ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts"

  • Abstract Number: 1131 • 2016 ACR/ARHP Annual Meeting

    Regulation of Rheumatoid Arthritis Synovial Fibroblast Cytokine Production By Inhibitor of DNA Binding-1 Via Crispr/Cas9 Transfection

    Ray A. Ohara1, Gautam Edhayan1, Thomas L. Saunders2, Thomas M. Lanigan3, Rachel Morgan1, W. Alexander Stinson4, Phillip L. Campbell5, Jerry Graham4, David A. Fox5 and Jeffrey H. Ruth5, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI, 3Vector Core, University of Michigan Medical School, Ann Arbor, MI, 4Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 5Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Inhibitor of DNA binding-1 (Id1) is a nuclear protein actively transcribed in endothelial progenitor cells (EPCs) and synovial fibroblasts. We previously identified Id1 as…
  • Abstract Number: 3146 • 2016 ACR/ARHP Annual Meeting

    Selective Deletion of a Pathogenic Subset Synovial Fibroblasts Attenuates Synovial Inflammation

    Adam Paul Croft, Joana Campos, Andrew Filer, Francesca Barone and Chris Buckley, Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom

    Background/Purpose:  Despite their role as key effector cells driving synovial inflammation and joint damage, fibroblast like synoviocytes (FLS) have yet to be targeted therapeutically. Fibroblast…
  • Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting

    KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis

    Mark Tanner1, Redwan Huq1, Rajeev Tajhya1, Michael Pennington2, Teresina Laragione3, Pércio Gulko4 and Christine Beeton5, 1Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, 2Peptides International, Louisville, KY, 3Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX

    Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
  • Abstract Number: 3178 • 2016 ACR/ARHP Annual Meeting

    Heart Dysfunction in Systemic Sclerosis: Involvement of a Novel Fibrogenic Stromal Cell Subset

    Mara Stellato1, Michal Rudnik1, Florian Renoux2, Elena Pachera1, Karl Sotlar3, Karin Klingel4, Joerg C. Henes5, Przemyslaw Blyszczuk6, Oliver Distler1 and Gabriela Kania1, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, 3Institute of Pathology, Ludwig Maximilians University, Munich, Germany, 4Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, 5Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, 6Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland

    Background/Purpose: Cardiac dysfunction is a significant cause of the high mortality in systemic sclerosis (SSc). Heart involvement in SSc patients resembles inflammatory dilated cardiomyopathy (iDCM)…
  • Abstract Number: 1558 • 2016 ACR/ARHP Annual Meeting

    Lower Expression of a Novel Cytoplasmic Long Noncoding RNA NR_122076 Contributes to Proliferation, Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis

    Yaoyao Zou, Siqi Xu, Qian Qiu, Shan Zeng, Maohua Shi, Youjun Xiao, Mingcheng Huang and Hanshi Xu, Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Guangzhou, China

    Background/Purpose:  Emerging evidence indicates that long noncoding RNAs (lncRNAs) play critical regulatory roles in various human diseases, especially in cancers and inflammatory disorders. However, the…
  • Abstract Number: 3215 • 2016 ACR/ARHP Annual Meeting

    ASK1 Is Regulated By IL-1β and TNF and Modulates Key Rheumatoid Arthritis (RA) Fibroblast-like Synoviocyte Functions (FLS)

    Gyrid Nygaard1, Deepa Hammaker2, David L. Boyle3, Astrid Clarke4, Li Li5, Julie Dipaolo6 and Gary Firestein7, 1Medicine, UC San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 3Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, 4GIlead, South San Francisco, CA, 5Gilead Sciences, South San Francisco, CA, 6Gilead, South San Francisco, CA, 7Medicine, UCSD, La Jolla, CA

    Background/Purpose: RA fibroblast-like synoviocytes (FLS) possess a unique aggressive phenotype characterized by increased cell growth, cytokine production and invasion. Previous unsuccessful attempts to target the…
  • Abstract Number: 1564 • 2016 ACR/ARHP Annual Meeting

    The Comprehensive Analysis for the Transcriptional Organization of Stimuli Responses in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients

    Haruka Tsuchiya1, Shuji Sumitomo1, Kazuyoshi Ishigaki2, Akari Suzuki2, Yuta Kochi2, Mineto Ota1, Yumi Tsuchida1, Hiroshi Inui3, Shuji Taketomi3, Yuho Kadono4, Sakae Tanaka3, Keishi Fujio1 and Kazuhiko Yamamoto1,2, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 3Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4Department of Orthopaedic Surgery, Graduate School of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose:   Fibroblast-like synoviocyte (FLS) is expected to be a novel therapeutic target for rheumatoid arthritis (RA) because of their contribution to pathogenesis. FLS expresses…
  • Abstract Number: 1661 • 2016 ACR/ARHP Annual Meeting

    Toll-like Receptor 4 Induced IL-20 and IL-24 Stimulate Osteoblast Mineralization and Are Increased in Spondyloarthritis

    Tue Wenzel Kragstrup1,2, Morten Nørgaard Andersen3, Berit Schiøttz-Christensen4, Anne Grethe Jurik5, Malene Hvid6 and Bent Deleuran1, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Aarhus University, Aarhus, Denmark, 4Hospital Lillebaelt, Middelfart, Denmark, 5Aarhus University Hospital, Aarhus, Denmark, 6Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

    Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves activation of the innate immune system, inflammation and new bone formation. The innate immune system is activated through…
  • Abstract Number: 1671 • 2016 ACR/ARHP Annual Meeting

    Pirfenidone Might Inhibit New Bone Formation in Spondyloarthritis: Proof of Concept Study Using Cell Culture Models

    Julie Laustsen1, Søren Lomholt1, Pernille Andersen2, Jens Kelsen3 and Tue Wenzel Kragstrup1,4, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark, 3Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark, 4Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose:  The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized…
  • Abstract Number: 1852 • 2016 ACR/ARHP Annual Meeting

    Decreased Expression of Sirtuin 7 By Lung Fibroblasts from Patients with Scleroderma Contributes to Elevated Collagen Production

    Anne E. Wyman1,2, Zahid Noor1, Nevins W. Todd1,2, Irina G. Luzina1,2 and Sergei P. Atamas1,2, 1University of Maryland School of Medicine, Baltimore, MD, 2Baltimore VA Medical Center, Baltimore, MD

    Background/Purpose:  Pulmonary fibrosis is a severe complication of systemic sclerosis (SSc). Changes in the expression levels of sirtuins (SIRTs), a family of NAD+-dependent histone deacetylases,…
  • Abstract Number: 1855 • 2016 ACR/ARHP Annual Meeting

    Phosphodiesterase-5 Inhibitors Attenuate Fibrotic Phenotype and Restore Anti-Fibrotic Resopnses of Cutaneous Fibroblasts in Patients with Scleroderma

    Vikas Agarwal1, Mohit kumar Rai1, Vinita Agrawal2, Harshit Singh1 and Saurabh Chaturvedi1, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India

    Background/Purpose:  Scleroderma (SSc) is a chronic autoimmune disease, characterized by excessive fibrosis of skin and internal organs due to uncontrolled proliferation of fibroblasts and deposition…
  • Abstract Number: 1857 • 2016 ACR/ARHP Annual Meeting

    A Novel Highly Selective 5-Hydroxytryptamine 2B (5-HT2B) Receptor Antagonist Ameliorating Fibrosis in Preclinical Models of Systemic Sclerosis

    Christina Wenglén1, Lars Pettersson2, Helena Arozenius2 and Gunilla Ekström1, 1R&D, AnaMar AB, Lund, Sweden, 2AnaMar AB, Lund, Sweden

    Background/Purpose:   Methods:   Results:   Conclusion: The results demonstrate that the 5-HT2B receptor antagonist AM1125 prevents pro-fibrotic events in human dermal fibroblasts and attenuates…
  • Abstract Number: 2071 • 2016 ACR/ARHP Annual Meeting

    Expression of Neuraminidase 1 (NEU1) Is Upregulated in the Lungs of Scleroderma Patients with Pulmonary Fibrosis, and Gene Delivery of NEU1 to Mouse Lungs Elicits Accumulation of CD8+ Lymphocytes and Collagen

    Irina G. Luzina1,2, Anne E. Wyman1,2, Virginia Lockatell2, Zahid Noor2, Nevins W. Todd1,2, Simeon E. Goldblum1,2 and Sergei P. Atamas1,2, 1Baltimore VA Medical Center, Baltimore, MD, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose:  We and others have previously reported that pulmonary fibrosis in patients with scleroderma is accompanied by pulmonary accumulation of predominantly CD8+ T lymphocytes. Earlier…
  • Abstract Number: 2072 • 2016 ACR/ARHP Annual Meeting

    Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells

    Ryosuke Saigusa1, Yoshihide Asano2, Takuya Miyagawa2, Megumi Hirabayashi2, Kouki Nakamura1, Shunsuke Miura3, Takashi Yamashita2, Yohei Ichimura1, Takehiro Takahashi1, Tetsuo Toyama2, Takashi Taniguchi1, Ayumi Yoshizaki2, Maria Trojanowska4 and Shinichi Sato1, 1Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 3University of Tokyo Graduate School of Medicine, Tokyo, Japan, 4Arthritis Center, Boston University, Arthritis Center, Boston, MA

    Background/Purpose:  Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity/inflammation, vasculopathy, and tissue fibrosis. Fli1 is a member of Ets family transcription…
  • Abstract Number: 2155 • 2016 ACR/ARHP Annual Meeting

    Crosstalk Between IL-6 and TNF-Alpha Signaling Pathway in Rheumatoid Arthritis Synovial Fibroblasts

    Alvaro Valin1, Yolanda Ruano2, Manuel J. Del Rey3, Carmen M. García-Herrero3, Eduardo Martín-Guerrero1, Beatriz Bravo4, Juan D. Cañete5, José L. Rodríguez-Peralto2 and Jose L. Pablos3,6, 1Grupo de Enfermedades Inflamatorias y Autoimmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 2Pathology Department, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 3Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 4Servicio de Traumatología y Cirugía Ortopédica, Hospital 12 de Octubre, Madrid, Spain, 5Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, 6Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain

    Background/Purpose:  Although elevated IL-6 and its soluble receptor (sIL6R) have been found in the serum and synovium of arthritic patients, the molecular mechanisms by which…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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