ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts"

  • Abstract Number: 1728 • 2014 ACR/ARHP Annual Meeting

    Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice

    Sarah Trinder1, Mary Tarriela2, Adrian Gilbane1, Robert Good3, Xu Shi-Wen4, David Abraham5 and Alan M. Holmes6, 1Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, 4Centre for Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, 5Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 6Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I.  The…
  • Abstract Number: 324 • 2014 ACR/ARHP Annual Meeting

    Regulation of TNF-α-Mediated Activation of Rheumatoid Synovial Fibroblasts By Transcription Factor Snail

    Chrong-Reen Wang1,2, Shih-Yao Chen3, Ai-Li Shiau4, I-Ming Jou5,6, Ming-Fei Liu1,2 and Chao-Liang Wu3, 1Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, 2Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, 3Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, 4Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 5Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, 6Orthopedics, National Cheng Kung University Hospital, Tainan, Taiwan

    Background/Purpose: Transcription factor Snail plays active roles in various biological functions and is involved in many disease states. We hypothesized that this molecule regulates TNF-α-mediated…
  • Abstract Number: 1710 • 2014 ACR/ARHP Annual Meeting

    Endothelin-1 Is a Downstream Mediator of Profibrotic Effects by Transforming Growth Factor-β1 in Systemic Sclerosis Skin Fibroblasts

    Tomoaki Higuchi1, Yasushi Kawaguchi1, Akiko Tochimoto1, Yuko Ota2, Yasuhiro Katsumata1, Takahisa Gono1, Masanori Hanaoka1, Yuko Okamoto1, Hidenaga Kawasumi1 and Hisashi Yamanaka3, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 210-22 Kawada-Cha Shinjuku-Ku, Tokyo Women's Medical University, Tokyo, Japan, 3Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by excess collagen deposition, vascular changes and production of autoantibodies that affects multiple organs.…
  • Abstract Number: 1704 • 2014 ACR/ARHP Annual Meeting

    CXCL4 Promotes Fibrosis By Increasing Expression of Extracellular Matrix Modifying Factors and By Facilitating Epithelial/Endothelial Mesenchymal Transition

    W. Marut1, A.J. Affandi1, A. Limpers1 and T.R.D.J. Radstake2, 1Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose Systemic sclerosis (SSc) is a degenerative disorder, characterized by vascular abnormalities and immunological disturbances followed by excessive fibrosis in multiple organ systems. In a…
  • Abstract Number: 1462 • 2014 ACR/ARHP Annual Meeting

    Cadherin-11 mRNA Expression in the Peripheral Blood of Rheumatoid Arthritis Patients As a Marker of Active Polyarthritis

    Petros P. Sfikakis1, Panagiotis F. Christopoulos1,2, Aristeidis G. Vaiopoulos1,2, Kalliopi Fragkiadaki1, Christina Katsiari3, Violetta Kapsimali4, George Lallas1, Panayiotis Panayiotidis4, Pinelopi Korkopoulou5 and Michael Koutsilieris2, 1First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, 2Department of Physiology, Athens University Medical School, Athens, Greece, 3Department of Rheumatology, School of Health Sciences, University of Thessaly, Larissa, Greece, 4Department of Microbiology, Athens University Medical School, Athens, Greece, 5Department of Pathology, Athens University Medical School, Athens, Greece

    Background/Purpose: Human rheumatoid arthritis synovial fibroblasts (RASF) implanted subcutaneously in immunodeficient mice trans-migrate through the vasculature and drive the progression from oligo- to poly-articular disease.…
  • Abstract Number: 2919 • 2014 ACR/ARHP Annual Meeting

    The Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Is Regulated By TGFß and PDGF and Modulates Cell Growth in Fibroblast-like Synoviocytes

    Anna-Karin Ekwall1, Deepa Hammaker2, John W. Whitaker3, William Bugbee4, Wei Wang5 and Gary S. Firestein6, 1Medicine, UC San Diego, La Jolla, CA, 2Medicine, University of California San Diego, La Jolla, CA, 3860 island ave, UCSD, San Diego, CA, 4Orthopaedics, Scripps Clinic, La Jolla, CA, 5Chemistry, UCSD, La Jolla, CA, 6Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA

    Background/Purpose: RA fibroblast-like synoviocytes (FLS) display an aggressive phenotype, such as increased cytokine production and cell growth. Currently no therapeutics specifically target FLS. To this…
  • Abstract Number: 1027 • 2014 ACR/ARHP Annual Meeting

    Hematopoietic Cell Kinase (HCK) As a Novel Regulator of Fibroblast-like Synoviocyte Function in RA

    Ying Wang1, Deepa Hammaker2, David L. Boyle3, Toshio Yoshizawa4 and Gary S. Firestein3, 1Medicine, UCSD, La Jolla, CA, 2Medicine, University of California San Diego, La Jolla, CA, 3Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, 4Exploratory Research Laboratories 1, Ono Pharmaceutical Co., Ltd., Osaka, Japan

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are key mediators of inflammation and joint damage in rheumatoid arthritis (RA) through the production of cytokines and matrix metalloproteinases (MMPs)…
  • Abstract Number: 2816 • 2014 ACR/ARHP Annual Meeting

    Distinctive DNA Methylome Signatures in Early Rheumatoid Arthritis (RA) Synoviocytes Compared with Longstanding (RA) and Other Inflammatory Arthritides

    Rizi Ai1, John W. Whitaker2, David L. Boyle3, Paul Peter Tak4, Danielle M. Gerlag5, Wei Wang6 and Gary S. Firestein3, 1Chemistry, UC San Diego, La Jolla, CA, 2860 island ave, UCSD, San Diego, CA, 3Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, 4Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, 5Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Chemistry, UCSD, La Jolla, CA

    Background/Purpose:   Epigenetics influences pathogenic mechanisms in autoimmunity. Recently, a stable RA DNA methylation signature in fibroblast-like synoviocytes (FLS) was defined in 2375 genes. The…
  • Abstract Number: 1038 • 2014 ACR/ARHP Annual Meeting

    Macrophage-Fibroblast Crosstalk Pathways Amplify RA Joint Pathology

    Laura T. Donlin1, Jennifer Ding1 and Lionel B. Ivashkiv1,2, 1Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 2Weill Cornell Graduate School of Medical Sciences, New York, NY

    Background/Purpose Macrophages and synovial fibroblasts represent key cellular drivers of RA. The goal of this study was to define how the complex cellular programs of…
  • Abstract Number: 2817 • 2014 ACR/ARHP Annual Meeting

    Histone Deacetylase One Contributes to the Auto-Aggressive Phenotype of Rheumatoid Arthritis

    Sarah Hawtree1, Munitta Muthana1, J. Mark Wilkinson2, Anthony G. Wilson1 and Mohammed Akil3, 1Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, 2Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, 3Rheumatology Department, Sheffield South Yorkshire, United Kingdom

    Background/Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS)…
  • Abstract Number: 1022 • 2014 ACR/ARHP Annual Meeting

    Fibroblast-like Synovial Cells and Monocytes Team up in the Organization and the Dynamic Modelling of the Synovial Tissue

    Ruth Byrne1, Karolina von Dalwigk2, Thomas Karonitsch1, Gunter Steiner3, Johannes Holinka4, Reinhard Windhager4, Josef Smolen5, Hans Peter Kiener1 and Clemens Scheinecker6, 1Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 5Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6Divison of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose The synovial lining tissue consists of fibroblast-like synoviocytes (FLS) and monocyte-derived macrophage-like synoviocytes (MLS) within a self-built meshwork of dense extracellular matrix (ECM) components.…
  • Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting

    The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    Stephanie M. Stanford1, William B. Kiosses2, Amanda M. Campbell3, Michael F. Maestre3, David L. Boyle4, Gary S. Firestein4 and Nunzio Bottini3, 1Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2The Scripps Research Institute, La Jolla, CA, 3La Jolla Institute for Allergy and Immunology, La Jolla, CA, 4Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA

    Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…
  • Abstract Number: 2231 • 2013 ACR/ARHP Annual Meeting

    The Actin-Crosslinking Protein Lasp-1 Regulates Synovial Fibroblast Migration and Cartilage Destruction In Arthritis

    Denise Beckmann1, Jan Hillen2, Marianne Heitzmann2, Catherine S. Chew3, Stefan Butz4, Dietmar Vestweber5, Hermann Pavenstädt6, Thomas Pap7 and Adelheid Korb-Pap2, 11nstitute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 2Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, 3Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, 4Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, 5Max Planck Institute of Molecular Biomedicine, Muenster, Germany, 6Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany, 7Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany

    Background/Purpose: Lasp-1 localizes at focal adhesions along stress fibres and leading edges of migrating cells and regulates the metastatic dissemination of tumors. Although rheumatoid arthritis…
  • Abstract Number: 2216 • 2013 ACR/ARHP Annual Meeting

    Tubastatin A, a Selective Histone Deacetylase-6 Inhibitor, Suppresses Synovial Inflammation and Joint Destruction In a Collagen Antibody-Induced Arthritis Mouse Model

    Joong Kyong Ahn1, Jaejoon Lee2, Hyemin Jeong2, Jiwon Hwang2, Seulkee Lee2, Ji Young Chai3, Inyoung Kim2,4, Eun Chung Hong5, Eun-Kyung Bae5, Hoon-Suk Cha2 and Eun-Mi Koh2, 1Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 3Division of Rheumatology, Jesang Hospital, Seongnam-si Gyeonggi-do, South Korea, 4MD, Seoul, South Korea, 5Samsung Biomedical Research Institute, Seoul, South Korea

    Background/Purpose: Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylasing histones, and HDAC inhibitors induce various cellular effects, including apoptosis, cell…
  • Abstract Number: 2227 • 2013 ACR/ARHP Annual Meeting

    The Anti-Proliferative Function of RSK2 in Synovial Fibroblasts Protects Against TNF-á-Induced Joint Destruction in Inflammatory Arthritis

    Anja Derer1, Christina Boehm1, Bettina Groetsch1, Michael Stock1, Kirsten Neubert2, Sybille Boehm3, Bettina Sehnert1, Georg Schett1, Axel J. Hueber4 and Jean-Pierre David5, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Clinical Research Group, Nikolaus-Fiebiger Center, University of Erlangen-Nuremberg, Erlangen, Germany, 3Institute of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 5Group Genes and Transcription, Institute of Osteology and Biomechanics (IOBM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Background/Purpose: The pro-inflammatory cytokine Tumor Necrosis Factor alpha (TNF-α) directly activates the ribosomal S6 kinase RSK2 in vitro. We recently demonstrated the protective effect of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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