Abstract Number: 771 • 2014 ACR/ARHP Annual Meeting
Development of a Bifluorescent Lineage Tracker Reporter Mouse Strain to Analyze the Phenotypic Conversion of Endothelial Cells into Myofibroblasts in Vivo. Application to Study the Synergistic Effects of Endothelin-1 on TGF-β1-Induced Endothelial-to-Mesenchymal Transition
Background/Purpose: Endothelial-to-mesenchymal transition (EndoMT) may be a crucial pathway in generating activated myofibroblasts, cells that play a pivotal role in the development of tissue and…Abstract Number: 1962 • 2014 ACR/ARHP Annual Meeting
Inflammatory Properties of Inhibitor of DNA Binding 1 As a Unique Fibroblast Derived Nuclear Protein
Background/Purpose: Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and…Abstract Number: 769 • 2014 ACR/ARHP Annual Meeting
Anti-Fibrotic Effects of an Investigational Drug: Bis-Oxetanyl Sulfoxide
Background/Purpose: The hallmark of pulmonary fibrosis is thickening and scarring of the tissue caused by increased deposition of extracellular matrix (ECM) proteins like collagen…Abstract Number: 1796 • 2014 ACR/ARHP Annual Meeting
Autotaxin Is Highly Expressed in Systemic Sclerosis (SSc) Skin, Mediates Dermal Fibrosis Via IL-6, and Is a Target for SSc Therapy
Background/Purpose Autotaxin (ATX) is an enzyme present in biological fluids that is responsible for the production of the lipid mediator, lysophosphatidic acid (LPA). We previously…Abstract Number: 749 • 2014 ACR/ARHP Annual Meeting
Progranulin Overproduction Due to Fli1 Deficiency Contributes to the Resistance of Dermal Fibroblasts to Tumor Necrosis Factor a in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a multisystem fibrotic connective tissue disease characterized by a dysregulated activation of fibroblasts following inflammation, autoimmune attacks, and vascular injuries.…Abstract Number: 1739 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Properties of CD271+ and CD271- Synovial Mesenchymal Cells
Background/Purpose Mesenchymal stem cells (MSC) have been isolated from synovium and represent a fraction of synovial fibroblast (SF) cultures. CD271+ is considered a MSC surface…Abstract Number: 327 • 2014 ACR/ARHP Annual Meeting
AMPK Activation in Inflammatory Arthritis
Background/Purpose: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase involved in the regulation of cellular energy homeostasis. It is a central regulator of both…Abstract Number: 1728 • 2014 ACR/ARHP Annual Meeting
Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice
Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I. The…Abstract Number: 324 • 2014 ACR/ARHP Annual Meeting
Regulation of TNF-α-Mediated Activation of Rheumatoid Synovial Fibroblasts By Transcription Factor Snail
Background/Purpose: Transcription factor Snail plays active roles in various biological functions and is involved in many disease states. We hypothesized that this molecule regulates TNF-α-mediated…Abstract Number: 1710 • 2014 ACR/ARHP Annual Meeting
Endothelin-1 Is a Downstream Mediator of Profibrotic Effects by Transforming Growth Factor-β1 in Systemic Sclerosis Skin Fibroblasts
Background/Purpose Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by excess collagen deposition, vascular changes and production of autoantibodies that affects multiple organs.…Abstract Number: 1704 • 2014 ACR/ARHP Annual Meeting
CXCL4 Promotes Fibrosis By Increasing Expression of Extracellular Matrix Modifying Factors and By Facilitating Epithelial/Endothelial Mesenchymal Transition
Background/Purpose Systemic sclerosis (SSc) is a degenerative disorder, characterized by vascular abnormalities and immunological disturbances followed by excessive fibrosis in multiple organ systems. In a…Abstract Number: 1462 • 2014 ACR/ARHP Annual Meeting
Cadherin-11 mRNA Expression in the Peripheral Blood of Rheumatoid Arthritis Patients As a Marker of Active Polyarthritis
Background/Purpose: Human rheumatoid arthritis synovial fibroblasts (RASF) implanted subcutaneously in immunodeficient mice trans-migrate through the vasculature and drive the progression from oligo- to poly-articular disease.…Abstract Number: 2919 • 2014 ACR/ARHP Annual Meeting
The Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Is Regulated By TGFß and PDGF and Modulates Cell Growth in Fibroblast-like Synoviocytes
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display an aggressive phenotype, such as increased cytokine production and cell growth. Currently no therapeutics specifically target FLS. To this…Abstract Number: 1027 • 2014 ACR/ARHP Annual Meeting
Hematopoietic Cell Kinase (HCK) As a Novel Regulator of Fibroblast-like Synoviocyte Function in RA
Background/Purpose: Fibroblast-like synoviocytes (FLS) are key mediators of inflammation and joint damage in rheumatoid arthritis (RA) through the production of cytokines and matrix metalloproteinases (MMPs)…Abstract Number: 2816 • 2014 ACR/ARHP Annual Meeting
Distinctive DNA Methylome Signatures in Early Rheumatoid Arthritis (RA) Synoviocytes Compared with Longstanding (RA) and Other Inflammatory Arthritides
Background/Purpose: Epigenetics influences pathogenic mechanisms in autoimmunity. Recently, a stable RA DNA methylation signature in fibroblast-like synoviocytes (FLS) was defined in 2375 genes. The…
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