Abstracts tagged "fibrosis"

Abstract Number: 1719 • 2014 ACR/ARHP Annual Meeting
Periostin May Promote Productin of Extracellular Matrix By Modulating TGF-β Signaling in Human Skin Fibroblasts
Yukie Yamaguchi¹, Noriko Koumitsu¹, Kazuhiko Arima², Kenji Izuhara² and Michiko Aihara³, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, ³Department of Environmental-immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Systemic sclerosis (SSc) results in significant morbidity and mortality due to organ fibrosis characterized by increased deposition of extracellular matrix (ECM). Periostin is one…
Abstract Number: 965 • 2014 ACR/ARHP Annual Meeting
Blockade of TLR4 Signaling By TAK242 Ameliorates Experimental Organ Fibrosis
Swati Bhattacharyya¹, Wenxia Wang¹, Zenshiro Tamaki², Yasuhiro Tsukimi³, Masashi Yamasaki³ and John Varga⁴, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Takeda Pharmaceutical Company Limited, Kanagawa, Japan, ⁴Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Our recent studies implicate innate immune signaling through Toll like receptor 4 (TLR4) in scleroderma pathogenesis. Aberrant production and accumulation of the endogenous TLR4…
Abstract Number: 967 • 2014 ACR/ARHP Annual Meeting
Mir-145 Protects Against Skin Fibrosis in Vivo by targeting TGF-β Signaling
Serena Vettori^1,2, Christian Beyer³, Matthias Brock¹, Naoki Iwamoto¹, Britta Maurer¹, Michelle Trenkmann¹, Astrid Jüngel¹, Renate E. Gay¹, Maurizio Calcagni⁴, Gabriele Valentini⁵, Steffen Gay¹, Joerg H. W. Distler³ and Oliver Distler¹, ¹Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ²Internal and Experimental Medicine, Second University of Naples, Naples, Italy, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland, ⁵Internal and Experimental Medicine, Second University of Naples, Napoli, Italy
Background/Purpose In vitro, miR-145 exerts anti-fibrotic effects in systemic sclerosis (SSc) by downregulating TGF-β signaling. In turn, ectopic TGF-β downregulates miR-145 thereby optimizing TGF-β signaling…
Abstract Number: 877 • 2014 ACR/ARHP Annual Meeting
Sildenafil Attenuates the Fibrotic Phenotype in Scleroderma Skin Fibroblasts
Tomoaki Higuchi¹, Yasushi Kawaguchi¹, Kae Takagi¹, Akiko Tochimoto¹, Yuko Ota², Yasuhiro Katsumata¹, Takahisa Gono¹, Masanori Hanaoka¹, Yuko Okamoto¹, Hidenaga Kawasumi¹ and Hisashi Yamanaka³, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²10-22 Kawada-Cha Shinjuku-Ku, Tokyo Women's Medical University, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is a connective tissue disease characterized by inflammation, vasculopathy and fibrosis. Tissue fibrosis directly contributes to mortality or quality of life.…
Abstract Number: 770 • 2014 ACR/ARHP Annual Meeting
Detection of Proteins in Lung Tissues of Patients with Systemic Sclerosis Using Tissue Microarrays
Frank Schneider¹ and Carol A. Feghali-Bostwick², ¹Pathology, University of Pittsburgh, Pittsburghh, PA, ²Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Research on systemic sclerosis (SSc)-associated interstitial lung disease (ILD) has been hindered by the paucity of lung tissues, as SSc patients with lung involvement…
Abstract Number: 767 • 2014 ACR/ARHP Annual Meeting
The Impact of Plasmacytoid Dendiritc Cells (pDCs) on Fibrosis in bleomycin–induced Murine Model of Systemic Sclerosis (SSc)
Suzanne Kafaja¹, Isela Valera¹, Anagha Divekar², Daniel E. Furst³ and Ram Singh¹, ¹Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Biolegend, San Diego, CA, ³Medicine/ Rheumatology, University of California, Los Angeles, Department of Medicine, Los Angeles, CA
Background/Purpose Pathogenesis of systemic sclerosis (SSc) remains unclear. Alterations in adaptive and innate immune responses, with increased T-cells that produce type 2 cytokines and impaired…
Abstract Number: 763 • 2014 ACR/ARHP Annual Meeting
Caveolin-1 and Peroxisome Proliferator-Activated Receptor Gamma Co-Regulate the Differentiation of Monocytes to Adipocytes and Myofibroblasts in Vivo and in Vitro
Rebecca Lee¹, Charles Reese², Michael Bonner¹, Beth Perry³, Richard M. Silver⁴, Richard P. Visconti⁵, Stanley Hoffman³ and Elena Tourkina⁶, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ⁵Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁶Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Skin fibrosis in scleroderma is associated with the loss of subcutaneous adipose tissue (lipodystrophy). The mechanisms underlying lipodystrophy and its relationship to fibrosis are…

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