Abstracts tagged "fibrosis"

Abstract Number: 1907 • 2015 ACR/ARHP Annual Meeting
Inhibition of Phosphodiesterase 4 (PDE4) Reduces Dermal Fibrosis By Interfering with the Release of Pro-Fibrotic Cytokines from M2-Macrophages
Christiane Maier, Christian Beyer, Jeorg HW Distler and Georg Schett, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: PDE4 catalyses the breakdown of the second messengers cAMP and cGMP to modulate intracellular effects. PDE4 is mainly expressed in inflammatory cells, and its…
Abstract Number: 1918 • 2015 ACR/ARHP Annual Meeting
Pharmacologic Targeting of Mitochondrial Dysfunction in Systemic Sclerosis: Enhanced SIRT3 Signaling
Kaname Akamata¹, Mitra Bhattacharyya¹, Mahesh Gupta², Jack Arbiser³, David Kamp⁴, Jun Wei¹ and John Varga¹, ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²University of Chicago, Departments of Surgery, Chicago, IL, ³Department of Dermatology, Emory University School of Medicine Winship Cancer Institute Atlanta Veterans Administration Health Center, Atlanta, GA, ⁴Department of Medicine, Division of Pulmonary & Critical Care Medicine, Jesse Brown VA Medical Center and Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Recent evidences suggest that cytosolic and mitochondrial reactive oxygen species (ROS), play pivotal roles in modulating TGF-β-induced profibrotic responses and are implicated in pathogenesis…
Abstract Number: 1919 • 2015 ACR/ARHP Annual Meeting
Genetic Deletion of Toll-like Receptor 4 (Tlr4) Abrogates TGF-β1-Induced Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells
Peter J. Wermuth¹ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology whose pathogenesis involves the regulation of a diverse range of molecular pathways. The…
Abstract Number: 1925 • 2015 ACR/ARHP Annual Meeting
Interleukin-35 Is Upregulated in Systemic Sclerosis and Its Serum Levels Are Increased in Early Disease
Michal Tomcík¹, Pawel Zerr², Katrin Palumbo-Zerr², Hana Storkanova¹, Hana Hulejova³, Maja Spiritovic⁴, Ondrej Kodet⁵, Jiri Stork⁵, Radim Becvar¹, Jiri Vencovsky¹, Karel Pavelka⁶, Maria Filkova⁷, Jorg HW Distler² and Ladislav Senolt⁸, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ⁴Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, ⁵Department of Dermatology and Venereology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁶Charles University, Prague, Czech Republic, ⁷Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁸Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Interleukin-35 (IL-35) is the most recent addition to the IL-12 family, which also comprises IL-12, IL-23 and IL-27. IL-35 consists of two chains, p35/IL-12a…
Abstract Number: 1926 • 2015 ACR/ARHP Annual Meeting
Wnt5a Activates Wnt/PCP-Signaling to Promote Fibroblast Activation and Fibrosis
Chih-Wei Chen¹, Neng-Yu Lin¹, Yun Zhang¹, Jingang Huang¹, Katrin Palumbo-Zerr¹, Alexandra Schambony², Christian Beyer¹, Georg Schett¹ and Jeorg HW Distler¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Biology, Development Biology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: While canonical Wnt/beta-catenin signaling has been identified as a core pathway of fibrosis in SSc, non-canonical Wnt signaling pathways have not yet been analyzed.…
Abstract Number: 1927 • 2015 ACR/ARHP Annual Meeting
Salinomycin Induces Potent Suppression of TGF-β1-Mediated Expression of Profibrotic Genes in Cultured Dermal Fibroblasts from Normal Donors and from Donors with Systemic Sclerosis (SSc): A Novel Anti-Fibrotic Treatment for Tissue Fibrosis in SSc
Peter J. Wermuth¹ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Activated myofibroblasts are the primary mediators of the excessive synthesis and deposition of collagens and other extracellular matrix (ECM) macromolecules during the pathogenesis of…
Abstract Number: 2150 • 2015 ACR/ARHP Annual Meeting
Treatment with Abatacept Prevents Experimental Dermal Fibrosis and Induces Regression of Established Inflammation-Driven Fibrosis
Matthieu Ponsoye¹, Camelia Frantz², Nadira Ruzehaji³, Muriel Elhai⁴, Barbara Ruiz¹, Anne Cauvet¹, Yannick Allanore⁵ and Jerome Avouac⁴, ¹INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ²Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ³INSERM U1016, Paris Descartes University, Paris, France, ⁴Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, And Eular Scleroderma Trials And Research (EUSTAR) Board, Paris, France
Background/Purpose: Early stages of systemic sclerosis (SSc) are characterized by inflammatory skin infiltrates mainly composed of activated T cells. Cytotoxic T-lymphocyte associated molecule-4 (CTLA-4) is…
Abstract Number: 2152 • 2015 ACR/ARHP Annual Meeting
Long Noncoding H19X Is a Key Mediator of Tgf-Beta Induced Pro-Fibrotic Effects in the Pathogenesis of Systemic Sclerosis and Other Fibrotic Diseases
Elena Pachera¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj³, Rucsandra Dobrota⁴, Matthias Brock⁵, Serena Vettori⁶, Claus Hellerbrand⁷, Carol A. Feghali-Bostwick⁸, Jeorg HW Distler⁹, Gabriela Kania¹⁰ and Oliver Distler¹¹, ¹Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, Schileren, Switzerland, ²Rheumatology, University of Texas Medical School at Houston, Houston, TX, ³Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ⁴Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Pulmonology, University Hospital Zurich, Schileren, Switzerland, ⁶Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁷Department of Internal Medicine I, University of Regensburg, Regensburg, Germany, ⁸Medicine, University of Pittsburgh, Pittsburgh, PA, ⁹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ¹¹Division of Rheumatology, University Hospital And Eular Scleroderma Trials And Research (EUSTAR) Board, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (LncRNAs) are emerging as a novel class of noncoding transcripts involved in the regulation of gene expression. So far, for only…
Abstract Number: 759 • 2014 ACR/ARHP Annual Meeting
The Anti-Fibrotic Effect of Endostatin-Derived Peptide Is Mediated By Urokinase
Tetsuya Nishimoto¹, Takahisa Takihara², Yunyun Su³, Roger Chambers⁴, Logan Mlakar⁴ and Carol Feghali-Bostwick⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Tokai University School of Medicine, Kanagawa, Japan, ³Medicine, Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC
Background/Purpose: Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality as a result of organ fibrosis.…
Abstract Number: 752 • 2014 ACR/ARHP Annual Meeting
Potential Roles of Toll-like Receptor 4 in the Murine Models of Systemic Sclerosis
Takehiro Takahashi, Yoshihide Asano, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Shinji Noda, Kaname Akamata and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Bleomycin (BLM)-induced fibrosis model and tight skin mice (TSK/+) model are well-established experimental murine models of human systemic sclerosis (SSc). Growing evidence has demonstrated…
Abstract Number: 3005 • 2014 ACR/ARHP Annual Meeting
Essential Role for Alternately Spliced Tenascin C and TLR4 Signaling in Persistent Organ Fibrosis
Swati Bhattacharyya^1,2, Wenxia Wang¹, Luisa Morales-Nebreda³, Katja Lakota³, Robert Lafyatis⁴, Monique E. Hinchcliff⁵, GR Scott Budinger³, Zenshiro Tamaki³ and John Varga⁶, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Transforming growth factor-beta stimulates collagen synthesis and myofibroblast differentiation, and is implicated as a key initiating factor in pathological tissue remodeling in scleroderma. However,…
Abstract Number: 1731 • 2014 ACR/ARHP Annual Meeting
Translocation of IGFBP-5 to the Nucleus and Its Interaction with Nucleolin Do Not Dictate Its Fibrotic Effects
Yunyun Su¹ and Carol Feghali-Bostwick², ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC
Background/Purpose: Insulin-like growth factor binding protein (IGFBP)-5 is one of six IGFBPs. IGFBP-5 is the most conserved member of the family. IGFBP-5 levels are increased…
Abstract Number: 1727 • 2014 ACR/ARHP Annual Meeting
Poly(ADP-ribose) Polymerase-1 (PARP-1) Suppresses the Profibrotic Effects of Transforming Growth Factor â in Systemic Sclerosis
Yun Zhang, University Hospital Of Erlangen, Erlangen, Germany
Background/Purpose The enzyme poly(ADP-ribose) polymerase-1 (PARP-1) transfers negatively charged ADP-ribose units from the donor β-NAD onto various substrate proteins either as mono- or oligomeric moieties…
Abstract Number: 1726 • 2014 ACR/ARHP Annual Meeting
Therapeutic Efficacy of Mesenchymal Stem Cells in Diffuse Murine Hypochlorite-Induced Systemic Sclerosis
Alexandre Maria¹, Claire Bony², Karine Toupet², Christian Jorgensen³, Philippe Guilpain⁴ and Daniele Noel⁵, ¹U844, Inserm, Montpellier, France, ²Inserm, Montpellier, France, ³Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Lapeyronie., Montpellier, France, ⁴Department of Internal Medicine, Montpellier, France, ⁵Inserm U844, UM1, Montpellier, France
Background/Purpose Systemic sclerosis (SSc) is a rare intractable disease with unmet medical need and fibrosis-related mortality. Absence of efficient treatments has prompted to develop novel…
Abstract Number: 1722 • 2014 ACR/ARHP Annual Meeting
TLR4 and TLR7 Are Required for Gadolinium Based Contrast Agent Induction of Dermal and Pulmonary Fibrosis in an Adenine-Induced Model of Chronic Renal Failure
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose : Nephrogenic Systemic Fibrosis (NSF) is a generalized progressive fibrotic disorder that occurs in some patients with renal insufficiency exposed to various gadolinium based…

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