Abstracts tagged "Fibroblasts"

Abstract Number: 1925 • 2015 ACR/ARHP Annual Meeting
Interleukin-35 Is Upregulated in Systemic Sclerosis and Its Serum Levels Are Increased in Early Disease
Michal Tomcík¹, Pawel Zerr², Katrin Palumbo-Zerr², Hana Storkanova¹, Hana Hulejova³, Maja Spiritovic⁴, Ondrej Kodet⁵, Jiri Stork⁵, Radim Becvar¹, Jiri Vencovsky¹, Karel Pavelka⁶, Maria Filkova⁷, Jorg HW Distler² and Ladislav Senolt⁸, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ⁴Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, ⁵Department of Dermatology and Venereology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁶Charles University, Prague, Czech Republic, ⁷Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁸Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Interleukin-35 (IL-35) is the most recent addition to the IL-12 family, which also comprises IL-12, IL-23 and IL-27. IL-35 consists of two chains, p35/IL-12a…
Abstract Number: 3104 • 2015 ACR/ARHP Annual Meeting
Abnormal DNA Methylation in a Novel PTPN11 Enhancer Increases Destructive Potential of Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS) and Joint Inflammation
Keisuke Maeshima¹, Stephanie M. Stanford², Deepa Hammaker¹, Cristiano Sacchetti², Rizi Ai³, Vida Zhang⁴, David L. Boyle⁵, Lifan Zeng⁶, German Muench⁷, Gen-Sheng Feng⁸, John Whitaker⁹, Zhong-Yin Zhang⁶, Wei Wang¹⁰, Nunzio Bottini² and Gary S. Firestein⁵, ¹Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁵Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁶Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, ⁷La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁸Pathology and Division of Biological Sciences, UC San Diego, La Jolla, CA, ⁹Janssen Pharmaceuticals, La Jolla, CA, ¹⁰Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) mediate disease pathogenesis by invading the joint extracellular matrix. The PTPN11 gene, encoding the tyrosine phosphatase SHP-2, is overexpressed…
Abstract Number: 1927 • 2015 ACR/ARHP Annual Meeting
Salinomycin Induces Potent Suppression of TGF-β1-Mediated Expression of Profibrotic Genes in Cultured Dermal Fibroblasts from Normal Donors and from Donors with Systemic Sclerosis (SSc): A Novel Anti-Fibrotic Treatment for Tissue Fibrosis in SSc
Peter J. Wermuth¹ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Activated myofibroblasts are the primary mediators of the excessive synthesis and deposition of collagens and other extracellular matrix (ECM) macromolecules during the pathogenesis of…
Abstract Number: 2012 • 2015 ACR/ARHP Annual Meeting
TNF Confers Pathogenic Memory in Synovial Fibroblasts Via Chromatin Remodeling, NF-Kb-Dependent Transcription and MAPK-Mediated mRNA Stabilization
Konstantinos Loupasakis¹, Christopher Sohn², Lionel B. Ivashkiv³ and George D. Kalliolias², ¹Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: We investigated mechanisms driving pathogenic behavior of synovial fibroblasts (FLS) in rheumatoid arthritis (RA). Methods: FLS from RA patients (1987 classification criteria) were extracted.…
Abstract Number: 2133 • 2015 ACR/ARHP Annual Meeting
Receptor Protein Tyrosine Phosphatase Alpha Enhances Rheumatoid Synovial Fibroblast Signaling and Promotes Arthritis in Mice
Stephanie M. Stanford¹, Mattias N. D. Svensson¹, Cristiano Sacchetti¹, Caila A. Pilo¹, Dennis J. Wu¹, William B. Kiosses², Annelie Hellvard³, Brith Bergum³, German R. Aleman Muench¹, Christian Elly¹, Yun-Cai Liu¹, Jeroen den Hertog^4,5, Ari Elson⁶, Jan Sap⁷, Piotr Mydel³, David L. Boyle⁸, Maripat Corr⁸, Gary S. Firestein⁸ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁴Hubrecht Institute-Koninklijke Nederlands Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, Netherlands, ⁵Institute of Biology Leiden, Leiden, Netherlands, ⁶Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel, ⁷Epigenetics and Cell Fate, Université Paris Diderot Sorbonne Paris Cité, Paris, France, ⁸Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) promote disease pathogenesis by aggressively invading the joint extracellular matrix. The focal adhesion kinase (FAK) signaling pathway is…
Abstract Number: 2135 • 2015 ACR/ARHP Annual Meeting
miRNA-223 Delivery to Synovial Fibroblasts Via Monocyte-Derived Extracellular Vesicles Promotes Their Proliferation
Florian M.P. Meier¹, Derek S. Gilchrist¹, Derek Baxter², Diane Vaughan¹, Margaret Mullin³, David W. McCarey⁴, Pawel Herzyk⁵, Julie Galbraith⁵, Donna McIntyre¹, Russka Shumnalieva⁶, Ulf Müller-Ladner⁷, Iain B. McInnes⁸ and Mariola Kurowska-Stolarska¹, ¹Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Department of Rheumatology, University Hospital Ayr, Ayr, United Kingdom, ³School of Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁴Glasgow Royal Infirmary, Glasgow, United Kingdom, ⁵Polyomics Facility, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom, ⁶Department of Internal Medicine, Clinic of Rheumatology, Sofia, Bulgaria, ⁷Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁸Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Recently, it was shown that extracellular vesicles (EV) convey microRNAs (miR) from platelets to endothelial cells1and regulate recipient cell gene expression. Interaction of synovial…
Abstract Number: 2137 • 2015 ACR/ARHP Annual Meeting
Critical Role of Fibroblast-like Synoviocytes Glycolytic Metabolism in Rheumatoid Arthritis
Ricard Garcia-Carbonell¹, Ajit Divakaruni¹, Alessia Lodi², Ildefonso Vicente-Suarez³, Hilde Cheroutre⁴, Gerry Boss¹, Arindam Saha¹, Stefano Tiziani⁵, Anne Murphy⁶, Gary S. Firestein⁷ and Monica Guma⁶, ¹University of California, San Diego, La Jolla, CA, ²nutritional Sciences, University of Texas at Austin, Austin, TX, ³LIAI, La Jolla, CA, ⁴Autoimmune Research, LIAI, La Jolla, CA, ⁵Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁶Pharmacology, University of California, San Diego, La Jolla, CA, ⁷Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Glucose metabolism is altered not only in tumor cell growth but also in immune cells on activation. However, little is known about glucose metabolism…
Abstract Number: 12 • 2015 ACR/ARHP Annual Meeting
Delta-like 1 Enhances the Production of Pro-Inflammatory Mediators By Fibroblast-like Synoviocytes
Chiyoko Sekine, Department of Clinical Research Medicine, Teikyo University School of Medicine, Tokyo, Japan
Background/Purpose: Notch signaling is known to regulate cell fate decision and differentiation during embryonic and post-natal development. I have been reported that a Notch ligand…
Abstract Number: 2446 • 2015 ACR/ARHP Annual Meeting
Synovial Fluid Proteins Differentiate Patients with Oligoarticular Juvenile Idiopathic Arthritis Who Are Destined to Extend from Those Who Will Remain Persistent in Course
AnneMarie C. Brescia¹, Megan M. Simonds², Kathleen E. Sullivan³ and Carlos D. Rose⁴, ¹Pediatric Rheumatology, Nemours A.I. duPont Hospital for Children, Wilmington, DE, ²Nemours Research, Nemours/AI duPont Hospital for Children, Wilmington, DE, ³Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Pediatrics, Nemours A.I. duPont Hospital for Children, Division of Pediatric Rheumatology, Thomas Jefferson University, Wilmington, DE
Background/Purpose: Children with oligoarticular juvenile idiopathic arthritis (JIA) who have an extended course (recruitment of 5 or more joints after 6 months of disease) have…
Abstract Number: 21 • 2015 ACR/ARHP Annual Meeting
Pseudostarvation Using the AMPK Activator Metformin Downregulates Inflammation in Rheumatoid Arthritis Synovial Tissue
Lorna Gallagher¹, Ursula Fearon², Douglas J. Veale³, David Kane⁴, Luke A. O'Neill⁵ and Ronan Mullan⁴, ¹Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland, ²St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ³St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ⁴Department of Rheumatology, Tallaght Hospital, TCD, Dublin 24, Ireland, ⁵Inflammation Research, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
Background/Purpose: AMP-activated protein kinase (AMPK) is a highly conserved, regulator of cellular energy status. In inflammation, AMPK inactivation is associated with increased glucose consumption through…
Abstract Number: 2515 • 2015 ACR/ARHP Annual Meeting
MEK5/ERK5, a Lynchpin of Human Cardiac Fibroblast Transdifferentiation to a Scarring Phenotype in Autoimmune Congenital Heart Block
Andrew Markham¹, Robert Clancy², Mukundan Attur³ and Jill P. Buyon², ¹Medicine, New York University School of Medicine, New York, NY, ²Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Transplacental passage of maternal autoantibodies (Ab) reactive with the SSA/Ro-SSB/La ribonucleoprotein complex is associated with the development of cardiac injury in the fetus passively…
Abstract Number: 1166 • 2015 ACR/ARHP Annual Meeting
Expression and Function of Proviral Integration Site for Moloney Murine Leukemia Virus 1 (PIM-1) Kinase in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Yong Seok Choi¹, You Jung Ha², Jaehyung Hur³, Eun Ha Kang⁴, Yeong Wook Song⁵ and Yun Jong Lee², ¹Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ²Division of Rheumatology, Department of Internal Medicine,Seoul National University Bundang Hospital, Seongnam, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ⁴Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: The Proviral Integration site of Moloney murine leukemia virus (PIM) kinases are important mediators of cell survival and considered as attractive targets in cancer…
Abstract Number: 2549 • 2015 ACR/ARHP Annual Meeting
Characterizing the RPTPσ Mediated Proteoglycan Switch As a Target for Rheumatoid Arthritis Therapy
Karen M. Doody¹, Stephanie M. Stanford¹, Mattias N. D. Svensson¹, Cristiano Sacchetti¹, Gary S. Firestein², A. Radu Aricescu³ and Nunzio Bottini^1,4, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ³Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, ⁴Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA
Background/Purpose: RPTPσ (gene PTPRS) is a protein tyrosine phosphatase that binds heparan sulfate- and chondroitin sulfate-containing proteoglycans with its extracellular immunoglobulin domains 1 and…
Abstract Number: 1169 • 2015 ACR/ARHP Annual Meeting
Crossregulatory Mechanisms Between Synovial Fibroblasts and Macrophages Relevant in RA Pathogenesis
Jennifer Ding¹, Lionel B. Ivashkiv² and Laura T. Donlin¹, ¹Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ²Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Macrophages and synovial fibroblasts function as key drivers of inflammation in rheumatoid arthritis (RA). We have developed a co-culture system that aims to define…
Abstract Number: 2573 • 2015 ACR/ARHP Annual Meeting
Confirmatory Analysis of Methylome Signatures in Rheumatoid Arthritis Using an Independent Dataset
Rizi Ai¹, Deepa Hammaker², Wei Wang³ and Gary S. Firestein⁴, ¹University of California San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁴Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Epigenetics can contribute to the pathogenesis of rheumatoid arthritis (RA). A DNA methylation signature that distinguishes RA fibroblast-like synoviocytes (FLS) from osteoarthritis (OA) FLS…

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