Abstracts tagged "fibrosis and systemic sclerosis"

Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting
Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis
Roberta Goncalves Marangoni¹, Benjamin Korman², Feng Fang¹, Monique Hinchcliff¹, Laszlo Otvos³, Philipp E. Scherer⁴, Warren Tourtellotte⁵ and John Varga⁶, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Temple University, Philadelphia, PA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Department of Pathology, Ward, Northwestern University, Chicago, IL, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
Abstract Number: 1857 • 2016 ACR/ARHP Annual Meeting
A Novel Highly Selective 5-Hydroxytryptamine 2B (5-HT2B) Receptor Antagonist Ameliorating Fibrosis in Preclinical Models of Systemic Sclerosis
Christina Wenglén¹, Lars Pettersson², Helena Arozenius² and Gunilla Ekström¹, ¹R&D, AnaMar AB, Lund, Sweden, ²AnaMar AB, Lund, Sweden
Background/Purpose: Methods: Results: Conclusion: The results demonstrate that the 5-HT2B receptor antagonist AM1125 prevents pro-fibrotic events in human dermal fibroblasts and attenuates…
Abstract Number: 2070 • 2016 ACR/ARHP Annual Meeting
Long Noncoding RNA H19X Is a Master Regulator of Extracellular Matrix Production in Systemic Sclerosis and Other Fibrotic Disease
Elena Pachera¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj¹, Rucsandra Dobrota¹, Matthias Brock³, Fina Kurreeman⁴, Jeska K. de Vries-Bouwstra⁴, Tobias Messemaker⁴, Carol Feghali-Bostwick⁵, Jeorg HW Distler⁶, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ³Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁶Internal Medicine 3, University of Erlangen, Erlangen, Germany
Background/Purpose: Long noncoding RNAs (lncRNAs) are an emerging class of large noncoding transcripts involved in the regulation of gene expression in health and disease. We…
Abstract Number: 3173 • 2016 ACR/ARHP Annual Meeting
Pan-PPAR Agonist IVA337 Is Effective in the Prevention of Experimental Lung Fibrosis and Related Pulmonary Hypertension
Jerome Avouac¹, Irena Konstantinova², Christophe Guignabert³, Sonia Pezet⁴, Anne Cauvet⁵, Jeremy Sadoine⁶, Thomas Guilbert⁴, Jean-Michel Luccarini⁷, Jean-Louis Junien⁷, Pierre Broqua⁷ and Yannick Allanore⁸, ¹Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ²Inventiva, Daix, France, ³Inserm UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France, ⁴Institut Cochin, INSERM U1016, Paris, France, ⁵INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ⁶Equipe d’Accueil (EA) 2496 Pathologie, Imagerie et Biothérapies Orofaciales, Faculty of Odontology, Paris Descartes University, Montrouge, France, ⁷Inventiva, DAIX, France, ⁸Rheumatology, Paris Descartes University, Paris, France
Background/Purpose: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors known to modulate fibrosis. The pan-PPAR agonist IVA337 recently demonstrated efficacy in prevention and treatment of experimental…
Abstract Number: 3174 • 2016 ACR/ARHP Annual Meeting
Apremilast Attenuates the Fibrogenic Phenotype of Dermal Fibroblasts from Patients with Systemic Sclerosis, Contributing to the Prevention of the Progression of Experimental Dermal Fibrosis
Tomoaki Higuchi¹, Yasushi Kawaguchi², Kae Takagi³, Akiko Tochimoto², Yuki Ichimura², Yasuhiro Katsumata², Hisae Ichida², Hidenaga Kawasumi², Hirokazu Nishina², Mari Tochihara², Akira Nishino², Shinya Hirahara², Rina Moriyama² and Hisashi Yamanaka⁴, ¹Institute Of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Medicine, Tokyo Women's Medical University medical Center East, Tokyo, Japan, ⁴Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a chronic fibrosing disorder that affects the skin and other internal organs. Inflammation, vasculopathy and fibrosis at the affected area…
Abstract Number: 3014 • 2015 ACR/ARHP Annual Meeting
Endotrophin: A Novel Adipokine Linking Adipose Tissue and Skin Fibrosis in Systemic Sclerosis
Roberta Goncalves Marangoni¹, Jun Wei², Monique E. Hinchcliff¹, Philipp E. Scherer³ and John Varga², ¹Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Adipocytes and their progenitor cells are embedded in a network of extracellular matrix that plays a role in regulating its function. Type 6 collagen…
Abstract Number: 3015 • 2015 ACR/ARHP Annual Meeting
Characterization of the Profibrotic/Antifibrotic Profile of microRNA Contained in Exosomes Isolated from Cultured Normal Human Dermal and Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition in Vitro
Sergio A. Jimenez¹, Sonsoles Piera-Velazquez², Peter J. Wermuth³ and Kerri Fasino⁴, ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA, ³Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ⁴Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Systemic Sclerosis (SSc) is characterized by progressive fibrosis of skin and multiple internal organs, severe alterations in the microvasculature, and numerous immunological abnormalities. Recently…
Abstract Number: 3018 • 2015 ACR/ARHP Annual Meeting
Paracrine Effect of Proteins Secreted By Normal Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition on the Expression of Genes Associated with Tissue Fibrosis in Normal Human Lung Fibroblasts
Sonsoles Piera-Velazquez¹, Kerri Fasino² and Sergio A. Jimenez³, ¹Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, ³Div Connective Tissue Diseases, Thomas Jefferson Univ, Philadelphia, PA
Background/Purpose: Progressive tissue fibrosis and microvascular alterations are the hallmarks of Systemic Sclerosis (SSc). The mechanisms involved in SSc pathogenesis are complex and have not…
Abstract Number: 3133 • 2015 ACR/ARHP Annual Meeting
The Anti-Fibrotic Effect of Endostatin-Derived Peptide Is Mediated By the Urokinase Pathway Via Binding to Enolase-1 and Urokinase Plasminogen Activator Receptor
Tetsuya Nishimoto¹, Takahisa Takihara², Logan Mlakar³, Yunyun Su⁴, Roger Chambers³ and Carol Feghali-Bostwick³, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Tokai University School of Medicine, Kanagawa, Japan, ³Medical University of South Carolina, Charleston, SC, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality. We recently demonstrated that the C-terminal…
Abstract Number: 1913 • 2015 ACR/ARHP Annual Meeting
Lysyl Oxidase Induces Fibrosis Via Upregulation of IL-6 and Serves As a Biomarker to Monitor Response to Therapy
Tetsuya Nishimoto¹, Takahisa Takihara², Logan Mlakar³ and Carol Feghali-Bostwick³, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Tokai University School of Medicine, Kanagawa, Japan, ³Medical University of South Carolina, Charleston, SC
Background/Purpose: Lysyl oxidase (LOX) is a copper-dependent amine oxidase whose primary function is the covalent crosslinking of collagens in the extracellular matrix (ECM). Fibrosis is…
Abstract Number: 2994 • 2015 ACR/ARHP Annual Meeting
The Global Microrna Profile of Systemic Sclerosis Whole Skin/Dermal Fibroblasts and the Role of the Xq26.3 miRNA Cluster As a TGF-b Pathway Positive Feedback Mechanism
Gloria Salazar¹, John Hagan², Minghua Wu³, Xinjian Guo⁴, Xiaodong Zhou⁴, Julio Charles¹, Maureen D Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²Neurosurgery, University of Texas at Houston, Houston, TX, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Internal Medicine, University of Texas Medical School at Houston, Houston, TX
Background/Purpose: MicroRNA (miRNA) are critical gene regulators that frequently play central roles in disease. Here, we report the miRNA expression signatures of systemic sclerosis (SSc)…
Abstract Number: 1728 • 2014 ACR/ARHP Annual Meeting
Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice
Sarah Trinder¹, Mary Tarriela², Adrian Gilbane¹, Robert Good³, Xu Shi-Wen⁴, David Abraham⁵ and Alan M. Holmes⁶, ¹Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ³Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, ⁵Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁶Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I. The…
Abstract Number: 1710 • 2014 ACR/ARHP Annual Meeting
Endothelin-1 Is a Downstream Mediator of Profibrotic Effects by Transforming Growth Factor-β1 in Systemic Sclerosis Skin Fibroblasts
Tomoaki Higuchi¹, Yasushi Kawaguchi¹, Akiko Tochimoto¹, Yuko Ota², Yasuhiro Katsumata¹, Takahisa Gono¹, Masanori Hanaoka¹, Yuko Okamoto¹, Hidenaga Kawasumi¹ and Hisashi Yamanaka³, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²10-22 Kawada-Cha Shinjuku-Ku, Tokyo Women's Medical University, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by excess collagen deposition, vascular changes and production of autoantibodies that affects multiple organs.…
Abstract Number: 1704 • 2014 ACR/ARHP Annual Meeting
CXCL4 Promotes Fibrosis By Increasing Expression of Extracellular Matrix Modifying Factors and By Facilitating Epithelial/Endothelial Mesenchymal Transition
W. Marut¹, A.J. Affandi¹, A. Limpers¹ and T.R.D.J. Radstake², ¹Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose Systemic sclerosis (SSc) is a degenerative disorder, characterized by vascular abnormalities and immunological disturbances followed by excessive fibrosis in multiple organ systems. In a…
Abstract Number: 966 • 2014 ACR/ARHP Annual Meeting
Adiponectin Is an Endogenous Anti-Fibrotic and Target in Systemic Sclerosis: Novel Link Between Fibrosis and Metabolism
Feng Fang¹, Roberta G. Marangoni¹, Xingchun Zhou², Wen Hong³, Boping Ye³, Asano Yoshihide⁴, Shinichi Sato⁵, Yuri Masui⁶, Chengning Zhang⁷, Katja Lakota⁸, Jun Wei⁹, Monique E. Hinchcliff⁷, Philipp Scherer¹⁰, Laszlo Otvos¹¹ and John Varga¹², ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²College of Life and Science, China Pharmaceutical University, Nanjing, China, ³China Pharmaceutical University, Nanjing, China, ⁴University of Tokyo, Tokyo, Japan, ⁵Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan, ⁶Department of Dermatology, University of Tokyo, Tokyo, Japan, ⁷Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ¹⁰University of Texas Southwestern Medical Center, Dallas, TX, ¹¹Temple University, Philadelphia, PA, ¹²Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose :Systemic sclerosis (SSc) skin fibrosis is associated with attenuated cutaneous adipose tissue and adipogenic gene expression. Levels of the adipose-derived cytokine adiponectin (APN) and…

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