ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts, Synovial"

  • Abstract Number: 1006 • ACR Convergence 2021

    MAA Modified and/or Citrullinated Proteins Stimulate Macrophages and Human Fibroblast-Like Synoviocytes to Increase the Secretion/Expression of Fractalkine Ligand (CX3CL1) and Fractalkine Receptor (CX3CR1)

    Nozima Aripova, Michael Duryee, Peter Maloley, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: In rheumatoid arthritis (RA) synovium, activated synovial fibroblasts and macrophages release inflammatory mediators that affect surrounding cells and accelerate disease progression. One such chemokine…
  • Abstract Number: 0013 • ACR Convergence 2021

    Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts

    Tadashi Hosoya1, Tetsuya Saito2, Hiroyuki Baba2, Nao Tanaka2, Seiji Noda2, Yoji Komiya2, Yasuhiro tagawa2, Akio Yamamoto2 and Shinsuke Yasuda2, 1Tokyo Medical and Dental University(TMDU), Tokyo, Japan, 2Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: Although current inflammation-targeted therapy improved the outcome of patients with rheumatoid arthritis (RA), the achievement of complete disease remission was still challenging. Since synovial…
  • Abstract Number: 1012 • ACR Convergence 2021

    Altered T Cell Responses, and Synergistic Regulation of Synovial Fibroblasts Function in Children with Down’s Syndrome-Associated Arthritis

    Serena Foo1, Achilleas Floudas2, Aisling O' Brien1, Sharon Ansboro1, Ronan Mullan3, Douglas Veale4, Emma MacDermott5, Derek Deely6, Charlene Foley6, Orla Killeen6 and Ursula Fearon1, 1Trinity College Dublin, Dublin, Ireland, 2Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, 3Tallaght University Hospital, Dublin, Ireland, 4University College Dublin, Dublin, Ireland, 5Children’s Health Ireland (CHI) at Crumlin, Dublin, Ireland, 6Children's Health Ireland, Crumlin, Dublin, Ireland

    Background/Purpose: Juvenile idiopathic arthritis (JIA) was thought to be the most common inflammatory arthritis in children. However an aggressive, erosive arthritis of little-known immunologic mechanism…
  • Abstract Number: 0018 • ACR Convergence 2021

    Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior

    Cecilia Ansalone1, Gyrid Nygaard1, Richard Ainsworth1, Rizi Ai1, Deepa Hammaker1, Narayanan Perumal2, Ken Weichert2, Frances Tung2, Lalitha Kodandapani2, Michael Sauder2, Elisabeth Mertsching2, Robert Benschop3, Wei Wang1, David Boyle1 and Gary Firestein1, 1University of California San Diego, San Diego, CA, 2Eli Lilly and Company, San Diego, CA, 3Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) display an aggressive phenotype, including abnormal migration and invasion. Using data from our previous studies defining the epigenetic…
  • Abstract Number: 1092 • ACR Convergence 2021

    Altered Metabolic Pathways in Synovial Fibroblasts of Individuals at Risk of Developing Rheumatoid Arthritis

    Tineke de Jong1, Simone Denis1, Paul Tak2, Riekelt Houtkooper1 and Lisa van Baarsen1, 1Amsterdam UMC, Amsterdam, Netherlands, 2Candel Therapeutics, Cambridge, United Kingdom

    Background/Purpose: Cellular metabolism has been studied in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) and osteoarthritis (OA) patients and raises the question whether observed metabolic…
  • Abstract Number: 0020 • ACR Convergence 2021

    Citrullination Drives the Expression of Pro-fibrotic Genes in Rheumatoid Arthritis Fibroblast-like Cells

    Peter Maloley, Evan Ryan, Nozima Aripova, Michael Duryee, Bryant England, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The pathophysiology of rheumatoid arthritis (RA) is hallmarked by joint inflammation, thickening of the pannus, and resultant joint destruction. Within the synovial tissue, citrullinated…
  • Abstract Number: 1249 • ACR Convergence 2021

    In Rheumatoid Arthritis, Inhibition of the Lactate Monocarboxylate Transporters-1, and -4 in Pathological Fibroblast-Like Synoviocytes Led to Decreased ChemokineProduction

    Morten Aagaard Nielsen1, Maithri Aspari2, Klaus Frommer3, Malene Hvid2, Tue Kragstrup2 and Bent Deleuran2, 1Aarhus University / Aarhus University Hopital, Aarhus, Denmark, 2Aarhus University, Aarhus, Denmark, 3Justus-Liebig-University Giessen, Bad Nauheim, Germany

    Background/Purpose: Pathological subsets of fibroblast-like synoviocytes (FLS) have recently been identified as key players in the aggravation of both persistent joint inflammation and destruction in…
  • Abstract Number: 0024 • ACR Convergence 2021

    Heterogeneity of Inflammatory HLA-DR+ Synovial Fibroblasts in Rheumatoid Arthritis Is Driven by Responses to Leukocyte-Derived Cytokines

    Melanie Smith1, Alejandro Kochen1, Vianne Gao2, Michail Schizas2, Edward DiCarlo1, Susan Goodman1, Christina Leslie3, Laura Donlin1 and Alexander Rudensky4, 1Hospital for Special Surgery, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center, New York, NY, 4Memorial Sloan Kettering Cancer Center / Howard Hughes Medical Institute, New York, NY

    Background/Purpose: Treatment-refractory rheumatoid arthritis (RA) represents a major unmet need with substantial societal burden. Targeting RA-associated fibroblast-like synoviocytes (FLS) may provide a less-immunosuppressive therapeutic option.…
  • Abstract Number: 1476 • ACR Convergence 2021

    Metabolic Reprogramming: Inhibiting Osteoarthritis-induced Expression of the Pyruvate Dehydrogenase Kinase Preserves Mitochondrial Respiration

    Alexandra Damerau1, Marieluise Kirchner2, Moritz Pfeiffenberger1, Duc Ha Do Nguyen1, Yannick Palmowski1, Benjamin Bartek1, Tazio Maleitzke1, Sebastian Hardt1, Tobias Winkler1, Frank Buttgereit3 and Timo Gaber1, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2Berlin Institute of Health and Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany, 3Charité – Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: Osteoarthritis (OA) is the most common degenerative joint disease worldwide, traditionally classified as non-inflammatory. Recently, attention has been drawn to the importance of synovitis…
  • Abstract Number: 0026 • ACR Convergence 2021

    Synovial Fibroblasts Acquire a Proinflammatory and Destructive Phenotype After Exposure to αS1-Casein (CSN1S1)

    Nadine Honke1, Tim Appel1, Matthias Schneider2 and Georg Pongratz3, 1Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Germany (* contributed equally), Düsseldorf, Germany, 2Policlinic & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany, 3Polyclinic and Functional Area for Rheumatology & Hiller Research Center Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany

    Background/Purpose: The milk protein αS1-Casein (CSN1S1) was described to be overexpressed in synovial tissue of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Recently we…
  • Abstract Number: 1927 • ACR Convergence 2021

    Heterogeneity of Juvenile Idiopathic Arthritis Synovial Fibroblasts Correlates to Disease Progression and Provides Compelling Diagnostic Data

    Megan Simonds1, Kathleen Sullivan2, Carlos Rose3 and AnneMarie Brescia4, 1Nemours, Wilmington, DE, 2The Children's Hospital of Philadelphia, Philadelphia, PA, 3Thomas Jefferson University/duPont Hospital for Children, Wilmington, DE, 4Nemours/A.I.duPont Hospital for Children, Wilmington, DE

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by…
  • Abstract Number: 0035 • ACR Convergence 2021

    Bromodomain Protein-regulated Stress Response in Rheumatoid Arthritis Synovial Fibroblasts

    Tanja Seifritz1, Thomas Züllig1, Larissa Moser1, Oliver Distler2, Caroline Ospelt1 and Kerstin Klein3, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland, 3Department of Rheumatology and Immunology, University Hospital Bern, Bern, Switzerland

    Background/Purpose: Hypoxia and subsequent oxidative stress are early events in the RA joint and contribute to the activation of synovial fibroblasts (SF). Small molecule inhibitors…
  • Abstract Number: 0041 • ACR Convergence 2021

    Vascularized ‘Synovium-on-a-Chip’ – A Novel and Adaptable Model for Dissecting Inflammatory Biology Underlying Rheumatoid Arthritis

    Theresa Wampler Muskardin1, Chao Ma2, Benteng Ma2, Kayla Van Buren3, Timothy Niewold4 and Weiqiang Chen2, 1Colton Center for Autoimmunity, NYU School of Medicine, New York, NY, 2New York University, New York, NY, 3Mnemo Therapeutics, New York, NY, 4Colton Center for Autoimmunity NYU School of Medicine, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common multisystem inflammatory condition, affecting approximately 1% of the world population. The mechanisms underlying RA are still incompletely defined…
  • Abstract Number: 0458 • ACR Convergence 2021

    Single Cell Profiling Reveals a Wnt-mediated Transcriptional Gradient That Drives Inflammation in Rheumatoid Arthritis Synovial Fibroblast Pathology

    Alisa Mueller1, Angela Zou1, Emily Taylor2, Triin Major2, David Gardner3, Adam Croft4, Roche Fibroblast Network Consortium5, Andrew Filer2, Christopher Buckley6, Kevin Wei1, Ilya Korsunsky1, Soumya Raychaudhuri1 and Michael Brenner7, 1Brigham and Women's Hospital, Boston, MA, 2University of Birmingham, Birmingham, United Kingdom, 3University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom, 4University of Birmingham, Halesowen, United Kingdom, 5Roche Innovation Center Basel, Basel, Switzerland, 6University of Oxford, Oxford, United Kingdom, 7Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: Synovial fibroblasts are key inflammatory aggressors in rheumatoid arthritis (RA) that mediate cartilage and bone destruction, yet therapies directly targeting these cells are lacking.…
  • Abstract Number: 0508 • ACR Convergence 2021

    The Impact of Macrophages Stimulated with Malondialdehyde-Acetaldehyde And/or Citrulline Modified Proteins on Fibroblasts Activation

    Nozima Aripova, Michael Duryee, Evan Ryan, Peter Maloley, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: In rheumatoid arthritis (RA), chronic synovial inflammation is accompanied by fibrotic responses that together lead to pannus formation and progressive joint damage. Exposure to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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