ACR Meeting Abstracts

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Abstracts tagged "Gene Expression"

  • Abstract Number: 0316 • ACR Convergence 2024

    Development and Evaluation of the Adult-onset Still’s Disease Activity Index Based on Whole RNA-seq Analysis: A Novel Approach Independent of Tocilizumab Treatment

    Mayu Magi1, Hiroto Yoshida1, Hiroya Tamai2, Kotaro Matsumoto2, Keiko Yoshimoto2, Yoshihiro Matsumoto1, Tetsuhiro Soeda1 and Yuko Kaneko2, 1Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan, 2Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Tocilizumab (TCZ), an anti-IL-6 receptor antibody, has been shown to be effective in the treatment of adult-onset Still's disease (AOSD), a systemic inflammatory disease.…
  • Abstract Number: 1105 • ACR Convergence 2024

    PDGFA and TGFB1, Key Genes to Discriminate Autoimmune Diseases-Related Interstitial Lung Disease from Idiopathic Pulmonary Fibrosis?

    Veronica Pulito-Cueto1, Belén Atienza-Mateo2, David Iturbe-Fernández3, Victor M. Mora-Cuesta3, Joao Carlos Batista-Liz1, María Sebastián Mora-Gil4, José M. Cifrián5, Ricardo Blanco-Alonso6 and Raquel Lopez-mejias1, 1IDIVAL, Santander, Spain, 2Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 3Immunopathology Group, Valdecilla Research Institute (IDIVAL) and Department of Pneumology, Marqués de Valdecilla University Hospital (HUMV), Santander, 4Immunopathology Group, Valdecilla Research Institute (IDIVAL) and Department of Rheumatology, Marqués de Valdecilla University Hospital (HUMV), Santander, 5Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, 6Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) constitutes one of the main causes of mortality in patients with autoimmune diseases (ADs) [1]. The early diagnosis of AD-ILD+…
  • Abstract Number: 2036 • ACR Convergence 2024

    CCN6 Gene Mutation Induces Mitochondrial Dysfunction: The Cause of Progressive Pseudo-rheumatoid Dysplasia

    Yanhong Li1, Xiufeng Bai2 and Yi Liu3, 1West China School of Medicine and West China Hospital, Sichuan University, Cheng Du, Sichuan, China, 2West China Hospital, Sichuan University, Chengdu, Sichuan, China (People's Republic), 3West China Hospital of Sichuan University, Chengdu, Sichuan, China

    Background/Purpose: Progressive pseudo-rheumatoid dysplasia (PPRD) is a rare autosomal recessive disorder characterized by non-inflammatory joint issues that primarily affect the articular cartilage. This leads to…
  • Abstract Number: 0666 • ACR Convergence 2024

    Interferon-stimulated Genes on Peripheral CD8+ T Cells of SLE Patients Were the Keys for Early Response to BAFF/APRIL-targeted Therapy

    Cuiling Fan1, Shixian Chen2 and Juan Li1, 1Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, China (People's Republic), 2Nanfang Hospital, Southern Medical University, guangzhou, China (People's Republic)

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. BAFF/APRIL-targeted therapy exert therapeutic effects through the inhibition of B-cell activating factor (BAFF) and a…
  • Abstract Number: 1132 • ACR Convergence 2024

    Guselkumab and Golimumab Combination Induction Therapy in Ulcerative Colitis Results in Early Local Tissue Healing That Is Sustained Through Guselkumab Maintenance Therapy

    Dylan Richards1, Marion Vetter1, Matthew Germinaro1, Bram Verstockt2, Raja Atreya3, Julián Panés4, Bruce E. Sands5, Brian G. Feagan6, Bradford McRae7, Daniel Cua1, Patrick Branigan1 and Tom C. Freeman1, 1Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 2Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, Leuven, Belgium, 3Department of Medicine I, Gastroenterology, Endocrinology and Pneumology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 4Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain, Barcelona, Spain, 5Icahn School of Medicine at Mount Sinai, New York, NY, USA, New York, NY, 6Alimentiv Inc, London, ON, Canada, London, ON, Canada, 7Janssen Research & Development, Cambridge, MA, USA, Cambridge, MA

    Background/Purpose: Combination induction therapy with guselkumab (GUS), an interleukin (IL)-23p19 subunit antagonist, and golimumab (GOL), a tumor necrosis factor (TNFα) antagonist, induced higher rates of…
  • Abstract Number: 2103 • ACR Convergence 2024

    Synovial Inflammation Is Increased in Females with Knee Osteoarthritis

    Caryn Hale1, Miguel Otero2, Dongmei Sun3, Michael Parides4, Edward Dicarlo5, dana Orange6, Yiyuan Wu7, William Robinson8, Bella Mehta5, Solana Cushing4, Peter Sculco4, Tristan Maerz9, Anne-Marie Malfait10, Daniel Ramirez11 and Aimee Colbath12, 1Memorial Sloan Kettering Cancer Center, New York, NY, 2Hospital for Special Surgery, NYC, 3Hospital for Special Surgery, Birmingham, AL, 4Hospital for Special Surgery, New York, NY, 5Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 6Rockefeller University, New York, NY, 7Weill Cornell Medicine, New York, NY, 8Division of Immunology and Rheumatology, Stanford University, and VA Palo Alto Health Care System, Stanford, CA, 9University of Michigan, Ann Arbor, MI, 10Rush University, New York, NY, 11Hospital for Special Surgery, Cartago, Costa Rica, 12Cornell University College of Veterinary Medicine, New York, NY

    Background/Purpose: Symptomatic knee osteoarthritis (OA) is more common in women than men. We sought to compare clinical and histological features and synovial gene expression between…
  • Abstract Number: 0711 • ACR Convergence 2024

    Molecular Signatures in the Skin as Predictors of Longitudinal Clinical Trajectories in Patients with Systemic Sclerosis

    Natania Field1, Monica Yang2, Niket Gupta1, Maxwell Shramuk1, Lutfiyya Muhammad1, Vivien Goh1, Monica Espinoza3, Yiwei Yuan3, Rezvan Parvizi3, Kathleen Aren4, Mary Carns4, Isaac Goldberg5, Lorinda Chung6, Dinesh Khanna7, Zsuzsanna McMahan8, Michael Whitfield3 and Monique Hinchcliff9, 1Northwestern Feinberg School of Medicine, Chicago, IL, 2UCSF, San Francisco, CA, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4Northwestern University Division of Rheumatology, Chicago, IL, 5Wayne State University School of Medicine, Detroit, MI, 6Stanford University, Woodside, CA, 7University of Michigan, Ann Arbor, MI, 8UTHealth Houston Division of Rheumatology, Houston, TX, 9Yale School of Medicine, Westport, CT

    Background/Purpose: It has become clear that classification by phenotype is insufficient to explain the heterogeneity in clinical progression for many rheumatic diseases. Systemic sclerosis (SSc)…
  • Abstract Number: 1458 • ACR Convergence 2024

    Synovial Transcriptomic Sex-Specific Differences in the Response to Biologics in Psoriatic Arthritis Patients

    Pauline KRUG1, angela De Sousa Leite2, Frédéric Lecouvet1, Maria Simona stoenoiu1 and Adrien Nzeusseu Toukap3, 1Cliniques universitaires St-Luc, Brussel, Belgium, 2Cliniques universitaires St-Luc, Brussels, Belgium, 3Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium

    Background/Purpose: Psoriatic arthritis (PsA) is a highly heterogeneous disease. The response to therapy is variable among patients (ref.). Therefore, we need a tailored approach. Biologic…
  • Abstract Number: 2200 • ACR Convergence 2024

    Whole Blood Transcriptome Profiling in Juvenile Systemic Sclerosis Patients Reveals Active Immune Upregulation and Enhanced Fibrotic Signature

    Rania Elbakri1, Amanda Robinson2, Anwesha Sanyal1 and Kathryn Torok3, 1University of Pittsburgh, pittsburgh, PA, 2University of Utah Health, Salt Lake City, UT, 3Division of Rheumatology, Scleroderma Center, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA

    Background/Purpose: Juvenile systemic sclerosis (jSSc) is a rare chronic autoimmune disorder characterized by skin thickening and multisystem organ involvement, leading to significant morbidity. The pathogenesis…
  • Abstract Number: 0759 • ACR Convergence 2024

    Macrophage-Lineage Cells in Giant Cell Arteritis Express MMP12, Phagocytosis and Osteoclast-associated Molecules That May Contribute to Destruction of the Tunica Media

    Makoto Sugihara1, Nobumasa Watanabe2, Yuichiro Hara2, Yasumasa Nishito3, Mai Kounoe4, Kazunari Sekiyama4, Eisuke Takamasu5, Naofumi Chinen6, Kota Shimada5 and Hideya Kawaji2, 1Department of Rheumatic Diseases, Tokyo Metropolitan Tama-Hokubu Medical Center, Tokyo, Japan, Higashimurayama-shi, Tokyo, Japan, 2Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 3Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 4Center for Medical Research Cooperation, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 5Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, Fuchu-shi, Tokyo, Japan, 6Department of Rheumatic Diseases, Tokyo Metropolitan Tama-Nambu Chiiki Hospital, Tokyo, Japan, Tama-shi, Tokyo, Japan

    Background/Purpose: Giant cell arteritis (GCA) is a large vessel vasculitis characterized by inflammatory cell infiltration and destruction of the tunica media. In this study, we…
  • Abstract Number: 1507 • ACR Convergence 2024

    To Develop a Method for Estimating Interferon Signatures in SLE from Routine Clinical Laboratory Tests

    Yoshinobu Koyama1, Yoshiharu Sato2, Yu Nakai1 and Moe Tokunaga3, 1Japanese Red Cross Okayama Hospital, Okayama, Japan, 2DNA Chip Research Inc., Tokyo, 3Japanese Red Cross Okayama Hospital, Okayama

    Background/Purpose: IFN signatures are known to play an important role in the pathogenesis of systemic autoimmune diseases such as SLE. Recently, therapeutic agents targeting IFN…
  • Abstract Number: 2316 • ACR Convergence 2024

    Gene Expression Profile Is Different Between Men and Women in Psoriatic Disease

    Pauline KRUG1, angela De Sousa Leite2, Frédéric Lecouvet1, Maria Simona stoenoiu1 and Adrien Nzeusseu Toukap3, 1Cliniques universitaires St-Luc, Brussel, Belgium, 2Cliniques universitaires St-Luc, Brussels, Belgium, 3Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium

    Background/Purpose: Psoriatic arthritis (PsA) is a highly heterogenous chronic inflammatory condition. Recent publications highlight differences between men and women in disease manifestation and response to…
  • Abstract Number: 0763 • ACR Convergence 2024

    Transcriptional Analysis of Both Normal and Abnormal TABs in Biopsy-proven GCA Reveals a Shared Gene Expression Profile Compared to Clinically Diverse Controls

    Ingrid Lindquist1, Dongseok Choi2, Suzanne Fei3, Kiana Vakil-Gilani4, Daniela Ghetie1, David Wilson5, Diva Salomao6, Hillary Stiefel7, Daniel Albert7, James Rosenbaum8 and Marcia Friedman1, 1OHSU, Division of Arthritis and Rheumatic Diseases, Portland, OR, 2OHSU, School of Public Halth, Portland, OR, 3OHSU, Oregon National Primate Research Center, Portland, OR, 4OHSU, Division of Arthritis and Rheumatic Diseases, Porltand, OR, 5OHSU, Casey Eye Institute, Porrtland, OR, 6Mayo Clinic, Division of Anatomic Pathology, Rochester, MN, 7OHSU, Casey Eye Institute, Portland, OR, 8Corvus Pharmaceuticals and Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: Giant cell arteritis (GCA) is the most common vasculitis in people over 50 years old and is a clinical diagnosis bolstered by pathologic findings on temporal…
  • Abstract Number: 1643 • ACR Convergence 2024

    Single Nuclei Multiome and Spatial Transcriptomic Analysis of Early, Untreated SSc Skin Identifies Signaling Interactions Between Macrophages and Fibroblasts

    Helen Jarnagin1, Dillon Popovich2, Rezvan Parvizi3, Rosemary Gedert4, Lam C. Tsoi5, Rachael Wasikowski5, Zhiyun Gong1, Madeline Morrisson6, Laurent Perreard7, Fred Kolling IV7, Dinesh Khanna4, Johann Gudjonsson4 and Michael Whitfield3, 1Dartmouth College, Lebanon, NH, 2Dartmouth College, West Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4University of Michigan, Ann Arbor, MI, 5Michigan, Dept. of Dermatology, Ann Arbor, MI, 6Geisel School of Medicine at Dartmouth College, Hanover, NH, 7Geisel School of Medicine, Dartmouth College, Lebanon

    Background/Purpose: We generated a vertically integrated dataset on treatment naïve patients with dcSSc (diffuse Systemic Sclerosis) skin that includes bulk RNA-seq, single nuclei multiome, and…
  • Abstract Number: 2385 • ACR Convergence 2024

    Increased Type I Interferon Inducible Genes Expression in the Peripheral Blood of Patients Presenting Cutaneous Lupus Erythematosus Manifestations

    Anastasia- Bilio Chronopoulou1, Maria Gerochristou2, Sylvia Raftopoulou3, Alexander Stratigos4 and Clio Mavragani5, 1National and Kapodistrian University of Athens, Athens, Greece, 2Andreas Syggros Hospital, National and Kapodistrian University of Athens, Athens, Greece, 3Molecular and Applied Physiology Unit, Department of Physiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece, 41st Department of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece, 5Department of Physiology and Pathophysiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece

    Background/Purpose: Cutaneous Lupus Erythematosus (CLE) is a chronic autoimmune skin disease characterized by a spectrum of cutaneous manifestations resulting from immune dysregulation and inflammation. While…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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