Abstracts tagged "fibrosis"

Abstract Number: 2704 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Psoriasis
Vishal Deshmukh¹, Melinda Pedraza¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, Timothy Seo¹, Benoit Melchior¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Psoriasis is an auto-immune disease of the skin, characterized by inflammation and fibrosis producing patches of red, itchy and scaly skin. Wnt signaling plays…
Abstract Number: 1926 • 2015 ACR/ARHP Annual Meeting
Wnt5a Activates Wnt/PCP-Signaling to Promote Fibroblast Activation and Fibrosis
Chih-Wei Chen¹, Neng-Yu Lin¹, Yun Zhang¹, Jingang Huang¹, Katrin Palumbo-Zerr¹, Alexandra Schambony², Christian Beyer¹, Georg Schett¹ and Jeorg HW Distler¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Biology, Development Biology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: While canonical Wnt/beta-catenin signaling has been identified as a core pathway of fibrosis in SSc, non-canonical Wnt signaling pathways have not yet been analyzed.…
Abstract Number: 1927 • 2015 ACR/ARHP Annual Meeting
Salinomycin Induces Potent Suppression of TGF-β1-Mediated Expression of Profibrotic Genes in Cultured Dermal Fibroblasts from Normal Donors and from Donors with Systemic Sclerosis (SSc): A Novel Anti-Fibrotic Treatment for Tissue Fibrosis in SSc
Peter J. Wermuth¹ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Activated myofibroblasts are the primary mediators of the excessive synthesis and deposition of collagens and other extracellular matrix (ECM) macromolecules during the pathogenesis of…
Abstract Number: 2150 • 2015 ACR/ARHP Annual Meeting
Treatment with Abatacept Prevents Experimental Dermal Fibrosis and Induces Regression of Established Inflammation-Driven Fibrosis
Matthieu Ponsoye¹, Camelia Frantz², Nadira Ruzehaji³, Muriel Elhai⁴, Barbara Ruiz¹, Anne Cauvet¹, Yannick Allanore⁵ and Jerome Avouac⁴, ¹INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ²Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ³INSERM U1016, Paris Descartes University, Paris, France, ⁴Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, And Eular Scleroderma Trials And Research (EUSTAR) Board, Paris, France
Background/Purpose: Early stages of systemic sclerosis (SSc) are characterized by inflammatory skin infiltrates mainly composed of activated T cells. Cytotoxic T-lymphocyte associated molecule-4 (CTLA-4) is…
Abstract Number: 2152 • 2015 ACR/ARHP Annual Meeting
Long Noncoding H19X Is a Key Mediator of Tgf-Beta Induced Pro-Fibrotic Effects in the Pathogenesis of Systemic Sclerosis and Other Fibrotic Diseases
Elena Pachera¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj³, Rucsandra Dobrota⁴, Matthias Brock⁵, Serena Vettori⁶, Claus Hellerbrand⁷, Carol A. Feghali-Bostwick⁸, Jeorg HW Distler⁹, Gabriela Kania¹⁰ and Oliver Distler¹¹, ¹Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, Schileren, Switzerland, ²Rheumatology, University of Texas Medical School at Houston, Houston, TX, ³Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ⁴Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Pulmonology, University Hospital Zurich, Schileren, Switzerland, ⁶Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁷Department of Internal Medicine I, University of Regensburg, Regensburg, Germany, ⁸Medicine, University of Pittsburgh, Pittsburgh, PA, ⁹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ¹¹Division of Rheumatology, University Hospital And Eular Scleroderma Trials And Research (EUSTAR) Board, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (LncRNAs) are emerging as a novel class of noncoding transcripts involved in the regulation of gene expression. So far, for only…
Abstract Number: 2154 • 2015 ACR/ARHP Annual Meeting
Inhibition of Gli Ameliorates the Pro-Fibrotic Effects of Transforming Growth Factor-Î² in Systemic Sclerosis
Ruifang Liang¹, Clara Dees², Katrin Palumbo-Zerr³, Yun Zhang³, Oliver Distler⁴, Georg Schett³ and Jeorg HW Distler³, ¹Rheumatology and Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Division of Rheumatology, University Hospital And Eular Scleroderma Trials And Research (EUSTAR) Board, Zurich, Switzerland
Background/Purpose: Hedgehog signaling plays a critical role in the pathogenesis of fibrosis in Systemic sclerosis (SSc). Besides canonical hedgehog signaling with Smoothened (Smo)-dependent activation of…
Abstract Number: 2155 • 2015 ACR/ARHP Annual Meeting
Inhibition of Sphingosine-1-Phosphate Signaling By AB22 As a Novel Strategy in the Treatment of Pulmonary Fibrosis Associated with Scleroderma
Ilia Atanelishvili¹, Yuichiro Shirai², Tanjina Akter³, Erik Stolarzewicz⁴, Rolf E Swenson⁵, Richard Silver⁶ and Galina S. Bogatkevich⁷, ¹Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ²Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, ³Medical University of South Carolina, charleston, SC, ⁴Chem-Master International Inc, Stony Brook, NY, ⁵Arroyo BioSciences, Silver Spring, MD, ⁶Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Activation of sphingosine-1-phosphate (S1P) signaling has been extensively documented in various fibrotic conditions including pulmonary fibrosis. The aim of this study was to provide…
Abstract Number: 190 • 2015 ACR/ARHP Annual Meeting
Ultrasound Imaging with Elastography for the Medical Treatment of Dupuytren’s Contracture
Paul John DeMarco¹, Alan K. Matsumoto¹, Nicole Thomas², Megan Bishop¹, Andrew Gregory DeMarco³, Guada Respicio¹, Ashley Beall¹, Robert Rosenberg¹, Theresa Bass-Goldman¹ and Herbert S. B. Baraf¹, ¹The Center for Rheumatology and Bone Research, Wheaton, MD, ²Rheumatology, Georgetown University Hospital, Washington DC, DC, ³Duquesne University, Pittsburgh, PA
Background/Purpose: Dupuytren’s contracture is a rheumatic disease characterized by an fibrotic reaction in the palmar aponeurosis, resulting in disability. Medical treatment with up to 3…
Abstract Number: 2984 • 2015 ACR/ARHP Annual Meeting
Scleroderma Bronchoalveolar Lavage Fluid Thrombin Activity: Correlation with Pulmonary Function
Merrideth Ashley Morris¹, Tanjina Akter², Paul Nietert³, Galina S. Bogatkevich² and Richard Silver⁴, ¹Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Division of Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Multiple lines of evidence identify thrombin as an important mediator of lung fibrosis in systemic sclerosis (SSc). In addition to demonstrating dramatically high levels…
Abstract Number: 832 • 2015 ACR/ARHP Annual Meeting
The Validity and Reliability of Online Obituaries As a Source of Mortality Data
Medha Soowamber¹, John T. Granton², Fatemeh Bavaghar-Zaeimi³ and Sindhu R. Johnson^4,5, ¹Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, ²Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, Toronto Scleroderma Program, Toronto Western Hospital and Mount Sinai Hospital, Toronto, ON, Canada, ⁴Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ⁵Institute of Health Policy, Management and Evaluation,, University of Toronto, Toronto, ON, Canada
Background/Purpose: Loss to follow-up is a major threat to the conduct of chronic disease cohort research. Tracking the survival status of patients who are lost…
Abstract Number: 3000 • 2015 ACR/ARHP Annual Meeting
Intrinsic Gene Expression Subset Predicts Improvement in Systemic Sclerosis Patients during Dasatinib (SprycelTM) Therapy
Viktor Martyanov¹, Jonathan Goldin², Kim Hyun³, Oumar Sy⁴, Wendy Hayes⁴, Shuyan Du⁴, Michael Whitfield¹ and John Varga⁵, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, ³Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, ⁴Bristol-Myers Squibb, Princeton, NJ, ⁵Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: Intrinsic gene expression subsets are molecular pathway-driven subtypes of systemic sclerosis (SSc) that have been reproduced across multiple cohorts of SSc patients. The goal…
Abstract Number: 1365 • 2015 ACR/ARHP Annual Meeting
Innate Lymphoid Cells. New Players in Systemic Sclerosis Correlate with Extent of Skin and Lung Fibrosis
Thomas Wohlfahrt¹, Stefanie Weber¹, Matthias Englbrecht², Clara Dees³, Christian Beyer³, Oliver Distler⁴, Georg Schett¹, Jorg HW Distler^1,3 and Andreas Ramming¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Research of Systemic Autoimmune Diseases, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Type 2 innate lymphoid cells (ILC2s), are recently identified as population of cells with lymphoid morphology lacking re-arranged antigen-specific receptors. Although findings in animal…
Abstract Number: 3008 • 2015 ACR/ARHP Annual Meeting
Role of PTP4A1 Tyrosine Phosphatase in Systemic Sclerosis
Cristiano Sacchetti¹, Stephanie Stanford², Yunpeng Bai³, Zhong-Yin Zhang⁴, Amin Gholami⁵, Gregory Seumois⁶, Maria Piera-Velazquez⁷, Sergio A. Jimenez⁸ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Indiana University, School of Medicine, Indianapolis, IN, ⁴Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, ⁵Bioinformatics Core, La Jolla Institute for Allergy and immunology, La Jolla, CA, ⁶Sequencing Facility, La Jolla Institute for Allergy and immunology, La Jolla, CA, ⁷Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA, ⁸Div Connective Tissue Diseases, Thomas Jefferson Univ, Philadelphia, PA
Background/Purpose: Systemic sclerosis (SSc) is a multi-system autoimmune connective tissue disorder that leads to fibrosis of the skin and internal organs, resulting in significant patient…
Abstract Number: 1886 • 2015 ACR/ARHP Annual Meeting
Myocardial Fibrosis Detected By Magnetic Resonance Imaging Is a Predictor of Heart Failure in Systemic Sclerosis (SSc) Patients
Tatiana Sofia Rodriguez-Reyna¹, Martha Morelos-Guzmán², Pamela Mercado Velazquez³, Pablo Henrandez-Reyes⁴, Karla Montero-Duarte⁵, Cynthia Martinez-Reyes⁶, Carlos Reyes-Utrera⁶ and Carlos Nunez Alvarez³, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Radiology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ³Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Mexico, ⁴Department of Cardiology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Department of Imaging and Radiology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁶Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Background/Purpose: In previous studies we showed that prevalence of myocardial fibrosis in SSc patients is 45% and is associated to diffuse disease (dcSSc) and lower…
Abstract Number: 3010 • 2015 ACR/ARHP Annual Meeting
Estrogens Inhibit the Profibrotic Effects of Transforming Growth Factor-Beta and Protect from the Development of Experimental Dermal Fibrosis
Jerome Avouac¹, Léa Baudoin², Anne Cauvet², Barbara Ruiz² and Yannick Allanore³, ¹Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ²INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ³Paris Descartes University, Rheumatology A department, Cochin Hospital, And Eular Scleroderma Trials And Research (EUSTAR) Board, Paris, France
Background/Purpose: Systemic sclerosis (SSc) primarily affects postmenopausal women. This sex bias could partly be explained by the action of estrogens on the immune system and/or…

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