Abstracts tagged "fibrosis"

Abstract Number: 763 • 2014 ACR/ARHP Annual Meeting
Caveolin-1 and Peroxisome Proliferator-Activated Receptor Gamma Co-Regulate the Differentiation of Monocytes to Adipocytes and Myofibroblasts in Vivo and in Vitro
Rebecca Lee¹, Charles Reese², Michael Bonner¹, Beth Perry³, Richard M. Silver⁴, Richard P. Visconti⁵, Stanley Hoffman³ and Elena Tourkina⁶, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ⁵Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁶Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Skin fibrosis in scleroderma is associated with the loss of subcutaneous adipose tissue (lipodystrophy). The mechanisms underlying lipodystrophy and its relationship to fibrosis are…
Abstract Number: 759 • 2014 ACR/ARHP Annual Meeting
The Anti-Fibrotic Effect of Endostatin-Derived Peptide Is Mediated By Urokinase
Tetsuya Nishimoto¹, Takahisa Takihara², Yunyun Su³, Roger Chambers⁴, Logan Mlakar⁴ and Carol Feghali-Bostwick⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Tokai University School of Medicine, Kanagawa, Japan, ³Medicine, Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC
Background/Purpose: Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality as a result of organ fibrosis.…
Abstract Number: 752 • 2014 ACR/ARHP Annual Meeting
Potential Roles of Toll-like Receptor 4 in the Murine Models of Systemic Sclerosis
Takehiro Takahashi, Yoshihide Asano, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Shinji Noda, Kaname Akamata and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Bleomycin (BLM)-induced fibrosis model and tight skin mice (TSK/+) model are well-established experimental murine models of human systemic sclerosis (SSc). Growing evidence has demonstrated…
Abstract Number: 3005 • 2014 ACR/ARHP Annual Meeting
Essential Role for Alternately Spliced Tenascin C and TLR4 Signaling in Persistent Organ Fibrosis
Swati Bhattacharyya^1,2, Wenxia Wang¹, Luisa Morales-Nebreda³, Katja Lakota³, Robert Lafyatis⁴, Monique E. Hinchcliff⁵, GR Scott Budinger³, Zenshiro Tamaki³ and John Varga⁶, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Transforming growth factor-beta stimulates collagen synthesis and myofibroblast differentiation, and is implicated as a key initiating factor in pathological tissue remodeling in scleroderma. However,…
Abstract Number: 1731 • 2014 ACR/ARHP Annual Meeting
Translocation of IGFBP-5 to the Nucleus and Its Interaction with Nucleolin Do Not Dictate Its Fibrotic Effects
Yunyun Su¹ and Carol Feghali-Bostwick², ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC
Background/Purpose: Insulin-like growth factor binding protein (IGFBP)-5 is one of six IGFBPs. IGFBP-5 is the most conserved member of the family. IGFBP-5 levels are increased…
Abstract Number: 1727 • 2014 ACR/ARHP Annual Meeting
Poly(ADP-ribose) Polymerase-1 (PARP-1) Suppresses the Profibrotic Effects of Transforming Growth Factor â in Systemic Sclerosis
Yun Zhang, University Hospital Of Erlangen, Erlangen, Germany
Background/Purpose The enzyme poly(ADP-ribose) polymerase-1 (PARP-1) transfers negatively charged ADP-ribose units from the donor β-NAD onto various substrate proteins either as mono- or oligomeric moieties…
Abstract Number: 1726 • 2014 ACR/ARHP Annual Meeting
Therapeutic Efficacy of Mesenchymal Stem Cells in Diffuse Murine Hypochlorite-Induced Systemic Sclerosis
Alexandre Maria¹, Claire Bony², Karine Toupet², Christian Jorgensen³, Philippe Guilpain⁴ and Daniele Noel⁵, ¹U844, Inserm, Montpellier, France, ²Inserm, Montpellier, France, ³Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Lapeyronie., Montpellier, France, ⁴Department of Internal Medicine, Montpellier, France, ⁵Inserm U844, UM1, Montpellier, France
Background/Purpose Systemic sclerosis (SSc) is a rare intractable disease with unmet medical need and fibrosis-related mortality. Absence of efficient treatments has prompted to develop novel…

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