chemokine Genes in Patients with Clinically Suspect Arthralgia; A Longitudinal Study During Progression to Inflammatory Arthritis or Non-Progression

    Judith Heutz1, Cleo Rogier2, Ellis Niemantsverdriet3, Susan van den Eeden4, Pascal de Jong5, Annemieke Geluk6 and Annette van der Helm-van Mil7, 1Erasmus Medical Center, Rotterdam, Netherlands, 2Erasmus MC, Rotterdam, Netherlands, 3LUMC, Leiden, Netherlands, 4Leiden University Medical Center (LUMC), Leiden, Netherlands, 5ErasmusMC, Hendrik Ido Ambacht, Netherlands, 6Leiden University Medical Center (LUMC), Leiden, Zuid-Holland, Netherlands, 7Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Autoantibody responses rise years before onset of inflammatory arthritis (IA) and are stable during transitioning from clinically suspect arthralgia (CSA) to IA (1). Cytokine…
  • Abstract Number: 0610 • ACR Convergence 2022

    Patient-derived Organoids Reveal Transcriptional Regulation of Synovial Lining Fibroblast Differentiation

    Sonia Presti1, Gerald FM Watts1, Zhu Zhu1, Kartik Bhamidipati1, Junning Case1, Yuhong Li1, Teri Bowman1, Suppawat Kongthong1, ilya Korsunsky1, Michael Brenner2 and Kevin Wei3, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Synovial lining fibroblasts secrete factors into the joint cavity that promote joint lubrication1. In inflammatory arthritis, sublining fibroblasts undergo marked expansion while lining fibroblasts…
  • Abstract Number: 1179 • ACR Convergence 2022

    Single Cell RNA Sequencing Analysis of Cryopreserved versus Fresh Skin Biopsy Samples from Systemic Sclerosis Patients and Healthy Controls

    Brian Skaug1, Marka Lyons1, Julio Charles1, Maureen Mayes2 and Shervin Assassi3, 1University of Texas McGovern Medical School at Houston, Houston, TX, 2Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX, 3McGovern Medical School, University of Texas, Houston, TX

    Background/Purpose: Single cell RNA Sequencing (scRNA-Seq) can elucidate tissue-resident cell populations and gene expression profiles with unprecedented granularity. Application of this approach to systemic sclerosis…
  • Abstract Number: 2233 • ACR Convergence 2022

    Machine Learning Uncovers Novel mRNAs Expressed in Fibromyalgia

    Lena Kolb1, Mark Rudolph1, Alan Kivitz2, Scott Rey1, Roberta Alexander1, Anja Kammesheidt3 and Geoffrey Stephens1, 1Exagen, Inc., Vista, CA, 2Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 3self, Laguna Beach, CA

    Background/Purpose: Fibromyalgia is a debilitating pain condition that affects roughly 12 million people in the United States. Although preliminary diagnostic criteria have been established by…
  • Abstract Number: 0329 • ACR Convergence 2022

    Scoring Personalized Molecular Portraits Identify Systemic Lupus Erythematosus Subtypes and Predict Individualized Drug Responses, Symptomatology and Disease Progression

    Daniel Toro-Domínguez1, Manuel Martinez-Bueno1, Raúl López-Domínguez2, Jordi Martorell-Marugán1, Elena Carnero-Montoro1, Guillermo Barturen1, Daniel W. Goldman3, Michelle Petri3, Pedro Carmona-Sáez2 and Marta Alarcon-Riquelme1, 1Center for Genomics and Oncological Research (GENYO), Granada, Spain, 2University of Granada, Granada, Spain, 3Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Systemic Lupus Erythematosus is a complex autoimmune disease that leads to important worsening of quality of life and mortality. Flares appear unpredictably during the…
  • Abstract Number: 0614 • ACR Convergence 2022

    Post-translationally Modified Fibrinogen Activated Macrophages Drive the Expression of Fibrotic Genes in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    nozima Aripova1, Michael Duryee1, carlos hunter1, Eric Daubach1, Evan Ryan1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Cellular interactions between synovial macrophages and human fibroblast-like synoviocytes (HFLS) contribute to articular inflammation and fibrosis in rheumatoid arthritis (RA), leading to subsequent joint…
  • Abstract Number: 1621 • ACR Convergence 2022

    Genome-wide Association Study in African American Systemic Sclerosis Patients Identifies a Novel Target – Transforming Growth Factor-β3 (TGFβ3)

    Urvashi Kaundal1, Julia Hartman2, Emilee Stenson1, Sarah Safran1, Chloe Borden1, Mousumi Sahu1, Janet Wang1, Andrea Conte1, Ami Shah3, Maureen Mayes4, Ayo Doumatey5, Amy Bentley5, Daniel Shriner5, Robyn Domsic6, Thomas Medsger7, Paula Ramos8, Richard Silver8, Virginia Steen9, John Varga10, Vivien Hsu11, Lesley Ann Saketkoo12, Elena Schiopu13, Dinesh Khanna14, Jessica Gordon15, Lindsey Criswell16, Heather Gladue17, Chris Derk18, Elana Bernstein19, S. Louis Bridges, Jr.15, Victoria Shanmugam20, Lorinda Chung21, Suzanne Kafaja22, Reem Jan23, Marcin Trojanowski24, Avram Goldberg25, Benjamin Korman26, Settara Chandrasekharappa5, Yongbing Zhao27, Stephen Brooks27, Stefania Dell'Orso1, Adebowale Adeyemo5, Charles Rotimi5, Elaine Remmers5, Daniel Kastner5, Francesco Boin28, Rafael Casellas27, Fredrick Wigley29 and Pravitt Gourh30, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, 3Johns Hopkins Rheumatology, Baltimore, MD, 4Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX, 5National Human Genome Research Institute, Bethesda, MD, 6University of Pittsburgh, Pittsburgh, PA, 7University of Pittsburgh School of Medicine, Pittsburgh, PA, 8Medical University of South Carolina, Charleston, SC, 9Georgetown University School of Medicine, Washington, DC, 10University of Michigan, Ann Arbor, MI, 11Rutgers-RWJ Medical School, South Plainfield, NJ, 12University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 13Michigan Medicine, Ann Arbor, MI, 14Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 15Hospital for Special Surgery, New York, NY, 16National Human Genome Research Institute, NIH, Bethesda, MD, 17Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 18University of Pennsylvania, Philadelphia, PA, 19Columbia University, New York, NY, 20George Washington University, Great Falls, VA, 21Stanford University, Stanford, CA, 22UCLA Department of Medicine, Division of Rheumatology, Los Angeles, CA, 23University of Chicago, Chicago, IL, 24Boston University School of Medicine, Boston, MA, 25NYU Langone Medical Center - NYU Hospital for Joint Diseases, Lake Success, NY, 26University of Rochester, Rochester, NY, 27National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 28Cedars-Sinai Medical Center, Los Angeles, CA, 29Johns Hopkins University, Baltimore, MD, 30National Institutes of Health, Bethesda, MD

    Background/Purpose: Transforming Growth Factor-β (TGFβ) isoforms play an important role in extracellular matrix biology. Increased TGFβ-regulated gene signature has been observed in lesional skin and…
  • Abstract Number: 0361 • ACR Convergence 2022

    Gene Expression Pathways Modulated by Anifrolumab in Systemic Lupus Erythematosus

    Tina Baker1, Sharifian Hoda2, Paul Newcombe1, Mark Lazarus1, Madhu Ramaswamy3, Nicola Ferrari1, Daniel Muthas2, Hussein Al-Mossawi1, Raj Tummala3, Eric F. Morand4, Richard A. Furie5, Edward Vital6 and Philip Brohawn3, 1AstraZeneca, Cambridge, United Kingdom, 2AstraZeneca, Gothenburg, Sweden, 3AstraZeneca, Gaithersburg, MD, 4Monash University, Melbourne, Australia, 5Northwell Health, Great Neck, NY, 6University of Leeds, Leeds, England, United Kingdom

    Background/Purpose: Anifrolumab is a monoclonal antibody to IFN-α receptor 1 that inhibits type I IFN signaling. In the phase 3 TULIP-1 and TULIP-2 trials, anifrolumab…
  • Abstract Number: 0633 • ACR Convergence 2022

    Identification of Systemic Lupus Erythematosus Endotypes by Analysis of Inflammatory and Immunologic Gene Expression Signatures

    Erika Hubbard1, Prathyusha Bachali2, Kathryn Kingsmore Allison1, Yisha He1, Michelle Catalina3, Amrie Grammer4 and Peter Lipsky1, 1AMPEL BioSolutions, Charlottesville, VA, 2AMPEL BioSolutions, Redmond, WA, 3AMPEL BioSolutions, Harvard, MA, 4AMPEL LLC, Charlottesville, VA

    Background/Purpose: One of the hallmarks of SLE is clinical and molecular heterogeneity. Recent work has leveraged next-generation sequencing techniques to identify molecular signatures characteristic of…
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