Abstracts tagged "Fibroblasts"

Abstract Number: 2155 • 2016 ACR/ARHP Annual Meeting
Crosstalk Between IL-6 and TNF-Alpha Signaling Pathway in Rheumatoid Arthritis Synovial Fibroblasts
Alvaro Valin¹, Yolanda Ruano², Manuel J. Del Rey³, Carmen M. García-Herrero³, Eduardo Martín-Guerrero¹, Beatriz Bravo⁴, Juan D. Cañete⁵, José L. Rodríguez-Peralto² and Jose L. Pablos^3,6, ¹Grupo de Enfermedades Inflamatorias y Autoimmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Pathology Department, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ³Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Servicio de Traumatología y Cirugía Ortopédica, Hospital 12 de Octubre, Madrid, Spain, ⁵Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁶Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain
Background/Purpose: Although elevated IL-6 and its soluble receptor (sIL6R) have been found in the serum and synovium of arthritic patients, the molecular mechanisms by which…
Abstract Number: 2157 • 2016 ACR/ARHP Annual Meeting
Share the Fate: Fibroblast-like Synoviocyte Cell-to-Cell Organelle Transfer Is Directed By the Inflammatory Microenvironment
Ruth Byrne¹, Isabel Olmos Calvo², Thomas Karonitsch³, Felix Kartnig⁴, Johannes Holinka⁵, Günter Steiner⁶, Peter Ertl⁷, Josef Smolen⁸ and Hans Peter Kiener⁹, ¹Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Nanotechnology, Austrian Institute for Technology, Vienna, Austria, ³Internal Medicine III, Vienna Medical University, Vienna, Austria, ⁴Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁵Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, ⁶Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁷Vienna University of Technology, Vienna, Austria, ⁸Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁹Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Fibroblast-like synoviocytes (FLS) form a complex tissue network via long-distance intercellular connections with wide intercellular matrix spaces. The adaptive synovial tissue response to inflammation…
Abstract Number: 806 • 2016 ACR/ARHP Annual Meeting
Single Cell Rnaseq Defines a Unique Transcriptome Profile for Myofibroblasts in the Skin of Patients with Systemic Sclerosis
Robert A. Lafyatis¹, Lisa Rice², Giuseppina Stifano², Jeff Browning^2,3 and Robert W. Simms⁴, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Boston University School of Medicine, Boston, MA, ³Boston university, Cambridge, MA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: Fibrosis in systemic sclerosis (SSc), as well as a wide variety of other fibrotic diseases, is largely driven by myofibroblasts. Myofibroblasts are known to…
Abstract Number: 2556 • 2016 ACR/ARHP Annual Meeting
Deficient Expression of the Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Induces S Phase Arrest in RA Fibroblast-like Synoviocytes (FLS)
Shinji Matsuda¹, Deepa Hammaker², Steven Dowdy³, David L. Boyle⁴ and Gary Firestein⁵, ¹Medicine, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³UC San Diego School of Medicine, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁵Medicine, UCSD, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development) was recently identified as an RA risk gene that has abnormally methylated loci and a functional enhancer SNP in…
Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting
Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis
Roberta Goncalves Marangoni¹, Benjamin Korman², Feng Fang¹, Monique Hinchcliff¹, Laszlo Otvos³, Philipp E. Scherer⁴, Warren Tourtellotte⁵ and John Varga⁶, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Temple University, Philadelphia, PA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Department of Pathology, Ward, Northwestern University, Chicago, IL, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
Abstract Number: 2566 • 2016 ACR/ARHP Annual Meeting
Hexokinase 2 As a Novel Metabolic Target for Rheumatoid Arthritis
Marta Fernandez Bustamante¹, Ricard Garcia-Carbonell², Jeffrey Smith², Gary Firestein¹, Shigeki Miyamoto² and Monica Guma¹, ¹Medicine, UCSD, La Jolla, CA, ²Pharmacology, UCSD, La Jolla, CA
Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Up-regulated…
Abstract Number: 1010 • 2016 ACR/ARHP Annual Meeting
Elucidating the Activation Profile of Systemic Sclerosis Macrophages
Michael S. Ball¹, Emilie P. Shipman¹, Mohamed A. Eltanbouly¹, Viktor Martyanov², Kimberly A. Archambault³, Mary A. Carns⁴, Esperanza Arroyo⁴, Kathleen Aren⁴, Monique Hinchcliff⁵, Michael L. Whitfield^2,3 and Patricia A. Pioli¹, ¹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: Genome-wide gene expression studies implicate macrophages (MØs) as mediators of fibrosis in systemic sclerosis (SSc) and our data indicate that MØs constitute the dominant…
Abstract Number: 2926 • 2016 ACR/ARHP Annual Meeting
Rorc Positive Th17, Th17/Th1, and Th17.1 Cells from the Blood of Treatment NaïVe RA Patients Differ in IL-17A but Are All Pathogenic When Co-Cultured with RA Synovial Fibroblasts
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar², Wendy Dankers³, Patrick Asmawidjaja², Anne-Marie Otten-Mus² and Erik Lubberts², ¹Room Nb-84, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background/Purpose: T cells play a central role in the early stages of rheumatoid arthritis (RA). In this context, we have shown increased proportions of memory…
Abstract Number: 1131 • 2016 ACR/ARHP Annual Meeting
Regulation of Rheumatoid Arthritis Synovial Fibroblast Cytokine Production By Inhibitor of DNA Binding-1 Via Crispr/Cas9 Transfection
Ray A. Ohara¹, Gautam Edhayan¹, Thomas L. Saunders², Thomas M. Lanigan³, Rachel Morgan¹, W. Alexander Stinson⁴, Phillip L. Campbell⁵, Jerry Graham⁴, David A. Fox⁵ and Jeffrey H. Ruth⁵, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI, ³Vector Core, University of Michigan Medical School, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA binding-1 (Id1) is a nuclear protein actively transcribed in endothelial progenitor cells (EPCs) and synovial fibroblasts. We previously identified Id1 as…
Abstract Number: 3146 • 2016 ACR/ARHP Annual Meeting
Selective Deletion of a Pathogenic Subset Synovial Fibroblasts Attenuates Synovial Inflammation
Adam Paul Croft, Joana Campos, Andrew Filer, Francesca Barone and Chris Buckley, Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Despite their role as key effector cells driving synovial inflammation and joint damage, fibroblast like synoviocytes (FLS) have yet to be targeted therapeutically. Fibroblast…
Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting
KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Mark Tanner¹, Redwan Huq¹, Rajeev Tajhya¹, Michael Pennington², Teresina Laragione³, Pércio Gulko⁴ and Christine Beeton⁵, ¹Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, ²Peptides International, Louisville, KY, ³Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
Abstract Number: 3178 • 2016 ACR/ARHP Annual Meeting
Heart Dysfunction in Systemic Sclerosis: Involvement of a Novel Fibrogenic Stromal Cell Subset
Mara Stellato¹, Michal Rudnik¹, Florian Renoux², Elena Pachera¹, Karl Sotlar³, Karin Klingel⁴, Joerg C. Henes⁵, Przemyslaw Blyszczuk⁶, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁴Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁶Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland
Background/Purpose: Cardiac dysfunction is a significant cause of the high mortality in systemic sclerosis (SSc). Heart involvement in SSc patients resembles inflammatory dilated cardiomyopathy (iDCM)…
Abstract Number: 1558 • 2016 ACR/ARHP Annual Meeting
Lower Expression of a Novel Cytoplasmic Long Noncoding RNA NR_122076 Contributes to Proliferation, Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis
Yaoyao Zou, Siqi Xu, Qian Qiu, Shan Zeng, Maohua Shi, Youjun Xiao, Mingcheng Huang and Hanshi Xu, Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Guangzhou, China
Background/Purpose: Emerging evidence indicates that long noncoding RNAs (lncRNAs) play critical regulatory roles in various human diseases, especially in cancers and inflammatory disorders. However, the…
Abstract Number: 3215 • 2016 ACR/ARHP Annual Meeting
ASK1 Is Regulated By IL-1β and TNF and Modulates Key Rheumatoid Arthritis (RA) Fibroblast-like Synoviocyte Functions (FLS)
Gyrid Nygaard¹, Deepa Hammaker², David L. Boyle³, Astrid Clarke⁴, Li Li⁵, Julie Dipaolo⁶ and Gary Firestein⁷, ¹Medicine, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁴GIlead, South San Francisco, CA, ⁵Gilead Sciences, South San Francisco, CA, ⁶Gilead, South San Francisco, CA, ⁷Medicine, UCSD, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) possess a unique aggressive phenotype characterized by increased cell growth, cytokine production and invasion. Previous unsuccessful attempts to target the…
Abstract Number: 1564 • 2016 ACR/ARHP Annual Meeting
The Comprehensive Analysis for the Transcriptional Organization of Stimuli Responses in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients
Haruka Tsuchiya¹, Shuji Sumitomo¹, Kazuyoshi Ishigaki², Akari Suzuki², Yuta Kochi², Mineto Ota¹, Yumi Tsuchida¹, Hiroshi Inui³, Shuji Taketomi³, Yuho Kadono⁴, Sakae Tanaka³, Keishi Fujio¹ and Kazuhiko Yamamoto^1,2, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ³Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ⁴Department of Orthopaedic Surgery, Graduate School of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Fibroblast-like synoviocyte (FLS) is expected to be a novel therapeutic target for rheumatoid arthritis (RA) because of their contribution to pathogenesis. FLS expresses…

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