Abstracts tagged "Fibroblasts"

Abstract Number: 1367 • 2015 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes Shape and Perpetuate the Inflammatory Immune Responses Associated with Antibiotic-Refractory Lyme Arthritis.
Klemen Strle¹, Robert Locchead², Annalisa Pianta³, Jameson T. Crowley³, Sheila Arvikar¹ and John Aversa⁴, ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Allery and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, ³Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Yale Medical Group, Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT
Background/Purpose: Antibiotic-refractory Lyme arthritis is defined as persistent synovitis for months to years after antibiotic therapy for Borrelia burgdorferi, the causative agent of Lyme disease.…
Abstract Number: 2710 • 2015 ACR/ARHP Annual Meeting
Necrox-7 Inhibits Cell Aggressiveness By Suppressing of NF-Kappa B Activation and Reactive Oxygen Species Generation in Human Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyun Jung Yoo^1,2, Jin Kyun Park², Eun Young Lee², Eun Bong Lee² and Yeong Wook Song^2,3, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component…
Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting
Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)
Rachel Audo^1,2, Bernard Combe^3,4, Michael Hahne⁵ and Jacques Morel⁶, ¹Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, ²IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ³Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁴Montpellier University, Montpellier, France, ⁵IGMM-CNRS UMR5535, Montpellier, France, ⁶Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…
Abstract Number: 2714 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Synovial Fibroblast Potentiates Mast Cell Degranulation and Migration Independent of Cell-to-Cell Contact
Hee-suk Lim¹, Jiyong Choi^2,3, Yeong Wook Song⁴ and Kichul Shin¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: A number of studies have shown that synovial mast cells (MCs) are activated, and elicit a pro-inflammatory role in rheumatoid arthritis (RA). Synovial MCs…
Abstract Number: 1627 • 2015 ACR/ARHP Annual Meeting
HIF-1alpha Knockdown Down-Regulates Glycolytic Metabolism and Induces Rheumatoid Synovial Fibroblast Cell Death
Manuel J. Del Rey¹, Alicia Usategui¹, Álvaro Valín¹, María Sánchez-Aragó², José M. Cuezva², Carmen M. García-Herrero¹, María Galindo¹, Juan D. Cañete³, Francisco J. Blanco⁴, Gabriel Criado¹ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Investigación Hospital 12 de Octubre, Universidad Autónoma de Madrid, Madrid, Spain, ³Unitat d’Artritis, Servei de Reumatologia, Hospital Clínic de Barcelona and Institut d’Investigacions Biomèdiques August Pí i Sunyer, Barcelona, Spain, ⁴Laboratorio de Investigación Osteoarticular y del Envejecimiento, Instituto de Investigación Biomédica de A Coruña, INIBIC, A Coruña, Spain
Background/Purpose: Intense synovial fibroblast (SF) hyperplasia contributes to the chronic inflammation and osteoarticular destruction that characterizes rheumatoid arthritis (RA). Hypoxia-inducible factor 1α (HIF-1α) plays a…
Abstract Number: 2719 • 2015 ACR/ARHP Annual Meeting
Track Along: Monocytes Follow Fibroblast-like Synoviocyte Network for Movement and Rest within the Synovial Tissue
Ruth Byrne¹, Karolina von Dalwigk², Gunter Steiner³, Johannes Holinka⁴, Reinhard Windhager⁴, Josef S. Smolen⁵, Hans Peter Kiener⁶ and Clemens Scheinecker⁷, ¹Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Orthopedics, Medical University of Vienna, Vienna, Austria, ⁵Dept of Medicine 3, Division of Rheumatology, Medical Univ Vienna, Vienna, Austria, ⁶Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁷Divison of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: The synovial lining tissue consists of fibroblast-like synoviocytes (FLS) and monocyte-derived macrophage-like synoviocytes (MLS) within a self-built meshwork of dense extracellular matrix (ECM) components.…
Abstract Number: 1915 • 2015 ACR/ARHP Annual Meeting
Pathogenetic Overlap Between Localised and Systemic Scleroderma: A Study of Nodular and Keloidal Morphea Occurring in Systemic Sclerosis
Emma C. Derrett-Smith¹, Nataliya Gak², Svetlana I. Nihtyanova³, Voon H. Ong³, Victoria Swale², Cate Orteu² and Christopher P. Denton⁴, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Division of Medicine, London, United Kingdom, ²Royal Free London NHS Foundation Trust, London, United Kingdom, ³Rheumatology, UCL Division of Medicine, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Localised scleroderma can occur in overlap with systemic sclerosis (SSc); nodular and keloidal morphea are rare subtypes but can be disfiguring and challenging to…
Abstract Number: 3004 • 2015 ACR/ARHP Annual Meeting
Scleroderma Keratinocytes Promote Fibroblast Activation Independent of TGF-ß
Sara S McCoy¹, Tamra J Reed¹, Pei-Suen Tsou², Dinesh Khanna³, J. Michelle Kahlenberg⁴ and Celine C. Berthier⁵, ¹Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a devastating fibrosing disease that primarily involves the skin, but may have life-threatening effects on the heart, lungs, gastrointestinal tract,…
Abstract Number: 1922 • 2015 ACR/ARHP Annual Meeting
Peripheral B Lymphocytes Secrete Both Interleukin 6 and Transforming Growth Factor-Beta and Potentiate Fibroblast Activation in Systemic Sclerosis
Nicolas Dumoitier^1,2,3,4, Sebastien Lofek^2,3,5, Alexis Regent⁶, Jonathan London⁷, Benjamin Chaigne^1,2,3,8, Benjamin Terrier^2,7,9,10, Nadine Varin-Blank^4,11 and Luc Mouthon^1,2,4,6, ¹Infection, Immunité, Inflammation, Institut Cochin, INSERM U1016, Paris, France, ²CNRS, UMR8104, Paris, France, ³Université Paris Descartes, Paris, France, ⁴Labex Inflamex, Université Sorbonne Paris Cité, Paris, France, ⁵Infection,Immunité, Inflammation, Institut Cochin, INSERM U1016, Paris, France, ⁶Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁷Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁸Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochinl, Paris, France, ⁹Infection, Immunité, Inflammation, Institut Cochin INSERM U1016, Paris, France, ¹⁰Université Paris Descartes, paris, France, ¹¹UFR SMBH, INSERM, UMR978, Bobigny, France
Background/Purpose: Systemic sclerosis (SSc) is a rare connective tissue disease characterized by fibroblasts activation, increased extra-cellular matrix synthesis associated with autoimmunity. However, the potential role…
Abstract Number: 3007 • 2015 ACR/ARHP Annual Meeting
Cold Receptor Expression and Function in Human Dermal Fibroblast: Possible Role in the Pathogenesis of Scleroderma Fibrosis
Yongqing Wang¹, John Sun¹, Shadia Nada², Nezam Altorok³ and Bashar Kahaleh⁴, ¹The University of Toledo, Toledo, OH, ²Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, ³Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, ⁴Medicine/Rheumatology, The University of Toledo, Toledo, OH
Background/Purpose: Enhanced cold sensitivity is an early and consistent phenomenon in scleroderma (SSc). We previously demonstrated increased expression of the transient receptor potential melastatine 8…
Abstract Number: 1923 • 2015 ACR/ARHP Annual Meeting
The Role of Inflammatory Myeloid Cell Compartment in Myocardial Fibrogenesis and Remodelling in Systemic Sclerosis
Veronika Haunerdinger¹, Przemyslaw Blyszczuk², Elena Pachera¹, Rucsandra Dobrota³, Britta Maurer¹, Ulrich Grabmaier⁴, Karl Sotlar⁵, Oliver Distler¹ and Gabriela Kania¹, ¹Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ²Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland, ³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Medical Clinic und Polyclinic I, Campus Großhadern, Maximilians University Munich, 81377 Munich, Germany, ⁵Institute of Pathology, Ludwig Maximilians University Munich, 81377 Munich, Germany
Background/Purpose: During the last years, there was a shift in systemic sclerosis (SSc)-related causes of death, indicating cardiac involvement and inflammatory dilated cardiomyopathy (iDCM) as…
Abstract Number: 3008 • 2015 ACR/ARHP Annual Meeting
Role of PTP4A1 Tyrosine Phosphatase in Systemic Sclerosis
Cristiano Sacchetti¹, Stephanie Stanford², Yunpeng Bai³, Zhong-Yin Zhang⁴, Amin Gholami⁵, Gregory Seumois⁶, Maria Piera-Velazquez⁷, Sergio A. Jimenez⁸ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Indiana University, School of Medicine, Indianapolis, IN, ⁴Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, ⁵Bioinformatics Core, La Jolla Institute for Allergy and immunology, La Jolla, CA, ⁶Sequencing Facility, La Jolla Institute for Allergy and immunology, La Jolla, CA, ⁷Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA, ⁸Div Connective Tissue Diseases, Thomas Jefferson Univ, Philadelphia, PA
Background/Purpose: Systemic sclerosis (SSc) is a multi-system autoimmune connective tissue disorder that leads to fibrosis of the skin and internal organs, resulting in significant patient…
Abstract Number: 2464 • 2014 ACR/ARHP Annual Meeting
Anti-Arthritic Effect of Tubastatin A, a Novel Histone Deacetylases-6 Inhibitor, Is Mediated By Stabilization of IkB Via Suppression of Ubiquitin-Proteasome Pathway
Eun Chung Hong¹, Hemin Jeong², Jiwon Hwang², Eun-Kyung Bae¹, Hyungjin Kim², Joong Kyong Ahn³, Hoon-Suk Cha², Eun-mi Koh⁴ and Jaejoon Lee⁴, ¹Samsung Biomedical Research Institute, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Sungkyunkwan univ. school of medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Histone deacetylase-6 (HDAC-6) functions as a non-epigenetic deacetylase for non-histone substrates and regulates microtubule-mediates processes such as cell migration, cell cycle arrest, and angiogenesis.…
Abstract Number: 774 • 2014 ACR/ARHP Annual Meeting
Endothelin-1 Synergistically Increases TGF-β-Induced Hif1α Expression Under Normoxic Conditions during Endothelial-to-Mesenchymal Transition in Murine Endothelial Cells. a Novel Mechanism for the Fibrogenic Effects of Endothelin
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Tissue hypoxia is a consequence of vascular damage and Hif-1α accumulation is a major mechanism of hypoxia response pathways. HIF-1α induces the transcriptional upregulation…
Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting
Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential
Manuel J. Del Rey¹, Regina Faré¹, Gabriel Criado², Alicia Usategui¹, Vanessa Miranda¹, Juan D. Cañete³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain
Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…

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