Session Type: ACR Concurrent Abstract Session
Session Time: 2:30PM-4:00PM
Interferon (IFN) signaling is upregulated
in dermatomyositis (DM) skin, but the relationship to
classic histopathologic features is unknown.
Thirty-nine skin biopsies from patients with dermatomyositis underwent gene expression analysis using Affymetrix arrays, as well as histologic analysis by a
blinded dermatopathologist. Biopsies were severity of several cardinal histopathologic
features, including basal vacuolar change (BV), dermal mucin
deposition, and perivascular inflammation. Type I and type
II IFN scores were generated .
Expression levels of IFN transcripts were measured by quantitative PCR. Univariate analysis was performed to evaluate the
association between IFN scores and IFN transcripts with key histopathologic
features, with subsequent multivariate models constructed to include
potentially confounding variables such as biopsy site, medication use, age, and
length of disease.
biopsies were highly
features. In univariate
analysis, was found to be associated with both
type I and type II IFN scores (p=0.0014 and p=0.004, respectively); these associations
remained significant in multivariate analysis. ermal
with the type I (, was associated with type II IFN score (p=0.0413), but
not the type I IFN score (p=0.3088). Additional features
epidermal atrophy, basement membrane,
and vessel damage were not statistically associated with .
Our results highlight
To cite this abstract in AMA style:Leatham HW, Rieger K, Chung L, Li S, Higgs BW, Yao Y, Sarin K, Fiorentino D. Activity of Type I and Type II Interferons in Dermatomyositis Skin Is Correlated with Characteristic Pathologic Features [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/activity-of-type-i-and-type-ii-interferons-in-dermatomyositis-skin-is-correlated-with-characteristic-pathologic-features/. Accessed September 23, 2020.
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