Abstracts tagged "Fibroblasts"

Abstract Number: 1661 • 2016 ACR/ARHP Annual Meeting
Toll-like Receptor 4 Induced IL-20 and IL-24 Stimulate Osteoblast Mineralization and Are Increased in Spondyloarthritis
Tue Wenzel Kragstrup^1,2, Morten Nørgaard Andersen³, Berit Schiøttz-Christensen⁴, Anne Grethe Jurik⁵, Malene Hvid⁶ and Bent Deleuran¹, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Aarhus University, Aarhus, Denmark, ⁴Hospital Lillebaelt, Middelfart, Denmark, ⁵Aarhus University Hospital, Aarhus, Denmark, ⁶Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves activation of the innate immune system, inflammation and new bone formation. The innate immune system is activated through…
Abstract Number: 1671 • 2016 ACR/ARHP Annual Meeting
Pirfenidone Might Inhibit New Bone Formation in Spondyloarthritis: Proof of Concept Study Using Cell Culture Models
Julie Laustsen¹, Søren Lomholt¹, Pernille Andersen², Jens Kelsen³ and Tue Wenzel Kragstrup^1,4, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark, ³Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized…
Abstract Number: 1852 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Sirtuin 7 By Lung Fibroblasts from Patients with Scleroderma Contributes to Elevated Collagen Production
Anne E. Wyman^1,2, Zahid Noor¹, Nevins W. Todd^1,2, Irina G. Luzina^1,2 and Sergei P. Atamas^1,2, ¹University of Maryland School of Medicine, Baltimore, MD, ²Baltimore VA Medical Center, Baltimore, MD
Background/Purpose: Pulmonary fibrosis is a severe complication of systemic sclerosis (SSc). Changes in the expression levels of sirtuins (SIRTs), a family of NAD+-dependent histone deacetylases,…
Abstract Number: 1855 • 2016 ACR/ARHP Annual Meeting
Phosphodiesterase-5 Inhibitors Attenuate Fibrotic Phenotype and Restore Anti-Fibrotic Resopnses of Cutaneous Fibroblasts in Patients with Scleroderma
Vikas Agarwal¹, Mohit kumar Rai¹, Vinita Agrawal², Harshit Singh¹ and Saurabh Chaturvedi¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India
Background/Purpose: Scleroderma (SSc) is a chronic autoimmune disease, characterized by excessive fibrosis of skin and internal organs due to uncontrolled proliferation of fibroblasts and deposition…
Abstract Number: 1857 • 2016 ACR/ARHP Annual Meeting
A Novel Highly Selective 5-Hydroxytryptamine 2B (5-HT2B) Receptor Antagonist Ameliorating Fibrosis in Preclinical Models of Systemic Sclerosis
Christina Wenglén¹, Lars Pettersson², Helena Arozenius² and Gunilla Ekström¹, ¹R&D, AnaMar AB, Lund, Sweden, ²AnaMar AB, Lund, Sweden
Background/Purpose: Methods: Results: Conclusion: The results demonstrate that the 5-HT2B receptor antagonist AM1125 prevents pro-fibrotic events in human dermal fibroblasts and attenuates…
Abstract Number: 2071 • 2016 ACR/ARHP Annual Meeting
Expression of Neuraminidase 1 (NEU1) Is Upregulated in the Lungs of Scleroderma Patients with Pulmonary Fibrosis, and Gene Delivery of NEU1 to Mouse Lungs Elicits Accumulation of CD8+ Lymphocytes and Collagen
Irina G. Luzina^1,2, Anne E. Wyman^1,2, Virginia Lockatell², Zahid Noor², Nevins W. Todd^1,2, Simeon E. Goldblum^1,2 and Sergei P. Atamas^1,2, ¹Baltimore VA Medical Center, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: We and others have previously reported that pulmonary fibrosis in patients with scleroderma is accompanied by pulmonary accumulation of predominantly CD8+ T lymphocytes. Earlier…
Abstract Number: 2072 • 2016 ACR/ARHP Annual Meeting
Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells
Ryosuke Saigusa¹, Yoshihide Asano², Takuya Miyagawa², Megumi Hirabayashi², Kouki Nakamura¹, Shunsuke Miura³, Takashi Yamashita², Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama², Takashi Taniguchi¹, Ayumi Yoshizaki², Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity/inflammation, vasculopathy, and tissue fibrosis. Fli1 is a member of Ets family transcription…
Abstract Number: 2155 • 2016 ACR/ARHP Annual Meeting
Crosstalk Between IL-6 and TNF-Alpha Signaling Pathway in Rheumatoid Arthritis Synovial Fibroblasts
Alvaro Valin¹, Yolanda Ruano², Manuel J. Del Rey³, Carmen M. García-Herrero³, Eduardo Martín-Guerrero¹, Beatriz Bravo⁴, Juan D. Cañete⁵, José L. Rodríguez-Peralto² and Jose L. Pablos^3,6, ¹Grupo de Enfermedades Inflamatorias y Autoimmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Pathology Department, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ³Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Servicio de Traumatología y Cirugía Ortopédica, Hospital 12 de Octubre, Madrid, Spain, ⁵Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁶Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain
Background/Purpose: Although elevated IL-6 and its soluble receptor (sIL6R) have been found in the serum and synovium of arthritic patients, the molecular mechanisms by which…
Abstract Number: 2157 • 2016 ACR/ARHP Annual Meeting
Share the Fate: Fibroblast-like Synoviocyte Cell-to-Cell Organelle Transfer Is Directed By the Inflammatory Microenvironment
Ruth Byrne¹, Isabel Olmos Calvo², Thomas Karonitsch³, Felix Kartnig⁴, Johannes Holinka⁵, Günter Steiner⁶, Peter Ertl⁷, Josef Smolen⁸ and Hans Peter Kiener⁹, ¹Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Nanotechnology, Austrian Institute for Technology, Vienna, Austria, ³Internal Medicine III, Vienna Medical University, Vienna, Austria, ⁴Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁵Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, ⁶Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁷Vienna University of Technology, Vienna, Austria, ⁸Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁹Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Fibroblast-like synoviocytes (FLS) form a complex tissue network via long-distance intercellular connections with wide intercellular matrix spaces. The adaptive synovial tissue response to inflammation…
Abstract Number: 806 • 2016 ACR/ARHP Annual Meeting
Single Cell Rnaseq Defines a Unique Transcriptome Profile for Myofibroblasts in the Skin of Patients with Systemic Sclerosis
Robert A. Lafyatis¹, Lisa Rice², Giuseppina Stifano², Jeff Browning^2,3 and Robert W. Simms⁴, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Boston University School of Medicine, Boston, MA, ³Boston university, Cambridge, MA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: Fibrosis in systemic sclerosis (SSc), as well as a wide variety of other fibrotic diseases, is largely driven by myofibroblasts. Myofibroblasts are known to…
Abstract Number: 2556 • 2016 ACR/ARHP Annual Meeting
Deficient Expression of the Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Induces S Phase Arrest in RA Fibroblast-like Synoviocytes (FLS)
Shinji Matsuda¹, Deepa Hammaker², Steven Dowdy³, David L. Boyle⁴ and Gary Firestein⁵, ¹Medicine, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³UC San Diego School of Medicine, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁵Medicine, UCSD, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development) was recently identified as an RA risk gene that has abnormally methylated loci and a functional enhancer SNP in…
Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting
Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis
Roberta Goncalves Marangoni¹, Benjamin Korman², Feng Fang¹, Monique Hinchcliff¹, Laszlo Otvos³, Philipp E. Scherer⁴, Warren Tourtellotte⁵ and John Varga⁶, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Temple University, Philadelphia, PA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Department of Pathology, Ward, Northwestern University, Chicago, IL, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
Abstract Number: 2566 • 2016 ACR/ARHP Annual Meeting
Hexokinase 2 As a Novel Metabolic Target for Rheumatoid Arthritis
Marta Fernandez Bustamante¹, Ricard Garcia-Carbonell², Jeffrey Smith², Gary Firestein¹, Shigeki Miyamoto² and Monica Guma¹, ¹Medicine, UCSD, La Jolla, CA, ²Pharmacology, UCSD, La Jolla, CA
Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Up-regulated…
Abstract Number: 1010 • 2016 ACR/ARHP Annual Meeting
Elucidating the Activation Profile of Systemic Sclerosis Macrophages
Michael S. Ball¹, Emilie P. Shipman¹, Mohamed A. Eltanbouly¹, Viktor Martyanov², Kimberly A. Archambault³, Mary A. Carns⁴, Esperanza Arroyo⁴, Kathleen Aren⁴, Monique Hinchcliff⁵, Michael L. Whitfield^2,3 and Patricia A. Pioli¹, ¹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: Genome-wide gene expression studies implicate macrophages (MØs) as mediators of fibrosis in systemic sclerosis (SSc) and our data indicate that MØs constitute the dominant…
Abstract Number: 2926 • 2016 ACR/ARHP Annual Meeting
Rorc Positive Th17, Th17/Th1, and Th17.1 Cells from the Blood of Treatment NaïVe RA Patients Differ in IL-17A but Are All Pathogenic When Co-Cultured with RA Synovial Fibroblasts
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar², Wendy Dankers³, Patrick Asmawidjaja², Anne-Marie Otten-Mus² and Erik Lubberts², ¹Room Nb-84, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background/Purpose: T cells play a central role in the early stages of rheumatoid arthritis (RA). In this context, we have shown increased proportions of memory…

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