Abstracts tagged "Gene Expression"

Abstract Number: 3005 • 2015 ACR/ARHP Annual Meeting
Pulmonary Arterial Hypertension-Associated Single Nucleotide Polymorphisms of Hypoxia-Inducible Factor-3a Gene Cause Constitutive Activation of the Endothelin-1 Gene Promoter
Katsutoshi Mizumoto¹, Kyohei Takatori¹, Sayaka Takatori¹, Ryota Yoshimoto¹, Kohei Eguchi¹, Daisuke Fujishiro¹, Satoru Kodama¹, Atsushi Kobayashi¹, Kensaku Okamoto¹, Yasushi Kawaguchi², Masakazu Haneda¹ and Yuichi Makino¹, ¹Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Pulmonary arterial hypertension (PAH) is a progressive and fatal complication in the patients with connective tissue diseases (CTD). Elevation of endothelin-1 (ET-1) levels in…
Abstract Number: 794 • 2015 ACR/ARHP Annual Meeting
CD163+ Macrophages Display Mixed Polarizations in Discoid Lupus Skin
Benjamin Chong¹, Lin-chiang Tseng¹, Gregory Hosler², Noelle Teske¹, Song Zhang³, David R. Karp⁴, Nancy J. Olsen⁵ and Chandra Mohan⁶, ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, ²Propath, Dallas, TX, ³Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, ⁴UT Southwestern Medical Center, Dallas, TX, ⁵Divsion of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA, ⁶Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Discoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus. Lesional skin of DLE patients contains macrophages that may transition from…
Abstract Number: 2012 • 2015 ACR/ARHP Annual Meeting
TNF Confers Pathogenic Memory in Synovial Fibroblasts Via Chromatin Remodeling, NF-Kb-Dependent Transcription and MAPK-Mediated mRNA Stabilization
Konstantinos Loupasakis¹, Christopher Sohn², Lionel B. Ivashkiv³ and George D. Kalliolias², ¹Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: We investigated mechanisms driving pathogenic behavior of synovial fibroblasts (FLS) in rheumatoid arthritis (RA). Methods: FLS from RA patients (1987 classification criteria) were extracted.…
Abstract Number: 3107 • 2015 ACR/ARHP Annual Meeting
Investigating the Ameliorating Effect of Pregnancy on Rheumatoid Arthritis Using Whole Transcriptome Analysis
Anuradha Mittal¹, Lior Pachter², J. Lee Nelson³, Hanne Kjaergaard⁴, Mette Smed⁴, Vibeke Zoffmann⁴, Jørn Olsen⁵, Merete Lund Hetland⁶, Ingileif Hallgrimsdottir² and Damini Jawaheer¹, ¹Children's Hospital Oakland Research Institute, Oakland, CA, ²University of California, Berkeley, Berkeley, CA, ³Immunogenetics, Fred Hutchinson Cancer Rsch, Seattle, WA, ⁴Juliane Marie Center, Copenhagen, Denmark, ⁵Aarhus University, Aarhus, Denmark, ⁶On behalf of all Depts of Rheumatology in Denmark, DANBIO, Glostrup Hospital, Glostrup, Denmark
Background/Purpose: Pregnancy is known to induce a natural improvement of Rheumatoid Arthritis (RA) symptoms in 50-75% of patients as gestation progresses. However, the underlying mechanisms…
Abstract Number: 944 • 2015 ACR/ARHP Annual Meeting
Activity of Type I and Type II Interferons in Dermatomyositis Skin Is Correlated with Characteristic Pathologic Features
Hayley W. Leatham¹, Kerri Rieger², Lorinda Chung³, Shufeng Li¹, Brandon W. Higgs⁴, Yihong Yao⁴, Kavita Sarin¹ and David Fiorentino¹, ¹Dermatology, Stanford University, Stanford, CA, ²Dermatopathology, Stanford University, Stanford, CA, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Translational Sciences, MedImmune, LLC, Gaithersburg, MD
Background/Purpose :Interferon (IFN) signaling is upregulated in dermatomyositis (DM) skin, but the relationship to classic histopathologic features is unknown. Methods :Thirty-nine skin biopsies from patients…
Abstract Number: 2069 • 2015 ACR/ARHP Annual Meeting
High Interferon Gene Signature Is Associated with Increased Disease Activity, Reduced Complement C3 and C4, and Increased Oral Corticosteroid Use in Systemic Lupus Erythematosus (SLE)
K Ranade, L Wang, P Brohawn, W Greth, J Drappa and G Illei, MedImmune, Gaithersburg, MD
Background/Purpose: Increased expression of genes inducible by type 1 interferons has been observed in a subset of patients with systemic lupus erythematosus (SLE). Oral corticosteroids…
Abstract Number: 3128 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis in Blood and Dermal Fibroblasts from Twin Pairs Discordant for Systemic Sclerosis
Paula S. Ramos¹, Thomas A. Medsger Jr.² and Carol A. Feghali-Bostwick¹, ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The etiology and mechanisms underlying the wide variation in disease heterogeneity and severity in systemic sclerosis (SSc) remain unknown. To assess the role of…
Abstract Number: 1072 • 2015 ACR/ARHP Annual Meeting
Baseline Gene Expression Profiles in 1760 Patients from Two Phase III Trials of BAFF/BLyS Blockade in SLE
Robert W Hoffman¹, Joan T Merrill², Marta E. Marta Alarcón Riquelme³, Michelle Petri⁴, Ernst R Dow⁵, Eric Nantz⁶, Laura K Nisenbaum⁵, Krista M Schroeder⁶, Wendy J Komocsar⁶, Narayanan B Perumal⁵, Matthew D Linnik⁶, Guilherme V Rocha⁶ and Richard E Higgs⁶, ¹Immunology-Medical, Eli Lilly and Company, Indianapolis, IN, ²OMRF, Oklahoma, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Johns Hopkins Lupus Center, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Eli Lilly and Company, Indiananpolis, IN, ⁶Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Elevated Type-I interferon (IFN) signature characterizes at least 50% of adults with SLE and has been associated with autoantibodies and more severe disease in…
Abstract Number: 2098 • 2015 ACR/ARHP Annual Meeting
Prioritizing Likely Causative Genes in Genome-Wide Association Studies (GWAS) Identified Risk Loci for Immune-Mediated Inflammatory Disorders Using Cell-Type Specific Expression Quantitative Loci (eQTL) Information
Elisa Docampo¹, Ming Fang¹, Julia Dmitrieva¹, Emilie Théâtre¹, Mahmoud Elansary¹, Rob Mariman¹, Ann-Stephan Gori¹, Myriam Mni¹, François Crins², Wouter Coppieters², Edouard Louis³ and Michel Georges¹, ¹Unit of Animal Genomics, GIGA-R Université de Liège, Liège, Belgium, ²GenoTranscriptomics platform, GIGA-R Université de Liège, Liège, Belgium, ³Department of Gastroenterology, University Hospital CHU of Liège, Liège, Belgium
<h1> Background/Purpose: </h1> Immune-mediated inflammatory disorders (IMIDs) share many genetic risk factors. Pleiotropy may exist at different levels and most of the underlying mechanisms are…
Abstract Number: 3259 • 2015 ACR/ARHP Annual Meeting
Immunoablation Followed By Autologous Stem Cell Transplantation in Systemic Sclerosis Patients Decreases Significantly the Interferon Signatrue
Shervin Assassi¹, Maureen D Mayes¹, Claudia Pedroza², Jeffrey T. Chang², Daniel E. Furst³, Leslie J. Crofford⁴, Richard Nash⁵, Peter McSweeney⁵, Mary Ellen Csuka⁶, Ellen Goldmuntz⁷, Lynette Keyes-Elstein⁸, Paul Wallace⁹ and Keith Sullivan¹⁰, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²University of Texas Medical School at Houston, Houston, TX, ³Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, Vanderbilt University, Nashville, TN, ⁵Colorado Blood Cancer Institute, Denver, CO, ⁶Rheum/Med Coll of Wisconsin, Med Coll of Wisconsin, Milwaukee, WI, ⁷NIAID, National Institutes of Health, Bethesda, MD, ⁸Rho Federal Systems, Inc., Chapel Hill, NC, ⁹Roswell Park, Buffalo, NY, ¹⁰Duke University, Durham, NC
Background/Purpose: Previous clinical trials have suggested that immunoablation followed by autologous hematopoietic cell transplantation (HCT) can lead to clinical improvements in systemic sclerosis (SSc). However,…
Abstract Number: 1099 • 2015 ACR/ARHP Annual Meeting
Single Cell RNA-Seq Analysis of Citrullinated Alpha-Enolase Peptide-Specific B Cells in RA
Yogita Ghodke-Puranik¹, Na Zhang², Jessica M. Dorschner¹, Anna Shmagel³, Zhongbo Jin¹, Philip Titcombe⁴, Timothy B. Niewold¹ and Daniel Mueller⁵, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Medicine, University of Minnesota Medical School, Minneapolis, MN, ³Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ⁴University of Minnesota Medical School, Minneapolis, MN, ⁵Medicine/Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: The high prevalence of citrullinated protein antibodies and improvement following rituximab anti-CD20 therapy both suggest that B cells are important in the pathogenesis of…
Abstract Number: 2100 • 2015 ACR/ARHP Annual Meeting
Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjögren’s Syndrome
Juliana Imgenberg-Kreuz¹, Johanna K Sandling^1,2, Jonas Carlsson Almlöf¹, Jessica Nordlund¹, Linnea Signér², Katrine B Norheim³, Roald Omdal³, Majia-Leena Eloranta², Lars Rönnblom², Ann-Christine Syvänen¹ and Gunnel Nordmark², ¹Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ³Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Epigenetic modifications have emerged as important contributing factors in the pathogenesis of autoimmune diseases, including primary Sjögren’s syndrome (pSS), and may act as a…
Abstract Number: 1116 • 2015 ACR/ARHP Annual Meeting
Decreased Expression of Negative Regulators of Toll-like Receptor Signaling and Increased TLR7 Responsiveness in Expanded IgD- CD27- B Cells from Systemic Lupus Erythematosus Patients
Scott Jenks¹, Benjamin Barwick² and Ignacio Sanz³, ¹Allergy, Immunology, and Rheumatology, Emory University School of Medicine, Atlanta, GA, ²Emory University, Altanta, GA, ³Medicine, Emory University, Atlanta, GA
Background/Purpose: B cell homeostasis is perturbed in SLE patients; in particular many patients with active disease have a large expansion of IgD- CD27- B cells…
Abstract Number: 2136 • 2015 ACR/ARHP Annual Meeting
Identification of Synovial Fibroblast Subsets That Define Pathology in Rheumatoid Arthritis
Fumitaka Mizoguchi¹, Kamil Slowikowski^2,3, Sook Kyung Chang¹, Deepak A. Rao⁴, Hung Nguyen¹, Erika H. Noss⁵, Brandon E. Earp⁶, Philip E. Blazar⁶, John Wright⁶, Barry P. Simmons⁶, Nir Hacohen^7,8,9, Peter A. Nigrovic^1,10, Soumya Raychaudhuri^2,3,11 and Michael B. Brenner¹, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Divison of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Broad Institute of MIT and Harvard, Cambridge, MA, ⁸Massachusetts General Hospital, Charlestown, MA, ⁹Harvard Medical School, Boston, MA, ¹⁰Division of Immunology, Boston Children's Hospital, Boston, MA, ¹¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Synovial fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). They expand as part of the pannus, mediate degradation of cartilage, amplify…
Abstract Number: 1132 • 2015 ACR/ARHP Annual Meeting
Altered Histone 3 Dynamics at the Matrix Metalloproteinase 1 (MMP1) Transcription Start Site Contributes to MMP1 Suppression in Betaine Supplemented Synovial Fibroblasts in Rheumatoid Arthritis
Selene Glück¹, Niharika Gaur¹, Michelle Trenkmann^1,2, Emmanuel Karouzakis¹, Fangfang Sun¹, Christoph Kolling³, Beat A. Michel¹, Renate E. Gay¹, Steffen Gay¹, Michel Neidhart¹ and Mojca Frank Bertoncelj¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ²St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ³Schulthess Clinic, Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: Synovial fibroblasts (SF) produce elevated levels of matrix degrading enzymes, including matrix metalloproteinase 1 (MMP1), in the joints of rheumatoid arthritis (RA) patients, leading…

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