Abstracts tagged "fibrosis"

Abstract Number: 2071 • 2016 ACR/ARHP Annual Meeting
Expression of Neuraminidase 1 (NEU1) Is Upregulated in the Lungs of Scleroderma Patients with Pulmonary Fibrosis, and Gene Delivery of NEU1 to Mouse Lungs Elicits Accumulation of CD8+ Lymphocytes and Collagen
Irina G. Luzina^1,2, Anne E. Wyman^1,2, Virginia Lockatell², Zahid Noor², Nevins W. Todd^1,2, Simeon E. Goldblum^1,2 and Sergei P. Atamas^1,2, ¹Baltimore VA Medical Center, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: We and others have previously reported that pulmonary fibrosis in patients with scleroderma is accompanied by pulmonary accumulation of predominantly CD8+ T lymphocytes. Earlier…
Abstract Number: 1907 • 2015 ACR/ARHP Annual Meeting
Inhibition of Phosphodiesterase 4 (PDE4) Reduces Dermal Fibrosis By Interfering with the Release of Pro-Fibrotic Cytokines from M2-Macrophages
Christiane Maier, Christian Beyer, Jeorg HW Distler and Georg Schett, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: PDE4 catalyses the breakdown of the second messengers cAMP and cGMP to modulate intracellular effects. PDE4 is mainly expressed in inflammatory cells, and its…
Abstract Number: 1918 • 2015 ACR/ARHP Annual Meeting
Pharmacologic Targeting of Mitochondrial Dysfunction in Systemic Sclerosis: Enhanced SIRT3 Signaling
Kaname Akamata¹, Mitra Bhattacharyya¹, Mahesh Gupta², Jack Arbiser³, David Kamp⁴, Jun Wei¹ and John Varga¹, ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²University of Chicago, Departments of Surgery, Chicago, IL, ³Department of Dermatology, Emory University School of Medicine Winship Cancer Institute Atlanta Veterans Administration Health Center, Atlanta, GA, ⁴Department of Medicine, Division of Pulmonary & Critical Care Medicine, Jesse Brown VA Medical Center and Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Recent evidences suggest that cytosolic and mitochondrial reactive oxygen species (ROS), play pivotal roles in modulating TGF-β-induced profibrotic responses and are implicated in pathogenesis…
Abstract Number: 1919 • 2015 ACR/ARHP Annual Meeting
Genetic Deletion of Toll-like Receptor 4 (Tlr4) Abrogates TGF-β1-Induced Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells
Peter J. Wermuth¹ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology whose pathogenesis involves the regulation of a diverse range of molecular pathways. The…
Abstract Number: 1925 • 2015 ACR/ARHP Annual Meeting
Interleukin-35 Is Upregulated in Systemic Sclerosis and Its Serum Levels Are Increased in Early Disease
Michal Tomcík¹, Pawel Zerr², Katrin Palumbo-Zerr², Hana Storkanova¹, Hana Hulejova³, Maja Spiritovic⁴, Ondrej Kodet⁵, Jiri Stork⁵, Radim Becvar¹, Jiri Vencovsky¹, Karel Pavelka⁶, Maria Filkova⁷, Jorg HW Distler² and Ladislav Senolt⁸, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ⁴Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, ⁵Department of Dermatology and Venereology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁶Charles University, Prague, Czech Republic, ⁷Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁸Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Interleukin-35 (IL-35) is the most recent addition to the IL-12 family, which also comprises IL-12, IL-23 and IL-27. IL-35 consists of two chains, p35/IL-12a…
Abstract Number: 1926 • 2015 ACR/ARHP Annual Meeting
Wnt5a Activates Wnt/PCP-Signaling to Promote Fibroblast Activation and Fibrosis
Chih-Wei Chen¹, Neng-Yu Lin¹, Yun Zhang¹, Jingang Huang¹, Katrin Palumbo-Zerr¹, Alexandra Schambony², Christian Beyer¹, Georg Schett¹ and Jeorg HW Distler¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Biology, Development Biology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: While canonical Wnt/beta-catenin signaling has been identified as a core pathway of fibrosis in SSc, non-canonical Wnt signaling pathways have not yet been analyzed.…
Abstract Number: 1927 • 2015 ACR/ARHP Annual Meeting
Salinomycin Induces Potent Suppression of TGF-β1-Mediated Expression of Profibrotic Genes in Cultured Dermal Fibroblasts from Normal Donors and from Donors with Systemic Sclerosis (SSc): A Novel Anti-Fibrotic Treatment for Tissue Fibrosis in SSc
Peter J. Wermuth¹ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Activated myofibroblasts are the primary mediators of the excessive synthesis and deposition of collagens and other extracellular matrix (ECM) macromolecules during the pathogenesis of…
Abstract Number: 2150 • 2015 ACR/ARHP Annual Meeting
Treatment with Abatacept Prevents Experimental Dermal Fibrosis and Induces Regression of Established Inflammation-Driven Fibrosis
Matthieu Ponsoye¹, Camelia Frantz², Nadira Ruzehaji³, Muriel Elhai⁴, Barbara Ruiz¹, Anne Cauvet¹, Yannick Allanore⁵ and Jerome Avouac⁴, ¹INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ²Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ³INSERM U1016, Paris Descartes University, Paris, France, ⁴Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, And Eular Scleroderma Trials And Research (EUSTAR) Board, Paris, France
Background/Purpose: Early stages of systemic sclerosis (SSc) are characterized by inflammatory skin infiltrates mainly composed of activated T cells. Cytotoxic T-lymphocyte associated molecule-4 (CTLA-4) is…
Abstract Number: 2152 • 2015 ACR/ARHP Annual Meeting
Long Noncoding H19X Is a Key Mediator of Tgf-Beta Induced Pro-Fibrotic Effects in the Pathogenesis of Systemic Sclerosis and Other Fibrotic Diseases
Elena Pachera¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj³, Rucsandra Dobrota⁴, Matthias Brock⁵, Serena Vettori⁶, Claus Hellerbrand⁷, Carol A. Feghali-Bostwick⁸, Jeorg HW Distler⁹, Gabriela Kania¹⁰ and Oliver Distler¹¹, ¹Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, Schileren, Switzerland, ²Rheumatology, University of Texas Medical School at Houston, Houston, TX, ³Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ⁴Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Pulmonology, University Hospital Zurich, Schileren, Switzerland, ⁶Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁷Department of Internal Medicine I, University of Regensburg, Regensburg, Germany, ⁸Medicine, University of Pittsburgh, Pittsburgh, PA, ⁹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ¹¹Division of Rheumatology, University Hospital And Eular Scleroderma Trials And Research (EUSTAR) Board, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (LncRNAs) are emerging as a novel class of noncoding transcripts involved in the regulation of gene expression. So far, for only…
Abstract Number: 2154 • 2015 ACR/ARHP Annual Meeting
Inhibition of Gli Ameliorates the Pro-Fibrotic Effects of Transforming Growth Factor-Î² in Systemic Sclerosis
Ruifang Liang¹, Clara Dees², Katrin Palumbo-Zerr³, Yun Zhang³, Oliver Distler⁴, Georg Schett³ and Jeorg HW Distler³, ¹Rheumatology and Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Division of Rheumatology, University Hospital And Eular Scleroderma Trials And Research (EUSTAR) Board, Zurich, Switzerland
Background/Purpose: Hedgehog signaling plays a critical role in the pathogenesis of fibrosis in Systemic sclerosis (SSc). Besides canonical hedgehog signaling with Smoothened (Smo)-dependent activation of…
Abstract Number: 2155 • 2015 ACR/ARHP Annual Meeting
Inhibition of Sphingosine-1-Phosphate Signaling By AB22 As a Novel Strategy in the Treatment of Pulmonary Fibrosis Associated with Scleroderma
Ilia Atanelishvili¹, Yuichiro Shirai², Tanjina Akter³, Erik Stolarzewicz⁴, Rolf E Swenson⁵, Richard Silver⁶ and Galina S. Bogatkevich⁷, ¹Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ²Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, ³Medical University of South Carolina, charleston, SC, ⁴Chem-Master International Inc, Stony Brook, NY, ⁵Arroyo BioSciences, Silver Spring, MD, ⁶Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Activation of sphingosine-1-phosphate (S1P) signaling has been extensively documented in various fibrotic conditions including pulmonary fibrosis. The aim of this study was to provide…
Abstract Number: 190 • 2015 ACR/ARHP Annual Meeting
Ultrasound Imaging with Elastography for the Medical Treatment of Dupuytren’s Contracture
Paul John DeMarco¹, Alan K. Matsumoto¹, Nicole Thomas², Megan Bishop¹, Andrew Gregory DeMarco³, Guada Respicio¹, Ashley Beall¹, Robert Rosenberg¹, Theresa Bass-Goldman¹ and Herbert S. B. Baraf¹, ¹The Center for Rheumatology and Bone Research, Wheaton, MD, ²Rheumatology, Georgetown University Hospital, Washington DC, DC, ³Duquesne University, Pittsburgh, PA
Background/Purpose: Dupuytren’s contracture is a rheumatic disease characterized by an fibrotic reaction in the palmar aponeurosis, resulting in disability. Medical treatment with up to 3…
Abstract Number: 2984 • 2015 ACR/ARHP Annual Meeting
Scleroderma Bronchoalveolar Lavage Fluid Thrombin Activity: Correlation with Pulmonary Function
Merrideth Ashley Morris¹, Tanjina Akter², Paul Nietert³, Galina S. Bogatkevich² and Richard Silver⁴, ¹Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Division of Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Multiple lines of evidence identify thrombin as an important mediator of lung fibrosis in systemic sclerosis (SSc). In addition to demonstrating dramatically high levels…
Abstract Number: 832 • 2015 ACR/ARHP Annual Meeting
The Validity and Reliability of Online Obituaries As a Source of Mortality Data
Medha Soowamber¹, John T. Granton², Fatemeh Bavaghar-Zaeimi³ and Sindhu R. Johnson^4,5, ¹Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, ²Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, Toronto Scleroderma Program, Toronto Western Hospital and Mount Sinai Hospital, Toronto, ON, Canada, ⁴Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ⁵Institute of Health Policy, Management and Evaluation,, University of Toronto, Toronto, ON, Canada
Background/Purpose: Loss to follow-up is a major threat to the conduct of chronic disease cohort research. Tracking the survival status of patients who are lost…
Abstract Number: 3000 • 2015 ACR/ARHP Annual Meeting
Intrinsic Gene Expression Subset Predicts Improvement in Systemic Sclerosis Patients during Dasatinib (SprycelTM) Therapy
Viktor Martyanov¹, Jonathan Goldin², Kim Hyun³, Oumar Sy⁴, Wendy Hayes⁴, Shuyan Du⁴, Michael Whitfield¹ and John Varga⁵, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, ³Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, ⁴Bristol-Myers Squibb, Princeton, NJ, ⁵Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: Intrinsic gene expression subsets are molecular pathway-driven subtypes of systemic sclerosis (SSc) that have been reproduced across multiple cohorts of SSc patients. The goal…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].