Abstracts tagged "Fibroblasts"

Abstract Number: 324 • 2014 ACR/ARHP Annual Meeting
Regulation of TNF-α-Mediated Activation of Rheumatoid Synovial Fibroblasts By Transcription Factor Snail
Chrong-Reen Wang^1,2, Shih-Yao Chen³, Ai-Li Shiau⁴, I-Ming Jou^5,6, Ming-Fei Liu^1,2 and Chao-Liang Wu³, ¹Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁵Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, ⁶Orthopedics, National Cheng Kung University Hospital, Tainan, Taiwan
Background/Purpose: Transcription factor Snail plays active roles in various biological functions and is involved in many disease states. We hypothesized that this molecule regulates TNF-α-mediated…
Abstract Number: 1710 • 2014 ACR/ARHP Annual Meeting
Endothelin-1 Is a Downstream Mediator of Profibrotic Effects by Transforming Growth Factor-β1 in Systemic Sclerosis Skin Fibroblasts
Tomoaki Higuchi¹, Yasushi Kawaguchi¹, Akiko Tochimoto¹, Yuko Ota², Yasuhiro Katsumata¹, Takahisa Gono¹, Masanori Hanaoka¹, Yuko Okamoto¹, Hidenaga Kawasumi¹ and Hisashi Yamanaka³, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²10-22 Kawada-Cha Shinjuku-Ku, Tokyo Women's Medical University, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by excess collagen deposition, vascular changes and production of autoantibodies that affects multiple organs.…
Abstract Number: 1704 • 2014 ACR/ARHP Annual Meeting
CXCL4 Promotes Fibrosis By Increasing Expression of Extracellular Matrix Modifying Factors and By Facilitating Epithelial/Endothelial Mesenchymal Transition
W. Marut¹, A.J. Affandi¹, A. Limpers¹ and T.R.D.J. Radstake², ¹Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose Systemic sclerosis (SSc) is a degenerative disorder, characterized by vascular abnormalities and immunological disturbances followed by excessive fibrosis in multiple organ systems. In a…
Abstract Number: 1462 • 2014 ACR/ARHP Annual Meeting
Cadherin-11 mRNA Expression in the Peripheral Blood of Rheumatoid Arthritis Patients As a Marker of Active Polyarthritis
Petros P. Sfikakis¹, Panagiotis F. Christopoulos^1,2, Aristeidis G. Vaiopoulos^1,2, Kalliopi Fragkiadaki¹, Christina Katsiari³, Violetta Kapsimali⁴, George Lallas¹, Panayiotis Panayiotidis⁴, Pinelopi Korkopoulou⁵ and Michael Koutsilieris², ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²Department of Physiology, Athens University Medical School, Athens, Greece, ³Department of Rheumatology, School of Health Sciences, University of Thessaly, Larissa, Greece, ⁴Department of Microbiology, Athens University Medical School, Athens, Greece, ⁵Department of Pathology, Athens University Medical School, Athens, Greece
Background/Purpose: Human rheumatoid arthritis synovial fibroblasts (RASF) implanted subcutaneously in immunodeficient mice trans-migrate through the vasculature and drive the progression from oligo- to poly-articular disease.…
Abstract Number: 2919 • 2014 ACR/ARHP Annual Meeting
The Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Is Regulated By TGFß and PDGF and Modulates Cell Growth in Fibroblast-like Synoviocytes
Anna-Karin Ekwall¹, Deepa Hammaker², John W. Whitaker³, William Bugbee⁴, Wei Wang⁵ and Gary S. Firestein⁶, ¹Medicine, UC San Diego, La Jolla, CA, ²Medicine, University of California San Diego, La Jolla, CA, ³860 island ave, UCSD, San Diego, CA, ⁴Orthopaedics, Scripps Clinic, La Jolla, CA, ⁵Chemistry, UCSD, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display an aggressive phenotype, such as increased cytokine production and cell growth. Currently no therapeutics specifically target FLS. To this…
Abstract Number: 1027 • 2014 ACR/ARHP Annual Meeting
Hematopoietic Cell Kinase (HCK) As a Novel Regulator of Fibroblast-like Synoviocyte Function in RA
Ying Wang¹, Deepa Hammaker², David L. Boyle³, Toshio Yoshizawa⁴ and Gary S. Firestein³, ¹Medicine, UCSD, La Jolla, CA, ²Medicine, University of California San Diego, La Jolla, CA, ³Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, ⁴Exploratory Research Laboratories 1, Ono Pharmaceutical Co., Ltd., Osaka, Japan
Background/Purpose: Fibroblast-like synoviocytes (FLS) are key mediators of inflammation and joint damage in rheumatoid arthritis (RA) through the production of cytokines and matrix metalloproteinases (MMPs)…
Abstract Number: 2816 • 2014 ACR/ARHP Annual Meeting
Distinctive DNA Methylome Signatures in Early Rheumatoid Arthritis (RA) Synoviocytes Compared with Longstanding (RA) and Other Inflammatory Arthritides
Rizi Ai¹, John W. Whitaker², David L. Boyle³, Paul Peter Tak⁴, Danielle M. Gerlag⁵, Wei Wang⁶ and Gary S. Firestein³, ¹Chemistry, UC San Diego, La Jolla, CA, ²860 island ave, UCSD, San Diego, CA, ³Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, ⁴Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁶Chemistry, UCSD, La Jolla, CA
Background/Purpose: Epigenetics influences pathogenic mechanisms in autoimmunity. Recently, a stable RA DNA methylation signature in fibroblast-like synoviocytes (FLS) was defined in 2375 genes. The…
Abstract Number: 1038 • 2014 ACR/ARHP Annual Meeting
Macrophage-Fibroblast Crosstalk Pathways Amplify RA Joint Pathology
Laura T. Donlin¹, Jennifer Ding¹ and Lionel B. Ivashkiv^1,2, ¹Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ²Weill Cornell Graduate School of Medical Sciences, New York, NY
Background/Purpose Macrophages and synovial fibroblasts represent key cellular drivers of RA. The goal of this study was to define how the complex cellular programs of…
Abstract Number: 2817 • 2014 ACR/ARHP Annual Meeting
Histone Deacetylase One Contributes to the Auto-Aggressive Phenotype of Rheumatoid Arthritis
Sarah Hawtree¹, Munitta Muthana¹, J. Mark Wilkinson², Anthony G. Wilson¹ and Mohammed Akil³, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, ³Rheumatology Department, Sheffield South Yorkshire, United Kingdom
Background/Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS)…
Abstract Number: 1022 • 2014 ACR/ARHP Annual Meeting
Fibroblast-like Synovial Cells and Monocytes Team up in the Organization and the Dynamic Modelling of the Synovial Tissue
Ruth Byrne¹, Karolina von Dalwigk², Thomas Karonitsch¹, Gunter Steiner³, Johannes Holinka⁴, Reinhard Windhager⁴, Josef Smolen⁵, Hans Peter Kiener¹ and Clemens Scheinecker⁶, ¹Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, ⁵Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Divison of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose The synovial lining tissue consists of fibroblast-like synoviocytes (FLS) and monocyte-derived macrophage-like synoviocytes (MLS) within a self-built meshwork of dense extracellular matrix (ECM) components.…
Abstract Number: 2818 • 2014 ACR/ARHP Annual Meeting
SH2 Domain-Containing Phosphatase 2 Promotes Aggressiveness of Rheumatoid Fibroblast-like Synoviocytes
Stephanie M. Stanford¹, German R. Aleman Muench¹, Cristiano Sacchetti¹, Lifan Zeng², David L. Boyle³, Gen-Sheng Feng⁴, Zhong-Yin Zhang², Maripat Corr³, Gary S. Firestein³ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, ³Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, ⁴Pathology, University of California at San Diego Division of Biological Sciences, La Jolla, CA
Background/Purpose In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint synovial membranes aggressively invade the extracellular matrix, destroying cartilage and bone. Although this cell…
Abstract Number: 994 • 2014 ACR/ARHP Annual Meeting
IL-7 Modulates B Cell Immunoglobulin Isotype Production and Increases B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) in Synovial Fibroblasts from Osteoarthritis (OA) and Rheumatoid Arthritis (RA) Patients
Georg Pongratz¹, Stephan Kuhn², Madlen Melzer², Torsten Lowin² and Rainer Straub³, ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose Interleukin(IL)-7 is increased in synovial fluid from rheumatoid arthritis (RA) patients as compared to osteoarthritis (OA) patients and has been attributed a proinflammatory role,…
Abstract Number: 2785 • 2014 ACR/ARHP Annual Meeting
Joint Specific Positional Differences in Coding and Noncoding Transcriptome of Synovial Fibroblasts As a Determinant of the Susceptibility of Synovial Joints to Rheumatoid Arthritis
Caroline Ospelt¹, Maria Armaka², Giancarlo Russo³, Anna Bratus³, Michelle Trenkmann⁴, Emmanuel Karouzakis¹, Christoph Kolling⁵, Renate E. Gay⁴, George Kollias⁶, Steffen Gay¹ and Mojca Frank Bertoncelj¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Institute of Immunology,, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, ³Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Schulthess Clinic, Zurich, Switzerland, ⁶Institute of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece
Background/Purpose The molecular mechanisms underlying the topographic differences in the susceptibility of synovial joints to develop rheumatoid arthritis (RA) are unknown. Positional embryonic expression of…
Abstract Number: 968 • 2014 ACR/ARHP Annual Meeting
Priming of WNT Signalling during Fibrosis Is Mediated By TGF-β Induced Axin-2 Downregulation
Justin Gillespie¹, Emma C. Derrett-Smith², Michael McDermott¹, Paul Emery³, Christopher P Denton⁴ and Francesco Del Galdo³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom

Background/Purpose Systemic Sclerosis (SSc) is characterized by autoimmune activation, vasculopathy and tissue fibrosis. Recently, activation of the Wnt/β-catenin signaling pathway in SSc fibroblasts has been…
Abstract Number: 2709 • 2014 ACR/ARHP Annual Meeting
Could a Fibroblast-Free Environment Protect the Microcirculation in Systemic Sclerosis? Evidence from Retinal Vascular Imaging Research
Evaggelia K. Aissopou¹, Vasiliki-Kalliopi Bournia¹, Athanase D. Protogerou¹, Stylianos Panopoulos¹, Theodore G. Papaioannou², Panayiotis G. Vlachoyiannopoulos¹, Marco Matucci-Cerinic³ and Petros P. Sfikakis¹, ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²Biomedical Engineering Unit, First University Dept. of Cardiology, Hippokration Hospital , Athens University Medical School, Athens, Greece, ³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Background/Purpose: A primary endothelial cell dysfunction is thought to be involved in systemic sclerosis (SSc)-associated fibroproliferative vasculopathy of the microcirculation and small arterioles, even in…

« Previous Page
1
…
6
7
8
9
10
…
12
Next Page »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.